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OBJECTIVE: The relationship between adiponectin (APN) pathway and Wnt pathway was explored through BMSCs, and the effect of low-level laser irradiation (LLLI) on bone marrow stromal cells (BMSCs) and its mechanism were further studied. MATERIALS AND METHODS: 3-week-old Sprague-Dawley (SD) rats were selected, and mesenchymal stem cells were separately cultured and purified. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to analyze cell proliferation. After osteogenic and adipogenic induction, cultures were conducted, respectively, cells were stained with alizarin red and oil red O. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expressions of osteogenesis-related genes, runt-related transcription factor 2 (RUNX2), and osteocalcin (OC) and those of adipogenesis-related genes, peroxisome proliferator-activated receptor-gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (c/EBPα). Western blotting was used to detect the expressions of β-catenin in the cytoplasm and nucleus. The lentiviral expression vector of adiponectin receptors (APN-R) was constructed, and the expression of APN receptor genes was silenced. The expressions of β-catenin in APN receptors and the nucleus within cells were detected. RESULTS: LLLI promoted the bone formation by inducing the differentiation direction of mesenchymal stem cells, increasing the number of osteoblasts in the bone marrow and inhibiting the reduction of the number of adipocytes. LLLI regulates the Wnt pathway, promotes the entry of β-catenin into the nucleus, activates the osteogenic effect of the Wnt pathway so as to promote the bone formation of osteoblasts and inhibit bone resorption of osteoclasts. LLLI promotes the entry of β-catenin into the nucleus and the osteogenic differentiation of BMSCs through the APN pathway. CONCLUSIONS: In summary, LLLI can promote osteogenesis and inhibit adipocytes formation, thus attenuating bone resorption of osteoclasts. The mechanism of LLLI is that it promotes the entry of β-catenin into the nucleus and regulates the Wnt pathway and the differentiation direction of mesenchymal stem cells through the APN signal pathway, thus promoting bone formation. [ABSTRACT FROM AUTHOR]

Objectives To review research and evidence-based resources on risk assessment, prevention, and early detection and its application in clinical nursing practice. Data Sources Journal articles, texts, and personal cancer prevention and early detection clinical program experience. Conclusion There are multiple roles and clinical settings for advance practice nurses to implement cancer risk assessment and promote the prevention and early detection of cancer for patients and their families. Implications for Nursing Practice Every patient deserves cancer risk assessment and clear recommendations for the primary, secondary, and tertiary prevention of cancer as appropriate. [ABSTRACT FROM AUTHOR]

Objectives To explore the roles of the Advanced Practice Nurse (APN), specifically the Nurse Practitioner (NP) in oncology and the issues, resources, and planning involved in establishing an NP clinic in the cancer setting. Data Sources Published peer reviewed literature, web-based resources, and cancer-related professional resources. Conclusion The number of cancer patients is increasing and demands for oncology services are rising. With a shortage of oncologists projected over the next decade, the oncology NP can play a key role in providing oncology services across the cancer continuum. Implications for Nursing Practice Oncology APNs in the role of Nurse Practitioner (NP) can facilitate and enhance the delivery of oncology care. Traditional and innovative opportunities exist for the NP including the establishment of a NP clinic in the cancer setting; ultimately providing needed oncology services and quality care for patients with cancer. [ABSTRACT FROM AUTHOR]

Objectives To explore the evolution and emerging roles of the Doctor of Nursing Practice (DNP) Advanced Practice Nurse (APN). Data Sources Published peer reviewed literature, cancer-related professional resources, and Web-based resources. Conclusion The DNP education has prepared the APN for process improvement initiatives, providing quality care, and evidence-based practice translation, which are critical with the emerging trends in this complex health care environment. Implications for Nursing Practice DNP-prepared APNs have the opportunity to impact oncology care across the cancer trajectory, in various settings, and in various innovative roles as entrepreneurs. [ABSTRACT FROM AUTHOR]

An overview of the efficacy of anti-predator netting (APN) used by the shellfish industry is presented. There is little support that the currently favored APN effectively protects farmed clams from predators. Evidence does suggest that APN leads to impacts and pollution. APN is an attractant for predators, e.g., crabs, by providing a refuge within Ulva sp. which attaches onto the surface of APN. APN entrains silt and organic matter and increases sediment temperatures degrading habitat underneath the APN. APN present hazards to fish and wildlife and is a source of plastics to the marine environment. The continued use of ineffective APN does not serve either the environment or industry well, and many of these issues could be addressed through the alternate use of “ancient” technology used by aboriginal people to maintain clam gardens; building of rock walls optimizing the amount of clam habitat thereby increasing numbers without the use of APN. [ABSTRACT FROM AUTHOR]

Abstract: The purpose of the current study was to evaluate advanced practice nurses'' perceptions of a prescription drug monitoring program (PDMP) related to their practice. Advanced practice nurses were asked how PDMP information affects patient care and drug diversion, if it inhibits care, and if they value the information. Overall, they felt the PDMP was an effective tool and played a positive role in their practice. [Copyright &y& Elsevier]

Abstract: Evidence-based practice at the point of care gives advance practice registered nurses and their patients immediate access to the most current evidence and research-backed information to treat the specific issue or health concern with which the patient presents. Patients without current complaints, but with questions and concerns can receive education regarding current preventive guidelines and recommendations for many illnesses, such as diabetes and obesity. Because nurses are the primary patient educators, advance practice nurses are in a unique position to impart diagnostic, treatment, and preventive education that may otherwise go unsaid. [Copyright &y& Elsevier]

Background: This is a case study of an advanced practice nurse (APN) practice response to 2003 Medicare D-associated payer changes. Description: Case study of changes in population/services after implementation of Medicare D policy considerations Study design: Case study with data at 3 time points and analyzed using descriptive statistics/central measures of tendency/dispersion Results: Largest changes found to affect public sector recipients/practice solvency Conclusions: Unintended consequences of healthcare policy change affect APN practice/health of vulnerable populations. Recommendations for entrepreneur APNs include supportive policy in addition to business preparation, education, and tools that generate safe strategies for alternate income streams during policy/payer changes. [Copyright &y& Elsevier]

The article offers basic chest radiograph interpretation information which allows readers to review relevant anatomy and physiology, summarize normal and abnormal findings on chest radiographs, and describe radiographic findings in common pulmonary and cardiac disorders. Considered a significant tool in managing critically ill patients, chest imaging/radiology is being used to detect abnormalities in the chest. The basic roentgen densities are gas, fat, water and bone.

Multifactorial changes within healthcare systems across the United States and beyond have forced hospitals to reevaluate the ways in which resources are used. With recent restrictions on resident work hours, the nurse practitioner has emerged as a front-line player in healthcare. This change, however, has brought with it more advanced therapies, treatments, and interventions which the nurse practitioner now practices more independently. As a result, the role of the trauma nurse practitioner emerged over the past few years to assist in meeting the complex demands of trauma programs. To date, little information on the demographic data and the background of these professionals has been published, nor has there been much discussion related to the orientation process for this innovative role. [ABSTRACT FROM AUTHOR]