16,201 results on '"A. Rosenberg"'
Search Results
2. A qualitative evidence synthesis exploring the attitudes, beliefs and values of the long-term care workforce towards palliative care.
- Author
-
Karacsony, S., Martyn, J-A., Rosenberg, J., and Andrews, S.
- Subjects
PATIENTS' families ,ATTITUDES toward death ,MEDICAL information storage & retrieval systems ,PROFESSIONAL ethics ,PALLIATIVE treatment ,MEDICAL personnel ,MEDICAL quality control ,LONG-term health care ,MEDICAL care ,CINAHL database ,EMOTIONS ,SYSTEMATIC reviews ,MEDLINE ,ATTITUDES of medical personnel ,COMMUNICATION ,FAMILY-centered care ,ONLINE information services ,MEDICAL needs assessment ,LABOR supply ,PSYCHOLOGY information storage & retrieval systems - Abstract
This qualitative systematic review aimed to identify and appraise the available qualitative evidence on the attitudes, beliefs, and values of the long-term care workforce towards palliative care. These attributes are important antecedents of behaviour in care provision. The qualitative findings were synthesized into two statements: 'Staff in long-term care facilities understand the importance of clear communication and family engagement for optimal palliative and end-of-life care (PEoLC)', and 'Staff in long-term care facilities deliver palliative and end-of-life care (PEoLC) that is both functional and interpersonal, while managing competing system, professional, and emotional demands.' Key findings showed favourable attitudes in key aspects of PEoLC. Beliefs were consistent with the broader healthcare literature on dying and death, and values favourably aligned with contemporary understandings of palliative care. The review's key findings extend the understanding of workforce attributes beyond knowledge of palliative care and show recognition of broader holistic domains of PEoLC that staff strive to address. Strategies for education and training that enable staff to promote these core holistic values are recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Initial management and outcomes of nonmalignant esophageal perforations: A Nationwide Inpatient Sample analysis.
- Author
-
Ashbrook, Matthew J., Theeuwen, Hailey A., Cheng, Vincent, Harano, Takashi, Wightman, Sean C., Atay, Scott M., Rosenberg, Graeme M., Udelsman, Brooks V., and Kim, Anthony W.
- Abstract
Management of esophageal perforation includes open surgery, minimally invasive surgery, and endoscopic stent placement. This study analyzed initial treatment and the associated short-term outcomes. A retrospective study using the National Inpatient Sample between October 2015 and December 2019 identified adults >18 years with esophageal perforation undergoing an initial nonelective esophageal procedure categorized into either open surgery, minimally invasive surgery, or endoscopic stent placement. Patients with esophageal cancer were excluded. Baseline characteristics and the van Walraven–weighted Elixhauser Comorbidity Index were identified. Outcomes included in-hospital mortality and postintervention complications. Univariable and multivariable Cox regression was used to compare in-hospital survival. In total, 3,345 patients met inclusion criteria: the median age was 62 years (interquartile range 50–72 years), and 1,310 (39%) were female. Open procedure was pursued in 2,650 (79%), minimally invasive surgery in 310 (9%), and endoscopic stent placement in 385 (12%) with no differences in van Walraven–weighted Elixhauser Comorbidity Index or mortality. Patients who underwent minimally invasive surgery had a greater proportion of gastrointestinal complications (P =.006); otherwise, there were no differences in postintervention complications. In total, 380 (11%) patients died and were significantly older, with greater van Walraven–weighted Elixhauser Comorbidity Index, and had more postintervention complications. Univariable Cox regression identified age (hazard ratio 1.95, P <.001), van Walraven–weighted Elixhauser Comorbidity Index (hazard ratio 1.06, P <.001), stent placement (hazard ratio 1.93, P =.045), and transfer from a health facility (HR 2.40, P =.049) as associated with decreased in-hospital survival. Multivariable Cox regression revealed age (hazard ratio 1.041, P <.001) and van Walraven–weighted Elixhauser comorbidity index (hazard ratio 1.055, P <.001) were associated with decreased in-hospital survival. Patients with esophageal perforation had an 11% in-hospital mortality rate and significant associated complications regardless of intervention. Increasing age and comorbidities are associated with poorer in-hospital survival. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. New Polymorph of Febuxostat Crystallized from Aqueous Solution with an Investigation of the Incidence of Pre-nucleation Clusters (PNCs) as Solute Precursors.
- Author
-
Omar, Waid, Rosenberg, Rose, and Cölfen, Helmut
- Published
- 2024
- Full Text
- View/download PDF
5. Publisher perspectives on plain language summaries of scientific publications: An Open Pharma survey.
- Author
-
Baróniková, Slávka, Rosenberg, Adeline, Winchester, Christopher C., Philippon, Valérie, Gordon, Jo, and Osório, Joana
- Subjects
SCIENTIFIC literature ,MEDICAL personnel ,SCIENTIFIC language ,CAREGIVERS ,BEST practices - Abstract
Plain language summaries (PLS) of scientific publications can help to make scientific literature more understandable. In healthcare, PLS can contribute to informed decision-making by healthcare professionals, patients, and their caregivers. In late 2022 and early 2023, the multi-sponsor collaboration Open Pharma developed a 16-question survey to collect the perspectives of journal editors and publishers on PLS and whether they align with the Open Pharma PLS recommendations. A total of 29 surveys were completed, representing 26 individual journals and seven publisher portfolios. Of these, 19 journals and two portfolios did not offer PLS as an option to authors, and one portfolio respondent was unsure. The survey showed variability in format, location, and peer review practices for PLS, and inconsistent tagging of PLS for PubMed indexing. The results highlight the need for more journals to accept PLS and follow best practice recommendations to ensure PLS are peer reviewed and [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. LATE DIAGNOSIS OF Cutibacterium acnes (FORMERLY Propionibacterium acnes) ENDOPHTHALMITIS AND THE IMPORTANCE OF DUAL TESTING WITH BACTERIAL CULTURE AND POLYMERASE CHAIN REACTION.
- Author
-
Rosenberg, Christopher R., Gensure, Rebekah H., Tri Ta Kim, David, Yumang, Marika, Suhler, Eric B., Phoebe Lin, and Flaxel, Christina J.
- Abstract
Purpose: The purpose of this study was to describe two cases of Cutibacterium acnes endophthalmitis that reinforce the importance of performing both bacterial culture and 16S polymerase chain reaction when the causative pathogen is unclear or difficult to culture, such as C. acnes. A case of C. acnes endophthalmitis complicated by subbuckle scleral perforation is illustrated with intraoperative photography. Methods: This is a two-case series. Results: Case 1 describes a case of C. acnes endophthalmitis in a longstanding pseudophakic patient after multiple vitrectomies for recurrent retinal detachment, complicated by subbuckle scleral perforation. Bacterial culture revealed C. acnes while 16S PCR was negative. Conversely, Case 2 demonstrates a case of chronic endophthalmitis diagnosed one year after cataract surgery. PCR (with repeat tap for confirmation) revealed C. acnes with a negative culture. Conclusion: When the causative pathogen of endophthalmitis is unclear, dual testing of microbial culture and C. acnes 16S PCR improves the diagnostic yield of investigations for fastidious pathogens. C. acnes can present as an indolent or virulent endophthalmitis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. New method for analysing spatial relationships of facial muscles on MRI: a pilot study.
- Author
-
Schutte, H., Bielevelt, F., Muradin, M.S.M., Bleys, R.L.A.W., and Rosenberg, A.J.W.P.
- Subjects
COMPUTER software testing ,FACIAL muscles ,THREE-dimensional imaging ,MAGNETIC resonance imaging ,PLASTIC surgery - Abstract
Dysfunction of the facial musculature can have significant physical, social, and psychological consequences. In surgeries such as cleft surgery or craniofacial bimaxillary osteotomies, the perioral facial muscles may be detached or severed, potentially altering their functional vectors and mimicry capabilities. Ensuring correct reconstruction and maintenance of anatomical sites and muscle vectors is crucial in these procedures. However, a standardized method for perioperative assessment of the facial musculature and function is currently lacking. The aim of this study was to develop a workflow to analyse the three-dimensional vectors of the facial musculature using magnetic resonance imaging (MRI) scans. A protocol for localizing the origins and insertions of these muscles was established. The protocol was implemented using the 3DMedX computer program and tested on 7 Tesla MRI scans obtained from 10 healthy volunteers. Inter- and intra-observer variability were assessed to validate the protocol. The absolute intra-observer variability was 2.6 mm (standard deviation 2.0 mm), and absolute inter-observer variability was 2.6 mm (standard deviation 1.5 mm). This study presents a reliable and reproducible method for analysing the spatial relationships and functional significance of the facial muscles. The workflow developed facilitates perioperative assessment of the facial musculature, potentially aiding clinicians in surgical planning and potentially enhancing the outcomes of midface surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Development and validation of the Atri-Risk Conduction Index risk score to predict risk of atrial fibrillation after typical atrial flutter ablation.
- Author
-
Grubb, Alex, Aleong, Ryan, Rosenberg, Michael A., Chang, Shu, Padalia, Kishan, Ashur, Carmel, Adewumi, Joseph, Saqi, Bilal, Varela, Daniel, Sandhu, Amneet, Cerbin, Lukasz, Barrett, Christopher, Tumolo, Alexis Z., Varosy, Paul, Zipse, Matthew M., Tzou, Wendy S., Garg, Lohit, and Sabzwari, Syed Rafay A.
- Abstract
Identification of patients at risk for atrial fibrillation (AF) after typical atrial flutter (tAFL) ablation is important to guide monitoring and treatment. The purpose of this study was to create and validate a risk score to predict AF after tAFL ablation We identified patients who underwent tAFL ablation with no AF history between 2017 and 2022 and randomly allocated to derivation and validation cohorts. We collected clinical variables and measured conduction parameters in sinus rhythm on an electrophysiology recording system (CardioLab, GE Healthcare). Univariate and multivariate logistic regressions (LogR) were used to evaluate association with AF development. A total of 242 consecutive patients (81% male; mean age 66 ± 11 years) were divided into derivation (n =142) and validation (n = 100) cohorts. Forty-two percent developed AF over median follow-up of 330 days. In multivariate LogR (derivation cohort), proximal to distal coronary sinus time (pCS-dCS) ≥70 ms (odds ratio [OR] 16.7; 95% confidence interval [CI] 5.6–49), pCS time ≥36 ms (OR 4.5; 95% CI 1.5–13), and CHADS 2 -VASc score ≥3 (OR 4.3; 95% CI 1.6–11.8) were independently associated with new AF during follow-up. The Atri-Risk Conduction Index (ARCI) score was created with 0 as minimal and 4 as high-risk using pCS-dCS ≥70 ms = 2 points; pCS ≥36 ms = 1 point; and CHADS 2 -VASc score ≥3 = 1 point. In the validation cohort, 0% of patients with ARCI score = 0 developed AF, whereas 89% of patients with ARCI score = 4 developed AF. We developed and validated a risk score using atrial conduction parameters and clinical risk factors to predict AF after tAFL ablation. It stratifies low-, moderate-, and high-risk patients and may be helpful in individualizing approaches to AF monitoring and anticoagulation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Enfortumab vedotin and pembrolizumab as first-line treatment in recurrent or metastatic head and neck squamous cell carcinoma: A cohort of the EV-202 trial.
- Author
-
Honma, Yoshitaka, Swiecicki, Paul L., Rosenberg, Ari Joseph, Hanna, Glenn J., Yang Bruce, Justine, Fujisawa, Takao, Muro, Kei, Kaplan, Jason B., Gorla, Seema Rao, Liu, Shubin, Meng, Changting, and Geiger, Jessica Lyn
- Published
- 2024
- Full Text
- View/download PDF
10. The reliability and validity of the juvenile idiopathic arthritis magnetic resonance scoring system for temporomandibular joints.
- Author
-
de Sonnaville, Willemijn F.C., Speksnijder, Caroline M., Zuithoff, Nicolaas P.A., ter Horst, Simone A.J., Nap, Frank J., Wulffraat, Nico M., Steenks, Michel H., and Rosenberg, Antoine J.W.P.
- Subjects
JUVENILE idiopathic arthritis ,TEMPOROMANDIBULAR joint ,CONTRAST-enhanced magnetic resonance imaging ,MAGNETIC resonance ,INTER-observer reliability - Abstract
In children with juvenile idiopathic arthritis (JIA), the temporomandibular joint (TMJ) can be involved. To prevent TMJ damage due to inflammation, early recognition is important, for which contrast-enhanced magnetic resonance imaging (MRI) is the gold standard. In this study, the interobserver reliability and construct validity of the Juvenile Idiopathic Arthritis Magnetic Resonance Scoring System for Temporomandibular Joints (JAMRIS-TMJ) was assessed. Two radiologists independently examined 38 MRIs using the JAMRIS-TMJ scoring system. Inter-observer reliability was assessed by Cohen's (weighted) kappa (κ), 95% confidence intervals (CIs) and absolute agreement (%). Construct validity was assessed by correlation between the JAMRIS-TMJ items and TMJ involvement, active maximum interincisal mouth opening (AMIO), and anterior maximum voluntary bite force (AMVBF). The interobserver reliability for the JAMRIS-TMJ items varied from poor to good (κ = 0.18–0.61). Joint enhancement had the highest reliability (κ = 0.61). Correlations were found between TMJ involvement, AMIO, and the JAMRIS-TMJ items, although variation between radiologists and TMJ side existed. No correlation was found between AMVBF and the JAMRIS-TMJ items for both radiologists. The strongest correlations were found between most of the JAMRIS-TMJ items and AMIO. Our findings support the utility of AMIO as a clinical measure of TMJ status in children with JIA. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Correction: Implications of Oxybate Dosing Regimen for Sleep, Sleep Architecture, and Disrupted Nighttime Sleep in Patients with Narcolepsy: A Commentary.
- Author
-
Rosenberg, Russell, Braceras, Rogelio, Macfadden, Wayne, Candler, Shawn, Black, Jed, and Ruoff, Chad
- Published
- 2024
- Full Text
- View/download PDF
12. Feasibility and economic benefits of community-based palliative care in regional Australia: A case study with cost analysis.
- Author
-
Merollini, Katharina M. D., Nabukalu, Doreen, Flynn, Trudi, Linn, Josie, Davis, Cindy, and Rosenberg, John
- Subjects
COMMUNITY health services ,COST control ,MEDICAL care use ,PALLIATIVE treatment ,COST analysis ,FUNDRAISING ,CHARITY ,ATTITUDES of medical personnel - Abstract
There is an increasing demand for community-based palliative care services in regional Australia, but feasibility and economic benefits are unclear. This study describes the financial components of service delivery, economic viability from a provider perspective, and potential cost-savings from a health service perspective. We used case study methodology and obtained data from the service provider performance measurement data, annual reports, and internal records. Economic viability included an appraisal of all financial activity, cash on hand, total assets, and liabilities from July 2019 to June 2022. Direct service provision data determined the value for money given total costs and outcomes. Annual cost savings due to decreased utilisation of other healthcare services were estimated using case study data and cost estimates from the literature. The service is largely funded by the government (61%) and community donations & fundraising (34%). Applying a conservative cost estimate based on a reduction of healthcare use (hospitalisations and emergency admissions), cost savings are estimated to range from AU$730 000 to AU$980 000 per year for the cohort of n = 160 clients in the last year of life alone. Average costs per person per year of providing palliative care services were much lower for these clients (AU$6194) compared to the national average for in-home (AU$8000) or hospital-based palliative care services (AU$15 373). The case study site is a viable community-based service but is highly dependent on government funding. It provides excellent value for money from a health service perspective and provides cost saving. Future studies should investigate the generalizability of results. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. Beat-AML 2024 ELN–refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy
- Author
-
Hoff, Fieke W., Blum, William G., Huang, Ying, Welkie, Rina Li, Swords, Ronan T., Traer, Elie, Stein, Eytan M., Lin, Tara L., Archer, Kellie J., Patel, Prapti A., Collins, Robert H., Baer, Maria R., Duong, Vu H., Arellano, Martha L., Stock, Wendy, Odenike, Olatoyosi, Redner, Robert L., Kovacsovics, Tibor, Deininger, Michael W., Zeidner, Joshua F., Olin, Rebecca L., Smith, Catherine C., Foran, James M., Schiller, Gary J., Curran, Emily K., Koenig, Kristin L., Heerema, Nyla A., Chen, Timothy, Martycz, Molly, Stefanos, Mona, Marcus, Sonja G., Rosenberg, Leonard, Druker, Brian J., Levine, Ross L., Burd, Amy, Yocum, Ashley O., Borate, Uma M., Mims, Alice S., Byrd, John C., and Madanat, Yazan F.
- Abstract
•Most (78%) patients aged ≥ 60 years with ND AML treated with LIT are classified as having 2022 ELN adverse risk.•The Beat-AML 2024 risk model incorporates IDH2, KRAS, MLL2, and TP53to refine risk stratification among patients aged ≥ 60 years given LIT.
- Published
- 2024
- Full Text
- View/download PDF
14. Phase transitions in random circuit sampling
- Author
-
Morvan, A., Villalonga, B., Mi, X., Mandrà, S., Bengtsson, A., Klimov, P. V., Chen, Z., Hong, S., Erickson, C., Drozdov, I. K., Chau, J., Laun, G., Movassagh, R., Asfaw, A., Brandão, L. T. A. N., Peralta, R., Abanin, D., Acharya, R., Allen, R., Andersen, T. I., Anderson, K., Ansmann, M., Arute, F., Arya, K., Atalaya, J., Bardin, J. C., Bilmes, A., Bortoli, G., Bourassa, A., Bovaird, J., Brill, L., Broughton, M., Buckley, B. B., Buell, D. A., Burger, T., Burkett, B., Bushnell, N., Campero, J., Chang, H.-S., Chiaro, B., Chik, D., Chou, C., Cogan, J., Collins, R., Conner, P., Courtney, W., Crook, A. L., Curtin, B., Debroy, D. M., Barba, A. Del Toro, Demura, S., Paolo, A. Di, Dunsworth, A., Faoro, L., Farhi, E., Fatemi, R., Ferreira, V. S., Burgos, L. Flores, Forati, E., Fowler, A. G., Foxen, B., Garcia, G., Genois, É., Giang, W., Gidney, C., Gilboa, D., Giustina, M., Gosula, R., Dau, A. Grajales, Gross, J. A., Habegger, S., Hamilton, M. C., Hansen, M., Harrigan, M. P., Harrington, S. D., Heu, P., Hoffmann, M. R., Huang, T., Huff, A., Huggins, W. J., Ioffe, L. B., Isakov, S. V., Iveland, J., Jeffrey, E., Jiang, Z., Jones, C., Juhas, P., Kafri, D., Khattar, T., Khezri, M., Kieferová, M., Kim, S., Kitaev, A., Klots, A. R., Korotkov, A. N., Kostritsa, F., Kreikebaum, J. M., Landhuis, D., Laptev, P., Lau, K.-M., Laws, L., Lee, J., Lee, K. W., Lensky, Y. D., Lester, B. J., Lill, A. T., Liu, W., Livingston, W. P., Locharla, A., Malone, F. D., Martin, O., Martin, S., McClean, J. R., McEwen, M., Miao, K. C., Mieszala, A., Montazeri, S., Mruczkiewicz, W., Naaman, O., Neeley, M., Neill, C., Nersisyan, A., Newman, M., Ng, J. H., Nguyen, A., Nguyen, M., Niu, M. Yuezhen, O’Brien, T. E., Omonije, S., Opremcak, A., Petukhov, A., Potter, R., Pryadko, L. P., Quintana, C., Rhodes, D. M., Rocque, C., Rosenberg, E., Rubin, N. C., Saei, N., Sank, D., Sankaragomathi, K., Satzinger, K. J., Schurkus, H. F., Schuster, C., Shearn, M. J., Shorter, A., Shutty, N., Shvarts, V., Sivak, V., Skruzny, J., Smith, W. C., Somma, R. D., Sterling, G., Strain, D., Szalay, M., Thor, D., Torres, A., Vidal, G., Heidweiller, C. Vollgraff, White, T., Woo, B. W. K., Xing, C., Yao, Z. J., Yeh, P., Yoo, J., Young, G., Zalcman, A., Zhang, Y., Zhu, N., Zobrist, N., Rieffel, E. G., Biswas, R., Babbush, R., Bacon, D., Hilton, J., Lucero, E., Neven, H., Megrant, A., Kelly, J., Roushan, P., Aleiner, I., Smelyanskiy, V., Kechedzhi, K., Chen, Y., and Boixo, S.
- Abstract
Undesired coupling to the surrounding environment destroys long-range correlations in quantum processors and hinders coherent evolution in the nominally available computational space. This noise is an outstanding challenge when leveraging the computation power of near-term quantum processors1. It has been shown that benchmarking random circuit sampling with cross-entropy benchmarking can provide an estimate of the effective size of the Hilbert space coherently available2–8. Nevertheless, quantum algorithms’ outputs can be trivialized by noise, making them susceptible to classical computation spoofing. Here, by implementing an algorithm for random circuit sampling, we demonstrate experimentally that two phase transitions are observable with cross-entropy benchmarking, which we explain theoretically with a statistical model. The first is a dynamical transition as a function of the number of cycles and is the continuation of the anti-concentration point in the noiseless case. The second is a quantum phase transition controlled by the error per cycle; to identify it analytically and experimentally, we create a weak-link model, which allows us to vary the strength of the noise versus coherent evolution. Furthermore, by presenting a random circuit sampling experiment in the weak-noise phase with 67 qubits at 32 cycles, we demonstrate that the computational cost of our experiment is beyond the capabilities of existing classical supercomputers. Our experimental and theoretical work establishes the existence of transitions to a stable, computationally complex phase that is reachable with current quantum processors.
- Published
- 2024
- Full Text
- View/download PDF
15. The Role of Animals in Buffering Against Cisgenderism in and Beyond Family Contexts for Trans Young People Living in Australia
- Author
-
Riggs, Damien W., Rosenberg, Shoshana, Taylor, Nik, and Fraser, Heather
- Abstract
Purpose: The purpose of the study reported in this paper was to explore the role of animals in buffering against cisgenderist violence experienced by trans young people. Method: Interviews were conducted with 17 Australian trans young people and one of their parents who spoke with us about their relationships with their animals living in the home, including in terms of animals providing a protective function against the negative effects of cisgenderism. The transcribed interviews were analyzed thematically. Results: Thematic analysis resulted in the development of three themes. First, at the psychological level, animals helped young people to combat feelings of dysphoria, wrought by the violent effects of social norms about gender. Second, at the interpersonal level, animals helped to soothe young people when they were faced with less than supportive or indeed hostile responses from family members and other people in their lives. Third, at the community level, the companionship provided by animals offered a buffer against feelings of marginalization premised on cisgenderist social norms. Conclusions: All three themes speak to the importance of conceptualizing violence in family contexts as more than just the obvious: as encompassing more subtle forms of marginalization that in their net effect may constitute forms of violence or microaggressions. As a counter to these subtle forms of violence, animals are thus perceived as playing an important role as confidantes, as offering a place of non-judgemental safety, and as a touchstone to the more-than-human.
- Published
- 2024
- Full Text
- View/download PDF
16. #AIAuthorship. The CJEM debate: is there a place for generative AI in data analysis and writing within scholarly manuscript preparation?
- Author
-
Atkinson, Paul, Lang, Eddy, Rosenberg, Hans, and Bell, Colin
- Published
- 2024
- Full Text
- View/download PDF
17. Cancer drug-tolerant persister cells: from biological questions to clinical opportunities
- Author
-
Russo, Mariangela, Chen, Mengnuo, Mariella, Elisa, Peng, Haoning, Rehman, Sumaiyah K., Sancho, Elena, Sogari, Alberto, Toh, Tzen S., Balaban, Nathalie Q., Batlle, Eduard, Bernards, Rene, Garnett, Mathew J., Hangauer, Matthew, Leucci, Eleonora, Marine, Jean-Christophe, O’Brien, Catherine A., Oren, Yaara, Patton, E. Elizabeth, Robert, Caroline, Rosenberg, Susan M., Shen, Shensi, and Bardelli, Alberto
- Abstract
The emergence of drug resistance is the most substantial challenge to the effectiveness of anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as drug-tolerant ‘persister’ (DTP) cells, have a prominent role in drug resistance. Although long recognized in bacterial populations which have acquired resistance to antibiotics, the presence of DTPs in various cancer types has come to light only in the past two decades, yet several aspects of their biology remain enigmatic. Here, we delve into the biological characteristics of DTPs and explore potential strategies for tracking and targeting them. Recent findings suggest that DTPs exhibit remarkable plasticity, being capable of transitioning between different cellular states, resulting in distinct DTP phenotypes within a single tumour. However, defining the biological features of DTPs has been challenging, partly due to the complex interplay between clonal dynamics and tissue-specific factors influencing their phenotype. Moreover, the interactions between DTPs and the tumour microenvironment, including their potential to evade immune surveillance, remain to be discovered. Finally, the mechanisms underlying DTP-derived drug resistance and their correlation with clinical outcomes remain poorly understood. This Roadmap aims to provide a comprehensive overview of the field of DTPs, encompassing past achievements and current endeavours in elucidating their biology. We also discuss the prospect of future advancements in technologies in helping to unveil the features of DTPs and propose novel therapeutic strategies that could lead to their eradication.
- Published
- 2024
- Full Text
- View/download PDF
18. Ventricular stimulation in patients with myotonic dystrophy type 1 may not predict future ventricular arrhythmias
- Author
-
Cerbin, Lukasz, Sandhu, Amneet, Rosenberg, Michael, Barrett, Christopher, Sabzwari, Rafay, Garg, Lohit, Tumolo, Alexis, Tzou, Wendy, Varosy, Paul, Von Alvensleben, Johannes, Zipse, Matthew, and Aleong, Ryan
- Abstract
Myotonic dystrophy type 1 (DM1) is associated with progressive conduction disease. Furthermore, DM1 patients are at risk ventricular arrhythmias (VAs), although prediction remains difficult. The 2022 Heart Rhythm Expert Consensus Statement gives a IIb recommendation to the use of electrophysiology study (EPS) to risk-stratify patients for VAs. The utility of EPS in predicting the development of VAs, however, has not been explored in this patient population.
- Published
- 2024
- Full Text
- View/download PDF
19. Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice
- Author
-
Latt, Khun Zaw, Yoshida, Teruhiko, Shrivastav, Shashi, Abedini, Amin, Reece, Jeff M., Sun, Zeguo, Lee, Hewang, Okamoto, Koji, Dagur, Pradeep, Ishimoto, Yu, Heymann, Jurgen, Zhao, Yongmei, Chung, Joon-Yong, Hewitt, Stephen, Jose, Pedro A., Lee, Kyung, He, John Cijiang, Winkler, Cheryl A., Knepper, Mark A., Kino, Tomoshige, Rosenberg, Avi Z., Susztak, Katalin, and Kopp, Jeffrey B.
- Abstract
Although hyponatremia and salt wasting are common in patients with HIV/AIDS, the understanding of their contributing factors is limited. HIV viral protein R (Vpr) contributes to HIV-associated nephropathy. To investigate the effects of Vpr on the distal tubules and on the expression level of the Slc12a3gene, encoding the sodium-chloride cotransporter (which is responsible for sodium reabsorption in distal nephron segments), single-nucleus RNA sequencing was performed on kidney cortices from three wild-type (WT) and three Vpr transgenic (Vpr Tg) mice. The percentage of distal convoluted tubule (DCT) cells was significantly lower in Vpr Tg mice compared with WT mice (P < 0.05); in Vpr Tg mice, Slc12a3expression was not significantly different in DCT cells. The Pvalb+ DCT1 subcluster had fewer cells in Vpr Tg mice compared with those in WT mice (P < 0.01). Immunohistochemistry revealed fewer Slc12a3+Pvalb+ DCT1 segments in Vpr Tg mice. Differential gene expression analysis between Vpr Tg and WT samples in the DCT cluster showed down-regulation of the Ier3gene, which is an inhibitor of apoptosis. The in vitroknockdown of Ier3by siRNA transfection induced apoptosis in mouse DCT cells. These observations suggest that the salt-wasting effect of Vpr in Vpr Tg mice is likely mediated by Ier3down-regulation in DCT1 cells and loss of Slc12a3+Pvalb+ DCT1 segments.
- Published
- 2024
- Full Text
- View/download PDF
20. New Polymorph of Febuxostat Crystallized from Aqueous Solution with an Investigation of the Incidence of Pre-nucleation Clusters (PNCs) as Solute Precursors
- Author
-
Omar, Waid, Rosenberg, Rose, and Cölfen, Helmut
- Abstract
A novel reproducible process for the preparation of Febuxostat (FX) using a double dosing titration method is achieved by titrating 80 mL of 3 mM Febuxostat sodium salt solution with 15 mM HCl and 6 mM Febuxostat sodium salt solution at a dosing rate of 0.2 mL/min. A new crystalline form (polymorph AQ) is prepared, which is characterized by being the exceptional form produced directly in an aqueous medium, in contrast to the known and registered forms that were produced only in organic solvent systems. The same crystal form is reproduced when crystallized at different temperatures ranging from 10 to 50 °C. However, the pH value at which the onset of nucleation occurs is affected due to its effect on nucleation kinetics. The key parameters affecting the metastable zone are studied. Decreasing the dosing rate can lead to narrowing of the metastable zone and delay in the onset of nucleation. Increasing the temperature can lead to widening of the metastable zone and delay in the onset of nucleation. Analytical ultracentrifugation (AUC) analysis was conducted on supersaturated solutions to investigate the incidence of prenucleation clusters (PNCs) as solute precursors to phase separation. The AUC analysis indicated that nucleation of Febuxostat relies on PNCs as solute precursors and may include liquid–liquid phase separation as an intermediate step.
- Published
- 2024
- Full Text
- View/download PDF
21. NAD deficiency contributes to progressive kidney disease in HIV-nephropathy mice
- Author
-
Yoshida, Teruhiko, Myakala, Komuraiah, Jones, Bryce A., Wang, Xiaoxin X., Shrivastav, Shashi, Santo, Briana A., Patel, Tatsat R., Zhao, Yongmei, Tutino, Vincent M., Sarder, Pinaki, Rosenberg, Avi Z., Winkler, Cheryl A., Levi, Moshe, and Kopp, Jeffrey B.
- Published
- 2024
- Full Text
- View/download PDF
22. Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results
- Author
-
Parkhurst, Maria, Goff, Stephanie L., Lowery, Frank J., Beyer, Rachel K., Halas, Hyunmi, Robbins, Paul F., Prickett, Todd D., Gartner, Jared J., Sindiri, Sivasish, Krishna, Sri, Zacharakis, Nikolaos, Ngo, Lien, Ray, Satyajit, Bera, Alakesh, Shepherd, Ryan, Levin, Noam, Kim, Sanghyun P., Copeland, Amy, Nah, Shirley, Levi, Shoshana, Parikh, Neilesh, Kwong, Mei Li M., Klemen, Nicholas D., Yang, James C., and Rosenberg, Steven A.
- Abstract
Adoptive cell transfer (ACT) with neoantigen-reactive T lymphocytes can mediate cancer regression. Here we isolated unique, personalized, neoantigen-reactive T cell receptors (TCRs) from tumor-infiltrating lymphocytes of patients with metastatic gastrointestinal cancers and incorporated the TCR α and β chains into gamma retroviral vectors. We transduced autologous peripheral blood lymphocytes and adoptively transferred these cells into patients after lymphodepleting chemotherapy. In a phase 2 single-arm study, we treated seven patients with metastatic, mismatch repair-proficient colorectal cancers who had progressive disease following multiple previous therapies. The primary end point of the study was the objective response rate as measured using RECIST 1.1, and the secondary end points were safety and tolerability. There was no prespecified interim analysis defined in this study. Three patients had objective clinical responses by RECIST criteria including regressions of metastases to the liver, lungs and lymph nodes lasting 4 to 7 months. All patients received T cell populations containing ≥50% TCR-transduced cells, and all T cell populations were polyfunctional in that they secreted IFNγ, GM-CSF, IL-2 and granzyme B specifically in response to mutant peptides compared with wild-type counterparts. TCR-transduced cells were detected in the peripheral blood of five patients, including the three responders, at levels ≥10% of CD3+cells 1 month post-ACT. In one patient who responded to therapy, ~20% of CD3+peripheral blood lymphocytes expressed transduced TCRs more than 2 years after treatment. This study provides early results suggesting that ACT with T cells genetically modified to express personalized neoantigen-reactive TCRs can be tolerated and can mediate tumor regression in patients with metastatic colorectal cancers. ClinicalTrials.gov registration: NCT03412877.
- Published
- 2024
- Full Text
- View/download PDF
23. MAVERICKS of HOLLYWOOD.
- Author
-
Belth, Alex, Holmes, Dave, Rosenberg, Josh, O'Keefe, Brian, Langmann, Brady, Stout, Kelly, Posnanski, Joe, and Rikhy, Trishna
- Abstract
This article explores a movement in Hollywood that is pushing for more authentic and daring entertainment. It showcases ten individuals who are at the forefront of this rebellion, including Jesse Eisenberg, Colman Domingo, Hiroyuki Sanada, Coralie Fargeat, and Lisa Joy and Jonathan Nolan. Each person's unique talents and fearlessness contribute to a resurgence of storytelling that surprises and resonates with audiences. The article also includes profiles of Anthony Ramos, Mike Faist, Alex Edelman, and Mikey Madison, providing insight into their careers and personal experiences in the industry. [Extracted from the article]
- Published
- 2024
24. Saving and failing: The Evolution of Polish-Jewish romantic Love and Marriage during WWII and in the State of Israel.
- Author
-
Rosenberg-Friedman, Lilach
- Abstract
The article examines the evolution of romantic love's role and its social meanings by centering on intermarried Jewish and non-Jewish couples between 1933 and 1959, with a focus on those who immigrated to Israel from Poland in the 1950s. It delves into the dynamics of romantic love and the complications it introduces within a post-traumatic community characterized by diverse nationalities, ethnicities, and religions, which affected both the marital relationship and societal integration. It illuminates the conflict between societal norms and personal emotional autonomy, underscoring romantic love's paradoxical nature as both a source of support and a challenge. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. Single point insulin sensitivity estimator index for identifying metabolic syndrome in US adults: NHANES 2017-march 2020.
- Author
-
Cho, Wonhee, Seo, Myong-Won, Rosenberg, Jared, and Kim, Joon Young
- Subjects
STATISTICS on Hispanic Americans ,METABOLIC syndrome diagnosis ,INSULIN sensitivity ,CARDIOVASCULAR diseases ,RECEIVER operating characteristic curves ,INSULIN ,DESCRIPTIVE statistics ,INSULIN resistance ,SURVEYS ,BLOOD sugar ,METABOLIC syndrome ,TRIGLYCERIDES ,COMPARATIVE studies ,FASTING ,ADULTS - Abstract
Single Point Insulin Sensitivity Estimator (SPISE) index was recently introduced as a reliable indirect indicator of insulin resistance, applicable to large population-based research. Here, we aimed to 1) examine racial/ethnic differences in SPISE index among US adults, 2) compare predictive power of SPISE index for metabolic syndrome (MetSyn) by race/ethnicity, and 3) evaluate its predictive power for MetSyn against other well-known IR indices including Triglyceride/HDL-C, Triglyceride-glucose index, homeostatic model assessment for insulin resistance, and inverse fasting insulin. A total of 2168 adults (814 white, 690 black, and 664 Hispanic) from NHANES 2017-March 2020 Pre-Pandemic Data was analyzed in this study. MetSyn was defined by the AHA/NHLBI criteria. SPISE index and insulin resistance indices were calculated by using physical and cardiometabolic parameters. SPISE index was lowest in Hispanic, followed by black and white, with no difference between white vs. black. The area under the curve of receiver operating characteristics of SPISE index for predicting MetSyn was highest in white (88 %), followed by Hispanic (86 %) and black (82 %) (P < 0.05 vs. black), with optimal cutoffs of 5.03, 4.84, and 4.89, respectively. In the total cohort, the predictive power of the SPISE index for MetSyn was 85 %, higher than the other insulin resistance indices (all P < 0.05). SPISE index outperforms various insulin resistance indices for predicting MetSyn in US adults, signifying its potential in large-scale observational studies. Race/ethnicity should be stratified when using the SPISE index as its predictive power and cutoffs for predicting MetSyn vary by race/ethnicity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. Perspectives and Update on the Global Shortage of Verteporfin (Visudyne®).
- Author
-
Sirks, Marc J., Subhi, Yousif, Rosenberg, Noa, Hollak, Carla E. M., Boon, Camiel J. F., Diederen, Roselie M. H., Yzer, Suzanne, Ossewaarde-van Norel, Jeannette, de Jong-Hesse, Yvonne, Schlingemann, Reinier O., Moss, Rob J., and van Dijk, Elon H. C.
- Published
- 2024
- Full Text
- View/download PDF
27. Symmetry as an Inter-Cultural Feature Constituting Beauty: Implicit and Explicit Beauty Evaluation of Visual Symmetry in Japan.
- Author
-
Leder, Helmut, Mikuni, Jan, Kawabata, Hideaki, and Rosenberg, Raphael
- Subjects
SYMMETRY ,JAPANESE art ,HABITUATION (Neuropsychology) ,ART exhibitions - Abstract
Symmetry has been recognized as one of the most important visual features to predict aesthetic preferences and was discussed as a potentially universal feature of beauty judgments. Recent studies have challenged such universality claims, by showing that art experts prefer asymmetric stimuli in explicit evaluations, suggesting that artistic training might modify the preference for symmetry. In the present study, we examine whether cultural habituation might also influence beauty judgments in regard to symmetry in abstract visual patterns. Given the traditional preference for asymmetry in Japanese art and design, we tested if Japanese participants (N = 31) evaluate symmetric abstract visual patterns as more beautiful than asymmetric ones in explicit and implicit (IAT) tasks. We found that Japanese participants clearly evaluated symmetric stimuli as more beautiful than asymmetric ones. We conclude that cultural habituation with asymmetry—in contrast to artistic training—did not cause higher beauty ratings for asymmetry. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
28. A Comprehensive Review of Syndromic Forms of Obesity: Genetic Etiology, Clinical Features and Molecular Diagnosis.
- Author
-
Carvalho, Laura Machado Lara, Jorge, Alexander Augusto de Lima, Bertola, Débora Romeo, Krepischi, Ana Cristina Victorino, and Rosenberg, Carla
- Published
- 2024
- Full Text
- View/download PDF
29. The Relationship Between First Presenting Neuropsychiatric Symptoms in Older Adults and Autopsy-Confirmed Memory Disorders.
- Author
-
Shaw, Jacob S., Leoutsakos, Jeannie M., and Rosenberg, Paul B.
- Abstract
• What is the primary question addressed by this study? The primary question addressed by this study was to examine the association between the first presenting neuropsychiatric symptom (NPS) in aging individuals and neuropathological diagnoses of memory disorders. • What is the main finding of this study? The main finding of this study was that specific first NPS were associated with Frontotemporal Dementia neuropathology (personality change and disinhibition) and Lewy Body Dementia neuropathology (psychosis and REM behavior disturbance), while many first NPS were associated with Alzheimer's Disease neuropathology. • What is the meaning of the finding? The significance of the finding is that since neuropsychiatric symptoms are frequently the first presenting symptom of dementia, their associations with well-defined neuropathological diagnoses may help clinicians predict the subtype of future dementias. Although dementia is typically considered a disease of cognitive decline, almost all patients present with neuropsychiatric symptoms (NPS) at some stage of their disease. Few studies have assessed the timing of NPS onset in relation to pathological diagnoses of neurodegenerative diseases. We sought to examine the association between the first presenting clinically significant NPS in aging individuals and neuropathological diagnoses of memory disorders. This retrospective longitudinal cohort study utilized the National Alzheimer's Coordinating Center (NACC) dataset, which includes participant data from 37 Alzheimer's Disease Research Centers collected between 2005 and 2022. Participants (N = 5,416) aged 45 years or older with Clinical Dementia Rating-Global ratings of less than or equal to 1 were included in this analysis. A total of 4,033 (74.5%) participants presented with at least one NPS at any NACC visit. To measure first NPS, the NACCBEHF variable was used, a clinician-rated variable defined as "the predominant symptom that was first recognized as a decline in the subject's behavior." Neuropathologic variables included assessments of Alzheimer's Disease, Frontotemporal Dementia, Lewy Body Dementia, Cerebral Amyloid Angiopathy, Hippocampal Sclerosis, and Cerebrovascular Disease. Presentation with any clinically significant first NPS was associated with several neuropathological diagnoses including Alzheimer's Disease, Frontotemporal Lobar Dementia with TDP-43 pathology, and Lewy Body Dementia. While specific first NPS were associated with Frontotemporal Dementia neuropathology (personality change and disinhibition) and Lewy Body Dementia neuropathology (psychosis and REM behavior disturbance), Alzheimer's Disease neuropathology was associated with the majority of NPS. Since neuropsychiatric symptoms are frequently the first presenting symptom of dementia, their associations with well-defined neuropathological diagnoses may help clinicians predict the subtype of future dementias. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
30. The microbiome of the appendix differs in patients with and without appendicitis: A prospective cohort study.
- Author
-
Fonnes, Siv, Mollerup, Sarah, Paulsen, Sarah Juel, Holzknecht, Barbara Juliane, Westh, Henrik, and Rosenberg, Jacob
- Abstract
Appendicitis seems to be a disease of infectious origin, but the detailed pathogenesis is unknown. We aimed to investigate the microbiome of the appendix lumen in patients with and without appendicitis, including a comparison of the subgroups of complicated versus uncomplicated appendicitis. This prospective observational cohort study included adult patients undergoing laparoscopic appendectomy for suspected appendicitis. According to histopathologic findings, the investigated groups consisted of patients with and without appendicitis, including subgroups of complicated versus uncomplicated appendicitis based on the surgical report. A swab of the appendix lumen was analyzed for genetic material from bacteria with shotgun metagenomics, and outcomes included analyses of microbiome diversity and differential abundance of bacteria. A total of 53 swabs from patients with suspected appendicitis were analyzed: 42 with appendicitis (16 complicated) and 11 without appendicitis. When comparing patients with and without appendicitis, they were equally rich in bacteria (alpha diversity), but the microbiome composition was dissimilar between these groups (beta diversity) (P <.01). No consistent bacterial species were detected in all patients with appendicitis, but a least 3 genera (Blautia , Faecalibacterium , and Fusicatenibacter) and 2 species, Blautia faecis and Blautia wexlerae , were more abundant in patients without appendicitis. For the subgroups complicated versus uncomplicated appendicitis, both measures for microbiome diversity were similar. The appendix microbiome composition of genetic material from bacteria in adult patients with and without appendicitis differed, but the microbiome was similar for patients with complicated versus uncomplicated appendicitis. Trial registration NCT03349814 [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
31. It's not a lie ... If you believe it: Narrative analysis of autobiographical memories reveals over-confidence disposition in patients who confabulate.
- Author
-
Balshin-Rosenberg, Faith, Ghosh, Vanessa, and Gilboa, Asaf
- Subjects
NARRATIVE inquiry (Research method) ,AUTOBIOGRAPHICAL memory ,CONFIDENCE ,FALSE memory syndrome ,PREFRONTAL cortex - Published
- 2024
- Full Text
- View/download PDF
32. Kulning: Acoustic and Perceptual Characteristics of a Calling Style Used Within the Scandinavian Herding Tradition.
- Author
-
Rosenberg, Susanne, Sundberg, Johan, and Lã, Filipa M.B.
- Abstract
Kulning , a loud, high-pitched vocal calling technique pertaining to the Scandinavian herding system, has attracted several researchers' attention, mainly focusing on cultural, phonatory and musical aspects. Less attention has been paid to the spectral and physiological properties that characterize Kulning tones, and also if there is a physiologically optimum pitch range. We analyzed tones produced by ten participants with varying experience in Kulning. They performed a phrase, pitch range G5 to C6 (784 to 1046 Hz), in three different conditions: starting (1) on pitch A5, (2) on the participant's preferred pitch, and (3) after the deepest possible inhalation, also on the participant's preferred pitch subglottal pressure (P sub) was measured as the oral pressure during /p/-occlusion. The quality of the Kulning was rated by a group of experts. The highest-rated tones all had a sound pressure level (SPL) at 0.3 m exceeding 115 dB and a pitch higher than 1010 Hz, while the SPL of the lowest rated tones was less than 108 dB at a pitch below 900 Hz. A multiple regression analysis was performed to evaluate the relationship between the ratings and P sub), SPL, level of the fundamental and the frequency at which a spectrum envelope dip occurred. Highly rated tones were started at maximum lung volumes, and on participants' preferred pitches. They all shared a high frequency of the spectrum envelope dip and a high level of the fundamental. In decreasing order of ratings, Condition 3 showed the highest values followed by Condition 2 and Condition 1. Each singer seemed to perform best within an individual P sub and pitch range. The relevance of the results to voice pedagogy, artistic, and compositional work is discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. MISIVA DE UNA CÉLULA A OTRA: VESÍCULAS EXTRACELULARES.
- Author
-
ROSENBERG, MARÍA LUCÍA, ODDO, ELISABET M., and AZURMENDI, PABLO J.
- Published
- 2024
34. Evaluating a novel 24-hour rest/activity rhythm marker of preclinical β-amyloid deposition.
- Author
-
Spira, Adam P, Liu, Fangyu, Zipunnikov, Vadim, Bilgel, Murat, Rabinowitz, Jill A, An, Yang, Di, Junrui, Bai, Jiawei, Wanigatunga, Sarah K, Wu, Mark N, Lucey, Brendan P, Schrack, Jennifer A, Wanigatunga, Amal A, Rosenberg, Paul B, Simonsick, Eleanor M, Walker, Keenan A, Ferrucci, Luigi, and Resnick, Susan M
- Published
- 2024
- Full Text
- View/download PDF
35. POST OR PROSECUTE? FACEBOOK, THE CRIMINAL JUSTICE SYSTEM AND SEXUAL ASSAULT VICTIMS' NEEDS.
- Author
-
Dancig-Rosenberg, Hadar, Rosenberg, Roy, and Peleg, Anat
- Subjects
SOCIAL media ,SEXUAL assault ,CRIME victims ,CRIMINAL justice system - Abstract
In recent years, social media have become a dominant arena for sexual assault victims to participate in the discourse on sexual violence and the social response to it. This collaborative discourse space allows victims of sexual assault to reveal their stories of victimization and stimulate public discourse about the (dys)function of the criminal justice system. This Article explores empirically, for the first time, how sexual assault victims who participated in the online discourse on Facebook about sexual assault perceived the capacity of social media to meet their needs compared to that of the criminal justice system. Findings are based on 499 responses to an online survey circulated on Israeli Facebook pages in 2016, the year before the launch of the #MeToo movement. The survey asked respondents to rank the subjective relative importance of eighteen potential therapeutic, criminal justice-related, personal, and social needs of sexual assault victims. It also asked respondents whether Facebook and the criminal justice system have the potential capacity to address each of the eighteen needs. Findings show that, generally, the level of appreciation of the criminal justice system was low and that it was perceived as unable to adequately address any of their needs. Its capacity to address therapeutic needs was perceived as lowest, but respondents reported that the criminal justice system was incapable of addressing even needs that are at the heart of the criminal justice enterprise and directly relate to its formal goals, such as incapacitation, deterrence, and severe punishment. By contrast, most respondents perceived Facebook as capable of providing adequate responses to therapeutic needs. Comparison of the scores achieved by each mechanism shows that the perceived capacity of Facebook to address victims' needs was valued higher than that of the criminal justice system in thirteen of eighteen needs, most of them therapeutic. The only needs that the criminal justice system was perceived to address better than Facebook were those associated with the assailants' accountability. We also checked whether social media and the criminal justice system substitute or complement each other and found a moderate level of complementarity between them. Overall, the perceived weighted capacity of Facebook to address the needs of victims was more than twice that of the criminal justice system. The gaps in how victims appreciated the different ways in which the two mechanisms met their needs shed light on the forces underlying the #MeToo movement. Findings also reveal that neither channel can fully address the needs of sexual assault victims. Each mechanism appears to meet some needs better than the other and to have its relative limitations. Victims deserve more than one path available to justice. Our findings show that instead of renouncing the criminal justice system as a relevant arena where victims can seek justice, we should reexamine how to improve its performance for victims by learning some lessons from social media platforms. [ABSTRACT FROM AUTHOR]
- Published
- 2023
36. Impact of Gift Giving During General Surgery Resident Match Interviewing Since Initiation of Virtual Interviews
- Author
-
Rosenberg, Meagan, Subillaga, Oswaldo, Perez Coulter, Aixa, Tashjian, David, Seymour, Neal, and Tirabassi, Michael V.
- Abstract
•Virtual interviewing is associated with a higher degree of heterogeneity in the type of gift received compared to gifts received by those doing in-person interviews.•Virtual interview participants are less likely to have a meal shared in a social setting—virtual or in-person—compared to in-person interviewees.•Gifts have a neutral to positive impact on interviewee perception and ranking of programs, however this does not change based on interview modality.
- Published
- 2024
- Full Text
- View/download PDF
37. Saving and failing: The Evolution of Polish-Jewish romantic Love and Marriage during WWII and in the State of Israel
- Author
-
Rosenberg-Friedman, Lilach
- Abstract
ABSTRACTThe article examines the evolution of romantic love’s role and its social meanings by centering on intermarried Jewish and non-Jewish couples between 1933 and 1959, with a focus on those who immigrated to Israel from Poland in the 1950s. It delves into the dynamics of romantic love and the complications it introduces within a post-traumatic community characterized by diverse nationalities, ethnicities, and religions, which affected both the marital relationship and societal integration. It illuminates the conflict between societal norms and personal emotional autonomy, underscoring romantic love’s paradoxical nature as both a source of support and a challenge.
- Published
- 2024
- Full Text
- View/download PDF
38. Anoxic waters constrain the vertical distribution of fish developmental stages in an oxygen minimum zone
- Author
-
Gutiérrez‐Bravo, Juan Gerardo, Sánchez‐Velasco, Laura, Jiménez‐Rosenberg, Sylvia Patricia Adelheid, Altabet, Mark A., Méndez‐Mendez, Sofia, and Cambronero‐Solano, Sergio
- Abstract
In the Eastern Tropical North Pacific Oxygen Minimum Zone (ETNP‐OMZ), fish larvae undergo development amidst highly variable dissolved oxygen environments. As OMZs expand, understanding the implications of low‐oxygen environments on fish development becomes increasingly relevant for fisheries management and ecosystem modeling. Using horizontal zooplankton tows to track five oxygen levels (oxic [200 μmol/kg], hypoxic [100 μmol/kg] suboxic [10 μmol/kg], anoxic [<1 μmol/kg], and deep [10 μmol/kg at ~ 1000 m depth]), this study analyzed the three‐dimensional distribution of fish larvae and adults across the ETNP‐OMZ. Results revealed a wide midwater anoxic core, extending from Costa Rica to Baja California, that was almost devoid of fish larvae (< 1 larvae/1000 m3). Early larval stages primarily inhabited the oxic and hypoxic levels above the core, while postflexion and transformation stages occurred across a wider oxygen gradient, including the deep level below the anoxic core. Epipelagic species (e.g., Auxissp.) were predominantly found in the surface oxic level, whereas coastal‐demersal species (e.g., Bregmaceros bathymaster, Ophidionspp.) were prevalent in the hypoxic level above the core. Meso‐bathypelagic species (e.g., Diogenichthys laternatus, Cyclothonespp.) were present throughout the study area, including below the anoxic core as transformation larvae and juveniles. These findings indicate that a vertical expansion of anoxic waters in OMZs could further constrain the habitat of epipelagic species, while also affecting the ontogenic vertical movements of meso‐bathypelagic species.
- Published
- 2024
- Full Text
- View/download PDF
39. Feasibility and Acceptability of the Promoting Resilience in Stress Management-Parent (PRISM-P) Intervention for Caregivers of Children with Craniofacial Conditions
- Author
-
Fladeboe, Kaitlyn M., Stock, Nicola Marie, Heike, Carrie L., Evans, Kelly N., Junkins, Courtney, Stueckle, Laura, O’Daffer, Alison, Rosenberg, Abby R., and Yi-Frazier, Joyce P.
- Abstract
Objectives Few evidence-based psychosocial programs exist within craniofacial care. This study (a) assessed feasibility and acceptability of the Promoting Resilience in Stress Management-Parent (PRISM-P) intervention among caregivers of children with craniofacial conditions and (b) described barriers and facilitators of caregiver resilience to inform program adaptation.Design In this single-arm cohort study, participants completed a baseline demographic questionnaire, the PRISM-P program, and an exit interview.Participants Eligible individuals were English-speaking legal guardians of a child <12-years-old with a craniofacial condition.Intervention PRISM-P included 4 modules (stress-management, goal-setting, cognitive-restructuring, meaning-making) delivered in 2 one-on-one phone or videoconference sessions 1–2 weeks apart.Main Outcome Measures Feasibility was defined as >70% program completion among enrolled participants; acceptability was defined as >70% willingness to recommend PRISM-P. Intervention feedback and caregiver-perceived barriers and facilitators of resilience were summarized qualitatively.Results Twenty caregivers were approached and 12 (60%) enrolled. The majority were mothers (67%) of a child <1-year-old diagnosed with a cleft lip and/or palate (83%) or craniofacial microsomia (17%). Of these, 8 (67%) completed PRISM-P and 7 (58%) completed interviews; 4 (33%) were lost-to-follow-up before PRISM-P and 1 (8%) before the interview. Feedback was highly positive, with 100% willing to recommend PRISM-P. Perceived barriers to resilience included uncertainty about their child's health; facilitators included social support, parental identity, knowledge, and control.Conclusions PRISM-P was acceptable among caregivers of children with craniofacial conditions but not feasible based on program completion rates. Barriers and facilitators of resilience support the appropriateness of PRISM-P for this population and inform adaptation.
- Published
- 2024
- Full Text
- View/download PDF
40. Machine learning-based preoperative analytics for the prediction of anastomotic leakage in colorectal surgery: a swiss pilot study
- Author
-
Taha-Mehlitz, Stephanie, Wentzler, Larissa, Angehrn, Fiorenzo, Hendie, Ahmad, Ochs, Vincent, Wolleb, Julia, Staartjes, Victor E., Enodien, Bassey, Baltuonis, Martinas, Vorburger, Stephan, Frey, Daniel M., Rosenberg, Robert, von Flüe, Markus, Müller-Stich, Beat, Cattin, Philippe C., Taha, Anas, and Steinemann, Daniel
- Abstract
Background: Anastomotic leakage (AL), a severe complication following colorectal surgery, arises from defects at the anastomosis site. This study evaluates the feasibility of predicting AL using machine learning (ML) algorithms based on preoperative data. Methods: We retrospectively analyzed data including 21 predictors from patients undergoing colorectal surgery with bowel anastomosis at four Swiss hospitals. Several ML algorithms were applied for binary classification into AL or non-AL groups, utilizing a five-fold cross-validation strategy with a 90% training and 10% validation split. Additionally, a holdout test set from an external hospital was employed to assess the models' robustness in external validation. Results: Among 1244 patients, 112 (9.0%) suffered from AL. The Random Forest model showed an AUC-ROC of 0.78 (SD: ± 0.01) on the internal test set, which significantly decreased to 0.60 (SD: ± 0.05) on the external holdout test set comprising 198 patients, including 7 (3.5%) with AL. Conversely, the Logistic Regression model demonstrated more consistent AUC-ROC values of 0.69 (SD: ± 0.01) on the internal set and 0.61 (SD: ± 0.05) on the external set. Accuracy measures for Random Forest were 0.82 (SD: ± 0.04) internally and 0.87 (SD: ± 0.08) externally, while Logistic Regression achieved accuracies of 0.81 (SD: ± 0.10) and 0.88 (SD: ± 0.15). F1 Scores for Random Forest moved from 0.58 (SD: ± 0.03) internally to 0.51 (SD: ± 0.03) externally, with Logistic Regression maintaining more stable scores of 0.53 (SD: ± 0.04) and 0.51 (SD: ± 0.02). Conclusion: In this pilot study, we evaluated ML-based prediction models for AL post-colorectal surgery and identified ten patient-related risk factors associated with AL. Highlighting the need for multicenter data, external validation, and larger sample sizes, our findings emphasize the potential of ML in enhancing surgical outcomes and inform future development of a web-based application for broader clinical use.
- Published
- 2024
- Full Text
- View/download PDF
41. Neoadjuvant Nivolumab Plus Chemotherapy Followed By Response-Adaptive Therapy for HPV+ Oropharyngeal Cancer: OPTIMA II Phase 2 Open-Label Nonrandomized Clinical Trial
- Author
-
Rosenberg, Ari J., Agrawal, Nishant, Juloori, Aditya, Cursio, John, Gooi, Zhen, Blair, Elizabeth, Chin, Jeffrey, Ginat, Daniel, Pasternak-Wise, Olga, Hasina, Rifat, Starus, Anna, Jones, Frederick S., Izumchenko, Evgeny, MacCracken, Ellen, Wolk, Rachelle, Cipriani, Nicole, Lingen, Mark W., Pearson, Alexander T., Seiwert, Tanguy Y., Haraf, Daniel J., and Vokes, Everett E.
- Abstract
IMPORTANCE: Immune checkpoint inhibitors improve survival in recurrent and/or metastatic head and neck cancer, yet their role in curative human papillomavirus−positive oropharyngeal cancer (HPV+ OPC) remains undefined. Neoadjuvant nivolumab and chemotherapy followed by response-adaptive treatment in HPV+ OPC may increase efficacy while reducing toxicity. OBJECTIVE: To determine the deep response rate and tolerability of the addition of neoadjuvant nivolumab to chemotherapy followed by response-adapted locoregional therapy (LRT) in patients with HPV+ OPC. DESIGN, SETTING, AND PARTICIPANTS: This phase 2 nonrandomized clinical trial conducted at a single academic center enrolled 77 patients with locoregionally advanced HPV+ OPC from 2017 to 2020. Data analyses were performed from February 10, 2021, to January 9, 2023. INTERVENTIONS: Addition of nivolumab to neoadjuvant nab-paclitaxel and carboplatin (studied in the first OPTIMA trial) followed by response-adapted LRT in patients with HPV+ OPC stages III to IV. MAIN OUTCOMES AND MEASURES: Primary outcome was deep response rate to neoadjuvant nivolumab plus chemotherapy, defined as the proportion of tumors with 50% or greater shrinkage per the Response Evaluation Criteria in Solid Tumors 1.1. Secondary outcomes were progression-free survival (PFS) and overall survival (OS). Swallowing function, quality of life, and tissue- and blood-based biomarkers, including programmed death-ligand 1 (PD-L1) expression and circulating tumor HPV-DNA (ctHPV-DNA), were also evaluated. RESULTS: The 73 eligible patients (median [range] age, 61 [37-82] years; 6 [8.2%] female; 67 [91.8%] male) started neoadjuvant nivolumab and chemotherapy. Deep responses were observed in 51 patients (70.8%; 95% CI, 0.59-0.81). Subsequent risk- and response-adaptive therapy was assigned as follows: group A, single-modality radiotherapy alone or transoral robotic surgery (28 patients); group B, intermediate-dose chemoradiotherapy of 45 to 50 Gray (34 patients); and group C, regular-dose chemoradiotherapy of 70 to 75 Gray (10 patients). Two-year PFS and OS were 90.0% (95% CI, 0.80-0.95) and 91.4% (95% CI, 0.82-0.96), respectively. By response-adapted group, 2-year PFS and OS for group A were 96.4% and 96.4%, and group B, 88.0% and 91.0%, respectively. Lower enteral feeding rates and changes in weight, as well as improved swallowing, were observed among patients who received response-adapted LRT. Pathologic complete response rate among patients who underwent transoral robotic surgery was 67.0%. PD-L1 expression was nonsignificantly higher for deeper responses and improved PFS, and ctHPV-DNA clearance was significantly associated with improved PFS. CONCLUSIONS AND RELEVANCE: This phase 2 nonrandomized clinical trial found that neoadjuvant nivolumab and chemotherapy followed by response-adapted LRT is feasible and has favorable tolerability, excellent OS, and improved functional outcomes in HPV+ OPC, including among patients with high-risk disease. Moreover, addition of nivolumab may benefit high PD-L1 expressors, and sensitive dynamic biomarkers (eg, ctHPV-DNA) are useful for patient selection. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03107182
- Published
- 2024
- Full Text
- View/download PDF
42. Rapid Weight Loss Drugs Give Junk Food Sellers a Pass.
- Author
-
ROSENBERG, MARTHA
- Abstract
A recent article from CounterPunch discusses the impact of rapid weight loss drugs on the prevalence of junk food advertising and availability. The ban on junk food advertising in London's public transport network in 2019 reportedly prevented 100,000 cases of obesity. However, in the United States, the popularity of weight loss drugs like Ozempic allows junk food advertising to continue without consequence. The article raises concerns about the long-term side effects of these drugs, including risks during surgery and various health conditions. It also criticizes the fat acceptance movement and argues for addressing the root causes of obesity, such as junk food advertising and ubiquity. [Extracted from the article]
- Published
- 2024
43. “HeRoEs WoRk HeRe”: An Exploration of the Impact of Pandemic Virtue Signaling on Nursing Culture
- Author
-
Babalola, Grace, Felag, Jack, Sarkar, Sumantra, Ertem, Zeynep, Walter, Shannon, Roberts, Marie-Claire Rosenberg, and Jesso, Stephanie Tulk
- Abstract
The COVID-19 pandemic significantly impacted healthcare systems and increased risks of moral distress and burnout among nurses and other healthcare workers. Past research indicates organizational culture can also contribute to burnout. During the pandemic, the term “healthcare heroes” was frequently used to express gratitude towards nurses and other healthcare workers. However, we argue that this phenomenon can be classified as a “virtue signal”, where a low-effort expression of moral support is used to justify or excuse a lack of real support through improved working conditions or fair compensation. This study explores how the usage of the label “hero” grew to signify frustration over nurses’ working conditions by examining social media posts on the r/nursing subreddit within the Reddit community. Data from 2018-2022 was analyzed to record the monthly usage of keywords related to nurses' experiences within pre, early, and late pandemic periods. Results indicate that the usage of and relationships between our keywords changed significantly over the course of the pandemic. The frequency of usage of the word “hero” spiked at the very start of the pandemic, but was later eclipsed by usage of the words “union” in the late pandemic period. “Netnographic” observations revealed how terms like “hero” and “pizza party” were frequently used in nurses’ posts to call out organizational virtue signaling and lack of appreciation. Our findings suggest that while the term “hero” was sometimes perceived as a virtue signal even before the pandemic, the usage of “hero” by nurses in r/nursing grew to signify an overall perception of a lack of support from healthcare organizations and the general public which may have led to increased motivation to unionize.
- Published
- 2024
- Full Text
- View/download PDF
44. CJEM debate series: #StillTheOne—while more challenging than ever, emergency medicine is still the best career path available for medical students
- Author
-
Rosenberg, Hans, Syed, Shahbaz, and Atkinson, Paul
- Published
- 2024
- Full Text
- View/download PDF
45. Second Primary Breast Cancer in Young Breast Cancer Survivors
- Author
-
Brantley, Kristen D., Rosenberg, Shoshana M., Collins, Laura C., Ruddy, Kathryn J., Tamimi, Rulla M., Schapira, Lidia, Borges, Virginia F., Warner, Ellen, Come, Steven E., Zheng, Yue, Kirkner, Gregory J., Snow, Craig, Winer, Eric P., and Partridge, Ann H.
- Abstract
IMPORTANCE: Among women diagnosed with primary breast cancer (BC) at or younger than age 40 years, prior data suggest that their risk of a second primary BC (SPBC) is higher than that of women who are older when they develop a first primary BC. OBJECTIVE: To estimate cumulative incidence and characterize risk factors of SPBC among young patients with BC. DESIGN, SETTING, AND PARTICIPANTS: Participants were enrolled in the Young Women’s Breast Cancer Study, a prospective study of 1297 women aged 40 years or younger who were diagnosed with stage 0 to III BC from August 2006 to June 2015. Demographic, genetic testing, treatment, and outcome data were collected by patient surveys and medical record review. A time-to-event analysis was used to account for competing risks when determining cumulative incidence of SPBC, and Fine-Gray subdistribution hazard models were used to evaluate associations between clinical factors and SPBC risk. Data were analyzed from January to May 2023. MAIN OUTCOMES AND MEASURES: The 5- and 10- year cumulative incidence of SPBC. RESULTS: In all, 685 women with stage 0 to III BC (mean [SD] age at primary BC diagnosis, 36 [4] years) who underwent unilateral mastectomy or lumpectomy as the primary surgery for BC were included in the analysis. Over a median (IQR) follow-up of 10.0 (7.4-12.1) years, 17 patients (2.5%) developed an SPBC; 2 of these patients had cancer in the ipsilateral breast after lumpectomy. The median (IQR) time from primary BC diagnosis to SPBC was 4.2 (3.3-5.6) years. Among 577 women who underwent genetic testing, the 10-year risk of SPBC was 2.2% for women who did not carry a pathogenic variant (12 of 544) and 8.9% for carriers of a pathogenic variant (3 of 33). In multivariate analyses, the risk of SPBC was higher among PV carriers vs noncarriers (subdistribution hazard ratio [sHR], 5.27; 95% CI, 1.43-19.43) and women with primary in situ BC vs invasive BC (sHR, 5.61; 95% CI, 1.52-20.70). CONCLUSIONS: Findings of this cohort study suggest that young BC survivors without a germline pathogenic variant have a low risk of developing a SPBC in the first 10 years after diagnosis. Findings from germline genetic testing may inform treatment decision-making and follow-up care considerations in this population.
- Published
- 2024
- Full Text
- View/download PDF
46. Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practice
- Author
-
Brennan, Paul N, Tavabie, Oliver D, Li, Wenhao, Marjot, Thomas, Corless, Lynsey, Fallowfield, Jonathan A, Jarvis, Helen, Mansour, Dina, McPherson, Stuart, Rosenberg, William, Rockell, Karen, Tomlinson, Jeremy, Yeoman, Andrew, Tsochatzis, Emmanuel A, Dillon, John F, Alazawi, William, and Abeysekera, Kushala W M
- Abstract
The American, European, and Latin American liver societies have proposed a change in the nomenclature we use to describe alcohol-related liver disease and non-alcoholic fatty liver disease. Additionally, a term encompassing both is now advocated: steatotic liver disease, which includes metabolic dysfunction associated steatotic liver disease (MASLD) and MASLD with greater alcohol consumption (MetALD). These classifications offer increased relevance for clinicians, researchers, and patients alike. In this Viewpoint, we discuss the basis for this nomenclature shift and how it was developed. We also explore the challenges that will be faced in the adoption of such change. The proposed change seeks to banish stigma associated with phrasing such as alcoholic and fatty. However stigma, particularly related to the term fatty, is culturally nuanced, and reflects different entities depending on location. If such a change is internationally accepted, there will be wide-reaching effects on practitioners in primary care and metabolic medicine, and on patients. We discuss those effects and the opportunities the nomenclature change could offer, particularly for patients with alcohol and metabolic risk factors who represent a group previously ignored by clinical trials.
- Published
- 2024
- Full Text
- View/download PDF
47. Assessment of PSA responses and changes in the rate of tumor growth (g-rate)with immune checkpoint inhibitors in US Veterans with prostate cancer
- Author
-
Leuva, Harshraj, Moran, George, Jamaleddine, Nader, Meseha, Mina, Zhou, Mengxi, Im, Yunju, Rosenberg, Ta-Chueh Melody, Park, Yeun-Hee Anna, Luhrs, Carol, Bates, Susan E., and Faiena, Izak
- Abstract
We examined data from US Veterans with prostate cancer (PC) to assess disease response to immune checkpoint inhibitors (ICI) as monotherapy or combined with abiraterone or enzalutamide to assess ICI efficacy in the real-world. We queried the VA corporate data warehouse (CDW) to identify Veterans with a diagnosis of PC who received ICI for any malignancy and had ≥1 PSA measurement while receiving ICI. To evaluate ICI monotherapy, we restricted analysis to Veterans who had not received LHRH agonists/antagonists, PC-directed medical therapy, or radiation/extirpative surgery of the bladder/prostate within and preceding the duration of ICI administration. For ICI combination analysis, we identified Veterans who received abiraterone or enzalutamide for PC while on ICI. We calculated rates of tumor (PSA) growth (g-rates), comparing them to a 1:2 matched reference cohort. We identified 787 Veterans with PC and ≥1 PSA measurement while receiving an ICI. Median duration of ICI therapy was 155 days. 223 Veterans received ICI monotherapy, with only 17(8%) having a reduction in PSA (median decline = 43%). 12 (5%) had PSA declines >30% (PSA30) which included 6 (3%) who had PSA reductions greater than 50% (PSA50). Median g-rates for ICI plus abiraterone (n = 20) or enzalutamide (n = 31) were 0.000689/d−1and 0.002819/d−1, respectively, and were statistically insignificant compared to g-rates of matched cohorts receiving abiraterone (g = 0.000925/d−1, P = 0.73) or enzalutamide (g = 0.001929/d−1, P = 0.58) alone. Our data align with clinical trial data in PC, demonstrating limited benefit from ICI monotherapy and predicting no survival benefit from simultaneous abiraterone or enzalutamide with an ICI using g-rate.
- Published
- 2024
- Full Text
- View/download PDF
48. Combat mass.
- Author
-
Akhil Kadidal, Jenning, Parakala, Akshara, and Rosenberg, Zach
- Abstract
The article presents the discussion on UK Ministry of Defence's (MoD) initiative to develop a common digital network for swarming systems, partnering with companies like Malloy Aeronautics and Sierra Nevada Corporation. Topics include explores Israel's development of the Legion-X autonomous combat solution, emphasizing human-machine teaming and the coordination of unmanned platforms for extended warfighter capabilities; and potential for collaboration and augmentation during operations.
- Published
- 2024
49. The Ability to Sustain Facial Expressions
- Author
-
Schutte, Hilde, Bielevelt, Freek, Emohamadian, Hafsa, Muradin, Marvick S.M., Bleys, Ronald L.A.W., and Rosenberg, Antoine J.W.P.
- Abstract
To gain more insight into facial muscle function, imaging during action would be optimal. Magnetic resonance imaging is highly suitable for visualizing facial muscles. However, magnetic resonance imaging requires the individual to remain as still as possible for a while. Knowledge of the ability to sustain facial expressions is requisite before scanning individuals. This could help adapting the scanning protocol to obtain optimal quality of imaging the muscles in action. A study, including 10 healthy volunteers, was done to perceive the extent of movement while holding facial expressions of smiling and pouting. During 6 minutes, 3-dimensional photographs were taken every consecutive minute while the participants maintained their facial expressions as motionless as possible. The movement was objectified by creating distance maps between the 2 models and calculating the Root Mean Square using the software 3DMedX. The results showed that most movements occurred in the first minute, with a decrease of the intensity of the expression. After the first minute, the expression, although less intense, could be held stable. This implies that magnetic resonance imaging scanning during facial expression is possible, provided that the scanning starts after the first minute has elapsed. In addition, results demonstrated that more slackening of the muscles while smiling compared with pouting.
- Published
- 2024
- Full Text
- View/download PDF
50. Durability of photocatalytic ZnO-based surface coatings and preservation of their antibacterial effect after simulated wear
- Author
-
Kook, Mati, Kaur, Harleen, Danilian, Dmytro, Rosenberg, Merilin, Kisand, Vambola, and Ivask, Angela
- Abstract
This study focused on antibacterial durability testing of surface coatings based on acrylic matrix-embedded UVA-activated ZnO. Such coatings on stainless steel were treated by dry rubbing, wet rubbing, and abrasive treatment to simulate wearing during everyday touching, cleaning, and aggressive scrubbing. Abrasive treatment caused clear topological changes to the surfaces, flattened the surface at the micrometer scale, and released a significant amount of surface material, which was partly acrylic matrix and partly the embedded ZnO. The highest release of Zn, the most prominent photocatalytic activity under UVA and the greatest antibacterial effect, was observed for abrasively treated surfaces. Although a small amount of surface material was released from surfaces after dry and wet rubbing, no significant increase in Zn release or photocatalytic activity was detected. On the contrary, antibacterial activity after those treatments decreased in comparison with untreated surfaces, likely due to partial surface masking by the released acrylic matrix. In summary, our results indicate that antimicrobial ZnO material immobilized in acrylic matrix creates stable surface coatings that may lose some of their efficacy during daily use and cleaning procedures, but activity of which will be retained during a more aggressive abrasion procedure.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.