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1. Adiposity impacts Cognitive Function in Asian populations: an Epidemiological and Mendelian Randomization study.

Author

Mina, Theresia, Weng, Yew Yik, Kiat, Ng Hong, Sadhu, Nilanjana, Wansaicheong, Gervais, Dalan, Rinkoo, Yan Wen, Dorrain Low, Chih Chiang, Benjamin Lam, Riboli, Elio, Sing, Lee Eng, Ngeow, Joanne, Elliott, Paul, Griva, Konstadina, Loh, Marie, Lee, Jimmy, and Chambers, John

Abstract

Obesity and related metabolic disturbances including diabetes, hypertension and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both obesity and metabolic disease, potentially amplifying the future burden of dementia in the region. We aimed to investigate the impact of adiposity and metabolic risk on cognitive function in Asian populations, using an epidemiological analysis and a two-sample Mendelian Randomization (MR) study.

Published
2023
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