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The incidence of digestive malignancies has increased in recent years, including colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pancreatic cancer. Advanced stages of these cancers are prone to metastasis, which seriously reduce the standard of living of patients and lead to decline in the survival rate of patients. So far there are no good specific drugs to stop this phenomenon. It is very important and urgent to find new biomarkers and therapeutic targets. Purinergic ligand-gated ion channel 7 receptor (P2X7R) is ATP-gated and nonselective ion channel receptor involved in many inflammatory processes and cancer progression. P2X7R is present in many cancer cells and promotes or inhibits cancer development through signal transduction. Studies have presented that P2X7R plays a role in the proliferation and migration of digestive system cancers, such as CRC, HCC and pancreatic cancer. Therefore, P2X7R may serve as a biomarker or therapeutic target for digestive system cancers. This paper describes the structure and function of P2X7R, and mainly reviews the research progress on the role of P2X7R in CRC, HCC and pancreatic cancer.

The toxicity of lead ions has become the severe challenge for the all-inorganic lead halide perovskite materials, although some works have reported the lead-free perovskite nanocrystals (NCs), the photoluminescence quantum yield (PLQY) of these materials is still unsatisfactory. Meanwhile, because the halogen ions can be easily exchanged, the controllable multicolor emission in perovskite NCs is difficult to realize in current reports. In this work, we introduced lanthanide ions into lead-free Cs3Sb2Cl9perovskite NCs. Benefitting from the energy transfer between Cs3Sb2Cl9perovskite NC host and lanthanide ions, the multicolor emission was realized. Based on controlling the doping concentration of Tb3+and Eu3+ions, the white light emission under UV excitation would be turned easily in the Tb3+/Eu3+codoped NCs. In addition, efficient energy transfer from perovskite NCs to Tb3+or Eu3+ions is beneficial to improving the optical properties of lead-free perovskite NCs, resulting in maximum PLQYs of red, green and white light emission of 22.6%, 19.7% and 28.5%, respectively. Finally, a white light emitting device (WLED) was fabricated with a power efficiency of 18.5 lm/W, which presents the Commission Internationale de l’Eclairage (CIE) of (0.33, 0.35).

Rapid and accurate detection of the zoonotic nematode Anisakis is poised to control its epidemic. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas-associated assay shows great potential in the detection of pathogenic microorganisms. The one-tube method integrated the CRISPR system with the recombinase polymerase amplification (RPA) system to avoid the risk of aerosol pollution; however, it suffers from low sensitivity due to the incompatibility of the two systems and additional manual operations. Therefore, in the present study, the agarose hydrogel boosted one-tube RPA-CRISPR/Cas12a assay was constructed by adding the CRISPR system to the agarose hydrogel, which avoided the initially low amplification efficiency of RPA caused by the cleavage of Cas12a and achieved reaction continuity. The sensitivity was 10-fold higher than that of the one-tube RPA-CRISPR/Cas12a system. This method was used for Anisakis detection within 80 min from the sample to result, achieving point-of-care testing (POCT) through a smartphone and a portable device. This study provided a novel toolbox for POCT with significant application value in preventing Anisakis infection.

This study aimed to investigate the dose-effect of iron on growth performance, antioxidant function, intestinal morphology, and mRNA expression of jejunal tight junction protein in 1- to 21-d-old yellow-feathered broilers. A total of 720 1-d-old yellow-feathered male broilers were allocated to 9 treatments with 8 replicate cages of 10 birds per cage. The dietary treatments were consisted of a basal diet (contained 79.6 mg Fe kg–1) supplemented with 0, 20, 40, 60, 80, 160, 320, 640, and 1,280 mg Fe kg–1in the form of FeSO4·7H2O. Compared with the birds in the control group, birds supplemented with 20 mg Fe kg–1had higher average daily gain (ADG) (P<0.0001). Adding 640 and 1,280 mg Fe kg–1significantly decreased ADG (P<0.0001) and average daily feed intake (ADFI) (P<0.0001) compared with supplementation of 20 mg Fe kg–1. Malondialdehyde (MDA) concentration in plasma and duodenum increased linearly (P<0.0001), but MDA concentration in liver and jejunum increased linearly (P<0.05) or quadratically (P<0.05) with increased dietary Fe concentration. The villus height (VH) in duodenum and jejunum, and the ratio of villus height to crypt depth (V/C) in duodenum decreased linearly (P˂0.05) as dietary Fe increased. As dietary Fe increased, the jejunal relative mRNA abundance of claudin-1decreased linearly (P=0.001), but the jejunal relative mRNA abundance of zona occludens-1 (ZO-1) and occludindecreased linearly (P˂0.05) or quadratically (P˂0.05). Compared with the supplementation of 20 mg Fe kg–1, the supplementation of 640 mg Fe kg–1or higher increased (P˂0.05) MDA concentrations in plasma, duodenum, and jejunum, decreased VH in the duodenum and jejunum, and the addition of 1,280 mg Fe kg–1reduced (P˂0.05) the jejunal tight junction protein (claudin-1, ZO-1, occludin) mRNA abundance. In summary, 640 mg of supplemental Fe kg–1or greater was associated with decreased growth performance, increased oxidative stress, disrupted intestinal morphology, and reduced mRNA expression of jejunal tight junction protein.

The autonomic nervous system dysfunction has been reported in up to 76% of stroke patients 7 days after an acute stroke. Heart rate variability (HRV) is one of the important indicators reflecting the balance of sympathetic and parasympathetic nerves. Therefore, we performed a systematic literature review of existing literature on the association between heart rate variability and the different types of stroke. We included studies published in the last 32 years (1990 to 2022). The electronic databases MEDLINE and PubMed were searched. We selected the research that met the inclusion or exclusion criteria. A narrative synthesis was performed. This review aimed to summarize evidence regarding the potential mechanism of heart rate variability among patients after stroke. In addition, the association of clinical characteristics of heart rate variability and stroke has been depicted. The review further discussed the relationship between post-stroke infection and heart rate variability, which could assist in curbing clinical infection in patients with stroke. HRVas a noninvasive clinical monitoring tool can quantitatively assess the changes in autonomic nervous system activity and further predict the outcome of stroke. HRV could play an important role in guiding the clinical practice for autonomic nervous system disorder after stroke.

Acute pancreatitis (AP) is one of the most common acute abdomen diseases with increasing incidence and substantial healthcare burden. Gut microbiota disturbance, mucosal barrier failure, and bacterial translocation are identified as the dominant cause of infected pancreatic necrosis and high mortality. With the advance of high-throughput sequencing, imbalance between beneficial and facultative pathogenic microorganisms with their metabolic activities in the development of AP has been increasingly recognized, whereas it remains unclear whether dysbacteriosis is the dominant cause of aggravating AP, or merely reflecting different epidemiological or environmental factors at the individual level. This review discussed the alterations of the gut microbiota and their metabolites during AP with detailed molecular mechanisms. Importantly, it highlights microbiome-based medical therapies which influence gut barrier function and immune homeostasis to mitigate inflammatory responses in AP. Our review will provide a novel roadmap of gastrointestinal microecology in AP progression, and contribute to the future development of microbiome-based diagnostic and therapeutic strategies in clinical practice.

Introducing AIE molecules at the interface reduces the interface defects of the device and improves its UV light utilization efficiency, and significantly improve the UV stability of the device.

Layered double hydroxides (LDH), as a green, easy to prepare and modify material, has been widely concerned in the field of electrochemical catalytic degradation of difficult to remove pollutants in water. In our work, modified LDH material is synthesized by doping La into the lattice of CoFe-LDH based on its unique electronic structure and large ionic radius, which is used to build the particle electrode to degrade the N-nitrosopyrrolidine (NPYR) in a three-dimensional continuous flow aerated electrocatalytic reactor. The LaCoFe-LDH particle electrodes can generate more active free radicals under electric field, which are beneficial to the degradation of pollutants. The degradation effect of NPYR in the system is satisfactory, and the removal rate reached 83.3% within 90 min. According to the results of characterization analysis, radical quenching experiment, and EPR test, La doping improves the electron transfer ability of the catalyst, which effectively accelerates the redox cycle of Fe2+/Fe3+and Co2+/Co3+to achieve sustainable catalysis of particle electrodes to form free radicals, thus enhancing the degradation of NPYR. The DFT calculation results of CoFeLa-LDH show that the energy required for oxygen adsorption by CoFeLa-LDH (-6.79 eV) is lower than that of CoFe-LDH (-6.08 eV), illustrating the improved adsorption properties of the material after La doping. According to the detection results of GC-MS and LC-MS, the possible degradation path of NPYR is proposed. Moreover, the toxicity of the products after degradation of NPYR is generally reduced, indicating that the system is environmentally friendly. The study provides new insights into the design of electrocatalytic materials in water treatment.

Four rare earth inorganic-organic hybrid compounds based on Keggin-type polyoxometalate {SiW12} with general formula [{RE(DMF)4(H2O)4RE(DMF)6}2{SiW12O40}3] (RE = La(1), Pr(2), Sm(3), Eu(4), DMF = N,N-dimethylformamide) were synthesized by the conventional solution method. Structure analyses indicate that four compounds are isostructural and are all built from three [SiW12O40]4–polyoxoanions and DMF ligands linked by RE3+. Compounds 1–4are extremely sensitive to UV light and present excellent photochromic properties, in which the coloring and fading time of samples are both no more than 2 min, and the reversible coloring-fading process can be repeated for at least 10 cycles with little fatigue, suggesting that compounds 1–4can be a series of fast-responsive and durable photochromic materials. Moreover, the solid-state photoluminescence spectra of compounds 3(Sm) and 4(Eu) display strong characteristic emissions of rare earth ions based on f–f transitions. Meanwhile, compound 4(Eu) has a longer fluorescence lifetime up to 566.74 μs. Notably, compounds 3(Sm) and 4(Eu) exhibit the switchable luminescence behavior induced by photochromism, which allows them to be used as potential molecular switches.

Healthy diet is essential for cardiovascular disease risk management, but its effects among Chinese patients, whose diets differ from Western diets, remain largely unknown.

While quasi-two-dimensional (quasi-2D) perovskites have good properties of cascade energy transfer, high exciton binding energy, and high quantum efficiency, which will benefit high-efficiency blue PeLEDs, inefficient domain distribution management and unbalanced carrier transport impede device performance improvement. Herein, (2-(9H-carbazol-9-yl)ethyl)phosphonic acid (2PACz) and methyl 2-aminopyridine-4-carboxylate (MAC) were simultaneously introduced to a blue quasi-2D perovskite film. Relying on the synergistic effect of 2PACz and MAC, it not only modulates the phase distribution inhibiting the n= 2 phase but also greatly improves the electrical property of the quasi-2D perovskite film. As a result, the as-modified blue quasi-2D PeLED demonstrated an external quantum efficiency (EQE) of 17.08% and a luminance of 10142 cd m–2. This study exemplifies the synergistic effect among dual additives and offers a new effective additive strategy modulating phase distribution and building balanced carrier transport, which paves the way for the fabrication of highly efficient blue PeLEDs.

Lanthanide-based nanomaterials have been extensively studied, owing to their unique optical properties. Strong electron coupling intensely affects the optical properties, as a kind of interaction between the metal luminescence centers, which usually depend on the otherness in valence states and/or spin states of metal ions. Herein, we presented that the strong electron coupling between trivalent lanthanide ions (LnIII) existed in molecular cluster-aggregates (MCAs) beyond the general consideration in valence and/or spin states. We synthesized a series of lanthanide-based MCAs with the generalized formula [Ln20(chp)30(CO3)12(NO3)6(H2O)6]({Ln20}). By comparing and analyzing the characteristics of homometallic and heterometallic {Ln20}MCAs, we found a regular and controlled phenomenon of metal-to-metal charge transfer (MMCT) which is a typical expression of strong electron coupling. This observation can be attributed to the shorter spacing between metals inside the polynuclear nanosized core of MCAs, indicating that MCAs are an excellent matrix material to study the effects of intermetallic interactions of LnIII, thus tailoring even customization in their luminescence performance.

Under hydrothermal and solvent-thermal conditions, we synthesized two novel polyoxometalate (POM)-based hybrids: [CuI4(Pz)2(H2O)8(PMoVI11MoVO40)]·3.5H2O (1, Pz = pyrazine) and [(C2H8N)5(HPMoVI9MoV3O40)]·DMF·4H2O (2). Single-crystal X-ray diffraction indicates that compound 1is a three-dimensional structure consisting of Cu (I), {PMo12} anions, Pz, and water, where Cu (I) can be considered as Lewis acid sites. Furthermore, both compounds 1and 2possess favorable catalysis activity in catalyzing the conversion of chemical warfare agent simulant 2-chloroethylethyl sulfide (CEES) to nontoxic production of 2-chloroethylethyl sulfoxide (CEESO) under ambient temperature. Significantly, 1could realize 98% conversion and 100% selectivity of CEES owing to the multisite synergy in the {PMoVI11MoVO40CuI8} units in which the tricoordinated Cu (I) could interact with S and O atoms from CEES and H2O2, respectively. This interaction not only decreases the distance of CEES from peroxomolybdenum species formed by H2O2but also activates CEES.

Quasi-two-dimensional (Q-2D) Ruddlesden-Popper perovskites have excellent optical performance due to self-assembling multiple quantum well structure. However, Q-2D perovskites usually contain a disordered phase distribution, which results in low emission efficiency. In this work, we introduced the 2-aminohexane ligand into the Q-2D perovskite films, reconstructed the phase distribution of the films. In addition, the defects were passivated after introducing the ligand, resulting in low trap density, so as to obtain high-quality Q-2D perovskite films. With this approach, the Q-2D perovskite light-emitting diodes (PeLEDs) achieved a maximum brightness of 187,869 cd m−2 and a peak external quantum efficiency of 21.6%.

The advancement and application of nanotechnology inevitably cause the release of nanoparticles (NPs) into the environment, in particular, zinc oxide (ZnO) NPs may seriously threaten the ecological safety of plants. This review focuses on the translocation and physiological responses of ZnO NPs in plants to systematically summarize the toxicological effects and molecular mechanisms of NPs. The results indicated that ZnO NPs migrated to tissues viauptake and translocation, gradually accumulated in intracellular and intercellular spaces, and led to physiological inhibition, nutrient imbalance, and photosynthesis perturbation in plants. This abiotic stress triggered the overproduction of reactive oxygen species (ROS) by perturbing cellular redox homeostasis, while the activation of antioxidant genes and alteration of KEGG pathways enhanced the ability of plants to resist phytotoxicity. Furthermore, ZnO NPs significantly altered metabolites associated with oxidative stress, antioxidant defense, membrane disorder and energy expenditure, affected carbon/nitrogen metabolism viathe TCA cycle and glycolysis pathway, and augmented cytotoxicity and genotoxicity by inducing DNA damage and inhibiting mitosis. More notably, the composite exposure of ZnO NPs with other substances is bifacial and may create potential mitigation or synergistic effects on plants in ecosystems, thus posing uncertain ecological risks. This review systematically provides clarification on the environmental fate of ZnO NPs in plants at the physiological and molecular levels, theoretical references on the toxicity mechanisms and potential risks of NPs, and directions and insights for future research to achieve strategies that minimize risks and maximize benefits.

Green synthesized titanium dioxide nanoparticles (g-TiO2NPs) have aroused widespread interest in agriculture. Nevertheless, whether they are safer than chemically synthesized TiO2NPs (c-TiO2NPs) remains to be demonstrated. Herein, the photosynthetic response of Lactuca sativaL. was evaluated by foliar spraying of 10, 100, 250, and 500 mg L−1c-TiO2NPs or g-TiO2NPs. Results indicated that NPs interfered with nutrient accumulation and the cellular redox state, and all treatments displayed inhibition of growth except the 10 mg L−1g-TiO2NP group. Photosynthetic parameters and FTIR analysis revealed that NP stress on photosynthesis was also manifested by lower photosystem activity (500 mg L−1) and disrupted Calvin cycle metabolism, but carbohydrates and proteins were more sensitive to c-TiO2NPs and g-TiO2NPs, respectively. Notably, both NPs promoted photosynthetic electron transfer (≤250 mg L−1), thus alleviating detrimental effects due to suppressed ATPase and Rubisco activity, thylakoid lysis, and chloroplast autophagy. Differently, chloroplasts were more responsive to ultraviolet (non-directly utilizable) and visible light under c-TiO2NP treatment, which facilitated the Hill reaction while posing a photo-oxidative risk to plants. In contrast, g-TiO2NPs were less phytotoxic, as evidenced by higher NADPH, ATPase activity, chlorophyll, and photosynthetic efficiency, and less chloroplast damage, where 10 mg L−1g-TiO2NPs effectively activated the plant defense system and improved light capture and conversion. Collectively, g-TiO2NPs showed lower phytotoxicity by modulating energy conversion processes in chloroplasts, which provided a cutting-edge research perspective for the application of nanopesticides.

Quasi-2D perovskites, multiquantum well materials with the energy cascade structure, exhibit impressive optoelectronic properties and a wide range of applications in various optoelectronic devices. However, the insufficient exciton energy transfer caused by the excess of small-nphases that induce nonradiative recombination and the spatially random phase distribution that impedes charge transport severely inhibit the device performance of light-emitting diodes (LEDs). Here, a faster energy transfer process and efficient carrier recombination are achieved by introducing the multifunctional additive 2-(methylsulfonyl)-4-(trifluoromethyl)benzoic acid (MTA) to manipulate the crystallization process of perovskites. The introduction of MTA not only constrains the PEA and restrains the formation of small-nphases to improve the energy transfer process but also optimizes the crystal orientation to promote charge transport. As a result, highly efficient pure green quasi-2D perovskite LEDs with a peak EQE of 25.9%, a peak current efficiency of 108.1 cd A–1, and a maximum luminance of 288798 cd m–2are achieved.

Carotenoids are involved in the formation of plant leaf color as well as photosystem photoprotection. This study showed that blue light significantly induced up-regulation of the total carotenoid content in the inner leaves of orange-head Chinese cabbage (OHCC). Furthermore, the transcriptomic analysis revealed that blue light treatment induced up-regulation of genes in photosynthesis (BrHY5-2, BrCOP1and BrDET1) and the methylerythritol 4-phosphate pathways (BrGGPS, BrDXSand BrHDR) upstream of the carotenoid metabolic pathway. Carotenoid metabolomic analysis revealed that the accumulation of several orange and red carotenoids (lycopene, zeaxanthin, β-carotene, lutein, and β-cryptoxanthin) after blue light treatment contributed to the deepening of the leaf coloration, suggesting that short-term blue light treatment could be used to boost nutritional quality. The light signal gene BrHY5-2participated in the blue light-induced transcriptional regulation of carotenoid biosynthesis in OHCC. Overexpression of BrHY5-2in Arabidopsissignificantly increased the total carotenoid content and the sensitivity to blue light. The above findings revealed new insights about blue-light-induced carotenoid synthesis and accumulation in OHCC lines. They suggested a new engineering approach to increase the nutritional value of vegetables.

The coordination of dual-heteroatom is an effective strategy to enhance the performance of oxygen evolution reaction (OER) of single-atom catalysts. Here, we synthesize Mn-SG-500 with isolated Mn sites coordinated with two sulfur and two oxygen atoms on graphene, and perform in-depth research on the structure-activity relationship for the OER. Under alkaline conditions, the Mn-SG-500 displays higher OER activity than commercial RuO2. Combining in-situstructure analysis and theoretical calculations, we identify Mn-S2O2as the catalytic active center, on which the oxidation of *O to *OOH is the rate-control step. The improved OER activity is attributed to the redistribution and optimization of Mn charges caused by the co-coordination of S and O. This work is helpful for further structure design and performance management of single-atom catalysts with dual-heteroatom doping.

Perovskite nanocrystals have been widely applied in the field of light-emitting diodes (LEDs) due to their excellent optoelectronic properties. However, there is generally a serious degradation of device efficiency when transferring the device from rigid to flexible substrates due to the high roughness, poor wettability, and low endurance temperature of flexible substrates. Herein, a highly flexible perovskite light-emitting diode (PeLED) by utilizing label paper as substrates and poly(methyl methacrylate) (PMMA) as the modified layer was reported. Compared with the reference device based on commonly used polyethylene terephthalate (PET) substrates, the label paper/PMMA-based devices did not show the degraded device performance when transferring from rigid to flexible substrates. This is mainly because of low roughness and good wettability of PMMA-modified label paper, which significantly improve the film-forming ability of the bottom electrode and functional layer. Furthermore, the flexibility of both devices was explored by a three-point bending flexural test, indicating that the label paper-based device has better bending stability than the polyethylene terephthalate-based one due to the lower flexural modulus for label paper. As a result, the label paper-based flexible PeLEDs exhibited the highest external quantum efficiency (EQE) of 14.3% among perovskite nanocrystal-based flexible LEDs and preeminent flexibility with 29% luminance degradation after bending for 1000 cycles at a small radius of 1.5 mm. This extension of the substrate to paper will widen the opportunity of PeLEDs in extremely flexible and inexpensive applications.

The Resource for Coronavirus 2019 (RCoV19) is an open-access information resource dedicated to providing valuable data on the genomes, mutations, and variantsof the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this updated implementation of RCoV19, we have made significant improvements and advancements over the previous version. Firstly, we have implemented a highly refined genome data curation model. This model now features an automated integration pipeline and optimized curation rules, enabling efficient daily updates of data in RCoV19. Secondly, we have developed a global and regional lineage evolution monitoring platform, alongside an outbreak risk pre-warningsystem. These additions provide a comprehensive understanding of SARS-CoV-2 evolution and transmission patterns, enabling better preparedness and response strategies. Thirdly, we have developed a powerful interactive mutation spectrum comparison module. This module allows users to compare and analyze mutation patterns, assisting in the detection of potential new lineages. Furthermore, we have incorporated a comprehensive knowledgebase on mutation effects. This knowledgebase serves as a valuable resource for retrieving information on the functional implications of specific mutations. In summary, RCoV19 serves as a vital scientific resource, providing access to valuable data, relevant information, and technical support in the global fight against COVID-19. The complete contents of RCoV19 are available to the public at https://ngdc.cncb.ac.cn/ncov/.

On-chip waveguide sensors are potential candidates for deep-space exploration because of their high integration and low power consumption. Since the fundamental absorption of most gas molecules exists in the mid-infrared (e.g., 3–12 μm), it is of great significance to fabricate wideband mid-infrared sensors with high external confinement factor (ECF). To overcome the limited transparency window and strong waveguide dispersion, a chalcogenide suspended nanorib waveguide sensor was proposed for ultra-wideband mid-infrared gas sensing, and three waveguide sensors (WG1–WG3) with optimized dimensions exhibit a wide waveband of 3.2–5.6 μm, 5.4–8.2 μm, and 8.1–11.5 μm with exceptionally high ECFs of 107–116%, 107–116%, and 116–128%, respectively. The waveguide sensors were fabricated by a two-step lift-off method without dry etching to reduce the process complexity. Experimental ECFs of 112%, 110%, and 110% were obtained at 3.291 μm, 4.319 μm, and 7.625 μm, respectively, through methane (CH4) and carbon dioxide (CO2) measurements. A limit of detection of 5.9 ppm was achieved for an averaging time of 64.2 s through the Allan deviation analysis of CH4at 3.291 μm, leading to a comparable noise equivalent absorption sensitivity of 2.3 × 10–5cm–1Hz–1/2as compared to the hollow-core fiber and on-chip gas sensors.

The mountainous terrain and warm-humid climates have fostered rich biodiversity in central China. Several national nature reserves have been listed on the World Network of UNESCO Biosphere Reserves. In this study, morphological characteristics of chrysophycean stomatocysts were analyzed in a 33-cm-long sediment core from Mulong Lake, a small alpine lake in the Three Gorges Reservoir region, central China. Thirty-two morphotypes of stomatocysts were identified in the sediment core according to the International Statospore Working Group guidelines, and illustrated by SEM micrographs. Of thirty-two cyst types, four cyst types were described as new to science. These stomatocysts generally prefer oligotrophic, electrolyte-poor and cold environments. This study highlights rich morphotypes of chrysophycean stomatocysts in alpine lakes of the subtropical monsoonal region, meanwhile, our results can create a taxonomical basis for further palaeoecological study in this lake, as well as similar alpine lakes.

Coarse β-columnar grains are often present in Ti–6Al–4V laser-additive-manufactured samples, resulting in anisotropic and inferior fatigue performance under dynamic loading. Fine-equiaxed grains (FEGs) with a mean grain size of approximately 139 μm were successfully obtained by a novel deposition strategy through coordinated regulation of direct energy deposition technological parameters. Microstructures were transformed from α′ martensite to α'' martensite. As a result, the comprehensive performance was significantly improved. Without the use of an argon atmosphere glovebox and post heat treatment, the tensile strength and elongation in the horizontal direction of the FEGs were 1091 MPa and 4.09%, respectively. The corrosion resistance was 11.71-fold higher than that of the coarse columnar grains (CCGs). Improving the microstructure and performance by optimizing pulsed laser parameters is simple, effective, and conducive to online regulation of the quality of laser additive samples.