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Facile regiospecific syntheses of 4α-hydroxyandrost-1-ene-3-one-17β-o1 1 and 4β-hydroxyandrost-1-ene-3-one-17β-ol 2 from androst-3-one-17β-benzoate 3, are described.

AbstractRadio-active azadirachtin, nimbin and salanin have been produced using 14C mevalonate and acetate as precursors under in vivo /in vitroconditions in the seed kernels of Azadirachta indica.

Fresh undried winter leaves of Azadirachta indica were fed with [2-14C, 4R-3H1] MVA. Atomic and isotopic ratios in nimocinol & nimocinolide, thus isolated showed the loss of one 14C from the side chain and four tritium atoms - one from side chain and three from apotetracyclic triterpene skeleton. The biosynthetic pathway thus established suggested the involvement of euphol (Δ8,9 compound) which is isomerised to butyrospermol (Δ7,8 compound) followed by an apo-rearrangement during which one methyl migrates from C-14 to C-8 and double bond from C-7 to C-14.

Radio-active azadirachtin, nimbin and salanin have been produced using 14C mevalonate and acetate as precursors under in vivo /in vitro conditions in the seed kernels of Azadirachta indica.