91 results on '"Ayers, Colby R."'
Search Results
2. The Relationship of Alcohol Consumption and HDL Metabolism in the Multiethnic Dallas Heart Study.
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Badia, Rohit R., Pradhan, Roma V., Ayers, Colby R., Chandra, Alvin, and Rohatgi, Anand
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ATHEROSCLEROSIS risk factors ,BIOMARKERS ,CARDIOVASCULAR diseases risk factors ,BINGE drinking ,RISK assessment ,ALCOHOL drinking ,HIGH density lipoproteins ,DRINKING behavior ,LONGITUDINAL method - Abstract
• Increasing alcohol consumption leads to increased HDL markers. • Moderate drinkers have higher HDL values compared to light drinkers. • Race and sex can modify the relationship between HDL and cholesterol efflux. • Unable to evaluate impact of HDL markers due to low number of cardiovascular events. Small studies have suggested that moderate alcohol consumption increases HDL cholesterol (HDL-C) levels and cholesterol efflux capacity (CEC), a main anti-atherosclerotic HDL function. This study aimed to understand the degree to which alcohol intake is associated with various HDL markers in a large, multiethnic population cohort, the Dallas Heart Study (DHS), and whether alcohol modifies the link between HDL markers and atherosclerotic cardiovascular disease (ASCVD). Participants of the DHS were included if they had self-reported alcohol intake and CEC measurements (N=2,919). Alcohol intake was analyzed continuously (grams/week) and as an ordered categorical variable (never, past, light, moderate, heavy, and binge drinkers). HDL-C, CEC, HDL particle number (HDL-P), HDL particle size (HDL-size), and ApoA-I were the primary HDL measures. After adjustment for confounding variables, increasing continuous measure of alcohol intake was associated with increased levels of all HDL markers. Moreover, as compared to moderate drinkers, light drinkers had decreased levels of the HDL markers. In a large, multiethnic cohort, increased alcohol intake was associated with increased levels of multiple markers of HDL metabolism. However, the association of HDL markers with ASCVD risk as modified by alcohol consumption is unable to be determined in this low-risk cohort. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Subclinical Myocardial Injury and the Phenotype of Clinical Congestion in Patients With Heart Failure and Reduced Left Ventricular Ejection Fraction.
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Thibodeau, Jennifer T., Pham, David D., Kelly, Samuel A., Ayers, Colby R., Garg, Sonia, Grodin, Justin L., and Drazner, Mark H.
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Background: Clinical congestion is associated with adverse outcomes in patients with heart failure. The pathophysiological mediators of this association remain uncertain.Methods and Results: We prospectively enrolled a cohort of patients with heart failure and reduced left ventricular ejection fraction and performed a detailed clinical examination followed on the same day by an invasive right heart catheterization and blood sampling for biomarkers. High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were measured. A clinical congestion score was calculated based on jugular venous pressure (cm H20 <10 = 0, 10-14 = 1, >14 = 2 points), bendopnea (0 vs 1), a third heart sound (0 vs 1), or peripheral edema (0-2). Congestion was categorized into tiers as absent (0 points), mild (1 point), or moderate to severe (≥ 2 points). We tested for associations of high-sensitivity troponin T, NT-proBNP, and elevated ventricular filling pressures with clinical congestion in both univariate and multivariable analyses. Of 153 participants, 65 (42%) had absent, 35 mild (23%), and 53 (35%) had moderate to severe clinical congestion. Congestion tier was associated with higher NT-proBNP and hs-troponin levels, and the right atrial pressure and pulmonary capillary wedge pressure (P < .001 for each). Increased congestion tier was also associated with the coexistent presence of elevated troponin T (≥52 ng/L), NT-proBNP (≥1000 pg/mL), and pulmonary capillary wedge pressure (≥22 mm Hg). Specifically, 78% of those with absent clinical congestion had 0 to 1 of these findings, whereas 75% of those with moderate-severe congestion had 2 or all 3 of these abnormalities (P < .001). An elevated hs-troponin was associated with mild or greater clinical congestion (odds ratio 3, 95% confidence interval 1.2-7.5, P = .02) in multivariable analysis adjusting for potential confounders including the right atrial pressure, pulmonary capillary wedge pressure, and NT-proBNP levels.Conclusions: Clinical congestion is a phenotype in which there is a high coexistent presence of elevated ventricular filling pressures, elevated natriuretic peptide levels, and subclinical myocardial injury. An elevated troponin was associated with clinical congestion in multivariable models that adjusted for ventricular filling pressures and natriuretic peptide levels. These data strengthen the evidence base for an association of elevated troponin with clinical congestion, suggesting that subclinical myocardial injury may be an important contributor to the pathophysiology of the congested state. [ABSTRACT FROM AUTHOR]- Published
- 2022
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4. Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial
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Neeland, Ian J, Marso, Steven P, Ayers, Colby R, Lewis, Bienka, Oslica, Robert, Francis, Wynona, Rodder, Susan, Pandey, Ambarish, and Joshi, Parag H
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Visceral and ectopic fat are key drivers of adverse cardiometabolic outcomes in obesity. We aimed to evaluate the effects of injectable liraglutide 3·0 mg daily on body fat distribution in adults with overweight or obesity without type 2 diabetes at high cardiovascular disease risk.
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- 2021
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5. Bendopnea Is Due To Elevated Left Ventricular Filling Pressures Rather Than Elevated Pulmonary Artery Pressures.
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Ravipati, Goutham, Thibodeau, Jennifer T, Pham, David D, Ayers, Colby R, Hardin, Elizabeth A, Grodin, Justin L, and Drazner, Mark H
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Bendopnea, or dyspnea within 30 seconds of bending forward while not holding one's breath, is a recently described symptom of heart failure that has been associated with elevated pulmonary capillary wedge pressure (PCWP) and pulmonary artery pressures (PAP). Whether this symptom is due to elevation in PCWP or due to elevation in PAP has not previously been elucidated. The development of bendopnea is due to elevation in left-ventricular filling pressure, or PCWP, rather than elevation in PAP. We prospectively enrolled a cohort of 209 patients who were undergoing right heart catheterization for clinically indicated purposes either for evaluation of heart failure with reduced ejection fraction (HFrEF, n=156) or non-World Health Organization class II pulmonary hypertension (PH, n=53). In this study, we analyzed data from the 83 patients with HFrEF who had a PCWP ≥ 16mmHg and the 52 patients with PH who had a mean PAP ≥ 20mmHg. A detailed clinical examination, including assessment of bendopnea, was conducted prior to the invasive hemodynamic assessment, and the cardiologist performing the catheterization was blinded to the physical examination findings. Logistic regression analysis tested the association of bendopnea with PCWP, mean PAP, and systolic PAP. Informed consent was obtained, and the Institutional Review Board approved the study protocol. Bendopnea was present in 37/135 (27%) subjects. Those with HFrEF versus PH were more likely to have bendopnea as well as an elevated PCWP, while there was no difference in the mean PAP between the groups (Figure). In univariable regression analysis, PCWP was associated with bendopnea (OR 1.1 [1.05, 1.15], p<0.001) but PASP was not (p=0.75). In models in which both PASP and PCWP were entered as covariates, PCWP (OR 1.1 [1.04, 1.15], p<0.001) remained associated with bendopnea but PASP (p=0.99) was not. Likewise, in a similar analysis with PCWP and MPA, PCWP was associated with bendopnea (OR 1.1 [1.04, 1.15], p=0.001), but MPA (p=0.44) was not. Elevated left sided ventricular filling pressure, rather than pulmonary artery pressures, are the hemodynamic basis of bendopnea. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Value of Coronary Artery Calcium Scanning in Association With the Net Benefit of Aspirin in Primary Prevention of Atherosclerotic Cardiovascular Disease
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Ajufo, Ezimamaka, Ayers, Colby R., Vigen, Rebecca, Joshi, Parag H., Rohatgi, Anand, de Lemos, James A., and Khera, Amit
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IMPORTANCE: Higher coronary artery calcium (CAC) identifies individuals at increased atherosclerotic cardiovascular disease (ASCVD) risk. Whether it can also identify individuals likely to derive net benefit from aspirin therapy is unclear. OBJECTIVE: To examine the association between CAC, bleeding, and ASCVD and explore the net estimated effect of aspirin at different CAC thresholds. DESIGN, SETTING, AND PARTICIPANTS: Prospective population-based cohort study of Dallas Heart Study participants, free from ASCVD and not taking aspirin at baseline. Data were analyzed between February 1, 2020, and July 15, 2020. EXPOSURES: Coronary artery calcium score in the following categories: 0, 1-99, and 100 or higher. MAIN OUTCOMES AND MEASURES: Major bleeding and ASCVD events were identified from International Statistical Classification of Diseases and Related Health Problems, Ninth Revision codes. Meta-analysis–derived aspirin effect estimates were applied to observed ASCVD and bleeding rates to model the net effect of aspirin at different CAC thresholds. RESULTS: A total of 2191 participants (mean [SD], age 44 [9.1] years, 1247 women [57%], and 1039 black individuals [47%]) had 116 major bleeding and 123 ASCVD events over a median follow-up of 12.2 years. Higher CAC categories (CAC 1-99 and ≥100 vs CAC 0) were associated with both ASCVD and bleeding events (hazard ratio [HR], 1.6; 95% CI, 1.1-2.4; HR, 2.6; 95% CI, 1.5-4.3; HR, 4.8; 95% CI, 2.8-8.2; P < .001; HR, 5.3; 95% CI, 3.6-7.9; P < .001), but the association between CAC and bleeding was attenuated after multivariable adjustment. Applying meta-analysis estimates, irrespective of CAC, aspirin use was estimated to result in net harm in individuals at low (<5%) and intermediate (5%-20%) 10-year ASCVD risk and net benefit in those at high (≥20%) ASCVD risk. Among individuals at lower bleeding risk, a CAC score of at least 100 identified individuals who would experience net benefit, but only in those at borderline or higher (≥5%) 10-year ASCVD risk. In individuals at higher bleeding risk, there would be net harm from aspirin irrespective of CAC and ASCVD risk. CONCLUSIONS AND RELEVANCE: Higher CAC is associated with both ASCVD and bleeding events, with a stronger association with ASCVD. A high CAC score identifies individuals estimated to derive net benefit from primary prevention aspirin therapy from those who would not, but only in the setting of lower bleeding risk and estimated ASCVD risk that is not low.
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- 2021
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7. Associations Between High-Density Lipoprotein Particles and Ischemic Events by Vascular Domain, Sex, and Ethnicity
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Singh, Kavisha, Chandra, Alvin, Sperry, Thomas, Joshi, Parag H., Khera, Amit, Virani, Salim S., Ballantyne, Christie M., Otvos, James D., Dullaart, Robin P.F., Gruppen, Eke G., Connelly, Margery A., Ayers, Colby R., and Rohatgi, Anand
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Supplemental Digital Content is available in the text.
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- 2020
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8. Racial Differences in Malignant Left Ventricular Hypertrophy and Incidence of Heart Failure
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Lewis, Alana A., Ayers, Colby R., Selvin, Elizabeth, Neeland, Ian, Ballantyne, Christie M., Nambi, Vijay, Pandey, Ambarish, Powell-Wiley, Tiffany M., Drazner, Mark H., Carnethon, Mercedes R., Berry, Jarett D., Seliger, Stephen L., DeFilippi, Christopher R., and de Lemos, James A.
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Supplemental Digital Content is available in the text.
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- 2020
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9. Effects of Empagliflozin Treatment on Cardiac Biomarkers in Adults With Metabolically Healthy Obesity: Results From a Randomized, Placebo-Controlled Clinical Trial
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Khan, Sadiya S., Agarwal, Anubha, Ayers, Colby R., Jin, Eunsook, and Neeland, Ian J.
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- 2021
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10. Ascending Aortic Dimensions in Former National Football League Athletes.
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Gentry III, James L., Carruthers, David, Joshi, Parag H., Maroules, Christopher D., Ayers, Colby R., de Lemos, James A., Aagaard, Philip, Hachamovitch, Rory, Desai, Milind Y., Roselli, Eric E., Dunn, Reginald E., Alexander, Kezia, Lincoln, Andrew E., Tucker, Andrew M., and Phelan, Dermot M.
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Background--Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown. Methods and Results--This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, P<0.0001; body surface area of 2.4 and 2.1 m², respectively, P<0.0001). Midascending aortic dimensions were obtained from computed tomographic scans performed as part of a NFL screening protocol or as part of the DHS. Compared with a population-based control group, former NFL athletes had significantly larger ascending aortic diameters (38±5 versus 34±4 mm; P<0.0001). A significantly higher proportion of former NFL athletes had an aorta of >40 mm (29.6% versus 8.6%; P<0.0001). After adjusting for age, race, body surface area, systolic blood pressure, history of hypertension, current smoking, diabetes mellitus, and lipid profile, the former NFL athletes still had significantly larger ascending aortas (P<0.0001). Former NFL athletes were twice as likely to have an aorta >40 mm after adjusting for the same parameters. Conclusions--Ascending aortic dimensions were significantly larger in a sample of former NFL athletes after adjusting for their size, age, race, and cardiac risk factors. Whether this translates to an increased risk is unknown and requires further evaluation. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Contemporary Epidemiology of Heart Failure in Fee-For-Service Medicare Beneficiaries Across Healthcare Settings.
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Khera, Rohan, Pandey, Ambarish, Ayers, Colby R., Agusala, Vijay, Pruitt, Sandi L., Halm, Ethan A., Drazner, Mark H., Das, Sandeep R., de Lemos, James A., and Berry, Jarett D.
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BACKGROUND: To assess the current landscape of the heart failure (HF) epidemic and provide targets for future health policy interventions in Medicare, a contemporary appraisal of its epidemiology across inpatient and outpatient care settings is needed. METHODS AND RESULTS: In a national 5% sample of Medicare beneficiaries from 2002 to 2013, we identified a cohort of 2 331 939 unique fee-for-service Medicare beneficiaries =65-years-old followed for all inpatient and outpatient encounters over a 10-year period (2004-2013). Preexisting HF was defined by any HF encounter during the first year, and incident HF with either 1 inpatient or 2 outpatient HF encounters. Mean age of the cohort was 72 years; 57% were women, and 86% and 8% were white and black, respectively. Within this cohort, 518 223 patients had preexisting HF, and 349 826 had a new diagnosis of HF during the study period. During 2004 to 2013, the rates of incident HF declined 32%, from 38.7 per 1000 (2004) to 26.2 per 1000 beneficiaries (2013). In contrast, prevalent (preexisting + incident) HF increased during our study period from 162 per 1000 (2004) to 172 per 1000 beneficiaries (2013) (P
trend <0.001 for both). Finally, the overall 1-year mortality among patients with incident HF is high (24.7%) with a 0.4% absolute decline annually during the study period, with a more pronounced decrease among those diagnosed in an inpatient versus outpatient setting (Pinteraction <0.001). CONCLUSIONS: In recent years, there have been substantial changes in the epidemiology of HF in Medicare beneficiaries, with a decline in incident HF and a decrease in 1-year HF mortality, whereas the overall burden of HF continues to increase. [ABSTRACT FROM AUTHOR]- Published
- 2017
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12. Identifying Familial Hypercholesterolemia Using a Blood Donor Screening Program With More Than 1 Million Volunteer Donors
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Jackson, Candace L., Keeton, James Z., Eason, Stephen J., Ahmad, Zahid A., Ayers, Colby R., Gore, M. Odette, McGuire, Darren K., Sayers, Merlyn H., and Khera, Amit
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IMPORTANCE: Familial hypercholesterolemia is an autosomal-dominant disorder that often causes premature coronary artery disease. Unfortunately, familial hypercholesterolemia remains largely undiagnosed. OBJECTIVE: To estimate the prevalence of familial hypercholesterolemia in a population of blood donors. DESIGN: This analysis of deidentified data from blood donors 16 years and older who donated to Carter BloodCare, one of the largest independent blood programs in the United States, between January 2002 and December 2016. Carter BloodCare, which serves a population of about 8 million in Texas, routinely measures total nonfasting serum cholesterol levels as part of a donor health screening program. Data analysis occurred from October 2017 to March 2019. EXPOSURE: Blood donation. MAIN OUTCOMES AND MEASURES: Familial hypercholesterolemia was defined using the Make Early Diagnosis to Prevent Early Death general population criteria, with total nonfasting serum cholesterol thresholds of 270, 290, 340, and 360 mg/dL for donors younger than 20 years, 20 to 29 years, 30 to 39 years, and 40 years or older, respectively (to convert cholesterol values to mmol/L, multiply by 0.0259). For repeated donors, the maximum observed total cholesterol level was used for analyses. RESULTS: The study included 1 178 102 individual donors with a total of 3 038 420 blood donations. Of all individual donors (median total cholesterol level, 183 [interquartile range (IQR), 157-212] mg/dL; median age, 32 [IQR, 19-47] years; 619 583 [52.6%] women), a total of 3473 individuals (or 1 in every 339) met criteria for familial hypercholesterolemia. This group had a median (IQR) total cholesterol of 332 (297-377) mg/dL. Estimated prevalence was higher at younger ages (<30 years: 1:257) compared with older ages (≥30 years: 1:469; P < .001) and in men (1:327) compared with women (1:351; P = .03). Among 2219 repeated donors who met familial hypercholesterolemia criteria at least once, 3116 of 10 833 total donations (28.8%) met FH criteria. CONCLUSIONS AND RELEVANCE: The prevalence of familial hypercholesterolemia using the Make Early Diagnosis to Prevent Early Death criteria in a large cohort of blood donors was similar to the estimated prevalence of this disorder in the general population. The blood donor screening program could be a novel strategy to detect and notify individuals with potential familial hypercholesterolemia, particularly younger individuals in whom early detection and treatment is especially helpful, as well as guide cascade screening.
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- 2019
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13. Delayed febrile response with bloodstream infections in patients with continuous-flow left ventricular assist devices
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Wrobel, Christopher A, Drazner, Mark H, Ayers, Colby R, Pham, David D, La Hoz, Ricardo M, Grodin, Justin L, Garg, Sonia, Mammen, Pradeep P A, Morlend, Robert M, Araj, Faris, Amin, Alpesh A, Cornwell, William K, and Thibodeau, Jennifer T
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Bloodstream infections (BSIs) are common in patients with continuous-flow left ventricular assist devices (CF-LVADs). Whether CF-LVADs modulate the febrile response to BSIs is unknown. We retrospectively compared the febrile response to BSIs in patients with heart failure (HF) with CF-LVADs versus a control population of patients with HF receiving inotropic infusions. BSIs were adjudicated using the Centers for Disease Control and Prevention and the National Healthcare Safety Network criteria. Febrile status (temperature =38°C, 100.4 °F), temperature at presentation with BSI, and the highest temperature within 72?hours (Tmax) were collected. We observed 59 BSIs in LVAD patients and 45 BSIs in controls. LVAD patients were more likely to be afebrile and to have a lower temperature at presentation than control (88% vs 58%, p=0.002,?and 37°C ±0.7 vs 37.7°C ±1.0, p=0.0009, respectively). By 72?hours, the difference in afebrile status diminished (53% vs 44%, p=0.42), and the Tmax was similar between the LVAD and control groups (37.9°C±0.9 vs 38.2°C±0.8, respectively, p=0.10). In conclusion, at presentation with a BSI, the vast majority of CF-LVAD patients were afebrile, an event which occurred at a higher frequency when compared with patients with advanced HF on chronic inotropes via an indwelling venous catheter. These data alert clinicians to have a very low threshold to obtain blood cultures in CF-LVAD patients even in the absence of fever. Further study is needed to determine whether a delayed or diminished febrile response represents another pathophysiological consequence of CF-LVADs.
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- 2019
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14. Delayed febrile response with bloodstream infections in patients with continuous-flow left ventricular assist devices
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Wrobel, Christopher A, Drazner, Mark H, Ayers, Colby R, Pham, David D, La Hoz, Ricardo M, Grodin, Justin L, Garg, Sonia, Mammen, Pradeep P A, Morlend, Robert M, Araj, Faris, Amin, Alpesh A, Cornwell, William K, and Thibodeau, Jennifer T
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Bloodstream infections (BSIs) are common in patients with continuous-flow left ventricular assist devices (CF-LVADs). Whether CF-LVADs modulate the febrile response to BSIs is unknown. We retrospectively compared the febrile response to BSIs in patients with heart failure (HF) with CF-LVADs versus a control population of patients with HF receiving inotropic infusions. BSIs were adjudicated using the Centers for Disease Control and Prevention and the National Healthcare Safety Network criteria. Febrile status (temperature ≥38°C, 100.4 °F), temperature at presentation with BSI, and the highest temperature within 72 hours (Tmax) were collected. We observed 59 BSIs in LVAD patients and 45 BSIs in controls. LVAD patients were more likely to be afebrile and to have a lower temperature at presentation than control (88% vs 58%, p=0.002, and 37°C ±0.7 vs 37.7°C ±1.0, p=0.0009, respectively). By 72 hours, the difference in afebrile status diminished (53% vs 44%, p=0.42), and the Tmax was similar between the LVAD and control groups (37.9°C±0.9 vs 38.2°C±0.8, respectively, p=0.10). In conclusion, at presentation with a BSI, the vast majority of CF-LVAD patients were afebrile, an event which occurred at a higher frequency when compared with patients with advanced HF on chronic inotropes via an indwelling venous catheter. These data alert clinicians to have a very low threshold to obtain blood cultures in CF-LVAD patients even in the absence of fever. Further study is needed to determine whether a delayed or diminished febrile response represents another pathophysiological consequence of CF-LVADs.
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- 2019
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15. Longitudinal Trends in Cardiovascular Risk Factor Profiles and Complications Among Patients Hospitalized for COVID-19 Infection: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry.
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Hall, Eric J., Ayers, Colby R., Kolkailah, Ahmed A., Rutan, Christine, Walchok, Jason, Williams IV, Joseph H., Wang, Tracy Y., Rodriguez, Fatima, Bradley, Steven M., Stevens, Laura, Hall, Jennifer L., Mallya, Pratheek, Roth, Gregory A., Morrow, David A., Elkind, Mitchell S.V., Das, Sandeep R., and de Lemos, James A.
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Background: The COVID-19 pandemic has evolved through multiple phases characterized by new viral variants, vaccine development, and changes in therapies. It is unknown whether rates of cardiovascular disease (CVD) risk factor profiles and complications have changed over time. Methods: We analyzed the American Heart Association COVID-19 CVD registry, a national multicenter registry of hospitalized adults with active COVID-19 infection. The time period from April 2020 to December 2021 was divided into 3-month epochs, with March 2020 analyzed separately as a potential outlier. Participating centers varied over the study period. Trends in all-cause in-hospital mortality, CVD risk factors, and in-hospital CVD outcomes, including a composite primary outcome of cardiovascular death, cardiogenic shock, new heart failure, stroke, and myocardial infarction, were evaluated across time epochs. Risk-adjusted analyses were performed using generalized linear mixed-effects models. Results: A total of 46 007 patient admissions from 134 hospitals were included (mean patient age 61.8 years, 53% male, 22% Black race). Patients admitted later in the pandemic were younger, more likely obese, and less likely to have existing CVD (P
trend ≤0.001 for each). The incidence of the primary outcome increased from 7.0% in March 2020 to 9.8% in October to December 2021 (risk-adjusted Ptrend =0.006). This was driven by an increase in the diagnosis of myocardial infarction and stroke (Ptrend <0.0001 for each). The overall rate of in-hospital mortality was 14.2%, which declined over time (20.8% in March 2020 versus 10.8% in the last epoch; adjusted Ptrend <0.0001). When the analysis was restricted to July 2020 to December 2021, no temporal change in all-cause mortality was seen (adjusted Ptrend =0.63). Conclusions: Despite a shifting risk factor profile toward a younger population with lower rates of established CVD, the incidence of diagnosed cardiovascular complications of COVID increased from the onset of the pandemic through December 2021. All-cause mortality decreased during the initial months of the pandemic and thereafter remained consistently high through December 2021. [ABSTRACT FROM AUTHOR]- Published
- 2023
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16. Soluble endothelial cell-selective adhesion molecule and incident cardiovascular events in a multiethnic population.
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Ren, Hao-Yu, Khera, Amit, de Lemos, James A., Ayers, Colby R., and Rohatgi, Anand
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Background: Cell adhesion molecules are key regulators of atherosclerotic plaque development, but circulating levels of soluble fragments, such as intercellular adhesion molecule (sICAM-1) and vascular cell adhesion molecule (sVCAM-1), have yielded conflicting associations with atherosclerotic cardiovascular disease (ASCVD). Endothelial cell-selective adhesion molecule (ESAM) is expressed exclusively in platelets and endothelial cells, and soluble ESAM (sESAM) levels have been associated with prevalent subclinical atherosclerosis. We therefore hypothesized that sESAM would be associated with incident ASCVD.Methods: sESAM, sICAM-1, and sVCAM-1 were measured in 2,442 participants without CVD in the Dallas Heart Study, a probability-based population sample aged 30-65 years enrolled between 2000 and 2002. ASCVD was defined as first myocardial infarction, stroke, coronary revascularization, or CV death. A total of 162 ASCVD events were analyzed over 10.4 years.Results: Increasing sESAM was associated with ASCVD, independent of risk factors (HR Q4 vs Q1: 2.7, 95% CI 1.6-4.6). Serial adjustment for renal function, sICAM-1, VCAM-1, and prevalent coronary calcium did not attenuate these associations. Continuous ESAM demonstrated similar findings (HR 1.31, 95% CI 1.2-1.4). Addition of sESAM to traditional risk factors improved discrimination and reclassification (delta c-index: P = .009; integrated-discrimination-improvement index P = .001; net reclassification index = 0.42, 95% CI 0.15-0.68). Neither sICAM-1 nor sVCAM-1 was independently associated with ASCVD.Conclusions: sESAM but not sICAM-1 or sVCAM-1 levels are associated with incident ASCVD. Further studies are warranted to investigate the role of sESAM in ASCVD. [ABSTRACT FROM AUTHOR]- Published
- 2017
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17. Defining coronary artery calcium concordance and repeatability - Implications for development and change: The Dallas Heart Study.
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Paixao, Andre R.M., Neeland, Ian J., Ayers, Colby R., Xing, Frank, Berry, Jarett D., de Lemos, James A., Abbara, Suhny, Peshock, Ronald M., and Khera, Amit
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Background Development and change of coronary artery calcium (CAC) are associated with coronary heart disease. Interpretation of serial CAC measurements will require better understanding of changes in CAC beyond the variability in the test itself. Methods Dallas Heart Study participants (2888) with duplicate CAC scans obtained minutes apart were analyzed to determine interscan concordance and 95% confidence bounds (ie: repeatability limits) for each discrete CAC value. These data derived cutoffs were then used to define change above measurement variation and determine the frequency of CAC development and change among 1779 subjects with follow up CAC scans performed 6.9 years later. Results Binary concordance (0 vs. >0) was 91%. The value of CAC denoting true development of CAC by exceeding the 95% confidence bounds for a single score of 0 was 2.7 Agatston units (AU). Among those with scores >0, the 95% confidence bounds for CAC change were determined by the following formulas: for CAC≤100AU: 5.6√CAC + 0.3*CAC – 3.1; for CAC>100AU: 12.4√CAC – 67.7. Using these parameters, CAC development occurred in 15.0% and CAC change occurred in 48.9%. Although 225 individuals (24.9%) had a decrease in CAC over follow up, only 1 (0.1%) crossed the lower confidence bound. Compared with prior reported definition of CAC development (ie: >0), the novel threshold of 2.7AU resulted in better measures of model performance. In contrast, for CAC change, no consistent differences in performance metrics were observed compared with previously reported definitions. Conclusion There is significant interscan variability in CAC measurement, including around scores of 0. Incorporating repeatability estimates may help discern true differences from those due to measurement variability, an approach that may enhance determination of CAC development and change. [ABSTRACT FROM AUTHOR]
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- 2017
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18. Factors Associated With Left Atrial Remodeling in the General Population.
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Oliver, Walter, Matthews, Gwendolyn, Ayers, Colby R., Garg, Sonia, Gupta, Sachin, Neeland, Ian J., Drazner, Mark H., Berry, Jarett D., Matulevicius, Susan, and de Lemos, James A.
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Background--Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts, few data are available describing factors influencing changes in left atrial (LA) structure. Methods and Results--Maximum LA volume was determined by cardiac magnetic resonance imaging among 748 participants in the Dallas Heart Study at 2 visits a mean of 8 years apart. Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac magnetic resonance imaging and detailed measurements of global and regional adiposity (by magnetic resonance imaging and dual-energy x ray absorptiometry) were assessed using multivariable linear regression. Greater ΔLAV was independently associated with black and Hispanic race/ethnicity, change in systolic blood pressure, LV mass and ΔLV mass, N-terminal probrain natriuretic peptide and change in N-terminal probrain natriuretic peptide, and body mass index (P<0.05 for each). In subanalyses, the associations of ΔLAV with LV mass parameters were driven by associations with baseline and ΔLV end diastolic volume (P<0.0001 for each) and not wall thickness (P=0.21). Associations of ΔLAV with body mass index were explained exclusively by associations with visceral fat mass (P=0.002), with no association seen between ΔLAV and subcutaneous abdominal fat (P=0.47) or lower body fat (P=0.30). Conclusions--Left atrial dilatation in the population is more common in black and Hispanic than in white individuals and is associated with parallel changes in the LV. LA dilatation may be mediated by blood pressure control and the development of visceral adiposity. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Effects of visceral adiposity on glycerol pathways in gluconeogenesis.
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Neeland, Ian J., Hughes, Connor, Ayers, Colby R., Malloy, Craig R., and Jin, Eunsook S.
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GLUCONEOGENESIS ,OVERWEIGHT persons ,OBESITY ,FATTY liver ,THERAPEUTICS ,BLOOD plasma ,DIAGNOSIS ,PHYSIOLOGY - Abstract
Objective To determine the feasibility of using oral 13 C labeled glycerol to assess effects of visceral adiposity on gluconeogenic pathways in obese humans. Research Design and Methods Obese (BMI ≥ 30 kg/m 2 ) participants without type 2 diabetes underwent visceral adipose tissue (VAT) assessment and stratification by median VAT into high VAT-fasting (n = 3), low VAT-fasting (n = 4), and high VAT-refed (n = 2) groups. Participants ingested [U- 13 C 3 ] glycerol and blood samples were subsequently analyzed at multiple time points over 3 h by NMR spectroscopy. The fractions of plasma glucose (enrichment) derived from [U- 13 C 3 ] glycerol via hepatic gluconeogenesis, pentose phosphate pathway (PPP), and tricarboxylic acid (TCA) cycle were assessed using 13 C NMR analysis of glucose. Mixed linear models were used to compare 13 C enrichment in glucose between groups. Results Mean age, BMI, and baseline glucose were 49 years, 40.1 kg/m 2 , and 98 mg/dl, respectively. Up to 20% of glycerol was metabolized in the TCA cycle prior to gluconeogenesis and PPP activity was minor (< 1% of total glucose) in all participants. There was a 21% decrease in 13 C enrichment in plasma glucose in the high VAT-fasting compared with low VAT-fasting group ( p = 0.03), suggesting dilution by endogenous glycerol. High VAT-refed participants had 37% less 13 C enrichment in glucose compared with high VAT-fasting ( p = 0.02). There was a trend toward lower [1,2- 13 C 2 ] (via PPP) and [5,6- 13 C 2 ]/[4,5,6- 13 C 3 ] (via TCA cycle) glucose in high VAT versus low VAT groups. Conclusions We applied a simple method to detect gluconeogenesis from glycerol in obese humans. Our findings provide preliminary evidence that excess visceral fat disrupts multiple pathways in hepatic gluconeogenesis from glycerol. [ABSTRACT FROM AUTHOR]
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- 2017
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20. Bendopnea and risk of adverse clinical outcomes in ambulatory patients with systolic heart failure.
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Thibodeau, Jennifer T., Jenny, Benjamin E., Maduka, Jeomi O., Divanji, Punag H., Ayers, Colby R., Araj, Faris, Amin, Alpesh A., Morlend, Robert M., Mammen, Pradeep P.A., and Drazner, Mark H.
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Background: Recently, the symptom of bendopnea, that is, shortness of breath when bending forwards such as when putting on shoes, has been described in heart failure patients and found to be associated with higher ventricular filling pressures, particularly in the setting of low cardiac index. However, it is not known whether bendopnea is associated with clinical outcomes.Methods: In a prospective convenience sample of 179 patients followed in our heart failure disease management clinic, we determined the presence of bendopnea at the time of enrollment and ascertained clinical outcomes through 1 year of follow-up. We performed univariate and stepwise multivariable modeling to test the association of bendopnea with clinical outcomes.Results: Bendopnea was present in 32 of 179 (18%) subjects. At 1 year, those with versus without bendopnea were at increased risk of the composite endpoint of death, heart failure admission, inotrope initiation, left ventricular assist device implantation, or cardiac transplantation in univariate (hazard ratio [HR] 1.9, P < .05) but not multivariable (HR 1.9, P = .11) analysis. Bendopnea was more strongly associated with short-term outcomes including heart failure admission at 3 months in both univariate (HR 3.1, P < .004) and multivariable (HR 2.5, P = .04) analysis.Conclusions: Bendopnea was associated with an increased risk of adverse outcomes in ambulatory patients with heart failure, particularly heart failure admission at 3 months. [ABSTRACT FROM AUTHOR]- Published
- 2017
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21. Disentangling the Pulmonary Capillary Wedge Pressure From the Pulmonary Artery Pressure as the Hemodynamic Underpinning of Bendopnea.
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Thibodeau, Jennifer T., Ravipati, Goutham, Pham, David D., Ayers, Colby R., Hardin, Elizabeth A., Chin, Kelly M., Grodin, Justin L., and Drazner, Mark H.
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- 2023
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22. Characterization and Trajectory of Coronary Artery Calcium Percentiles: The Dallas Heart Study.
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Eades, Micah T., Paixao, Andre R.M., Mehta, Anurag, Ayers, Colby R., Joshi, Parag H., Berry, Jarett D., de Lemos, James A., and Khera, Amit
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- 2019
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23. Adherence with physical activity monitoring wearable devices in a community-based population: observations from the Washington, D.C., Cardiovascular Health and Needs Assessment.
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Yingling, Leah R, Mitchell, Valerie, Ayers, Colby R, Peters-Lawrence, Marlene, Wallen, Gwenyth R, Brooks, Alyssa T, Troendle, James F, Adu-Brimpong, Joel, Thomas, Samantha, Henry, JaWanna, Saygbe, Johnetta N, Sampson, Dana M, Johnson, Allan A, Graham, Avis P, Graham, Lennox A, Wiley, Kenneth L, and Powell-Wiley, Tiffany
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Wearable mobile health (mHealth) technologies offer approaches for targeting physical activity (PA) in resource-limited, community-based interventions. We sought to explore user characteristics of PA tracking, wearable technology among a community-based population within a health and needs assessment. In 2014-2015, we conducted the Washington, D.C., Cardiovascular Health and Needs Assessment in predominantly African-American churches among communities with higher obesity rates and lower household incomes. Participants received a mHealth PA monitor and wirelessly uploaded PA data weekly to church data collection hubs. Participants (n = 99) were 59 ± 12 years, 79% female, and 99% African-American, with a mean body mass index of 33 ± 7 kg/m2. Eighty-one percent of participants uploaded PA data to the hub and were termed "PA device users." Though PA device users were more likely to report lower household incomes, no differences existed between device users and non-users for device ownership or technology fluency. Findings suggest that mHealth systems with a wearable device and data collection hub may feasibly target PA in resource-limited communities.
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- 2017
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24. Longitudinal Trends in Cardiovascular Risk Factor Profiles and Complications Among Patients Hospitalized for COVID-19 Infection: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry
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Hall, Eric J., Ayers, Colby R., Kolkailah, Ahmed A., Rutan, Christine, Walchok, Jason, Williams, Joseph H., Wang, Tracy Y., Rodriguez, Fatima, Bradley, Steven M., Stevens, Laura, Hall, Jennifer L., Mallya, Pratheek, Roth, Gregory A., Morrow, David A., Elkind, Mitchell S.V., Das, Sandeep R., and de Lemos, James A.
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- 2023
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25. Coronary Artery Calcium Improves Risk Classification in Younger Populations.
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Paixao, Andre R.M., Ayers, Colby R., El Sabbagh, Abdallah, Sanghavi, Monika, Berry, Jarett D., Rohatgi, Anand, Kumbhani, Dharam J., McGuire, Darren K., Das, Sandeep R., de Lemos, James A., and Khera, Amit
- Abstract
Objectives This study sought to assess the effect of coronary artery calcium (CAC) on coronary heart disease (CHD) risk prediction in a younger population. Background CAC measured by computed tomography improves CHD risk classification in older adults, but the effectiveness of CAC in younger populations has not been fully assessed. Methods In the DHS (Dallas Heart Study), a multiethnic probability-based population sample, traditional CHD risk factors and CAC were measured in participants without baseline cardiovascular disease or diabetes. Incident CHD—defined as CHD death, myocardial infarction, or coronary revascularization—was assessed over a median follow-up of 9.2 years. Predicted CHD risk was assessed with a Weibull model inclusive of traditional risk factors before and after the addition of CAC as ln(CAC + 1). Participants were divided into 3 10-year risk categories, <6%, 6% to <20%, and ≥20%, and the net reclassification improvement (NRI) was calculated. We also performed a random-effects meta-analysis of NRI from previous studies inclusive of older individuals. Results The analysis comprised 2,084 participants; mean age was 44.4 ± 9.0 years. CAC was independently associated with incident CHD (hazard ratio per SD: 1.90, 95% confidence interval [CI] 1.51 to 2.38; p < 0.001). The addition of CAC to the traditional risk factor model resulted in significant improvement in the C-statistic (delta = 0.03; p = 0.003). Among participants with CHD events, the addition of CAC resulted in net correct upward reclassification of 21%, and among those without CHD, a net correct downward reclassification of 0.5% (NRI: 0.216, p = 0.012). Results remained significant when the outcome was restricted to CHD death and myocardial infarction and when individuals with diabetes were included. The NRI observed in this study was similar to the pooled estimate from previous studies (0.200, 95% CI: 0.140 to 0.258) and the addition of our study to the meta-analysis did not result in significant heterogeneity (I 2 = 0%). Conclusions CAC scoring also improves CHD risk classification in younger adults. [ABSTRACT FROM AUTHOR]
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- 2015
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26. Multimodality Strategy for Cardiovascular Risk Assessment
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de Lemos, James A., Ayers, Colby R., Levine, Benjamin, deFilippi, Christopher R., Wang, Thomas J., Hundley, W. Gregory, Berry, Jarett D., Seliger, Stephen L., McGuire, Darren K., Ouyang, Pamela, Drazner, Mark H., Budoff, Matthew, Greenland, Philip, Ballantyne, Christie M., and Khera, Amit
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Supplemental Digital Content is available in the text.
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- 2017
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27. Sex-Based Differences in Cardiometabolic Biomarkers
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Lew, Jeanney, Sanghavi, Monika, Ayers, Colby R., McGuire, Darren K., Omland, Torbjørn, Atzler, Dorothee, Gore, Maria O., Neeland, Ian, Berry, Jarett D., Khera, Amit, Rohatgi, Anand, and de Lemos, James A.
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Supplemental Digital Content is available in the text.
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- 2017
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28. Disentangling the Pulmonary Capillary Wedge Pressure From the Pulmonary Artery Pressure as the Hemodynamic Underpinning of Bendopnea
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Thibodeau, Jennifer T., Ravipati, Goutham, Pham, David D., Ayers, Colby R., Hardin, Elizabeth A., Chin, Kelly M., Grodin, Justin L., and Drazner, Mark H.
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- 2023
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29. In-hospital cardiopulmonary arrests in patients with left ventricular assist devices.
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Garg, Sonia, Ayers, Colby R, Fitzsimmons, Catherine, Meyer, Dan, Peltz, Matthias, Bethea, Brian, Cornwell, William, Araj, Faris, Thibodeau, Jennifer, and Drazner, Mark H
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Background: Basic and advanced cardiac life support guidelines do not address resuscitation of patients with continuous-flow (CF) left ventricular assist devices (LVADs). As the population of LVAD patients increases, it becomes important to understand how to provide emergency care to such patients. METHODS AND RESULTS: We retrospectively reviewed a consecutive series of patients with an implanted CF-LVAD who had an in-hospital cardiopulmonary arrest at our medical center from January 2011 to October 2013. We compared them with a matched cohort of patients without LVADs who had an inhospital cardiopulmonary arrest during the same time period. Code documentation was used to determine arrest characteristics, perfusion assessment techniques, and time to cardiopulmonary resuscitation (CPR) initiation. There were 415 in-hospital arrests during the study period, and 4% (n 5 16) occurred in patients with CF-LVADs. Response teams used various approaches to assess arterial perfusion, including palpation or Doppler of the arterial pulse and measurement of blood pressure by Doppler or arterial line. Nine of the 16 patients required CPR, but only 5 (56%) received CPR in !2 minutes. In the control group (n 5 32) of patients without an LVAD, 22 received CPR, which was initiated within 2 minutes in all (100%) of the patients. CONCLUSIONS: Cardiopulmonary arrests in LVAD patients accounted for 4% of all arrests in our center. We identified important time delays in CPR initiation, highlighting the need to develop resuscitation guidelines for this patient population. [ABSTRACT FROM AUTHOR]
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- 2014
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30. GlycA, hsCRP differentially associated with MI, ischemic stroke: In the Dallas Heart Study and Multi-Ethnic Study of Atherosclerosis
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Riggs, Kayla A., Joshi, Parag H., Khera, Amit, Otvos, James D., Greenland, Philip, Ayers, Colby R., and Rohatgi, Anand
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•GlycA more strongly predicted incident MI.•hsCRP more strongly predicted incident ischemic stroke.•GlycA may detect other inflammatory risk not captured by hsCRP
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- 2022
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31. New-Onset Atrial Fibrillation in Patients Hospitalized With COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Registry.
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Rosenblatt, Anna G., Ayers, Colby R., Rao, Anjali, Howell, Stacey J., Hendren, Nicholas S., Zadikany, Ronit H., Ebinger, Joseph E., Daniels, James D., Link, Mark S., de Lemos, James A., and Das, Sandeep R.
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Background: New-onset atrial fibrillation (AF) in patients hospitalized with COVID-19 has been reported and associated with poor clinical outcomes. We aimed to understand the incidence of and outcomes associated with new-onset AF in a diverse and representative US cohort of patients hospitalized with COVID-19.Methods: We used data from the American Heart Association COVID-19 Cardiovascular Disease Registry. Patients were stratified by the presence versus absence of new-onset AF. The primary and secondary outcomes were in-hospital mortality and major adverse cardiovascular events (MACE; cardiovascular death, myocardial infarction, stroke, cardiogenic shock, and heart failure). The association of new-onset AF and the primary and secondary outcomes was evaluated using Cox proportional-hazards models for the primary time to event analyses.Results: Of the first 30 999 patients from 120 institutions across the United States hospitalized with COVID-19, 27 851 had no history of AF. One thousand five hundred seventeen (5.4%) developed new-onset AF during their index hospitalization. New-onset AF was associated with higher rates of death (45.2% versus 11.9%) and MACE (23.8% versus 6.5%). The unadjusted hazard ratio for mortality was 1.99 (95% CI, 1.81-2.18) and for MACE was 2.23 (95% CI, 1.98-2.53) for patients with versus without new-onset AF. After adjusting for demographics, clinical comorbidities, and severity of disease, the associations with death (hazard ratio, 1.10 [95% CI, 0.99-1.23]) fully attenuated and MACE (hazard ratio, 1.31 [95% CI, 1.14-1.50]) partially attenuated.Conclusions: New-onset AF was common (5.4%) among patients hospitalized with COVID-19. Almost half of patients with new-onset AF died during their index hospitalization. After multivariable adjustment for comorbidities and disease severity, new-onset AF was not statistically significantly associated with death, suggesting that new-onset AF in these patients may primarily be a marker of other adverse clinical factors rather than an independent driver of mortality. Causality between the MACE composites and AF needs to be further evaluated. [ABSTRACT FROM AUTHOR]- Published
- 2022
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32. Association between number of live births and markers of subclinical atherosclerosis: The Dallas Heart Study
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Sanghavi, Monika, Kulinski, Jacquelyn, Ayers, Colby R, Nelson, David, Stewart, Robert, Parikh, Nisha, de Lemos, James A, and Khera, Amit
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Aims Higher parity has been associated with increased maternal risk of cardiovascular disease, but the mechanism is not well delineated. Whether the number of live births is associated with coronary and aortic subclinical atherosclerosis has not been fully evaluated.Methods and results Women from the Dallas Heart Study, a multiethnic population-based cohort of subjects aged 30–65 years, were included if they had data on self-reported live births and coronary artery calcium (CAC) measured by computed tomography or aortic wall thickness (AWT) by MRI. Coronary artery calcium was positive if >10 Agatston units, and aortic wall thickness if greater than the 75thpercentile reference point for age and gender. Among the 1644 women included in the study, the mean age was 45 years and 55% were Black. Sequential multivariable models were done adjusting for age, race, traditional cardiovascular risk factors, body mass index, income, education, hormone replacement therapy, oral contraceptives, and physical activity. Using women with 2–3 live births as the reference, those with four or more live births had an increased prevalence of elevated coronary artery calcium (odds ratio (OR) 2.2, 95% confidence interval (CI) 1.28–3.65) and aortic wall thickness (OR 1.6, 95% CI 1.04–2.41). Women with 0–1 live births also had increased coronary artery calcium (OR 1.9, 95% CI 1.16–3.03) and aortic wall thickness (OR 1.5, 95% CI 1.05–2.09) after multivariable adjustment.Conclusion The number of live births is associated with subclinical coronary and aortic atherosclerosis, with an apparent U-shaped relationship. Further studies are needed to confirm this association and explore the biological underpinnings of these findings.
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- 2016
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33. Applying a Big Data Approach to Biomarker Discovery
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de Lemos, James A., Rohatgi, Anand, and Ayers, Colby R.
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- 2015
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34. Coronary Artery Calcification and Family History of Myocardial Infarction in the Dallas Heart Study.
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Paixao, Andre R. M., Berry, Jarett D., Neeland, Ian J., Ayers, Colby R., Rohatgi, Anand, de Lemos, James A., and Khera, Amit
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Objectives This study aimed to investigate the independent and joint associations between family history of myocardial infarction (FH) and coronary artery calcification (CAC) with incident coronary heart disease (CHD). Background FH and CAC are associated with each other and with incident CHD. It is not known whether FH retains its predictive value after CAC results are accounted for. Methods Among 2,390 participants without cardiovascular disease enrolled in the Dallas Heart Study, we assessed FH (myocardial infarction in a first-degree relative) and prevalent CAC by electron-beam computed tomography. The primary outcome, a composite of CHD-related death, myocardial infarction, and percutaneous or surgical coronary revascularization, was assessed over a mean follow-up of 8.0 ± 1.2 years. The individual and joint associations with the CHD composite outcome were determined for FH and CAC. Results The mean age of the population was 44 ± 9 years; 32% had FH and 47% had a CAC score of 0. In multivariate models adjusted for traditional risk factors, FH was independently associated with CHD (adjusted hazard ratio: 2.6; 95% confidence interval: 1.6 to 4.2; p < 0.001). Further adjustment for prevalent CAC did not diminish this association (adjusted hazard ratio: 2.6; 95% confidence interval: 1.6 to 4.2; p < 0.001). FH and CAC were additive: CHD event rates in those with both FH and CAC were 8.8% vs. 3.3% in those with prevalent CAC alone (p < 0.001). CHD rates were 1.9% in those with FH alone compared with 0.4% in those with neither FH nor CAC (p < 0.017). Among subjects without CAC, FH characterized a group with a more unfavorable cardiometabolic profile. Conclusions FH provided prognostic information that was independent of and additive to CAC. Among those with CAC, FH identified subjects at particularly high short-term risk, and, among those without it, selected a group with an adverse risk-factor profile. [ABSTRACT FROM AUTHOR]
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- 2014
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35. Prediction of 30-year risk for cardiovascular mortality by fitness and risk factor levels: the Cooper Center Longitudinal Study.
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Wickramasinghe, Chanaka D, Ayers, Colby R, Das, Sandeep, de Lemos, James A, Willis, Benjamin L, and Berry, Jarett D
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Background: Fitness and traditional risk factors have well-known associations with cardiovascular disease (CVD) death in both short-term (10 years) and across the remaining lifespan. However, currently available short-term and long-term risk prediction tools do not incorporate measured fitness.Methods and Results: We included 16 533 participants from the Cooper Center Longitudinal Study (CCLS) without prior CVD. Fitness was measured using the Balke protocol. Sex-specific fitness levels were derived from the Balke treadmill times and categorized into low, intermediate, and high fit according to age- and sex-specific treadmill times. Sex-specific 30-year risk estimates for CVD death adjusted for competing risk of non-CVD death were estimated using the cause-specific hazards model and included age, body mass index, systolic blood pressure, fitness, diabetes mellitus, total cholesterol, and smoking. During a median follow-up period of 28 years, there were 1123 CVD deaths. The 30-year risk estimates for CVD mortality derived from the cause-specific hazards model demonstrated overall good calibration (Nam-D'Agostino χ(2) [men, P=0.286; women, P=0.664] and discrimination (c statistic; men, 0.81 [0.80-0.82] and women, 0.86 [0.82-0.91]). Across all risk factor strata, the presence of low fitness was associated with a greater 30-year risk for CVD death.Conclusions: Fitness represents an important additional covariate in 30-year risk prediction functions that may serve as a useful tool in clinical practice. [ABSTRACT FROM AUTHOR]- Published
- 2014
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36. High-Sensitivity Cardiac Troponin I Assay to Screen for Acute Rejection in Patients With Heart Transplant.
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Patel, Parag C., Hill, Douglas A., Ayers, Colby R., Lavingia, Bhavna, Kaiser, Patricia, Dyer, Adrian K., Barnes, Aliessa P., Thibodeau, Jennifer T., Mishkin, Joseph D., Mammen, Pradeep P.A., Markham, David W., Stastny, Peter, Ring, W. Steves, de Lemos, James A., and Drazner, Mark H.
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A noninvasive biomarker that could accurately diagnose acute rejection (AR) in heart transplant recipients could obviate the need for surveillance endomyocardial biopsies. We assessed the performance metrics of a novel high-sensitivity cardiac troponin I (cTnI) assay for this purpose.Stored serum samples were retrospectively matched to endomyocardial biopsies in 98 cardiac transplant recipients, who survived ≥3 months after transplant. AR was defined as International Society for Heart and Lung Transplantation grade 2R or higher cellular rejection, acellular rejection, or allograft dysfunction of uncertain pathogenesis, leading to treatment for presumed rejection. cTnI was measured with a high-sensitivity assay (Abbott Diagnostics, Abbott Park, IL). Cross-sectional analyses determined the association of cTnI concentrations with rejection and International Society for Heart and Lung Transplantation grade and the performance metrics of cTnI for the detection of AR. Among 98 subjects, 37% had ≥1 rejection episode. cTnI was measured in 418 serum samples, including 35 paired to a rejection episode. cTnI concentrations were significantly higher in rejection versus nonrejection samples (median, 57.1 versus 10.2 ng/L; P<0.0001) and increased in a graded manner with higher biopsy scores (P
trend <0.0001). The c-statistic to discriminate AR was 0.82 (95% confidence interval, 0.76-0.88). Using a cut point of 15 ng/L, sensitivity was 94%, specificity 60%, positive predictive value 18%, and negative predictive value 99%.A high-sensitivity cTnI assay seems useful to rule out AR in cardiac transplant recipients. If validated in prospective studies, a strategy of serial monitoring with a high-sensitivity cTnI assay may offer a low-cost noninvasive strategy for rejection surveillance. [ABSTRACT FROM AUTHOR]- Published
- 2014
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37. Racial Differences in Natriuretic Peptide Levels
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Gupta, Deepak K., de Lemos, James A., Ayers, Colby R., Berry, Jarett D., and Wang, Thomas J.
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The purpose of this study was to assess whether N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels differ according to race/ethnicity.
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- 2015
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38. Association of 3.0-T Brain Magnetic Resonance Imaging Biomarkers With Cognitive Function in the Dallas Heart Study
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Gupta, Mohit, King, Kevin S., Srinivasa, Rajiv, Weiner, Myron F., Hulsey, Keith, Ayers, Colby R., Whittemore, Anthony, McColl, Roderick W., Rossetti, Heidi C., and Peshock, Ronald M.
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IMPORTANCE: Understanding the relationships between age-related changes in brain structure and cognitive function has been limited by inconsistent methods for assessing brain imaging, small sample sizes, and racially/ethnically homogeneous cohorts with biased selection based on risk factors. These limitations have prevented the generalizability of results from brain morphology studies. OBJECTIVE: To determine the association of 3.0-T structural brain magnetic resonance (MR) imaging measurements with cognitive function in the multiracial/multiethnic, population-based Dallas Heart Study. DESIGN, SETTING, AND PARTICIPANTS: Whole-brain, 2-dimensional, fluid-attenuated inversion recovery and 3-dimensional, magnetization-prepared, rapid acquisition with gradient echo MR imaging at 3.0 T was performed in 1645 Dallas Heart Study participants (mean [SD] age, 49.9 [10.5] years; age range, 19-85 years) who received both brain MR imaging and cognitive screening with the Montreal Cognitive Assessment between September 18, 2007, and December 28, 2009. Measurements were obtained for white matter hyperintensity volume, total brain volume, gray matter volume, white matter volume, cerebrospinal fluid volume, and hippocampal volume. Linear regression and a best predictive model were developed to determine the association of MR imaging biomarkers with the Montreal Cognitive Assessment total score and domain-specific questions. MAIN OUTCOMES AND MEASURES: High-resolution anatomical MR imaging was used to quantify brain volumes. Scores on the screening Montreal Cognitive Assessment were used for cognitive assessment in participants. RESULTS: After adjustment for demographic variables, total brain volume (P < .0001, standardized estimate [SE] = .1069), gray matter volume (P < .0001, SE = .1156), white matter volume (P = .008, SE = .0687), cerebrospinal fluid volume (P = .012, SE = −.0667), and hippocampal volume (P < .0001) were significantly associated with cognitive performance. A best predictive model identified gray matter volume (P < .001, SE = .0021), cerebrospinal fluid volume (P = .01, SE = .0024), and hippocampal volume (P = .004, SE = .1017) as 3 brain MR imaging biomarkers significantly associated with the Montreal Cognitive Assessment total score. Questions specific to the visuospatial domain were associated with the most brain MR imaging biomarkers (total brain volume, gray matter volume, white matter volume, cerebrospinal fluid volume, and hippocampal volume), while questions specific to the orientation domain were associated with the least brain MR imaging biomarkers (only hippocampal volume). CONCLUSIONS AND RELEVANCE: Brain MR imaging volumes, including total brain volume, gray matter volume, cerebrospinal fluid volume, and hippocampal volume, were independently associated with cognitive function and may be important early biomarkers of risk for cognitive insult in a young multiracial/multiethnic population. A best predictive model indicated that a combination of multiple neuroimaging biomarkers may be more effective than a single brain MR imaging volume measurement.
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- 2015
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39. Relation of Regional Fat Distribution to Left Ventricular Structure and Function.
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Neeland, Ian J., Gupta, Sachin, Ayers, Colby R., Turer, Aslan T., Rame, J. Eduardo, Das, Sandeep R., Berry, Jarett D., Khera, Amit, McGuire, Darren K., Vega, Gloria L., Grundy, Scott M., de Lemos, James A., and Drazner, Mark H.
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The relation of body fat distribution to left ventricular (LV) structure and function is poorly defined.A total of 2710 participants without heart failure or LV dysfunction in the Dallas Heart Study underwent dual energy x-ray absorptiometry and MRI assessment of fat distribution, LV morphology, and hemodynamics. Cross-sectional associations of fat distribution with LV structure and function were examined after adjustment for age, sex, race, comorbidities, and lean mass. Mean age was 44 years with 55% women; 48% blacks; and 44% obese. After multivariable adjustment, visceral adipose tissue was associated with concentric remodeling characterized by lower LV end-diastolic volume (β=-0.21), higher concentricity (β=0.20), and wall thickness (β=0.09; P<0.0001 for all). In contrast, lower body subcutaneous fat was associated with higher LV end-diastolic volume (β=0.48), reduced concentricity (β=-0.50), and wall thickness (β=-0.28, P<0.0001 for all). Visceral adipose tissue was also associated with lower cardiac output (β=-0.10, P<0.05) and higher systemic vascular resistance (β=0.08, P<0.05), whereas lower body subcutaneous fat associated with higher cardiac output (β=0.20, P<0.0001) and lower systemic vascular resistance (β=-0.18, P<0.0001). Abdominal subcutaneous fat showed weaker associations with concentric remodeling and was not associated with hemodynamics. Among the subset of obese participants, visceral adipose tissue, but not abdominal subcutaneous fat, was significantly associated with concentric remodeling.Visceral adipose tissue, a marker of central adiposity, was independently associated with concentric LV remodeling and adverse hemodynamics. In contrast, lower body subcutaneous fat was associated with eccentric remodeling. The impact of body fat distribution on heart failure risk requires prospective study. [ABSTRACT FROM AUTHOR]
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- 2013
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40. Discordant effects of rosiglitazone on novel inflammatory biomarkers.
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Gada, Elan, Owens, Andrew W., Gore, M. Odette, See, Raphael, Abdullah, Shuaib M., Ayers, Colby R., Rohatgi, Anand, Khera, Amit, de Lemos, James A., and McGuire, Darren K.
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Background: Although rosiglitazone favorably affects myriad intermediate markers of atherosclerosis, it appears to increase myocardial infarction (MI) risk. We analyzed the effects of rosiglitazone on a panel of 8 novel circulating biomarkers, 4 of which are independently associated with atherosclerosis: lymphotoxin β receptor, peptidoglycan recognition protein 1, chemokine ligand 23, and soluble receptor for advanced glycation end products (sRAGE) as well as on high-sensitivity C-reactive protein (hs-CRP). Methods: Blood samples were analyzed at baseline and after 6 months of study treatment from subjects with type 2 diabetes with or at high risk for coronary artery disease in a randomized trial comparing rosiglitazone versus placebo. Results: Data from 111 subjects (rosiglitazone 55, placebo 56) were analyzed. Mean age was 56 years, 41% were women, and 66% were nonwhite. Compared with baseline values, rosiglitazone adversely affected levels of lymphotoxin β receptor (1.7 vs 2.4 ng/mL, P = .002), peptidoglycan recognition protein 1 (29.0 vs 30.1 ng/mL, P = .01), and chemokine ligand 23 (0.76 vs 0.84 ng/mL, P = .02) and favorably affected levels of sRAGE (inversely associated with atherosclerosis, 1.1 vs 1.4 ng/mL, P = .003) and hs-CRP (0.42 vs 0.31 ng/mL, P = .02); no changes were observed with rosiglitazone in the other biomarkers. In the placebo group, change was observed only for sRAGE (1.0 vs 1.1 ng/mL, P = .046). Conclusion: Rosiglitazone adversely affected 3 novel biomarkers and favorably affected a fourth previously associated with atherosclerosis while improving hs-CRP, as has previously been shown. Whether these complex effects on circulating inflammatory biomarkers contribute to the signal of increased MI risk with rosiglitazone and whether pioglitazone has similar effects warrant further investigation. [Copyright &y& Elsevier]
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- 2013
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41. Relationship of Right- to Left-Sided Ventricular Filling Pressures in Advanced Heart Failure.
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Drazner, Mark H., Velez-Martinez, Mariella, Ayers, Colby R., Reimold, Sharon C., Thibodeau, Jennifer T., Mishkin, Joseph D., Mammen, Pradeep P.A., Markham, David W., and Patel, Chetan B.
- Abstract
Although right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP) are correlated in heart failure, in a sizeable minority of patients, the RAP and PCWP are not tightly coupled. The basis of this variability in the RAP/PCWP ratio, and whether it conveys prognostic value, is not known.We analyzed the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial database. Baseline characteristics, including echocardiographic assessment of right ventricular (RV) structure and function, and invasively measured hemodynamic parameters, were compared among tertiles of the RAP/PCWP ratio. Multivariable Cox proportional hazard models assessed the association of RAP/PCWP ratio with the primary ESCAPE outcome (6-month death or hospitalization [days]) adjusting for systolic blood pressure, blood urea nitrogen, 6-minute walk distance, and PCWP. The RAP/PCWP tertiles were 0.27 to 0.4 (tertile 1); 0.41 to 0.615 (tertile 2), and 0.62 to 1.21 (tertile 3). Increasing RAP/PCWP was associated with increasing median right atrial area (23, 26, 29 cm
2 , respectively; P<0.005), RV area in diastole (21, 27, 27 cm2 , respectively; P<0.005), and pulmonary vascular resistance (2.4, 2.9, 3.6 woods units, respectively; P=0.003), and lower RV stroke work index (8.6, 8.4, 5.5 g·m/m2 per beat, respectively; P<0.001). RAP/PCWP ratio was associated with death or hospitalization within 6 months (hazard ratio, 1.16 [1, 1.4]; P<0.05).Increased RAP/PCWP ratio was associated with higher pulmonary vascular resistance, reduced RV function (manifest as a larger right atrium and ventricle and lower RV stroke work index), and an increased risk of adverse outcomes in patients with advanced heart failure. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
42. Addition of highly sensitive troponin T and N-terminal pro-B-type natriuretic peptide to electrocardiography for detection of left ventricular hypertrophy: results from the Dallas Heart Study.
- Author
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Martinez-Rumayor AA, de Lemos JA, Rohatgi AK, Ayers CR, Powell-Wiley TM, Lakoski SG, Berry JD, Khera A, Das SR, Martinez-Rumayor, Abelardo A, de Lemos, James A, Rohatgi, Anand K, Ayers, Colby R, Powell-Wiley, Tiffany M, Lakoski, Susan G, Berry, Jarett D, Khera, Amit, and Das, Sandeep R
- Abstract
Left ventricular hypertrophy (LVH) is an independent, modifiable risk factor for cardiovascular disease. However, current screening strategies are limited. In 2478 participants without clinical disease from the Dallas Heart Study, we evaluated a multimarker screening strategy that complements electrocardiographic (ECG) criteria for LVH with 2 biomarkers, amino-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T. An integer LVH risk score from 0 to 3 was determined as the sum of the following: (1) LVH by Sokolow-Lyon ECG; (2) amino-terminal pro-B-type natriuretic peptide in the highest sex-specific quartile; and (3) detectable cardiac troponin T. Cardiac magnetic resonance imaging-determined LVH served as the primary outcome. The probability of LVH increased from 2% with an LVH risk score of 0 to 50% with a score of 3 (P<0.001). Sokolow-Lyon ECG afforded low sensitivity (26% [95% confidence interval {CI}, 17-32%]) and high specificity (96% [95% CI, 95-97%]), whereas a risk score ≥2 offered higher sensitivity (44% [95% CI, 34-51%]) with good specificity (90% [95% CI, 89-93%]) and a score threshold of 1 offered reasonable sensitivity (76% [95% CI, 67-83%]) with lower specificity (55% [95% CI, 53-61%]) and high negative predictive value (98% [95% CI, 97-98%]). Area under the receiver operator characteristic curve improved from 0.760 (95% CI, 0.716-0.804) for ECG alone to 0.798 (95% CI, 0.754-0.842) for the LVH risk score (P=0.0012), consistent with modest improvement in overall discrimination. Better screening for LVH may be achieved by combining simple tests, which collectively provide additional information compared with ECG alone. Further studies are needed to evaluate the impact and cost-effectiveness of a multimarker screening strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
43. Addition of Highly Sensitive Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Electrocardiography for Detection of Left Ventricular Hypertrophy.
- Author
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Martinez-Rumayor, Abelardo A., de Lemos, James A., Rohatgi, Anand K., Ayers, Colby R., Powell-Wiley, Tiffany M., Lakoski, Susan G., Berry, Jarett D., Khera, Amit, and Das, Sandeep R.
- Abstract
The article discusses the results of a study that evaluates left ventricular hypertrophy (LVH) detection by means of a multimarker screening strategy that complements electrocardiographic (ECG). The screening method consisted of two biomarkers, amino-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T. The study concludes that combining simple tests that collectively provide additional information compared with ECG alone is a better way to screen for LVH.
- Published
- 2013
- Full Text
- View/download PDF
44. The natural history of new-onset heart failure with a severely depressed left ventricular ejection fraction: Implications for timing of implantable cardioverter-defibrillator implantation.
- Author
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Teeter, William A., Thibodeau, Jennifer T., Rao, Krishnasree, Brickner, M. Elizabeth, Toto, Kathleen H., Nelson, Lauren L., Mishkin, Joseph D., Ayers, Colby R., Miller, Justin G., Mammen, Pradeep P.A., Patel, Parag C., Markham, David W., and Drazner, Mark H.
- Abstract
Background: Guidelines recommend that patients with new-onset systolic heart failure (HF) receive a trial of medical therapy before an implantable cardiac defibrillator (ICD). This strategy allows for improvement of left ventricular ejection fraction (LVEF), thereby avoiding an ICD, but exposes patients to risk of potentially preventable sudden cardiac death during the trial of medical therapy. Methods: We reviewed a consecutive series of patients with HF of <6 months duration with a severely depressed LVEF (<30%) evaluated in a HF clinic (N = 224). The ICD implantation was delayed with plans to reassess LVEF approximately 6 months after optimization of β-blockers. Mortality was ascertained by the National Death Index. Results: Follow-up echocardiograms were performed in 115 of the 224 subjects. Of these, 50 (43%) had mildly depressed or normal LVEF at follow-up (“LVEF recovery”) such that an ICD was no longer indicated. In a conservative sensitivity analysis (using the entire study cohort, whether or not a follow-up echocardiogram was obtained, as the denominator), 22% of subjects had LVEF recovery. Mortality at 6, 12, and 18 months in the entire cohort was 2.3%, 4.5%, and 6.8%, respectively. Of 87 patients who tolerated target doses of β-blockers, only 1 (1.1%) died during the first 18 months. Conclusion: Patients with new-onset systolic HF have both a good chance of LVEF recovery and low 6-month mortality. Achievement of target β-blocker dose identifies a very low-risk population. These data support delaying ICD implantation for a trial of medical therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
45. Physical activity participation, health perceptions, and cardiovascular disease mortality in a multiethnic population: The Dallas Heart Study.
- Author
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Mathieu, Reese A., Powell-Wiley, Tiffany M., Ayers, Colby R., McGuire, Darren K., Khera, Amit, Das, Sandeep R., and Lakoski, Susan G.
- Abstract
Background: Physical activity (PA) participation differs by ethnicity, but contributing factors and cardiovascular (CV) outcomes related to these disparities are not well understood. We determined whether health beliefs regarding the benefit of PA contribute to ethnic differences in participation and assessed how these differences impact CV mortality. Methods: The Dallas Heart Study is a longitudinal study of CV health. We assessed PA participation and health perceptions by questionnaire among 3,018 African American, Hispanic, and white men and women at baseline visit (2000-2002). Participant mortality was obtained through 2008 using the National Death Index. Results: African Americans (odds ratio 0.65, 95% CI 0.53-0.80) and Hispanics (odds ratio 0.34, 95% CI 0.26-0.45) were less likely to be physically active compared with whites even after accounting for income, educational status, age, sex, body mass index, diabetes, hypertension, and hyperlipidemia. Beliefs regarding the benefits of PA did not contribute to this disparity, as >94% of individuals felt PA was effective in preventing a heart attack across ethnicity. Physical activity participation was associated with a lower risk of all-cause mortality (hazard ratio [HR] 0.66, 95% CI 0.46-0.93) and CV disease death (HR 0.56, 95% CI 0.32-0.97) in multivariable adjusted models. Similar results were seen when restricting to African Americans (CV disease death, HR 0.57, 95% CI 0.31-1.05). Conclusions: Ethnic minorities reported less PA participation, and lack of PA was associated with higher CV mortality overall and among African Americans. Health perception regarding the benefits of PA did not contribute to this difference, indicating there are other ethnic-specific factors contributing to physical inactivity that require future study. [Copyright &y& Elsevier]
- Published
- 2012
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46. Left Ventricular Hypertrophy, Aortic Wall Thickness, and Lifetime Predicted Risk of Cardiovascular Disease: The Dallas Heart Study.
- Author
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Gupta, Sachin, Berry, Jarett D., Ayers, Colby R., Peshock, Ronald M., Khera, Amit, de Lemos, James A., Patel, Parag C., Markham, David W., and Drazner, Mark H.
- Subjects
CARDIAC hypertrophy ,AORTA abnormalities ,CARDIOVASCULAR diseases risk factors ,LEFT heart ventricle diseases ,HEART disease epidemiology ,CORONARY disease ,ATHEROSCLEROSIS - Abstract
Objectives: To examine whether individuals with low short-term risk of coronary heart disease but high lifetime predicted risk of cardiovascular disease (CVD) have greater prevalence of left ventricular (LV) hypertrophy and increased aortic wall thickness (AWT) than those with low short-term and low lifetime risk. Background: Lifetime risk prediction can be used for stratifying individuals younger than 50 years of age into 2 groups: low short-term/high lifetime and low short-term/low lifetime predicted risk of CVD. Individuals with low short-term/high lifetime risk have a greater burden of subclinical atherosclerosis as measured by coronary artery calcium and carotid intima-media thickness. However, >75% of individuals with low short-term/high lifetime risk do not have detectable coronary artery calcium, suggesting the presence of alternative subclinical abnormalities. Methods: We stratified 1,804 Dallas Heart Study subjects between the ages of 30 and 50 years who had cardiac magnetic resonance into 3 groups: low short-term (<10% 10-year risk of coronary heart disease)/low lifetime predicted risk (<39% lifetime risk of CVD), low short-term (<10%)/high lifetime risk (≥39%), and high short-term risk (≥10%, prevalent diabetes, or previous stroke, or myocardial infarction). In those with low short-term risk, we compared measures of LV hypertrophy and AWT between those with low versus high lifetime risk. Results: Subjects with low short-term/high lifetime risk compared with those with low short-term/low lifetime risk had increased LV mass (men: 95 ± 17 g/m
2 vs. 90 ± 12 g/m2 and women: 75 ± 14 g/m2 vs. 71 ± 10 g/m2 , respectively; p < 0.001 for both). LV concentricity (mass/volume), wall thickness, and AWT were also significantly greater in those with high lifetime risk in this comparison (p < 0.001 for all), but LV end-diastolic volume was not (p > 0.3). These associations persisted among participants without detectable coronary artery calcium. Conclusions: Among individuals 30 to 50 years of age with low short-term risk, a high lifetime predicted risk of CVD is associated with concentric LV hypertrophy and increased AWT. [Copyright &y& Elsevier]- Published
- 2010
- Full Text
- View/download PDF
47. Association of Health Aging and Body Composition (ABC) Heart Failure score with cardiac structural and functional abnormalities in young individuals.
- Author
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Gupta, Sachin, Berry, Jarett D., Ayers, Colby R., Matulevicius, Susan A., Peshock, Ronald M., Patel, Parag C., Markham, David W., and Drazner, Mark H.
- Abstract
Background: The Health ABC Heart Failure score has recently been shown to predict 5-year risk of incident heart failure in the elderly. We tested whether this risk score is associated with subclinical phenotypes of heart failure in a younger population. Methods: We stratified participants in the Dallas Heart Study aged 30 to 65 years who had a cardiac magnetic resonance imaging and no self-reported history of heart failure or cardiomyopathy into 4 previously defined Health ABC Heart Failure risk groups: low (<5%), average (5%-10%), high (10%-20%), and very high (>20% risk for heart failure within 5 years). We compared left ventricular (LV) structural and functional parameters and levels of B-type natriuretic peptide (BNP) and N-terminal proBNP among the 4 groups. Results: In the study cohort (N = 2,540), the percentage of subjects in the low-, average-, high-, and very high risk groups was 78%, 15%, 6%, and 1%, respectively. Indexed LV mass (80 ± 15 vs 90 ± 20 vs 95 ± 25 vs 116 ± 41 g/m
2 ), concentricity (1.6 ± 0.3 vs 1.8 ± 0.4 vs 2.0 ± 0.5 vs 2.2 ± 0.7 g/mL), median BNP (2.8 vs 3.7 vs 4.9 vs 7.5 pg/mL) and N-terminal proBNP (26 vs 30 vs 40 vs 58 pg/mL), and prevalent LV systolic dysfunction and LV hypertrophy progressively increased across risk groups (P < .001 for all) independent of gender or method of indexing LV mass. Conclusions: The Health ABC Heart Failure score was associated with subclinical cardiac structural changes in the general population 30 to 65 years of age, suggesting that it may be a valid tool for identification of young individuals at increased risk for heart failure. [Copyright &y& Elsevier]- Published
- 2010
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48. A 4-Tiered Classification of Left Ventricular Hypertrophy Based on Left Ventricular Geometry The Dallas Heart Study.
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Khouri, Michel O., Peshock, Ronald M., Ayers, Colby R., de Lemos, James A., and Drazner, Mark H.
- Subjects
HYPERTROPHY ,LEFT heart ventricle ,VENTRICULAR remodeling ,MAGNETIC resonance imaging ,CARDIAC volume ,HEART failure ,DIAGNOSIS - Abstract
The article presents a study which introduces the 4-tiered classification of left ventricular hypertrophy (LVH) to monitor the LV concentricity and LV end-diastolic volume (LVEDV). It states that the study was made on 2803 subjects of the Dallas Heart Study, wherein they underwent cardiac magnetic resonance imaging (MRI). It reveals that subjects with eccentric LVH can be classified into two groups such as with dilated hypertrophy and the large group with no thick of dilated hypertrophy.
- Published
- 2010
- Full Text
- View/download PDF
49. Association Between Bendopnea and Key Parameters of Cardiopulmonary Exercise Testing in Patients With Advanced Heart Failure.
- Author
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Dominguez-Rodriguez, Alberto, Thibodeau, Jennifer T., Abreu-Gonzalez, Pedro, Ayers, Colby R., Jimenez-Sosa, Alejandro, JrAranda, Juan M., Drazner, Mark H., and Aranda, Juan M Jr
- Published
- 2016
- Full Text
- View/download PDF
50. Association of Cystatin C With Left Ventricular Structure and Function: The Dallas Heart Study.
- Author
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Patel, Parag C., Ayers, Colby R., Murphy, Sabina A., Peshock, Ronald, Khera, Amit, de Lemos, James A., Balko, Jody A., Gupta, Sachin, Mammen, Pradeep P. A., Drazner, Mark H., and Markham, David W.
- Subjects
CYSTATINS ,HYPERTROPHY ,LEFT heart ventricle ,HEART physiology ,MEDICAL imaging systems ,HEART failure - Abstract
The article presents a study that investigates on the association of cystatin c on the function and structure of left ventricular (LV). The study was carried out from the participants of Dallas Heart Study whose age ranges from 30 to 65 years wherein their cystatin c level and concentricity were assessed using cardiac magnetic resonance imaging (MRI). The study reveals that high level of cystatin c establish a link on the development of LV mass and hypertrophy.
- Published
- 2009
- Full Text
- View/download PDF
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