Search

Abstract: In recent years, theories about the anti-inflammatory properties of vitamin D in demyelinating disease have been well substantiated by human studies examining relapse reduction, MRI lesion activity and risk of MS conversion. However, the evidence that vitamin D may protect against neurodegeneration has not been established as of yet, and comes with the challenges of a manageable target over a manageable time period. Such challenges might be overcome by the anterior visual pathway (AVP) model of the central nervous system, which allows the non-invasive study (e.g. imaging, electrophysiology and clinical) of form and function within a much shorter time frame than pure clinical activity. This review outlines the state of current knowledge about vitamin D in demyelinating disease, and highlights the potential utility of using the AVP to study its neuroprotective effects. [Copyright &y& Elsevier]

Abstract: Isolated primary malignant lymphoma rarely arises from the anterior visual pathway. A 59-year-old previously healthy man presented with progressive, painless, bilateral visual disturbance. Neurological imaging revealed an enhancing mass arising from the optic chiasm. Open biopsy was carried out under monitoring of visual evoked potentials and a histopathological diagnosis of diffuse large B-cell lymphoma was made. As systemic examination did not show any evidence of systemic lymphoma, we concluded that this patient had an isolated primary malignant lymphoma at the anterior visual pathway. [Copyright &y& Elsevier]

The article focuses on a study which examined the secondary functional changes of the visual cortex in patients with glaucoma and pituitary adenomas. Results of the study showed that there was greater activation on the left side of the bilateral occipital lobes of patients with pituitary adenoma after left eye stimulation. The study also found decreased intensity and range in occipital activation in the left and right stimulation groups than those in the control group.