777 results on '"An, Yingli"'
Search Results
2. Predicting Peptide Permeability Across Diverse Barriers: A Systematic Investigation.
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Tan, Xiaorong, Liu, Qianhui, Fang, Yanpeng, Zhu, Yingli, Chen, Fei, Zeng, Wenbin, Ouyang, Defang, and Dong, Jie
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- 2024
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3. Positive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study.
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Bing Wu, Nan Sheng, Zheng Li, Jinghua Wang, Saisai Ji, Feng Zhao, Yitao Pan, Yingli Qu, Yuan Wei, Linna Xie, Yawei Li, Xiaojian Hu, Changzi Wu, Zheng Zhang, Yidan Qiu, Xulin Zheng, Wenli Zhang, Xuehua Hu, Haocan Song, and Jiayi Cai
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BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substance (PFAS) has endocrine-disrupting properties and may affect blood pressure. Endogenous hormones also play a crucial role in the progression of hypertension. However, their interaction with hypertension remains to be explored. METHODS: This study included 10 794 adults aged =18 years from the China National Human Biomonitoring program. Weighted multiple logistic regression and linear regression were used to examine the associations of serum PFAS with hypertension, diastolic blood pressure, and systolic blood pressure. Joint effects of PFAS mixtures on hypertension, diastolic blood pressure, and systolic blood pressure were evaluated using quantile-based g-computation. Additive and multiplicative interactions were used to assess the role of PFAS with testosterone and estradiol on hypertension. RESULTS: The prevalence of hypertension in Chinese adults was 35.50%. Comparing the fourth quartile with the first quartile, odds ratio (95% CI) of hypertension were 1.53 (1.13-2.09) for perfluorononanoic acid, 1.40 (1.03-1.91) for perfluorodecanoic acid, 1.34 (1.02-1.78) for perfluoroheptane sulfonic acid, and 1.46 (1.07-1.99) for perfluorooctane sulfonic acid. Moreover, PFAS mixtures, with perfluorononanoic acid contributing the most, were positively associated with hypertension, diastolic blood pressure, and systolic blood pressure. PFAS and endogenous hormones had an antagonistic interaction in hypertension. For example, the relative excess risk ratio, attributable proportion, and synergy index for perfluorononanoic acid and estradiol were -3.61 (-4.68 to -2.53), -1.65 (-2.59 to -0.71), and 0.25 (0.13-0.47), respectively. CONCLUSIONS: Perfluorononanoic acid, perfluorodecanoic acid, perfluoroheptane sulfonic acid, perfluorooctane sulfonic acid, and PFAS mixtures showed positive associations with hypertension, systolic blood pressure, and diastolic blood pressure. Positive associations of PFAS with hypertension might be attenuated by increased levels of endogenous sex hormones. [ABSTRACT FROM AUTHOR]
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- 2024
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4. The Influence of Cu Powders Doping on Magnetic and Mechanical Properties of Sm₂Co₁₇ Permanent Magnets
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Zhou, Bo, Ding, Yong, Song, Shuaikang, Wang, Chunguo, Wang, Chaozhong, Liu, Lei, Sun, Yingli, and Yan, Aru
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In this work, the influence of Cu powders doping on the magnetic and mechanical properties of Sm2Co17 permanent magnets is systematically investigated. For high-energy-product Sm2Co17 (low initial Cu content), the intrinsic coercivity is significantly improved from 11.7 to 25.7 kOe with 1 wt.% Cu powders doping. The flux loss (soaking at 300 °C for 2 h) is reduced from 7.4% to 3.8%, and the average flexure strength is improved from 60.2 to 74.1 MPa. For high-temperature-resistant Sm2Co17 (high initial Cu content), the intrinsic coercivity is slightly reduced from 39.2 to 38.3 kOe with 1 wt.% Cu powders doping. The flux loss (soaking at 300 °C for 2 h) is increased from 1.4% to 3.4%, and the average flexure strength is improved from 86.7 to 93.2 MPa. The differences in magnetic properties change of these two Sm2Co17 permanent magnets are closely related with their initial Cu content. The doped Cu is prone to diffuse into intragranular cell boundaries in magnet with low initial Cu content. The increased Cu content in intragranular cell boundaries benefits the improvement of intrinsic coercivity, thus enhancing the thermal stability and reducing the flux loss. Doping Cu powders may increase the Cu-rich phase around ground boundaries, which will hinder the grain growth during heat treatment. The decrease of grain size will enhance the flexure strength, while it will increase the flux loss.
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- 2024
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5. Oleuropein Reduces Mycoplasma pneumonia-Induced Pneumonia in Mice via Down-Regulating the Inflammatory Response
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Deng, Yingli and Chen, Dongli
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Graphical Abstract:
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- 2024
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6. Association between serum potassium, risk and prognosis of peritonitis in peritoneal dialysis patients - results from the Peritoneal Dialysis Telemedicine-assisted Platform Cohort (PDTAP) Study
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Wang, Zi, Ma, Xiaoying, Li, Shaomei, Pei, Huaying, Zhao, Jinghong, Zhang, Ying, Xiong, Zibo, Liao, Yumei, Li, Ying, Lin, Qiongzhen, Hu, Wenbo, Li, Yulin, Zheng, Zhaoxia, Duan, Liping, Fu, Gang, Guo, Shanshan, Zhang, Beiru, Yu, Rui, Hao, Li, Liu, Guiling, Zhao, Zhanzheng, Xiao, Jing, Shen, Yulan, Zhang, Yong, Du, Xuanyi, Ji, Tianrong, Wang, Caili, Deng, Lirong, Yue, Yingli, Chen, Shanshan, Ma, Zhigang, Li, Yingping, Zuo, Li, Zhao, Huiping, Zhang, Xianchao, Wang, Xuejian, Liu, Yirong, Gao, Xinying, Chen, Xiaoli, Li, Hongyi, Du, Shutong, Zhao, Cui, Xu, Zhonggao, Zhang, Li, Chen, Hongyu, Li, Li, Wang, Lihua, Yan, Yan, Ma, Yingchun, Wei, Yuanyuan, Zhou, Jingwei, Li, Yan, Sun, Fuyun, and Dong, Jie
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Background: Hypokalemia has been associated with an increased risk of peritoneal dialysis (PD)-associated peritonitis. However, hypokalemia is commonly associated with malnutrition, inflammation, and severe coexisting comorbidities, which thus are suspected of being potential confounders. This study was aimed at testing whether hypokalemia was independently associated with the occurrence and prognosis of PD-associated peritonitis. Methods: A national-level dataset from the Peritoneal Dialysis Telemedicine-assisted Platform Cohort (PDTAP) Study was used to explore the independent association of serum potassium with PD-associated peritonitis. Unmatched and propensity score-adjusted multivariate competing risk models, as well as univariate competing risk models following 1:1 propensity score matching, were conducted to balance potential biases between patients with and without hypokalemia. The association between potassium levels prior to peritonitis and treatment failure due to peritonitis was also investigated. Results: During a median follow-up of 25.7 months in 7220 PD patients, there was a higher incidence of peritonitis in patients with serum potassium below 4.0 mmol/L compared to those with higher serum levels (677 [0.114/patient-year] vs. 914 [0.096/patient-year], P= 0.001). After adjusting for demographics, laboratory tests, residual renal function, and medication use, baseline potassium levels below 4.0 mmol/L were not linked to an increased risk of peritonitis, with a hazard ratio of 0.983 (95% CI 0.855–1.130, P= 0.810). This result remained consistent in both the propensity score adjusted multivariate competing risk regression (HR = 0.974, 95% CI 0.829–1.145, P= 0.750) and the univariate competing risk regression after 1:1 propensity score matching (Fine-Gray test, P= 0.218). The results were similar when analyzing patients with serum potassium level above or below 3.5 mmol/L. Lastly, hypokalemia before the occurrence of peritonitis was not independently associated with treatment failure. Conclusion: Hypokalemia was not found to be an independent risk factor for PD-associated peritonitis or treatment failure of peritonitis in China. Graphical abstract:
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- 2024
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7. Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Type 2 Diabetes: A Prospective Cohort Study
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Fu, Yanqi, Lu, Meng, Zhang, Kun, Sun, Ying, Tan, Xiao, Wang, Ningjian, Xu, Fei, Jiang, Boren, Lu, Yingli, and Wang, Bin
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- 2024
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8. Novel insights into modifiable risk factors for arteriovenous fistula failure and the importance of CKD lipid profile: A meta-analysis
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Wei, Shizhuo, Liu, Naimeng, Fu, Yingli, and Sun, Mindan
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Background: Arteriovenous fistula (AVF) failure can occur in patients undergoing hemodialysis (HD). In this study, we explored the correlation between hyperlipidemia and AVF failure in patients undergoing HD. Moreover, we compared the lipid profiles of patients with chronic kidney disease (CKD) with those of healthy people to provide a basis for lipid-lowering in patients undergoing HD.Method and analysis: We searched PubMed, Web of Science, Embase, the Cochrane library, CNKI, CBM, the China Science Periodical Database, and the China Science and Technology Journal Database. The final search was conducted on August 31, 2021, and the search period was restricted between 2000 and August 31, 2021, without publication restrictions. All studies met the inclusion criteria, and the influences of sex, age, geographical location, diagnosis method, and publication year were excluded. The data were analyzed using the random-effects model and the fixed-effects model.Results: Twenty-eight studies were included in the meta-analysis with 121,666 patients in the CKD group and 1714 patients in the AVF failure group. Triglyceride concentration in patients with CKD was higher than in healthy subjects (MD: −31.56, 95% CI: −41.23 to −21.90, p< 0.00001). A high total cholesterol (TC) concentration (MD: 6.97, 95% CI: 2.19–11.74, p= 0.004) and a high low-density lipoprotein cholesterol (LDL-C) concentration (MD: 23.83, 95% CI: 18.48–29.18, p< 0.00001) were associated with AVF failure. Furthermore, HDL-C was lower in the AVF failure group than in the AVF patency group (MD: −2.68, 95% CI: −4.60 to −0.76, p= 0.006).Conclusion: Our analysis indicates that the AVF failure may be related to the increase of TC/LDL-C and the decrease of HDL-C. Although current guidelines do not consider intensive lipid-lowering therapy as necessary in patients undergoing HD, our research indicates that patients with AVF undergoing HD may need regular TC/LDL-C-lowering therapy to prevent AVF failure. However, this issue still needs well designed prospective trials.
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- 2024
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9. Adsorption of cationic dyes in wastewater with magnetic κ-carrageenan nanoparticles
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Zhu, Yun, Ma, Lei, Wang, Lina, Li, Xiaofen, Yang, Zhi, Yuan, Mingwei, Li, Wenyi, Ma, Xiaoyan, Gao, Yuntao, Xiong, Huabin, Chen, Minghong, Wang, Yingli, and Xiao, Yi
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The application of innovative adsorbents with high adsorption capacity and easy recovery in wastewater treatment has always been of great concern. This study employed κ-carrageenan to enhance the dispersion of magnetic nanoparticles and improve their stability through Ca2+and Na+crosslinkinelg. XRD, FTIR, SEM and EDS revealed that the magnetic nanoparticles were coated with κ-carrageenan. The synthesized MΚC@Fe3O4MNPs exhibited a stable structure and multiple adsorption sites, which was beneficial for the treatment of cationic dyes in wastewater. The absorption results indicated that abundant active sites on the surface of the adsorbent efficiently adsorbed the three cationic dyes. Through optimization experiments, the MΚC@Fe3O4MNPs demonstrated maximum adsorption capacities of 729.9 mg/g, 184.1 mg/g, and 311.0 mg/g for methylene blue, malachite green, and safranin T, respectively. The adsorbent could maintain excellent adsorption efficiency even after 5 cycles of use. The adsorption mechanisms for the three cationic dyes included electrostatic interactions, n-π interactions, and hydrogen bonding. Therefore, the MΚC@Fe3O4MNPs showed highly efficient adsorption and separation of cationic dyes and are suitable candidates for dye wastewater treatment.
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- 2024
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10. Dynamic load adjustment strategy for carbon dioxide refrigeration system based on hidden Markov model
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Jiang, Yucheng, Zhou, Yingli, Wang, Qi, and Li, Guangpeng
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- 2024
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11. Lipid Hydrolysis, Oxidation, and Fatty Acid Formation Pathway Mapping of Synergistically Fermented Sausage and Characterization of Lipid Mediating Genes
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Woldemariam, Kalekristos Yohannes, Wang, Zhengkai, Cai, Min, Li, Min, Jiang, Wenxiang, Hu, Zhichaw, Li, Jinjuan, Tang, Wensheng, Jiao, Yushan, Liu, Yingli, Zheng, Qiankun, and Wang, Jing
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Starter cultures play a significant role in lipid hydrolysis, prevention of lipid oxidation, and synthesis of fatty acid in fermented sausage, enhancing product quality. In this study, five synergistic bacterial strains were used, including Pediococcus pentosaceus(B-3), Latilactobacillus sakeiDLS-24 (D-24), Latilactobacillus acidophilusDLS-29 (D-29), Lactiplantibacillus pentosus(B-1), and Lactiplantibacillus plantarum(B-2). Sausage B1B3D24 gave the highest free fatty acid with 39.45 g/100 g at 45-Day. Based on 2-thiobarbituric acid reactive substance, B2B3 contains 112.68 MDA/kg. Lipoxygenase activity displays the lowest in B1B3D24 with 0.095 μmol/min·mg followed by B2B3 with 0.145 μmol/min·mg. B1B3D24 contains 11.35 g/kg of monounsaturated fatty acid with the highest content in eicosenoic acid (C20:1) and palmitoleic acid (C16:1). The fatty acid synthesis pathway in B1B3D24 contains an active positive interaction with PUFA to increase the isotopomers of ω-3 and ω-6 fatty acids. In addition, lipid mediating genes in B1B3D24 show the highest counts in fatty-acid synthase, carbonyl reductase 4, 3-oxoacyl-[acyl-carrier-protein] synthase III, hydroxysteroid 17-beta dehydrogenase 8, and acetyl-CoA carboxylase.
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- 2024
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12. Predicting Peptide Permeability Across Diverse Barriers: A Systematic Investigation
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Tan, Xiaorong, Liu, Qianhui, Fang, Yanpeng, Zhu, Yingli, Chen, Fei, Zeng, Wenbin, Ouyang, Defang, and Dong, Jie
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Peptide-based therapeutics hold immense promise for the treatment of various diseases. However, their effectiveness is often hampered by poor cell membrane permeability, hindering targeted intracellular delivery and oral drug development. This study addressed this challenge by introducing a novel graph neural network (GNN) framework and advanced machine learning algorithms to build predictive models for peptide permeability. Our models offer systematic evaluation across diverse peptides (natural, modified, linear and cyclic) and cell lines [Caco-2, Ralph Russ canine kidney (RRCK) and parallel artificial membrane permeability assay (PAMPA)]. The predictive models for linear and cyclic peptides in Caco-2 and RRCK cell lines were constructed for the first time, with an impressive coefficient of determination (R2) of 0.708, 0.484, 0.553, and 0.528 in the test set, respectively. Notably, the GNN framework behaved better in permeability prediction with larger data sets and improved the accuracy of cyclic peptide prediction in the PAMPA cell line. The R2increased by about 0.32 compared with the reported models. Furthermore, the important molecular structural features that contribute to good permeability were interpreted; the influence of cell lines, peptide modification, and cyclization on permeability were successfully revealed. To facilitate broader use, we deployed these models on the user-friendly KNIME platform (https://github.com/ifyoungnet/PharmPapp). This work provides a rapid and reliable strategy for systematically assessing peptide permeability, aiding researchers in drug delivery optimization, peptide preselection during drug discovery, and potentially the design of targeted peptide-based materials.
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- 2024
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13. Modified peroral endoscopic myotomy technique with retrograde on-demand myotomy for achalasia: a retrospective cohort study (with video)
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Cao, Tingting, Sun, Haibo, Yang, Dong, Tao, Ke, Tang, Ying, Fu, Yingli, and Xu, Hong
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Background: Although myotomy is crucial in peroral endoscopic myotomy (POEM) surgeries, its optimum length remains controversial. Herein, we propose a modified POEM with new method of tailoring myotomy length aim to evaluate the safety, efficacy, and clinical outcomes of this modified POEM compared with standard POEM in type I or II achalasia. Methods: Seventy-five patients with type I or II achalasia who underwent POEM at the First Hospital of Jilin University between January 2018 and December 2022 were retrospectively analyzed. According to the myotomy approach, these patients were divided into the retrograde on-demand myotomy (RDM, n= 34), with myotomy beginning on gastric side and length tailored by determining the degree of lower esophageal sphincter (LES) distention, and standard myotomy (SM, n= 41) groups. The baseline data, myotomy length, operation time, clinical success rate, adverse event rate, and reflux-related adverse events were compared and analyzed. Results: The median myotomy length in the RDM group was significantly shorter than that in the SM group (6 vs. 8 cm, respectively; p< 0.001). Moreover, the median myotomy time in the RDM group was significantly shorter than that in the SM group (10 vs. 16 min, respectively; p< 0.001). POEM was successfully performed in all the patients. At the 2-year follow-up, high clinical success rates were observed in both the RDM and SM groups (92.0% vs. 93.3%, respectively; p= 1.000). The incidence of intraoperative adverse events and postoperative reflux-related adverse events was low and comparable in both groups. Conclusions: RDM POEM is a safe and effective method for patients with type I or II achalasia. Furthermore, it has a shorter myotomy length and operation time than standard POEM technique.
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- 2024
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14. Sequential Point Clouds: A Survey
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Wang, Haiyan and Tian, Yingli
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Point clouds have garnered increasing research attention and found numerous practical applications. However, many of these applications, such as autonomous driving and robotic manipulation, rely on sequential point clouds, essentially adding a temporal dimension to the data (i.e., four dimensions) because the information of the static point cloud data could provide is still limited. Recent research efforts have been directed towards enhancing the understanding and utilization of sequential point clouds. This paper offers a comprehensive review of deep learning methods applied to sequential point cloud research, encompassing dynamic flow estimation, object detection & tracking, point cloud segmentation, and point cloud forecasting. This paper further summarizes and compares the quantitative results of the reviewed methods over the public benchmark datasets. Ultimately, the paper concludes by addressing the challenges in current sequential point cloud research and pointing towards promising avenues for future research.
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- 2024
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15. Flavor Perception and Formation Mechanism of Empty Cup Aroma in Soy Sauce Aroma Type Baijiu.
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Dan Qin, Jiawen Duan, Yi Shen, Yahan Yan, Yunran Shen, Yingli Jiang, Hehe Li, Jinyuan Sun, Wei Dong, Huan Cheng, Xingqian Ye, and Baoguo Sun
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- 2024
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16. Associations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study.
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Xulin Zheng, Yitao Pan, Yingli Qu, Saisai Ji, Jinghua Wang, Zheng Li, Feng Zhao, Bing Wu, Linna Xie, Yawei Li, Haocan Song, Xiaojian Hu, Yidan Qiu, Zheng Zhang, Wenli Zhang, Yanwei Yang, Jiayi Cai, Yuanduo Zhu, Ying Zhu, and Zhaojin Cao
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- 2024
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17. Current Status of Self-transcendence among Lung Cancer Patients and Its Influencing Factors.
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Xue YANG, Yu LUO, Lijuan YE, Yingli YU, and Daxing ZHU
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RISK assessment ,PSYCHOTHERAPY ,TRANSCENDENCE (Philosophy) ,QUESTIONNAIRES ,DECISION making in clinical medicine ,DESCRIPTIVE statistics ,LUNG tumors ,CANCER patient psychology ,SOCIAL support ,SELF-perception - Abstract
Background and objective Different degrees of self-transcendence exist in lung cancer patients, which can stimulate patients' self-awareness and promote them to face negative events in life positively, thus improving patients' quality of life and treatment outcomes. However, there are few reports on self-transcendence in lung cancer patients in China, and the related influencing factors have not yet been clarified. This study aims to investigate the current situation of self-transcendence in lung cancer patients and explore its risk factors, so as to provide a theoretical basis for clinical intervention decision-making. Methods 243 lung cancer patients who were admitted to the Department of Lung Cancer Center of West China Hospital, Sichuan University from September 2023 to February 2024 were enrolled as the study subjects; general information questionnaire, self-transcendence scale, Herth hope scale and social support scale were used for the investigation. The influencing factors related to self-transcendence of lung cancer patients were analyzed. Results The total mean score of self-transcendence in lung cancer patients was (44.73±8.94); the total mean score of hope level was (37.60±4.98), and the total mean score of social support was (41.31±7.27). Self-transcendence was positively correlated with hope level and social support (P<0.001, P<0.001). Education, hope level and social support were influencing factors of self-transcendence in lung cancer patients (P<0.05, P<0.001, P<0.05). Conclusion Self-transcendence in lung cancer patients was at a low level and was influenced by hope level and social support. Healthcare professionals should pay attention to improving the hope level of lung cancer patients, carrying out targeted psychological interventions, and at the same time guiding them to enhance the perception of social support, so as to promote the realization of self-transcendence in patients. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Tracing terrane origin through petrographic and geochronologic proxies: Insights from the Devonian deposits of the Bainaimiao arc terrane in the Central Asian Orogenic Belt.
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Ma, Shouxian, Zhang, Yingli, Wang, Dongsheng, and Wang, Zongqi
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[Display omitted] • The Chaganhebu Formation was deposited in a retroarc foreland basin. • The Chaganhebu sandstone cobbles were derived from a Grenville Orogen source. • The Bainaimiao arc terrane was a fragment of NW Laurentia. The Bainaimiao arc terrane (BAT) is a major subduction-accretionary system in the southeastern Central Asian Orogenic Belt, and its tectonic origin is a hotly debated topic. In this paper, we used petrography and zircon U-Pb-Hf isotopes to determine the provenance of the Chaganhebu Formation. We utilized the detrital zircon U-Pb ages of sandstone cobbles from Lower Chaganhebu to trace tectonic origin of the BAT. The presence of a south-directed paleocurrent, arc granitic cobbles during 457–430 Ma, and detrital zircon age populations of 1.6–0.4 Ga, indicate that the Chaganhebu Formation was sourced from the BAT. The cobble lithologies of conglomerates from the Lower Chaganhebu Formation indicate that the source rock assemblage comprises sedimentary rocks, granite, volcanic elements, and vein quartz. The Chaganhebu Formation exhibits a progradational sequence with matrix-supported conglomerates at its base, along with an upward increase in metasedimentary clasts and Precambrian recycled zircons. The above evidence indicates that the BAT experienced considerable uplift and exhumation in a retroarc foreland system. The sandstone cobbles from the Lower Chaganhebu are characterized by Grenville Orogen sources of 1.6–1.0 Ga age populations, and resemble the Upper Bayan Obo Group in the North China Craton. This similarity suggests that the BAT encompasses a Precambrian sedimentary basement in the Damaoqi region. Furthermore, the detrital zircon U-Pb ages of the sandstone cobbles, and the findings of previous studies on the crystalline basement and geomagnetic pole, demonstrate that the BAT represented a fragment that rifted from NW Laurentia during the breakup of the Rodinia supercontinent. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Cetyltrimethylammonium-chloride assisted in situ metabolic incorporation of nano-sized ROS-generating cascade-reaction containers in Gram-positive and Gram-negative peptidoglycan layers for the control of bacterially-induced sepsis.
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Yang, Guang, Wang, Da-Yuan, Song, Jianwen, Ren, Yijin, An, Yingli, Busscher, Henk J., van der Mei, Henny C., and Shi, Linqi
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IRON oxide nanoparticles ,BACTERIAL cell walls ,GRAM-negative bacteria ,IRON oxides ,SEPSIS ,BLOOD coagulation - Abstract
Cascade-reaction containers generating reactive oxygen species (ROS) as an alternative for antibiotic-based strategies for bacterial infection control, require endogenous oxygen-sources and ROS-generation close to or preferably inside target bacteria. Here, this is achieved by cetyltrimethylammonium-chloride (CTAC) assisted in situ metabolic labeling and incorporation of mesoporous SiO 2 -nanoparticles, dual-loaded with glucose-oxidase and Fe 3 O 4 -nanoparticles as cascade-reaction containers, inside bacterial cell walls. First, azide-functionalized d-alanine (D-Ala-N 3) was inserted in cell wall peptidoglycan layers of growing Gram-positive pathogens. In Gram-negatives, this could only be achieved after outer lipid-membrane permeabilization, using a low concentration of CTAC. Low concentrations of CTAC had no adverse effect on in vitro blood clotting or hemolysis nor on the health of mice when blood-injected. Next, dibenzocyclooctyne-polyethylene-glycol modified, SiO 2 -nanoparticles were in situ click-reacted with d-Ala-N 3 in bacterial cell wall peptidoglycan layers. Herewith, a two-step cascade-reaction is facilitated inside bacteria, in which glucose-oxidase generates H 2 O 2 at endogenously-available glucose concentrations, while subsequently Fe 3 O 4 -nanoparticles catalyze generation of •OH from the H 2 O 2 generated. Generation of •OH inside bacterial cell walls by dual-loaded mesoporous SiO 2 -nanoparticles yielded more effective in vitro killing of both planktonic Gram-positive and Gram-negative bacteria suspended in 10 % plasma than SiO 2 -nanoparticles solely loaded with glucose-oxidase. Gram-positive or Gram-negative bacterially induced sepsis in mice could be effectively treated by in situ pre-treatment with tail-vein injected CTAC and d-Ala-N 3 , followed by injection of dual-loaded cascade-reaction containers without using antibiotics. This makes in situ metabolic incorporation of cascade-reaction containers as described attractive for further investigation with respect to the control of other types of infections comprising planktonic bacteria. In situ metabolic-incorporation of cascade-reaction-containers loaded with glucose-oxidase and Fe 3 O 4 nanoparticles into bacterial cell-wall peptidoglycan is described, yielding ROS-generation from endogenous glucose, non-antibiotically killing bacteria before ROS inactivates. Hitherto, only Gram-positives could be metabolically-labeled, because Gram-negatives possess two lipid-membranes. The outer membrane impedes direct access to the peptidoglycan. This problem was solved by outer-membrane permeabilization using a quaternary-ammonium compound. Several studies on metabolic-labeling perform crucial labeling steps during bacterial-culturing that in real-life should be part of a treatment. In situ metabolic-incorporation as described, can be applied in well-plates during in vitro experiments or in the body as during in vivo animal experiments. Surprisingly, metabolic-incorporation proceeded unhampered in blood and a murine, bacterially-induced sepsis could be well treated. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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20. Cardiovascular health, sleeping duration, and risk of mortality in current and former smokers.
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Yu, Bowei, Sun, Ying, Yu, Yuefeng, Yu, Yuetian, Wang, Yuying, Wang, Bin, Tan, Xiao, Wang, Yu, Lu, Yingli, and Wang, Ningjian
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To investigate the associations of ideal cardiovascular health metrics (ICVHMs) with all-cause mortality among former and current smokers compared with never smokers. A total of 378,147 participants [mean age (SD) years: 56.3 (8.1); 47.2 % men] were included from the UK Biobank cohort. The ICVHMs were combined Life's simple 7 from the American Heart Association and sleep duration time. The association was explored using COX regression models. During a median follow-up of 13.3 years, we documented 24,594 deaths. Compared with never smokers, among former smokers, the multivariable-adjusted hazard ratio (HR) for all-cause mortality was 1.82 (95%CI 1.71–1.92) for participants who had ≤2 ICVHMs and 1.03 (0.97–1.10) for participants who had ≥6 ICVHMs; among current smokers, the HRs for mortality were 2.74 (2.60–2.89) and 2.18 (1.78–2.67). The phenomenon was more pronounced among participants younger than 60 years [HR (95%CI), 1.82 (1.71–1.95) for ≤2 ICVHMs vs 1.04 (0.96–1.12) for ≥6 ICVHMs with age ≥60 years and 1.83 (1.62–2.06) vs 0.98 (0.88–1.11) with age <60 years among former smokers; 2.66 (2.49–2.85) vs 2.44 (1.84–3.24) with age ≥60 years and 2.85 (2.62–3.10) vs 1.96 (1.47–2.61) with age <60 years among current smokers]. In addition, the HR for mortality of each 1-number increment in ICVHMs was 0.87 (0.86–0.89) among former smokers and 0.91 (0.89–0.94) among current smokers. Our findings indicated the importance of adherence to have more ICVHMs in the mortality risk among former smokers, and priority of smoking cessation in current smokers. Studies have found that former smokers still have higher risks of lung cancer and all-cause mortality than never-smokers. The next question is whether the effects of previous or current smoking could be ameliorated by eight ideal cardiovascular health metrics (ICVHMs). We aim to explore whether ICVHMs may counteract the risk of all-cause mortality among former and current smokers. The results showed that only former smokers with ≥6 ICVHMs exhibited a comparable risk of all-cause mortality with never smokers. Furthermore, current smokers even having ≥6 ICVHMs still exhibited a higher risk of all-cause mortality compared with never smokers. • Only former smokers with ≥6 ICVHMs exhibited a comparable risk of all-cause mortality with never smokers. • Current smokers even having ≥6 ICVHMs still exhibited a higher risk of all-cause mortality compared with never smokers. • Participants younger than 60 years showed a more significant reduction in the risk of mortality. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Synergistic defect passivation and strain compensation toward efficient and stable perovskite solar cells
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Bian, Liqiang, Xin, Zhe, Zhao, Yuanyuan, Gao, Lei, Dou, Zhi, Li, Linde, Guo, Qiyao, Duan, Jialong, Dou, Jie, Wang, Yingli, Zhang, Xinyu, Jiang, Chi, Sun, Liqing, Zhang, Qiang, and Tang, Qunwei
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DPOB molecules passivated interface defects, released residual strain, and induced band bending to enhance hole extraction and transport. The champion PCE of CsPbBr3PSC achieved 10.87%.
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- 2024
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22. The effects of vitamin D and gene polymorphisms on susceptibility to thyroid peroxidase antibody positivity
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Cheng, Jing, Ye, Lin, Chen, Yingchao, Han, Bing, Wang, Ningjian, Li, Qin, and Lu, Yingli
- Abstract
The etiology of Hashimoto's thyroiditis (HT) involves genetic and environmental factors. There is a lack of clarity regarding the relationship between Vitamin D and HT. This study aimed to investigate the effect of Vitamin D and gene polymorphisms on thyroid peroxidase antibody (TPOAb) positivity.
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- 2024
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23. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial
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Liu, Jiamin, Li, Yan, Ge, Jinzhuo, Yan, Xiaofang, Zhang, Haibo, Zheng, Xin, Lu, Jiapeng, Li, Xi, Gao, Yan, Lei, Lubi, Liu, Jing, Li, Jing, Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Lin, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yan, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, Xinli, Yu, Yi, Yuan, Biao, Zeng, Chunmei, Zhai, Na, Zhai, Xiaojuan, Zhan, Hongju, Zhang, Aizhen, Zhang, Baohua, Zhang, Bin, Zhang, Caizhu, Zhang, Chaoying, Zhang, Chengbo, Zhang, Chunlai, Zhang, Churuo, Zhang, Fan, Zhang, Feiqin, Zhang, Ge, Zhang, Haibo, Zhang, Hailin, Zhang, Hanxue, Zhang, Huaixing, Zhang, Hui, Zhang, Huijuan, Zhang, Jinguo, Zhang, Jingyu, Zhang, Jinyun, Zhang, Jisheng, Zhang, Jun, Zhang, Lei, Zhang, Li, Zhang, Li, Zhang, Liang, Zhang, Lifeng, Zhang, Lina, Zhang, Liping, Zhang, Liping, Zhang, Min, Zhang, Ping, Zhang, Qiang, Zhang, Rufang, Zhang, Ruifen, Zhang, Shengde, Zhang, Siqi, Zhang, Sufang, Zhang, Tingting, Zhang, Wanyue, Zhang, Weiliang, Zhang, Xiaohan, Zhang, Xiaohong, Zhang, Xiaojuan, Zhang, Xin, Zhang, Xin, Zhang, Xue, Zhang, Xuewei, Zhang, Yachen, Zhang, Yang, Zhang, Yanyan, Zhang, Yaojie, Zhang, Yingyu, Zhang, Yuan, Zhang, Yun, Zhang, Yunfeng, Zhang, Zaozhang, Zhang, Zhichao, Zhao, Baihui, Zhao, Dan, Zhao, Fuxian, Zhao, Guizeng, Zhao, Haijie, Zhao, Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, and Zuo, Zhaokai
- Abstract
Uncertainty exists about whether lowering systolic blood pressure to less than 120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes and patients with previous stroke.
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- 2024
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24. H2S-Powered Nanomotors for Active Therapy of Tumors by Inducing Ferroptosis and Lactate-Pyruvate Axis Disorders
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Wang, Weixin, Fu, Renquan, Gao, Rui, Luo, Lei, Wang, Zhongchao, Xue, Yingli, Sun, Jiahui, Pan, Min, Hong, Miaofang, Qiao, Lingyan, Qiao, Weiwei, Mei, Qibing, Wu, Jianming, Wang, Yini, Zhong, Yali, Liu, Jin, and Tong, Fei
- Abstract
Disruption of the symbiosis of extra/intratumoral metabolism is a good strategy for treating tumors that shuttle resources from the tumor microenvironment. Here, we report a precision treatment strategy for enhancing pyruvic acid and intratumoral acidosis to destroy tumoral metabolic symbiosis to eliminate tumors; this approach is based on PEGylated gold and lactate oxidase-modified aminated dendritic mesoporous silica with lonidamine and ferrous sulfide loading (PEG-Au@DMSNs/FeS/LND@LOX). In the tumor microenvironment, LOX oxidizes lactic acid to produce pyruvate, which represses tumor cell proliferation by inhibiting histone gene expression and induces ferroptosis by partial histone monoubiquitination. In acidic tumor conditions, the nanoparticles release H2S gas and Fe2+ions, which can inhibit catalase activity to promote the Fenton reaction of Fe2+, resulting in massive ·OH production and ferroptosis via Fe3+. More interestingly, the combination of H2S and LND (a monocarboxylic acid transporter inhibitor) can cause intracellular acidosis by lactate, and protons overaccumulate in cells. Multiple intracellular acidosis is caused by lactate-pyruvate axis disorders. Moreover, H2S provides motive power to intensify the shuttling of nanoparticles in the tumor region. The findings confirm that this nanomedicine system can enable precise antitumor effects by disrupting extra/intratumoral metabolic symbiosis and inducing ferroptosis and represents a promising active drug delivery system candidate for tumor treatment.
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- 2024
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25. Birth weight, ideal cardiovascular health metrics in adulthood, and incident cardiovascular disease
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Sun, Ying, Wang, Bin, Yu, Yuefeng, Wang, Yuying, Tan, Xiao, Zhang, Jihui, Qi, Lu, Lu, Yingli, Wang, Ningjian, and Ni, Jing
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- 2024
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26. New structural features and pinning-evolved coercivity mechanism: A potential route for developing high coercivities in anisotropic Sm-Fe-N material
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Ye, Liming, Wang, Fengqing, Liu, Yang, Zhou, Haoran, Liu, Lei, Ding, Yong, Sun, Yingli, and Yan, Aru
- Abstract
Sm-Fe-N material holds immense promise as new material for developing next generation permanent magnets. However, the achievement of high coercivity in this material remains a big challenge, and moreover new coercivity theories beyond the commonly considered nucleation-type mechanism needs exploration. This study describes both the yielding of anisotropic Sm-Fe-N powders with high coercivities and the discovery of new coercivity mechanism by a systematic study using a designed milling preparation method. As a result, a random-direction cleavage behavior with unexpected XRD peak shifts and formation of new micron-sized flower-like particles were found in the yielded Sm-Fe-N powders. The grain sizes of the powders are of nanoscale dimension and they refine gradually as the milling time increases. The measured coercivity is up to 15.0 kOe, which is a substantial increase of approximately 36.4% compared to the original commercial powders and among the highest reported values via the milling preparation method (commonly below 13 kOe). The yielded powders also demonstrate a new dual-type coercivity mechanism (combing both nucleation-type and pinning-type control effect), and the improved pining effect contributes to the high coercivities. This study opens the door of utilizing pinning effect for achieving high coercivities in anisotropic Sm-Fe-N material.
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- 2024
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27. Gate Voltage- and Bias Voltage-Tunable Staggered-Gap to Broken-Gap Transition Based on WSe2/Ta2NiSe5 Heterostructure for Multimode Optoelectronic Logic Gate.
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Zhu, Tao, Liu, Kai, Zhang, Yao, Meng, Si, He, Mengfei, Zhang, Yingli, Yan, Minglu, Dong, Xiaoxiang, Li, Xiaobo, Jiang, Man, and Xu, Hua
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- 2024
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28. Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
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Lin, Simei, Wang, Liang, Jia, Yingli, Sun, Ying, Qiao, Panshuang, Quan, Yazhu, Liu, Jihan, Hu, Huihui, Yang, Baoxue, and Zhou, Hong
- Abstract
Diabetic lipo-toxicity is a fundamental pathophysiologic mechanism in DM and is now increasingly recognized a key determinant of DKD. Targeting lipid metabolic disorders is an important therapeutic strategy for the treatment of DM and its complications, including DKD. This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. Then RPTCs and LPIN1 knockdown or overexpressed HK-2 cells induced by PA were used to investigate the mechanism. We found that the expression of lipin-1 increased early and then decreased in kidney during the progression of DKD. Glucose and lipid metabolic disorders and renal insufficiency were found in these 2 types of diabetic mouse models. Interestingly, lipin-1 deficiency might be a pathogenic driver of DKD-to-CKD transition, which could further accelerate the imbalance of renal lipid homeostasis, the dysfunction of mitochondrial and energy metabolism in PTECs. Mechanistically, lipin-1 deficiency resulted in aggravated PTECs injury to tubulointerstitial fibrosis in DKD by downregulating FAO via inhibiting PGC-1α/PPARα mediated Cpt1α/HNF4α signaling and upregulating SREBPs to promote fat synthesis. This study provided new insights into the role of lipin-1 as a regulator for maintaining lipid homeostasis in the kidney, especially PTECs, and its deficiency led to the progression of DKD. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Nonlinear relationship between body mass index and serum uric acid: An observational and Mendelian randomization study among Chinese adults.
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Fu, Yanqi, Yu, Yuefeng, Wang, Yuying, Sun, Ying, Zhang, Kun, Xu, Fei, Wang, Ningjian, Wang, Bin, and Lu, Yingli
- Abstract
Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA), and importantly, the causal role of BMI in SUA remains unclear. We aimed to evaluate the BMI-SUA relationship and its causality among Chinese adults using observational and Mendelian randomization (MR) analyses. Study included 6641 adults from East China. A genetic risk score based on 14 BMI-associated East Asian variants was formulated. One-sample MR and non-linear MR analyses assessed the causal link between BMI_GRS and SUA levels. Mean BMI levels were 24.8 (SD 3.4) and 24.3 (SD 3.6) kg/m
2 in men and women, respectively. Spline models revealed gender-specific BMI-SUA associations: a reverse J-shape for men and a J-shape for women (P-values for nonlinearity <0.05). In men, BMI showed a positive correlation with SUA levels when BMI was below 29.6 kg/m2 (beta coefficient 19.1 [95 % CI 15.1, 23.0] μmol/L per 1-SD increase in BMI), while in women, BMI exhibited a negative correlation with SUA levels when the BMI was less than 21.7 kg/m2 (beta coefficient −12.9 [95 % CI -21.6, −4.1] μmol/L) and a positive correlation when BMI exceeded 21.7 kg/m2 (beta coefficient 13.3 [95 % CI 10.9, 15.8] μmol/L). Furthermore, MR analysis suggested non-linear BMI-SUA link in women but not men. Our study indicates a non-linear correlation between BMI and SUA in both genders. It is noteworthy that in women, this correlation may have a causal nature. Nevertheless, further longitudinal investigations are required to authenticate our findings. • We observed a reverse J-shaped relationship between BMI and serum uric acid for men and a J-shaped relationship for women. • MR analyses confirmed nonlinearity between genetically predicted BMI and serum uric acid in women but not in men. • Our findings provide novel insight into the sex-dependent effect of BMI on the risk of hyperuricemia. [ABSTRACT FROM AUTHOR]- Published
- 2024
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30. Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment.
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Xu, Xiaolan, Zhang, Jiaming, Wang, Tao, Li, Jing, Rong, Yukang, Wang, Yanfang, Bai, Chenxia, Yan, Qing, Ran, Xiaohua, Wang, Yingli, Zhang, Tianhong, Sun, Jin, and Jiang, Qikun
- Subjects
TOXINS ,DRUG delivery systems ,CANCER treatment ,CYTOTOXINS ,ANTIBODY-drug conjugates - Abstract
The non-selective cytotoxicity of toxins limits the clinical relevance of the toxins. In recent years, toxins have been widely used as warheads for antibody‒drug conjugates (ADCs) due to their efficient killing activity against various cancer cells. Although ADCs confer certain targeting properties to the toxins, low drug loading capacity, possible immunogenicity, and other drawbacks also limit the potential application of ADCs. Recently, non-ADC delivery strategies for toxins have been extensively investigated. To further understand the application of toxins in anti-tumor, this paper provided an overview of prodrugs, nanodrug delivery systems, and biomimetic drug delivery systems. In addition, toxins and their combination strategies with other therapies were discussed. Finally, the prospect and challenge of toxins in cancer treatment were also summarized. This review summarizes various non-antibody‒drug conjugates delivery approaches, mainly including prodrugs, nano-drug delivery systems (NDDS), and biomimetic drug delivery systems. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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31. Freeform Metasurface-Assisted Waveguide Coupler for Guided Wave Polarization Manipulation and Spin–Orbit Angular Momentum Conversion.
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Chen, Tianqu, Xu, Mingfeng, Pu, Mingbo, Zeng, Qingji, Zheng, Yuhan, Xiao, Yuting, Ha, Yingli, Guo, Yinghui, Zhang, Fei, Chi, Nan, and Luo, Xiangang
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- 2024
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32. DAABNet: depth-wise asymmetric attention bottleneck for real-time semantic segmentation.
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Tang, Qingsong, Chen, Yingli, Zhao, Minghui, Min, Shitong, and Jiang, Wuming
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- 2024
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33. Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018.
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Ji, Saisai, Qu, Yingli, Sun, Qi, Zhao, Feng, Qiu, Yidan, Li, Zheng, Li, Yawei, Song, Haocan, Zhang, Miao, Zhang, Wenli, Fu, Hui, Cai, Jiayi, Zhang, Zhuona, Zhu, Ying, Cao, Zhaojin, Lv, Yuebin, and Shi, Xiaoming
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- 2024
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34. Gate Voltage- and Bias Voltage-Tunable Staggered-Gap to Broken-Gap Transition Based on WSe2/Ta2NiSe5Heterostructure for Multimode Optoelectronic Logic Gate
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Zhu, Tao, Liu, Kai, Zhang, Yao, Meng, Si, He, Mengfei, Zhang, Yingli, Yan, Minglu, Dong, Xiaoxiang, Li, Xiaobo, Jiang, Man, and Xu, Hua
- Abstract
Two-dimensional (2D) materials with superior properties exhibit tremendous potential in developing next-generation electronic and optoelectronic devices. Integrating various functions into one device is highly expected as that endows 2D materials great promise for more Moore and more-than-Moore device applications. Here, we construct a WSe2/Ta2NiSe5heterostructure by stacking the p-type WSe2and the n-type narrow gap Ta2NiSe5with the aim to achieve a multifunction optoelectronic device. Owing to the large interface potential barrier, the heterostructure device reveals a prominent diode feature with a large rectify ratio (7.6 × 104) and a low dark current (10–12A). Especially, gate voltage- and bias voltage-tunable staggered-gap to broken-gap transition is achieved on the heterostructure device, which enables gate voltage-tunable forward and reverse rectifying features. As results, the heterostructure device exhibits superior self-powered photodetection properties, including a high detectivity of 1.08 × 1010Jones and a fast response time of 91 µs. Additionally, the intrinsic structural anisotropy of Ta2NiSe5endows the heterostructure device with strong polarization-sensitive photodetection and high-resolution polarization imaging. Based on these characteristics, a multimode optoelectronic logic gate is realized on the heterostructure via synergistically modulating the light on/off, polarization angle, gate voltage, and bias voltage. This work shed light on the future development of constructing high-performance multifunctional optoelectronic devices.
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- 2024
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35. Optimized optical catenary structures empower compact on-chip polarization detector
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Zhou, Pu, She, Senwei, Ha, Yingli, Guo, Yinhui, Fan, Yulong, Li, Xiong, Pu, Mingbo, Zhao, Kaiyue, Wang, Lijun, and Luo, Xiangang
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- 2024
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36. Multi-objectives optimization for catenary meta-optics via field-driven optimization
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Zhou, Pu, Chen, Siran, Zhang, Fei, Ha, Yingli, Pu, Mingbo, Guo, Yinghui, Xu, Mingfeng, Li, Lanting, and Luo, Xiangang
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- 2024
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37. Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018
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Ji, Saisai, Qu, Yingli, Sun, Qi, Zhao, Feng, Qiu, Yidan, Li, Zheng, Li, Yawei, Song, Haocan, Zhang, Miao, Zhang, Wenli, Fu, Hui, Cai, Jiayi, Zhang, Zhuona, Zhu, Ying, Cao, Zhaojin, Lv, Yuebin, and Shi, Xiaoming
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Inconsistent results have been reported regarding the association between low-to-moderate arsenic (As) exposure and diabetes. The effect of liver dysfunction on As-induced diabetes remains unclear. The cross-sectional study included 10,574 adults from 2017–2018 China National Human Biomonitoring. Urinary total As (TAs) levels were analyzed as markers of As exposure. Generalized linear mixed models and restricted cubic splines models were used to examine the relationships among TAs levels, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations, and diabetes prevalence. Mediating analysis was performed to assess whether liver dysfunction mediated the association between TAs and diabetes. Overall, the OR (95% CI) of diabetes in participants in the second, third, and fourth quartiles of TAs were 1.08 (0.88, 1.33), 1.17 (0.94, 1.45), and 1.52 (1.22, 1.90), respectively, in the fully adjusted models compared with those in the lowest quartile. Serum ALT was positively associated with TAs and diabetes. Additionally, mediation analyses showed that ALT mediated 4.32% of the association between TAs and diabetes in the overall population and 8.86% in the population without alcohol consumption in the past year. This study suggested that alleviating the hepatotoxicity of As could have implications for both diabetes and liver disease.
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- 2024
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38. Tool Center Point Calibration via Posture-Sequence Particle Swarm Optimization
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Gao, Ziqi, Li, Yingli, Luo, Yang, Sun, Jincheng, Ying, Yuhan, Jiang, Yunxiang, Zhao, Xingang, and Zhao, Yiwen
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Robots’ manipulation accuracy is heavily determined by the calibration accuracy of the tool center point (TCP). This article proposes posture-sequence particle swarm optimization (PS2O) for TCP calibration. First, the mechanism of the condition number and the minimum eigenvalue of the regression matrix on the calibration accuracy are analyzed. Second, a multiobjective optimization problem is constructed based on the condition number, the minimum eigenvalue, and the sum of adjacent posture distances. Finally, an optimized posture sequence is obtained by applying the particle swarm optimization (PSO) algorithm to the constructed multiobjective optimization problem. Simulations and experiments demonstrate that the error of TCP calibration can be characterized by the condition number and the minimum eigenvalue of the regression matrix. Compared with random posture sampling, the optimized posture sequence for sampling reduces the norm of the calibration error by 38.66%. Thus, PS2O has great potential to improve robots’ manipulation accuracy.
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- 2024
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39. Quantitative MRI on MR-Linacs: Towards Biological Image-Guided Adaptive Radiotherapy.
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van Houdt, Petra J., Li, Shaolei, Yang, Yingli, and van der Heide, Uulke A.
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Recognizing the potential of quantitative imaging biomarkers (QIBs) in radiotherapy, many studies have investigated the prognostic value of quantitative MRI (qMRI). With the introduction of MRI-guided radiotherapy systems, the practical challenges of repeated imaging have been substantially reduced. Since patients are treated inside an MRI scanner, acquisition of qMRI can be done during each fraction with limited or no prolongation of the fraction duration. In this review paper, we identify the steps that need been taken to move from MR as an imaging technique to a useful biomarker for MRI-guided radiotherapy (MRgRT). [ABSTRACT FROM AUTHOR]
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- 2024
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40. Rational Design of a Core–Shelled Ti3AlC2@La2Zr2O7 Composite for High-Temperature Broadband Microwave Absorption.
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Sun, Xinyu, Li, Yaxiong, Li, Xiangcheng, Chen, Pingan, and Zhu, Yingli
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- 2023
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41. Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategiesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4bm00843j
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Yang, Mei, Zhu, Yuanyuan, Wei, Xiaodan, Feng, Jinteng, He, Yingli, Jiang, Jue, Zhou, Qi, Zhang, Mingzhen, Zhang, Guangjian, and Ma, Wenqi
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Background: Ulcerative colitis (UC) is a debilitating chronic inflammatory bowel disease, and current treatments primarily focus on suppressing inflammation with limited efficacy. However, the resolution of inflammation also plays a crucial role in UC prognosis. Combining anti-inflammatory and pro-inflammatory resolution interventions may be a promising approach for treating UC. Materials and methods: The nano-bomb nanoparticles were validated for their ability to load CD98 siRNA (siCD98) and Annexin A1-mimetic peptides (Ac2-26 peptides), as well as release CO2upon lysosomal escape. Surface modification with hyaluronic acid (HA) was assessed for its capability to target inflammatory tissues and cells. Biocompatibility and biosafety were evaluated through in vitroand in vivostudies. The anti-inflammatory and pro-resolving effects of siCD98@NPs and Ac2-26@NPs, both individually and in combination, were evaluated by measuring ROS production, pro-inflammatory cytokine expression, CD98 gene expression, and macrophage polarization. Results: These nanoparticles could efficiently load siCD98 and Ac2-26 peptides and release CO2under acidic pH in the endo/lysosome to deliver drugs to the cytoplasm. HA could effectively target the inflammatory tissue and cells, showing good biocompatibility and biosafety both in vitroand in vivo. siCD98@NPs and Ac2-26@NPs showed anti-inflammatory effects by eliminating the over-production of ROS and down-regulating the expression of pro-inflammatory cytokines (TNF-α and IL-1β) and the CD98 gene; meanwhile, it showed pro-resolving function by inhibiting M0 to pro-inflammatory M1 macrophage conversion, with a more pronounced effect when combined with siCD98 and Ac2-26. The oral administration of chitosan-alginate hydrogel-encapsulated nanoparticles in UC model mice effectively alleviated inflammatory symptoms, reduced the expression of pro-inflammatory cytokines (TNF-α and IL-1β) and the CD98 gene, restored intestinal barrier function, and promoted M1 to M2 polarization, with a more pronounced effect when combined. Conclusion: By combining anti-inflammatory and pro-resolution interventions, these nanoparticles offer a novel therapeutic approach. This study offered a new approach for combination therapy of UC.
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- 2024
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42. Remote limb ischemic preconditioning alleviated spinal cord injury through inhibiting proinflammatory immune response and promoting the survival of spinal neurons
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Yan, Yitong, Li, Zihan, Zhang, Shuangyue, Bai, Fan, Jing, Yingli, Huang, Fubiao, and Yu, Yan
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Study design: Experimental animal study. Objectives: To investigate the protective effect of remote limb ischemia preconditioning (RLPreC) on traumatic spinal cord injury (SCI) and explore the underlying biological mechanisms using RNA sequencing. Setting: China Rehabilitation Science Institute; Beijing; China. Methods: spinal cord injury was induced in mice using a force of 0.7 N. RLPreC treatment was administered. Motor function, pain behavior, and gene expression were assessed. Results: RLPreC treatment significantly improved motor function and reduced pain-like behavior in SCI mice. RNA-Seq analysis identified 5247 differentially expressed genes (DEGs). GO analysis revealed enrichment of immune response, inflammatory signaling, and synaptic transmission pathways among these DEGs. KEGG analysis indicated suppression of inflammation and promotion of synapse-related pathways. Conclusions: RLPreC is a promising therapeutic strategy for improving motor function and alleviating pain after traumatic SCI. RNA-Seq analysis provides insights into potential therapeutic targets and warrants further investigation.
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- 2024
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43. GMILT: A Novel Transformer Network That Can Noninvasively Predict EGFR Mutation Status
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Zhao, Wei, Chen, Weidao, Li, Ge, Lei, Du, Yang, Jiancheng, Chen, Yanjing, Jiang, Yingjia, Wu, Jiangfen, Ni, Bingbing, Sun, Yeqi, Wang, Shaokang, Sun, Yingli, Li, Ming, and Liu, Jun
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Noninvasively and accurately predicting the epidermal growth factor receptor (EGFR) mutation status is a clinically vital problem. Moreover, further identifying the most suspicious area related to the EGFR mutation status can guide the biopsy to avoid false negatives. Deep learning methods based on computed tomography (CT) images may improve the noninvasive prediction of EGFR mutation status and potentially help clinicians guide biopsies by visual methods. Inspired by the potential inherent links between EGFR mutation status and invasiveness information, we hypothesized that the predictive performance of a deep learning network can be improved through extra utilization of the invasiveness information. Here, we created a novel explainable transformer network for EGFR classification named gated multiple instance learning transformer (GMILT) by integrating multi-instance learning and discriminative weakly supervised feature learning. Pathological invasiveness information was first introduced into the multitask model as embeddings. GMILT was trained and validated on a total of 512 patients with adenocarcinoma and tested on three datasets (the internal test dataset, the external test dataset, and The Cancer Imaging Archive (TCIA) public dataset). The performance (area under the curve (AUC)
$=0.772$ $=0.856$ $=0.756$ - Published
- 2024
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44. Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia
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Yang, Lin, Zhang, Zhaoru, Jiang, Penglei, Kong, Delin, Yu, Zebin, Shi, Danrong, Han, Yingli, Chen, Ertuo, Zheng, Weiyan, Sun, Jie, Zhao, Yanmin, Luo, Yi, Shi, Jimin, Yao, Hangping, Huang, He, and Qian, Pengxu
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RNA-binding proteins (RBPs) are pivotal in acute myeloid leukaemia (AML), a lethal disease. Although specific phase separation-competent RBPs are recognized in AML, the effect of their condensate formation on AML leukaemogenesis, and the therapeutic potential of inhibition of phase separation are underexplored. In our in vivo CRISPR RBP screen, fibrillarin (FBL) emerges as a crucial nucleolar protein that regulates AML cell survival, primarily through its phase separation domains rather than methyltransferase or acetylation domains. These phase separation domains, with specific features, coordinately drive nucleoli formation and early processing of pre-rRNA (including efflux, cleavage and methylation), eventually enhancing the translation of oncogenes such as MYC. Targeting the phase separation capability of FBL with CGX-635 leads to elimination of AML cells, suggesting an additional mechanism of action for CGX-635 that complements its established therapeutic effects. We highlight the potential of PS modulation of critical proteins as a possible therapeutic strategy for AML.
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- 2024
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45. Fluorescent Aptamer-Polyethylene Glycol Functionalized Graphene Oxide Biosensor for Profenofos Detection in Food
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Xiong, Jin’en, Li, Shuang, Li, Yi, Chen, Yingli, Liu, Yu, Gan, Junlan, Ju, Jiahui, Xian, Yaoling, and Xiong, Xiaohui
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A biosensor based on self-assembled ssDNA(aptamer) and polyethylene glycol functionalized graphene oxide(GO-PEG) has been designed for sensing profenofos in food. The sensor has employed the fluorescence “on/off” switching strategy in a single step in homogeneous solution. Compared to traditional detection methods, the strategy proposed here is simple, convenient, fast and sensitive. Furthermore, compared with the general aptamer-GO structure, this aptamer-GO-PEG structure is in possession of a better detection performance, which is largely attributed to the improvement of the biocompatibility and the adjustment of the adsorption capacity of GO by grafting the blocking agent PEG onto the surface of GO. Additionally, the improved biocompatibility of GO shows better stability in salt solutions and physiological solutions, which is more conducive to its practical application in foods. In this project, profenofos had been detected with the proposed strategy, and the limit of detection has been controlled to be 0.21 ng/mL. This aptasensing assay has been applied to determining profenofos in (spiked)tap water, cabbage and milk with the recovery values ranging from 93.1% to 108.5%, from 90.8% to 113.2% and from 105.9% to 114.2%, respectively.
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- 2024
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46. The Influence of Disciplinary Variation and Speaker Characteristics on the Use of Hedges and Boosters in Zhihu Live Talks
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Yuan, Wen, Jin, Yue, and Yang, Yingli
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Background: Zhihu live talks, as a major online knowledge commodity, enable speakers to provide professional information and interact with the audiences. The use of hedges and boosters has been associated with the realization of such a goal. Literature review: Previous research has indicated the relevance of disciplines or genres in the use of hedges and boosters in academic discourse; however, little is known about the use of these metadiscourse markers in Zhihu live talks as a new register for popularizing professional knowledge. Research questions: 1. What are the disciplinary variations in the use of hedges and boosters in medical science and health (Med) and education (Edu) live talks? 2. To what extent do speakers’ characteristics (i.e., expertise and community status) have an impact on the use of hedges and boosters in Med and Edu live talks? Research methods: We collected the transcripts of 123 Med and 126 Edu live talks, as well as the demographic information of each speaker. Following a framework adapted from Hu and Cao, we conducted an analysis of the frequencies and functions of hedges and boosters, and how they associate with speaker characteristics in each category of live talks. Results: The two corpora exhibited significant differences in the frequencies and functions of hedges/boosters, and the differences can be attributed to the conventions of knowledge making in medicine and education disciplines. In addition, speaker characteristics have some impact on the use of hedges and boosters, such as speakers’ levels of conformity to disciplinary conventions or their strategic efforts in relational management. Conclusion: The findings can guide different speakers to configure metadiscourse to inform, argue, and direct while popularizing professional knowledge of different disciplines.
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- 2024
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47. Gas Sensitivity of In0.3Ga0.7As Surface QDs Coupled to Multilayer Buried QDs
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Wang, Guodong, Liu, Zengguang, Wang, Junjun, Yang, Yingli, Liu, Xiaolian, Zhang, Xinran, Zhang, Liwei, and Cao, Guohua
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A detailed analysis of the electrical response of In0.3Ga0.7As surface quantum dots (SQDs) coupled to 5-layer buried quantum dots (BQDs) is carried out as a function of ethanol and acetone concentration while temperature-dependent photoluminescence (PL) spectra are also analyzed. The coupling structure is grown by solid source molecular beam epitaxy. Carrier transport from BQDs to SQDs is confirmed by the temperature-dependent PL spectra. The importance of the surface states for the sensing application is once more highlighted. The results show that not only the exposure to the target gas but also the illumination affect the electrical response of the coupling sample strongly. In the ethanol atmosphere and under the illumination, the sheet resistance of the coupling structure decays by 50% while it remains nearly constant for the reference structure with only the 5-layer BQDs but not the SQDs. The strong dependence of the electrical response on the gas concentration makes SQDs very suitable for the development of integrated micrometer-sized gas sensor devices.
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- 2024
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48. Multi-Instance Multi-Task Learning for Joint Clinical Outcome and Genomic Profile Predictions From the Histopathological Images
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Shao, Wei, Shi, Hang, Liu, Jianxin, Zuo, Yingli, Sun, Liang, Xia, Tiansong, Chen, Wanyuan, Wan, Peng, Sheng, Jianpeng, Zhu, Qi, and Zhang, Daoqiang
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With the remarkable success of digital histopathology and the deep learning technology, many whole-slide pathological images (WSIs) based deep learning models are designed to help pathologists diagnose human cancers. Recently, rather than predicting categorical variables as in cancer diagnosis, several deep learning studies are also proposed to estimate the continuous variables such as the patients’ survival or their transcriptional profile. However, most of the existing studies focus on conducting these predicting tasks separately, which overlooks the useful intrinsic correlation among them that can boost the prediction performance of each individual task. In addition, it is sill challenge to design the WSI-based deep learning models, since a WSI is with huge size but annotated with coarse label. In this study, we propose a general multi-instance multi-task learning framework (HistMIMT) for multi-purpose prediction from WSIs. Specifically, we firstly propose a novel multi-instance learning module (TMICS) considering both common and specific task information across different tasks to generate bag representation for each individual task. Then, a soft-mask based fusion module with channel attention (SFCA) is developed to leverage useful information from the related tasks to help improve the prediction performance on target task. We evaluate our method on three cancer cohorts derived from the Cancer Genome Atlas (TCGA). For each cohort, our multi-purpose prediction tasks range from cancer diagnosis, survival prediction and estimating the transcriptional profile of gene TP53. The experimental results demonstrated that HistMIMT can yield better outcome on all clinical prediction tasks than its competitors.
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- 2024
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49. Interpretable machine learning model integrating clinical and elastosonographic features to detect renal fibrosis in Asian patients with chronic kidney disease
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Chen, Ziman, Wang, Yingli, Ying, Michael Tin Cheung, and Su, Zhongzhen
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Background: Non-invasive renal fibrosis assessment is critical for tailoring personalized decision-making and managing follow-up in patients with chronic kidney disease (CKD). We aimed to exploit machine learning algorithms using clinical and elastosonographic features to distinguish moderate-severe fibrosis from mild fibrosis among CKD patients. Methods: A total of 162 patients with CKD who underwent shear wave elastography examinations and renal biopsies at our institution were prospectively enrolled. Four classifiers using machine learning algorithms, including eXtreme Gradient Boosting (XGBoost), Support Vector Machine (SVM), Light Gradient Boosting Machine (LightGBM), and K-Nearest Neighbor (KNN), which integrated elastosonographic features and clinical characteristics, were established to differentiate moderate-severe renal fibrosis from mild forms. The area under the receiver operating characteristic curve (AUC) and average precision were employed to compare the performance of constructed models, and the SHapley Additive exPlanations (SHAP) strategy was used to visualize and interpret the model output. Results: The XGBoost model outperformed the other developed machine learning models, demonstrating optimal diagnostic performance in both the primary (AUC = 0.97, 95% confidence level (CI) 0.94–0.99; average precision = 0.97, 95% CI 0.97–0.98) and five-fold cross-validation (AUC = 0.85, 95% CI 0.73–0.98; average precision = 0.90, 95% CI 0.86–0.93) datasets. The SHAP approach provided visual interpretation for XGBoost, highlighting the features’ impact on the diagnostic process, wherein the estimated glomerular filtration rate provided the largest contribution to the model output, followed by the elastic modulus, then renal length, renal resistive index, and hypertension. Conclusion: This study proposed an XGBoost model for distinguishing moderate-severe renal fibrosis from mild forms in CKD patients, which could be used to assist clinicians in decision-making and follow-up strategies. Moreover, the SHAP algorithm makes it feasible to visualize and interpret the feature processing and diagnostic processes of the model output. Graphical Abstract:
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- 2024
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50. Thermal Compensation System for Silicon Piezoresistive Pressure Sensors Based on Surface Fitting and Wild Horse Algorithm
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Su, Wenbin, Ren, Wei, Han, Xiangguang, Hua, Yingli, Mu, Xinrong, Huang, Mimi, Chen, Shuai, Wang, Shengqi, Cui, Zeyu, and Zhao, Libo
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Silicon piezoresistive pressure sensors suffer from temperature effects significantly. The thermal compensation system based on surface fitting and wild horse algorithm is proposed to overcome the nonlinearity. The polynomial coefficients in surface fitting are optimized using the wild horse algorithm. A platinum resistance thermometer (PRT) integrated in the silicon layer of the pressure sensor is employed to capture the local temperature variations. The extracted pressure and temperature changes are fed to the compensation algorithm via digital circuits. The results of calibration experiments show that the PRT has a maximum absolute error of
$1.24 \Omega $ - Published
- 2024
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