55 results on '"A, Shotan"'
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2. Spin Dynamics of a Solid-State Qubit in Proximity to a Superconductor
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Monge, Richard, Delord, Tom, Proscia, Nicholas V., Shotan, Zav, Jayakumar, Harishankar, Henshaw, Jacob, Zangara, Pablo R., Lozovoi, Artur, Pagliero, Daniela, Esquinazi, Pablo D., An, Toshu, Sodemann, Inti, Menon, Vinod M., and Meriles, Carlos A.
- Abstract
A broad effort is underway to understand and harness the interaction between superconductors and spin-active color centers with an eye on hybrid quantum devices and novel imaging modalities of superconducting materials. Most work, however, overlooks the interplay between either system and the environment created by the color center host. Here we use a diamond scanning probe to investigate the spin dynamics of a single nitrogen-vacancy (NV) center proximal to a superconducting film. We find that the presence of the superconductor increases the NV spin coherence lifetime, a phenomenon we tentatively rationalize as a change in the electric noise due to a superconductor-induced redistribution of charge carriers near induced redistribution of charge carriers near the NV. We then build on these findings to demonstrate transverse-relaxation-time-weighted imaging of the superconductor film. These results shed light on the dynamics governing the spin coherence of shallow NVs, and promise opportunities for new forms of noise spectroscopy and imaging of superconductors.
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- 2023
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3. Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome
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Kalantar-Zadeh, Kamyar, Schwartz, Gregory G., Nicholls, Stephen J., Buhr, Kevin A., Ginsberg, Henry N., Johansson, Jan O., Kulikowski, Ewelina, Lebioda, Kenneth, Toth, Peter P., Wong, Norman, Sweeney, Michael, Ray, Kausik K., Ray, Kausik K., Schwartz, Gregory G., Nicholls, Stephen J., Kalantar-Zadeh, Kaymar, Toth, Peter, Ginsberg, Henry, Sweeney, Michael, Wong, Norman, Johansson, Jan, Lorenzatti, Alberto, Vico, Marisa, Milanova, Maria, Milicevic, Goran, Popovic, Zeljko, Ebelt, Henning, Kiss, Róbert Gábor, Lewis, Basil, Llamas, Edmundo Bayram, Banach, Maciej, Tereschenko, Sergey, Pavlovic, Milan, Pella, Daniel, Chiang, Chern-En, Lonn, Eva, Watkins, Paul, Waters, David, Szarek, Michael, Currier, Judith, Leiter, Lawrence Alan, McMurray, John, Petrie, Mark, Jhund, Pardeep, Walters, Matthew, Connolly, Eugene, Lang, Ninian, Schiavi, Lilia, Vico, Marisa, Maffei, Laura, Bordonava, Anselmo, Prado, Aldo, Vallejos, Julio, Farias, Javier, Nardone, Lucrecia, Resk, Jorge, Caruso, Orlando, Lorenzatti, Alberto, Maldonado, Natacha, Padilla, Lucio, Hominal, Miguel, Luquez, Hugo, Sposetti, Georgina, Caccavo, Alberto, Glenny, Jorge, Mansilla, Virginia, Alvarez, Maria, Parody, Maria, Sarjanovich, Rodolfo, Klyver, Maria, Valdez, Maria Eugenia, Colombo, Hugo, Baccaro, Claudia, Visco, Virginia, Bono, Julio, Cuneo, Carlos, Pácora, Fredy Ferré, Guzman, Pablo, Piskorz, Daniel, Vogel, Daniel, Grigorov, Mladen, Gatzov, Plamen, Stoyanov, Miroslav, Apostolova, Emilya, Milanova, Maria, Petrov, Ivo, Angelov, Atanas, Lazov, Petar, Grigorova, Valentina, Yanev, Todor, Vuchkova, Emilena, Vassilev, Dobrin, Tisheva, Snezhanka, Gelev, Valeri, Canecki-Varzic, Silvia, Popovic, Zeljko, Tusek, Srecko, Šunić, Ema Drvodelić, Milicevic, Goran, Jandric-Balen, Marica, Marinic, Nikolina, Moser, Natasa, Ebelt, Henning, Natour, Mohammed, Schwimmbeck, Peter, Appel, Karl-Friedrich, Kleinertz, Klaus, Merkely, Béla, Papp, András, Kiss, Robert, Kovács, Zsolt, Vértes, András, Sárszegi, Zsolt, Kis, Ernö, Benedek, Amália, Takács, János, Papp, Aniko, Matoltsy, Andras, Andrassy, Peter, Ungi, Imre, Shechter, Michael, Atar, Shaul, Shotan, Avraham, Vazan, Alicia, Alcalai, Ronny, Lotan, Chaim, Lewis, Basil, Hayek, Tony, Moriel, Mady, Katz, Amos, Liberty, Idit, Harman-Boehm, Ilana, Schiff, Elad, Kracoff, Oscar, Rozenman, Yoseph, Mosseri, Morris, Slezak, Ladislav, Sabbah, Muhammad, Zeltser, David, Adawi, Khaled, Omary, Muhamed, Ness, Rosane Abramof, Adawi, Faiad, Ruiz, Jose Garza, Carrillo, Jorge, Nevarez Ruiz, Luis Alejandro, Hernandez, Pedro Garcia, Arechavaleta-Granell, Maria, los Rios Ibarra, Manuel De, Velasco-Sanchez, Raul, Molina, Hugo Laviada, Morales, Lucas Solis, Gonzalez, Efrain Montano, Esperón, Guillermo Llamas, Bayram Llamas, Edmundo Alfredo, Rocha, Cynthia Mustieles, Suarez-Otero, Rodrigo, Real, Manuel Aguilera, Cruz, Eliud Montes, Lopez, Humberto Alvarez, Vaca, Susano Lara, Fanghanel-Salmon, Guillermo, Herrera, Carlos Hernandez, Saldaña, Joel Rodriguez, Garcia, Elier Pedroza, Velázquez, Maricela Vidrio, Briones, Ignacio Rodriguez, Hamer, Bas, Slagboom, Ton, Zurakowski, Aleksander, Debinski, Marcin, Kobielusz-Gembala, Iwona, Bartkowiak, Radoslaw, Rajzer, Marek, Witkowski, Adam, Kowalisko, Alicja, Piepiorka, Marek, Stania, Karol, Domzal, Michal, Korecki, Janusz, Korzeniak, Romuald, Mazurkiewicz, Lukasz, Mirek-Bryniarska, Ewa, Banach, Maciej, Madziarska, Katarzyna, Mlodziankowski, Adam, Rewerska, Barbara, Gaciong, Zbigniew, Mazurkiewicz, Maciej, Maksimov, Ivan, Shvarts, Yuri, Khaisheva, Larisa, Samitin, Vasily, Boldueva, Svetlana, Zykov, Mikhail, Barbarash, Olga, Kostenko, Victor, Kulibaba, Elena, Smolenskaya, Olga, Tarasov, Nikolay, Shogenov, Zaur, Strongin, Leonid, Kuzin, Anatoly, Makukhin, Valeriy, Nikolaev, Konstantin, Tereschenko, Sergey, Vezikova, Natalya, Miloradovic, Vladimir, Pavlovic, Milan, Ilic, Marina Deljanin, Simic, Dragan, Pudar-Brankovic, Georgina, Jozic, Tanja, Dodic, Slobodan, Ristic, Arsen, Hinic, Sasa, Mitov, Vladimir, Stokuca-Korac, Natasa, Stokic, Edita, Celic, Vera, Despotovic, Nebojsa, Dincic, Dragan, Tosic, Biljana Putnikovic, Selakovic, Aleksandar, Pella, Daniel, Banik, Milan, Fedacko, Jan, Micko, Karol, Duris, Tibor, Kokles, Martin, Lachova, Beata, Dzupina, Andrej, Mazur, Juraj, Buganova, Ingrid, Behuncik, Milan, Vadinova, Silvia, Yeh, Hung-I, Chiang, Chern-En, Lee, Cheng-Hen, Hsieh, I-Chang, Jiunn-Lee, Lin, Lin, We-Hsiang, Wu, Yen-Wen, Hsia, Chien Hsun, and Lo, Ping Han
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- 2021
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4. Acute diagonal-induced ST-elevation myocardial infarction and electrocardiogram-guidance in the era of primary coronary intervention: New insights into an old tool
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Abu Fanne, Rami, Kleiner Shochat, Michael, Shotan, Avraham, Frimerman, Aharon, Maraga, Emad, Amsalem, Naama, Levi, Yaniv, and Meisel, Simcha R
- Abstract
Background: Previous studies, published before the advent of primary reperfusion, described the electrocardiographic features of ST-segment elevation myocardial infarction (STEMI) caused by total diagonal artery occlusion, as demonstrated at pre-discharge coronary angiography. We aimed to assess the electrocardiographic and echocardiographic features in STEMI unequivocally attributed to a diagonal lesion in the era of primary coronary intervention.Methods: The electrocardiograms and echocardiograms of patients sustaining STEMI caused by diagonal artery involvement were compared with those of patients with STEMI attributed to proximal or mid left anterior descending artery (LAD) lesions. ST-segment deviations were measured at four different points in each lead and analyzed against TIMI flow and SNuH score. The electrocardiographic and echocardiographic features of each group were mapped.Results: In contrast to previous studies claiming an ever-present incidence of at least 1-mm ST-segment elevation in leads I and aVL with diagonal STEMI, we report 86% of any ST-elevation in leads I, aVL and V2 (64–71% for ST-elevation >1 mm). Both higher SNuH score and pre-intervention TIMI flow were associated with larger lateral ST-elevations (85.7% and 86.4–95.5%, respectively). Higher prevalence of ST-depression in the inferior leads reflecting reciprocal changes was observed in patients with diagonal-induced STEMI (57–76% vs. 24–51% in LAD obstructions, p<0.05).Conclusion: The most sensitive and predictive sign for acute ischemia was any degree of ST-deviation measured 1 mm beyond the J point. ST-elevations in I, aVL and V2, sparing V3-V5, strongly favor isolated diagonal lesion. Proximal LAD lesion lacking ST-segment elevations in leads I and aVL is primarily due to wraparound LAD anatomy.
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- 2020
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5. Microcavity-coupled emitters in hexagonal boron nitride
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Proscia, Nicholas V., Jayakumar, Harishankar, Ge, Xiaochen, Lopez-Morales, Gabriel, Shotan, Zav, Zhou, Weidong, Meriles, Carlos A., and Menon, Vinod M.
- Abstract
Integration of quantum emitters in photonic structures is an important step in the broader quest to generate and manipulate on-demand single photons via compact solid-state devices. Unfortunately, implementations relying on material platforms that also serve as the emitter host often suffer from a tradeoff between the desired emitter properties and the photonic system practicality and performance. Here, we demonstrate “pick and place” integration of a Si3N4microdisk optical resonator with a bright emitter host in the form of ∼20-nm-thick hexagonal boron nitride (hBN). The film folds around the microdisk maximizing contact to ultimately form a hybrid hBN/Si3N4structure. The local strain that develops in the hBN film at the resonator circumference deterministically activates a low density of defect emitters within the whispering gallery mode volume of the microdisk. These conditions allow us to demonstrate cavity-mediated out-coupling of emission from defect states in hBN through the microdisk cavity modes. Our results pave the route toward the development of chip-scale quantum photonic circuits with independent emitter/resonator optimization for active and passive functionalities.
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- 2020
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6. The impact of left ventricular ejection fraction on heart failure patients with pulmonary hypertension.
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Zafrir, Barak, Carasso, Shemy, Goland, Sorel, Zilberman, Liaz, Klempfner, Robert, Shlomo, Nir, Radzishevsky, Evgeny, Hasin, Tal, Shotan, Avraham, Vazan, Alicia, Weinstein, Jean Marc, Kinany, Wadi, Dragu, Robert, Maor, Elad, Grosman-Rimon, Liza, and Amir, Offer
- Abstract
The most common cause of pulmonary hypertension (PH) in developed countries is left heart disease (LHD, group 2 PH). The development of PH in heart failure (HF) patients is indicative of worse outcomes. The aim of this study was to evaluate the long term outcomes of HF patients with PH in a national long-term registry. Study included 9 cardiology centers across Israel between 01/2013–01/2015, with a 12-month clinical follow-up and 24-month mortality follow-up. Patients were age ≥18 years old with HF and pre-inclusion PH due to left heart disease determined by echocardiography [estimated systolic pulmonary arterial pressure (SPAP) ≥ 50 mmHg]. Patients were categorized into 3 groups: HF with reduced (HFrEF < 40%), mid-range (HFmrEF 40–49%), and preserved (HFpEF ≥ 50%) ejection fraction. The registry included 372 patients, with high prevalence of cardiovascular risk factors. Median HF duration was 4 years and 65% were in severe HF New York Heart Association (NYHA) classification ≥3. Mean systolic pulmonary artery pressure (SPAP) was 62 ± 11 mmHg. During 2-years of follow-up, 54 patients (15%) died. Univariable predictors of mortality included NYHA grade 3–4, chronic renal failure, and SPAP ≥ 65 mmHg. Severe PH was associated with mortality in HFpEF, but not HFmrEF or HFrEF, and remained significant after multivariable adjustment with an adjusted hazard ratio of 2.99, (95%CI 1.29–6.91, p = 0.010). The combination of HFpEF with severe PH was independently associated with increased mortality. Currently, HFpEF patients are included with group 2 PH patients. Defining HFpEF with severe PH as a sub-class may be more appropriate, as these patients are at increased risk and deserve special consideration. [ABSTRACT FROM AUTHOR]
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- 2019
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7. PO-02-086 A NOVEL ANTIBIOTIC DELIVERY APPROACH FOR SALVAGE OF CARDIOVASCULAR-IMPLANTABLE ELECTRONIC DEVICES WITH LOCALIZED INFECTION.
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Chorin, Ehud, Topaz, Moris, Schwartz, Lorin A., Hochstadt, Aviram, Shotan, Avraham, Ashkenazi, Itamar, Kazatsker, Mark, Carmel, Narin, Topaz, Guy, Oron, Yoram, margolis, gilad, Nof, Eyal, Beinart, Roy, Glikson, Michael, Mazo, Anna, Milman, Anat, Dekel, Michal, Banai, Shmuel, Rosso, Raphael, and Viskin, Sami
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- 2023
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8. Near-deterministic activation of room-temperature quantum emitters in hexagonal boron nitride
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Proscia, Nicholas V., Shotan, Zav, Jayakumar, Harishankar, Reddy, Prithvi, Cohen, Charles, Dollar, Michael, Alkauskas, Audrius, Doherty, Marcus, Meriles, Carlos A., and Menon, Vinod M.
- Abstract
Applications of quantum science to computing, cryptography, and imaging are on their way to becoming key next-generation technologies. Owing to the high-speed transmission and exceptional noise properties of photons, quantum photonic architectures are likely to play a central role. A long-standing hurdle, however, has been the realization of robust, device-compatible single-photon sources that can be activated and controlled on demand. Here we demonstrate large arrays of room-temperature quantum emitters in two-dimensional hexagonal boron nitride (hBN). The large energy gap inherent to this van der Waals material stabilizes the emitters at room temperature within nanoscale regions defined by substrate-induced deformation of few-atomic-layer hBN. Combining analytical and numerical modeling, we show that emitter activation is the result of carrier trapping in deformation potential wells localized near the points where the hBN film reaches the highest curvature. Through the control of pillar geometry, we demonstrate an average of ∼2 emitters per site for the smallest pillars (75 nm diameter). These findings set the stage for realizing arrays of room-temperature single-photon sources through the combined control of strain and external electrostatic potentials.
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- 2018
9. Non-Invasive Lung IMPEDANCE-Guided Preemptive Treatment in Chronic Heart Failure Patients: A Randomized Controlled Trial (IMPEDANCE-HF Trial).
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Shochat, Michael Kleiner, Shotan, Avraham, Blondheim, David S., Kazatsker, Mark, Dahan, Iris, Asif, Aya, Rozenman, Yoseph, Kleiner, Ilia, Weinstein, Jean Marc, Frimerman, Aaron, Vasilenko, Lubov, and Meisel, Simcha R.
- Abstract
Background: Previous investigations have suggested that lung impedance (LI)-guided treatment reduces hospitalizations for acute heart failure (AHF). A single-blind 2-center trial was performed to evaluate this hypothesis (ClinicalTrials.gov-NCT01315223).Methods: The study population included 256 patients from 2 medical centers with chronic heart failure and left ventricular ejection fraction ≤35% in New York Heart Association class II-IV, who were admitted for AHF within 12 months before recruitment. Patients were randomized to a control group treated by clinical assessment and a monitored group whose therapy was also assisted by LI, and followed for at least 12 months. Noninvasive LI measurements were performed with a new high-sensitivity device. Patients, blinded to their assignment group, were scheduled for monthly visits in the outpatient clinics. The primary efficacy endpoint was AHF hospitalizations; the secondary endpoints were all-cause hospitalizations and mortality.Results: There were 67 vs 158 AHF hospitalizations during the first year (P < .001) and 211 vs 386 AHF hospitalizations (P < .001) during the entire follow-up among the monitored patients (48 ± 32 months) and control patients (39 ± 26 months, P = .01), respectively. During the follow-up, there were 42 and 59 deaths (hazard ratio 0.52, 95% confidence interval 0.35-0.78, P = .002) with 13 and 31 of them resulting from heart failure (hazard ratio 0.30, 95% confidence interval 0.15-0.58 P < .001) in the monitored and control groups, respectively. The incidence of noncardiovascular death was similar.Conclusion: Our results seem to validate the concept that LI-guided preemptive treatment of chronic heart failure patients reduces hospitalizations for AHF as well as the incidence of heart failure, cardiovascular, and all-cause mortality. [ABSTRACT FROM AUTHOR]- Published
- 2016
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10. Aortic dimensions by multi-detector computed tomography vs. echocardiography.
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Blondheim, David S., Vassilenko, Lubov, Glick, Yair, Asif, Aya, Nachtigal, Alicia, Meisel, Simcha R., Shochat, Michael, Shotan, Avraham, and Zeina, Abdel-Rauf
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Objective Clinical follow-up of aortic dimensions is performed interchangeably by multi-detector computed tomography (MDCT) and by cardiac echocardiography (ECHO). This study assesses the relationship between measurements of the aortic diameter by MDCT and ECHO at various predetermined locations using several methods. Methods The aortic diameter was measured at 6 locations between the aortic annulus and the aortic arch in 49 patients who underwent both MDCT and ECHO. Measurements were performed by three methods: internal-to-internal edge (INT), external-to-internal edge (MIX), and external-to-external edge (EXT). Measurements by MDCT and ECHO were made by an experienced radiologist and cardiologist, respectively, both blinded to results and images from the other modality. Results The average aortic diameter at all locations was significantly different between the MDCT and ECHO by all three methods (INT: 30.0 ± 5.8 mm vs. 27.8 ± 5.9 mm; MIX: 31.5 ± 5.8 mm vs. 30.8 ± 5.8 mm; EXT: 32.9 ± 6.6 mm vs. 33.8 ± 6.5 mm, p < 0.002 for all). While mean absolute differences between INT and EXT methods were similar (3.5 ± 3.1 mm and 3.4 ± 2.7 mm, respectively), the absolute difference using the MIX method was significantly smaller (3.1 ± 2.8 mm; p < 0.001 for INT vs. MIX; p < 0.05 for EXT vs. MIX). Conclusions There is considerable variability between MDCT and ECHO measurements of the ascending aorta. Measuring the aortic diameter by the MIX provides the closest measurements and is advised for long-term follow-up. [ABSTRACT FROM AUTHOR]
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- 2016
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11. Optical control of room-temperature valley polaritons
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Sun, Zheng, Gu, Jie, Ghazaryan, Areg, Shotan, Zav, Considine, Christopher R., Dollar, Michael, Chakraborty, Biswanath, Liu, Xiaoze, Ghaemi, Pouyan, Kéna-Cohen, Stéphane, and Menon, Vinod M.
- Abstract
The formation of half-light half-matter quasiparticles under strong coupling results in properties unique from those of the constituent components. Fingerprints of both light and matter are imprinted on the new quasiparticles, called polaritons. In the context of two-dimensional (2D) materials, this opens up the possibility of exploiting the intriguing spin–valley physics of a bare semiconductor combined with the light mass of the photonic component for possible quantum technologies. Specifically, the valley degree of freedom, which remained largely unexplored until the advent of these materials, is highly attractive in this context as it provides an optically accessible route for the control and manipulation of electron spin. Here, we report the observation of room-temperature strongly coupled light–matter quasiparticles that are valley polarized because of the coupling of photons with specific helicity to excitons that occupy quantum mechanically distinct valleys in momentum space. The realization of valley polaritons in 2D semiconductor microcavities presents the first step towards engineering valley-polaritonic devices.
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- 2017
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12. Novel system for measuring giant spectral images and its application for cancer detection
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Farkas, Daniel L., Nicolau, Dan V., Leif, Robert C., Kumar, Pramod, Marin, Irina, Necula, Daniela, Bronshtein-Berger, Irena, Linder, Moshe, Shotan, Zav, Zimmerman-Moreno, Gali, Mayer, Arnaldo, Barshack, Iris, and Garini, Yuval
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- 2017
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13. Collateral pressure and flow in acute myocardial infarction with total coronary occlusion correlate with angiographic collateral grade and creatine kinase levels.
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Meisel, Simcha R., Shochat, Michael, Frimerman, Aaron, Asif, Aya, Blondheim, David S., Shani, Jacob, Rozenman, Yoseph, and Shotan, Avraham
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Background: The validity of angiographic collateral grade according to the Rentrop classification during acute myocardial infarction (AMI) and its relation to flow in occluded coronary arteries before angioplasty have never been evaluated. Methods: We assessed the validity of the angiographic collateral grade according to Rentrop classification in relation to collateral pressure and flow beyond occluded coronary arteries during AMI. Pressure distal to coronary artery occlusions before balloon dilatation was measured in 111 patients undergoing angioplasty for AMI. We calculated the collateral flow index (CFI) and compared it to observed Rentrop grade and measured creatine kinase sum. Results: The values of pressure distal to coronary artery occlusions with respect to collateral grades 0 to 3 were 33 ± 12, 37 ± 13, 42 ± 10, and 60 ± 14 mm Hg (P < .0001). Overall CFI was 0.35 ± 0.13 (median 0.33), with CFI values of 0.3 ± 0.13, 0.33 ± 0.13, 0.39 ± 0.1, and 0.57 ± 0.2 for collateral grades 0 to 3, respectively (P < .0001). Larger creatine kinase elevation (P < .016) and higher white blood cell count (P < .022) were recorded in the lowest tertile CFI compared with highest tertile CFI group; but no difference in the global, regional, or infarct-related regional left ventricular contraction was found. Conclusions: These observations demonstrate that the Rentrop classification is valid in AMI patients with occluded coronary arteries and that collaterals are recruited acutely. These collaterals, whose pressure-derived CFI during AMI was shown for the first time to be higher than its value reported in chronic conditions, may limit the immediate myocardial damage or the systemic inflammatory response. No impact on global or regional cardiac contraction was detected in a population where most patients were treated early. [Copyright &y& Elsevier]
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- 2010
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14. Blood transfusion for acute decompensated heart failure--friend or foe?
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Garty M, Cohen E, Zuchenko A, Behar S, Boyko V, Iakobishvili Z, Mittelman M, Battler A, Shotan A, Gottlieb S, Caspi A, Hasdai D, and Heart Failure Survey in ISrael (HFSIS) Investigators
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- 2009
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15. Blood transfusion for acute decompensated heart failure—friend or foe?
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Garty, Moshe, Cohen, Eytan, Zuchenko, Alexander, Behar, Solomon, Boyko, Valentina, Iakobishvili, Zaza, Mittelman, Moshe, Battler, Alexander, Shotan, Avraham, Gottlieb, Shmuel, Caspi, Avraham, and Hasdai, David
- Abstract
Background: In acute coronary syndromes (ACSs), blood transfusion (BT) has been associated with worse outcomes. The impact of BT among patients with acute decompensated heart failure (ADHF) remains unknown. Methods: Propensity score analysis of patients with ADHF with and without BT in a national heart failure (HF) survey was used in this study. Results: Of the 4,102 enrolled patients, 2,335 had ADHF, of whom 166 (7.1%) received BT. These patients were older (75.6% vs 73.6%, P = .04), more likely to be females (54.8% vs 43.9%, P = .007), more likely to have diabetes (59.0% vs 51.1%, P = .04) and renal dysfunction (59.0% vs 40.2%, P < .001), and more likely to receive inotropes (16.9% vs 8.0%, P < .001), but they had similar rates of ACS (41.0% vs 39.4%, P = .69) and prior HF (64.5% vs 70.0%, P = .23). Nadir hemoglobin levels were commonly <10 g/dL in BT patients (92.7% vs 8.0%); 15 BT patients had bleeding complications, of which 10 are major bleeding. Major predictors for BT were ACS (OR 1.85, 95% CI 1.15-2.96), inotropes use (OR 2.36, 95% CI 1.22-4.55), and nadir hemoglobin (OR 0.18 per 1 g/dL increase, 95% CI 0.14-0.22). In-hospital, 30-day, 1-year, and 4-year unadjusted mortality rates were higher for BT patients (10.8% vs 5.2%, P = .02; 11.0% vs 8.5%, P = .27; 39.6% vs 28.5%, P = .03; 69.5% vs 59.5%, P = .01, respectively). However, in 103 propensity-matched pairs (c-statistic 0.97), short-term mortality tended to be lower with BT (8.7% vs 14.6%, P = .20; 9.7% vs 18.4%, P = .08; 38.8% vs 42.7%, P = .59; and 72.8% vs 76.7%, P = .52, respectively). Conclusions: Acute decompensated HF patients receiving BT had worse clinical features and unadjusted outcomes, but BT per se seemed to be safe and perhaps even beneficial. [Copyright &y& Elsevier]
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- 2009
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16. Transient ST-elevation myocardial infarction: Clinical course with intense medical therapy and early invasive approach, and comparison with persistent ST-elevation myocardial infarction.
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Meisel, Simcha R., Dagan, Yasmin, Blondheim, David S., Dacca, Samir, Shochat, Michael, Kazatsker, Mark, Asif, Aya, Frimerman, Aaron, and Shotan, Avraham
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MYOCARDIAL infarction ,ELECTROCARDIOGRAPHY ,GLYCOPROTEINS ,CORONARY disease - Abstract
Patients presenting with ST-elevation myocardial infarction (STEMI), whose symptoms and electrocardiographic changes completely resolve upon admission and before the administration of reperfusion therapy, pose a therapeutic dilemma. The optimal management of this syndrome, termed here as transient STEMI (TSTEMI), has not yet been fully determined. We describe 69 prospectively recorded patients with TSTEMI, of which 63 patients (56.7 ± 11 years, 48 men) were available for long-term follow-up out of 1244 consecutive patients with acute myocardial infarction (5%). Patients with TSTEMI treated with intravenous isosorbide dinitrate, aspirin, and clopidogrel, and/or with glycoprotein IIb/IIIa inhibitors were compared with a control group of matched patients with STEMI without resolution, who were treated conventionally. The time interval from symptom onset to presentation at the emergency department of patients with TSTEMI was 1.7 ± 1.3 hours, and to first recording of ST elevations, 1.5 ± 1.4 hours. Symptoms and electrocardiographic changes fully resolved 1.2 ± 0.8 hours later, 1 hour after aspirin and nitrate administration. Coronary angiography, performed 36 ± 39 hours (median, 24 hours) from admission, demonstrated no obstructive lesion or single-vessel obstructive disease in 43 patients (70%). Primary coronary intervention was performed in 48 patients (77%), and 8 patients (13%) were referred to surgery. Left ventricular ejection fraction was within normal limits, and peak creatine kinase was mildly elevated. Patients with TSTEMI had less extensive coronary artery disease (P < .038), better thrombolysis in myocardial infarction flow on angiography (P < .01), lower peak creatine kinase level (P < .001), higher left ventricular ejection fraction (P < .0001), and lower likelihood to sustain a second additional coronary event after index admission (P = .024) than patients with STEMI. Transient STEMI was associated with less myocardial damage, less extensive coronary artery disease, higher thrombolysis in myocardial infarction flow grade in culprit artery, and better cardiac function. These data suggest that immediate intense medical therapy with an early invasive approach is an appropriate therapy in patients with TSTEMI. [Copyright &y& Elsevier]
- Published
- 2008
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17. Pre-admission NT-proBNP improves diagnostic yield and risk stratification – the NT-proBNP for EValuation of dyspnoeic patients in the Emergency Room and hospital (BNP4EVER) study
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Meisel, Simcha R, Januzzi, James L, Medvedovski, Margarita, Sharist, Moshe, Shochat, Michael, Ashkar, Jalal, Peschansky, Pavel, Haim, Shmuel Bar, Blondheim, David S, Glikson, Michael, and Shotan, Avraham
- Abstract
Background: Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) level is useful to diagnose or exclude acutely decompensated heart failure (ADHF) in dyspnoeic patients presenting to the emergency department (ED).Aim: To evaluate the impact of ED NT-proBNP testing on admission, length of stay (LOS), discharge diagnosis and long-term outcome.Methods: Dyspnoeic patients were randomized in the ED to NT-proBNP testing. Admission and discharge diagnoses, and outcomes were examined.Results: During 17 months, 470 patients were enrolled and followed for 2.0±1.3 years. ADHF likelihood, determined at study conclusion by validated criteria, established ADHF diagnosis as unlikely in 86 (17%), possible in 120 (24%), and likely in 293 (59%) patients. The respective admission rates in these subgroups were 80, 91, and 96%, regardless of blinding, and 61.9% of blinded vs. 74.5% of unblinded ADHF-likely patients were correctly diagnosed at discharge (p=0.029), with similar LOS. 2-year mortality within subgroups was unaffected by test, but was lower in ADHF-likely patients with NT-proBNP levels below median (5000 pg/ml) compared with those above median (p=0.002). Incidence of recurrent cardiac events tracked NT-proBNP levels.Conclusion: ED NT-proBNP testing did not affect admission, LOS, 2-year survival, or recurrent cardiac events among study patients but improved diagnosis at discharge, and allowed risk stratification even within the ADHF-likely group. (ClinicalTrials.gov#NCT00271128)
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- 2012
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18. Fluid overload contributing to heart failure
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Shotan, Avraham, Dacca, Samir, Shochat, Michael, Kazatsker, Marc, Blondheim, David S., and Meisel, Simcha
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Background. In advanced heart failure, the compensatory responses to reduced cardiac output, in spite of fluid retention, lead to maladaptive consequences.Methods. We performed a Medline survey for fluid overload and heart failure as well as reviewing textbook chapters.Results. The increased sympathetic nervous system, renin–angiotensin–aldosterone system, and antidiuretic hormone stimulation and release lead to a vicious cycle—augmenting pre-load, contractility and after-load, as well as increased fluid overload. The elevated work load on an already failed cardio-circulatory system results in further deterioration. Plasma volume is usually increased in untreated patients with increased extracellular fluid. However, it may range from reduced to increased in treated patients. Currently, diuretics remain the initial first line of therapy. In refractory cases, restoring plasma volume and osmolality, by adding albumin or hypertonic saline solutions, neurohormonal antagonists such as vasopressin receptors antagonists, aldosterone antagonists, or administration of nesiritide, may help in overcoming fluid overload.Conclusion. Exact measurement of plasma volume in various forms of heart failure and adjusting the treatment accordingly, establishing favourable and detrimental effects of various therapies, and introducing additional and new therapeutic options require further investigation.
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- 2005
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19. Abciximab in Carotid Stenting for Postsurgical Carotid Restenosis: Intermediate Results
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Schneiderman, Jacob, Morag, Benyamina, Gerniak, Alexander, Rimon, Uri, Varon, David, Seligsohn, Uri, Shotan, Avraham, and Adar, Raphael
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Purpose: To report intermediate results of a pilot study in which the glycoprotein IIb/IIIa receptor antagonist abciximab was given to patients during percutaneous carotid stenting for recurrent internal carotid artery (ICA) stenosis. The objective was to prevent procedure-related cerebral embolic events and decrease the incidence of recurrent stenosis.Methods: Sixteen patients (9 women; mean age 66.5 years, range 39–78) with severe ICA recurrent stenosis (>80%) underwent balloon angioplasty and stenting. Before the procedure, abciximab was administered intravenously as a bolus (0.25 mg/kg) followed by a 12-hour continuous infusion (10 µg/min).Results: Fifteen patients received stents (14 Wallstent and 1 Strecker); 1 vessel was dilated with only 50% improvement in luminal diameter. Two stented arteries had residual stenosis (<30%) but satisfactory luminal diameter was achieved in the remaining 13 (81%) arteries. There were no neurological ischemic events during or following the procedure, nor were there any bleeding or peripheral vascular complications. Duplex surveillance studies up to 12 months revealed no significant recurrent stenosis in the treated vessels.Conclusions: The administration of abciximab in conjunction with percutaneous revascularization procedures for postsurgical carotid artery stenosis may reduce cerebral ischemic episodes. It may also attenuate restenosis in the treated artery.
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- 2000
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20. Are coronary patients at higher risk with digoxin therapy? An ongoing controversy
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Reicher-Reiss, H., Jonas, M., Boyko, V., Shotan, A., Goldbourt, U., and Behar, S.
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- 1999
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21. Pharmacokinetic and Pharmacodynamic Evaluation of Atenolol during and after Pregnancy
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Hurst, Agneta K., Shotan, Avraham, Hoffman, Kristina, Johnson, Janet, Goodwin, T. Murphy, Koda, Robert, and Elkayam, Uri
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Study Objective. To evaluate changes due to pregnancy on atenolol's pharmacokinetics, response of maternal heart rate to atenolol, and the drug's effect on fetal heart rate.
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- 1998
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22. Calcium antagonists and mortality in patients with coronary artery disease: A Cohort study of 11,575 patients
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Braun, Shimon, Boyko, Valentina, Behar, Solomon, Reicher-Reiss, Henrietta, Shotan, Avi, Schlesinger, Zwi, Rosenfeld, Tiberio, Palant, Abraham, Friedensohn, Aharon, Laniado, Shlomo, Goldbourt, Uri, and Participants, Bezafibrate Infarction Prevention Study
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Objectives. This study sought to establish the risk ratio for mortality associated with calcium antagonists in a large population of patients with chronic coronary artery disease.
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- 1996
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23. Plasma cyclic guanosine monophosphate in chronic heart failure: Hemodynamic and neurohormonal correlations and response to nitrate therapy
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Shotan, Avraham, Mehra, Anil, Ostrzega, Enrique, Hsueh, Willa, Do, Yang S, Fisher, Delbert A, Hurst, Agneta, Johnson, Janet V, and Elkayam, Uri
- Abstract
This study evaluated the relation between plasma cyclic guanosine monophosphate (cGMP) and hemodynamic and neurohormonal parameters in patients with chronic congestive heart failure and assessed the effect of organic nitrate on plasma cGMP levels. Plasma cGMP was fourfold higher in 18 patients with congestive heart failure compared with 15 control subjects (16.7 ± 9.7 versus 4.0 ± 1.0 pmol/ml; p < 0.0001) but did not correlate with plasma levels of catecholamines, renin, atrial natriuretic peptide, or with baseline hemodynamic values. The administration of a hemodynamically effective dose of oral isosorbide dinitrate (40 mg) resulted in a transient reduction in plasma cGMP from 16.7 ± 9.7 pmol/ml at baseline to 13.0 ± 6.6 pmol/ml at 1 hour (p < 0.05). This change was associated with small and statistically insignificant changes in neurohormonal values and had no relation to any of the hemodynamic changes. We concluded that (1) elevated plasma cGMP in congestive heart failure does not correlate with other neurohormonal or hemodynamic parameters and may be an independent parameter of heart failure, (2) in contrast to previously documented nitrate-mediated increases in intracellular cGMP, nitrate therapy results in a reduction in plasma cGMP, and (3) changes in plasma cGMP cannot serve as a surrogate measurement of changes in intracellular cGMP.Clinical Pharmacology and Therapeutics (1993) 54, 638–644; doi:10.1038/clpt.1993.201
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- 1993
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24. Effects of Captopril on Metabolic and Hemodynamic Alterations in Global Ischemia and Reperfusion in the Isolated Working Rat Heart
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Arad, M, Shotan, A, Horowitz, L, Klein, R, and Rabinowitz, B
- Abstract
In the isolated working rat heart model, we studied metabolic and hemodynamic effects of 5- and 30-min global ischemia followed by reperfusion and assessed the potentially beneficial effect of captopril 80 μg/ml added throughout the experiment. Creatine kinase (CK) and catecholamines were measured in coronary effluent. De novo eicosanoids (prostaglandin E2) synthesis was assessed in endocardial explants. Hemodynamic alterations occurred after 30-min ischemia and were reflected most dramatically by a reduction in cardiac output (CO 72 ± 10 of baseline values in captopril vs. 68 ± 16 in controls) without significant differences as a result of treatment. Captopril shortened reperfusion ventricular fibrillation (VF) duration (6.9 ± 1.2 vs. 13.6 ± 8.7 min, p < 0.05) but had no effect on VF incidence. No differences occurred in norepinephrine (NE) outflow, whereas total CK release was greater in controls. Five controls versus none of the treated hearts (p < 0.05) released trace amounts of epinephrine during reperfusion. Increased de novo PGE2 synthesis was demonstrated after 5-min I (465 ± 168 vs. 238 ± 75 pg/100 mg tissue per hour, p < 0.01). Captopril stimulated production of PGE2in normoxic hearts (p < 0.02), but the difference was no more apparent in ischemic hearts. We conclude that captopril produces some biochemical and electrophysiologic evidence of myocardial salvage, but these effects are not sufficient to induce hemodynamic improvement after global ischemia and reperfusion.
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- 1992
25. Calcium channel blockers in heart failure
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Elkayam, Uri, Shotan, Avraham, Mehra, Anilkumar, and Ostrzega, Enrique
- Abstract
The rationale for the use of calcium enamel bleckers in patients with chronic heart failure lies in their vasodilator action, antiischemic effect, ability to lessen left ventricular diastole dysfunction and data showing their effect in preventing progression of myocardiai dysfunction in animals with cardiomyopathy. Despite initial studies reporting improvement of the hemodynamic profile with nifedipine, further evaluation showed variable results, with hemodynamic worsening seen in up to 29% of patients. Longer-term controued studies evaluating Symptoms and clinical status demonstrated worsening chronic heart failure in ~25% of patients within 8 weeks of nifedipine therapy. Although diltiazem has a lesser myo cardial depresseset effect and its short-term use was associated with less frequent hemodynamic and clinical worsening, long-tern exposure te the drug in a large group of paients with chronic heart failure due to left ventricular systolic dysfunction after myocardial infarction resulted in an increased incidence of cardiac events, with worsening heart failure and death. The use of verapamil in a simiar patient cohort showed the loss of its demostrated protective effect in patients with clinical evidence of heart failure.
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- 1993
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26. Usefulness of Beta-Blocker Therapy in Patients With Non-Insulin-Dependent Diabetes Mellitus and Coronary Artery Disease
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Jonas, M., Reicher-Reiss, H., Boyko, V., Shotan, A., Mandelzweig, L., Goldbourt, U., and Behar, S.
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- 1996
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27. In vivo assessment of the inotropic and toxic effects of oxidized ouabain
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Arad, M., Shotan, A., Heller, M., Rabinowitz, B., and Uretzki, G.
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Oxidized ouabain, a product of the oxidative cleavage of the rhamnose ring in ouabain has been found to have a higher inotropic toxic ratio in cultured cardiac myocytes.
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- 1993
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28. Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)
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Ramlakhan, Karishma P., Johnson, Mark R., Lelonek, Malgorzata, Saad, Aly, Gasimov, Zaur, Sharashkina, Natalia V., Thornton, Patrick, Arstall, Margaret, Hall, Roger, Roos-Hesselink, Jolien W., Hall, Roger, Roos-Hesselink, Jolien, Stein, Joerg, Parsonage, William Anthony, Budts, Werner, De Backer, Julie, Grewal, Jasmin, Marelli, Ariane, Kaemmerer, Harald, Jondeau, Guillaume, Johnson, Mark, Maggioni, Aldo P., Tavazzi, Luigi, Thilen, Ulf, Elkayam, Uri, Otto, Catherine, Sliwa, Karen, Aquieri, A., Saad, A., Vega, H. Ruda, Hojman, J., Caparros, J.M., Blanco, M. Vazquez, Arstall, M., Chung, C.M., Mahadavan, G., Aldridge, E., Wittwer, M., Chow, Y.Y., Parsonage, W.A., Lust, K., Collins, N., Warner, G., Hatton, R., Gordon, A., Nyman, E., Stein, J., Donhauser, E., Gabriel, H., Bahshaliyev, A., Guliyev, F., Hasanova, I., Jahangirov, T., Gasimov, Z., Salim, A., Ahmed, C.M., Begum, F., Hoque, M.H., Mahmood, M., Islam, M.N., Haque, P.P., Banerjee, S.K., Parveen, T., Morissens, M., De Backer, J., Demulier, L., de Hosson, M., Budts, W., Beckx, M., Kozic, M., Lovric, M., Kovacevic-Preradovic, T., Chilingirova, N., Kratunkov, P., Wahab, N., McLean, S., Gordon, E., Walter, L., Marelli, A., Montesclaros, A.R., Monsalve, G., Rodriguez, C., Balthazar, F., Quintero, V., Palacio, W., Cadavid, L.A. Mejía, Ortiz, E. Munoz, Hoyos, F. Fortich, Guerrero, E. Arevalo, Ricardo, J. Gandara, Penagos, J. Velasquez, Vavera, Z., Prague, Popelova, J., Vejlstrup, N., Grønbeck, L., Johansen, M., Ersboll, A., Elrakshy, Y., Eltamawy, K., Abd-El Aziz, M. Gamal, El Nagar, A., Ebaid, H., Elenin, H. Abo, Saed, M., Farag, S., Makled, W., Sorour, K., Ashour, Z., El-Sayed, G., Meguid Mahdy, M. Abdel, Taha, N., Dardeer, A., Shabaan, M., Saad, A., Ali, M., Moceri, P., Duthoit, G., Gouton, M., Nizard, J., Baris, L., Cohen, S., Ladouceur, M., Khimoud, D., Iung, B., Berger, F., Olsson, A., Gembruch, U., Merz, W.M., Reinert, E., Clade, S., Kliesch, Y., Wald, C., Sinning, C., Kozlik-Feldmann, R., Blankenberg, S., Zengin-Sahm, E., Mueller, G., Hillebrand, M., Hauck, P., von Kodolitsch, Y., Zarniko, N., Baumgartner, Muenster H., Schmidt, R., Hellige, A., Tutarel, O., Kaemmerer, H., Kuschel, B., Nagdyman, N., Motz, R., Maisuradze, D., Frogoudaki, A., Iliodromitis, E., Anastasiou-Nana, M., Marousi, Triantafyllis, D., Bekiaris, G., Karvounis, H., Giannakoulas, G., Ntiloudi, D., Mouratoglou, S.A., Temesvari, A., Balint, H., Kohalmi, D., Merkely, B., Liptai, C., Nemes, A., Forster, T., Kalapos, A., Berek, K., Havasi, K., Ambrus, N., Shelke, A., Kawade, R., Patil, S., Martanto, E., Aprami, T.M., Purnomowati, A., Cool, C.J., Hasan, M., Akbar, R., Hidayat, S., Dewi, T.I., Permadi, W., Soedarsono, D.A., Ansari-Ramandi, M.M., Samiei, N., Tabib, A., Kashfi, F., Ansari-Ramandi, S., Rezaei, S., Farhan, H. Ali, Al-Hussein, A., Al-Saedi, G., Mahmood, G., Yaseen, I.F., Al-Yousuf, L., AlBayati, M., Mahmood, S., Raheem, S., AlHaidari, T., Dakhil, Z., Thornton, P., Donnelly, J., Bowen, M., Blatt, A., Elbaz-Greener, G., Shotan, A., Yalonetsky, S., Goland, S., Biener, M., Assenza, G. Egidy, Bonvicini, M., Donti, A., Bulgarelli, A., Prandstraller, D., Romeo, C., Crepaz, R., Sciatti, E., Metra, M., Orabona, R., Ali, L. Ait, Festa, P., Fesslova, V., Bonanomi, C., Calcagnino, M., Lombardi, F., Colli, A.M., Ossola, M.W., Gobbi, C., Gherbesi, E., Tondi, L., Schiavone, M., Squillace, M., Carmina, M.G., Maina, A., Macchi, C., Gollo, E., Comoglio, F.M., Montali, N., Re, P., Bordese, R., Todros, T., Donvito, V., Marra, W. Grosso, Sinagra, G., D'Agata Mottolese, B., Bobbo, M., Gesuete, V., Rakar, S., Ramani, F., Niwa, K., Mekebekova, D., Mussagaliyeva, A., Lee, T., Mirrakhimov, E., Abilova, S., Bektasheva, E., Neronova, K., Lunegova, O., Žaliūnas, R., Jonkaitienė, R., Petrauskaitė, J., Laucevicius, A., Jancauskaite, D., Lauciuviene, L., Gumbiene, L., Lankutiene, L., Glaveckaite, S., Laukyte, M., Solovjova, S., Rudiene, V., Chee, K.H., Yim, C.C.-W., Ang, H.L., Kuppusamy, R., Watson, T., Caruana, M., Estensen, M.-E., Kayani, M.G.A. Mahmood, Munir, R., Tomaszuk-Kazberuk, A., Sobkowicz, B., Przepiesc, J., Lesniak-Sobelga, A., Tomkiewicz-Pajak, L., Komar, M., Olszowska, M., Podolec, P., Wisniowska-Smialek, S., Lelonek, M., Faflik, U., Cichocka-Radwan, A., Plaskota, K., Trojnarska, O., Guerra, N., de Sousa, L., Cruz, C., Ribeiro, V., Jovanova, S., Petrescu, V., Jurcut, R., Ginghina, C., Coman, I. Mircea, Musteata, M., Osipova, O., Golivets, T., Khamnagadaev, I., Golovchenko, O., Nagibina, A., Ropatko, I., Gaisin, I.R., Shilina, L. Valeryevna, Sharashkina, N., Shlyakhto, E., Irtyuga, O., Moiseeva, O., Karelkina, E., Zazerskaya, I., Kozlenok, A., Sukhova, I., Jovovic, L., Prokšelj, K., Koželj, M., Askar, A.O., Abdilaahi, A.A., Mohamed, M.H., Dirir, A.M., Sliwa, K., Manga, P., Pijuan-Domenech, A., Galian-Gay, L., Tornos, P., Subirana, M.T., T, M., Subirana, Oliver, J.M., Garcia-Aranda Dominguez, B., Gonzalez, I. Hernandez, Jimenez, J.F. Delgado, Subias, P. Escribano, Murga, N., Elbushi, A., Suliman, A., Jazzar, K., Murtada, M., Ahamed, N., Dellborg, M., Furenas, E., Jinesjo, M., Skoglund, K., Eriksson, P., Gilljam, T., Thilen, U., Tobler, D., Wustmann, K., Schwitz, F., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Lopes, B.M. Santos, Meier, L., Arrigo, M., de Boer, K., Konings, T., Wajon, E., Wagenaar, L.J., Polak, P., Pieper, E.P.G., Roos-Hesselink, J., Baris, L., van Hagen, I., Duvekot, H., Cornette, J.M.J., De Groot, C., van Oppen, C., Sarac, L., Esen, O. Batukan, Enar, S. Catirli, Mondo, C., Ingabire, P., Nalwanga, B., Semu, T., Salih, B.T., Almahmeed, W.A.R., Wani, S., Farook, F.S. Mohamed, Ain, Al, Gerges, F., Komaranchath, A.M., Al bakshi, F., Al Mulla, A., Yusufali, A.H., Al Hatou, E.I., Bazargani, N., Hussain, F., Hudsmith, L., Thompson, P., Thorne, S., Bowater, S., Money-Kyrle, A., Clifford, P., Ramrakha, P., Firoozan, S., Chaplin, J., Bowers, N., Adamson, D., Schroeder, F., Wendler, R., Hammond, S., Nihoyannopoulos, P., Norfolk, Norwich, Hall, R., Freeman, L., Veldtman, G., Kerr, J., Tellett, L., Scott, N., Bhatt, A.B., DeFaria Yeh, D., Youniss, M.A., Wood, M., Sarma, A.A., Tsiaras, S., Stefanescu, A., Duran, J.M., Stone, L., Majdalany, D.S., Chapa, J., Chintala, K., Gupta, P., Botti, J., Ting, J., Davidson, W.R., Wells, G., Sparks, D., Paruchuri, V., Marzo, K., Patel, D., Wagner, W., Ahanya, S.N., Colicchia, L., Jentink, T., Han, K., Loichinger, M., Parker, M., Wagner, W., Longtin, C., Yetman, A., Erickson, K., Cramer, J., Tsai, S., Fletcher, B., Warta, S., Cohen, C., Lindblade, C., Puntel, R., Nagaran, K., Croft, N., Gurvitz, M., Otto, C., Talluto, C., Murphy, D., and Perlroth, M.G.
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- 2021
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29. The c- reactive protein to troponin ratio enhances the differentiation of perimyocarditis from acute myocardial infarction
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Kobo, O, Meisel, SR, Hamuda, N, Natour, R, Saada, M, Abu Fanne, R, Amsalem, N, Levin, C, Frimerman, A, Levi, Y, Shotan, A, Roguin, A, and Kleiner Shochat, M
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- 2021
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30. Cardiomyopathy and Pregnancy: Considerations for Women with Severe Reduced Left Ventricular Dysfunction
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Shotan, Avraham, Roos-Hesselink, Jolien, Bari, Lucia, Goland, Sorel, Yekel, Yael, and Elkayam, Uri
- Abstract
Women with dilated cardiomyopathy or LV dysfunction (LVEF <40%) from other etiology are at increased risk of maternal and fetal mortality and morbidity. They should undergo preconception evaluation, risk assessment and treatment modification including discontinuation and replacement of contraindicated medications. A close follow-up and treatment by a multidisciplinary team is recommended at all stages: preconception, gestation, delivery and postpartum. An early gestational and delivery plan has to be prepared to face complications and to achieve a successful delivery and outcome. Long-term postpartum cardiac follow-up is recommended anticipating potential adverse effects of pregnancy.
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- 2021
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31. Corrigendum to "Non-Invasive Lung Impedance-Guided Preemptive Treatment in Chronic Heart Failure Patients: A Randomized Controlled Trial (Impedance-HF Trial)": Journal of Cardiac Failure Vol. 22 No. 9, pp. 713-722.
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Shochat, Michael Kleiner, Shotan, Avraham, Blondheim, David S., Kazatsker, Mark, Dahan, Iris, Asif, Aya, Rozenman, Yoseph, Kleiner, Ilia, Weinstein, Jean Marc, Frimerman, Aaron, Vasilenko, Lubov, and Meisel, Simcha R.
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- 2017
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32. 034 - One Year Follow Up after Termination Non-Invasive Lung IMPEDANCE-Guided Preemptive Treatment in Chronic Heart Failure Patients: A Randomized Controlled Trial (IMPEDANCE-HF Trial).
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Shochat, Michael Kleiner, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Kleiner, Ilia, Blondheim, David, Weinstein, Jean Marc, and Meisel, Simcha
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- 2016
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33. Risk Assessment of Re-Hospitalizations for Heart Failure During 30 Days After Discharge for Acute Heart Failure.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Kleiner, Ilia, Dahan, Iris, Asif, Aya, Blondheim, David, and Meisel, Simcha
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- 2015
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34. Lung Impedance-guided Therapy of Patients with Chronic Heart Failure Improves Clinical Outcome.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Kleiner, Ilia, Dahan, Iris, Asif, Aya, Blondheim, David, and Meisel, Simcha
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- 2015
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35. Lung Impedance Guided Preemptive Treatment of Evolving Pulmonary Congestion-Edema in Course of Acute Myocardial Infarction Reduces Use of Furosemide.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Levy, Yaniv, Blondheim, David, and Meisel, Simcha
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- 2012
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36. The Time Course of the Pulmonary Edema Development During ST Elevation Myocardial Infarction.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Shochat, Ilia, Levy, Yaniv, Blondheim, David, and Meisel, Simcha
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- 2012
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37. Importance of Lung Impedance Monitoring in the Outpatient Clinic for Predicting and Preventing of Hospitalizations Patients With Chronic Heart Failure.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Shochat, Elena, Levy, Yaniv, Blondheim, David, and Meisel, Simcha
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- 2012
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38. Comparison of the Predictive Values of NT-proBNP and Lung Impedance Measurements in the Course of BNP-Guided Treatment of CHF Patients.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Shochat, Ilia, Levy, Yaniv, Blondheim, David, and Meisel, Simcha
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- 2012
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39. NT-proBNP-Guided Preemptive Treatment of Outpatients With Chronic Heart Failure Followed in a out Hospital Clinic.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Shochat, Ilia, Levy, Yaniv, and Blondheim, David
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- 2012
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40. Short and Long-Term Outcome of Impedance-Guided Preemptive Therapy Provided to Prevent Pulmonary Congestion-Edema in the Course of Acute Myocardial Infarction.
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Shochat, Michael, Shotan, Avraham, Kazatsker, Mark, Asif, Aya, Dahan, Iris, Shochat, Elena, Levy, Yaniv, Blondheim, David, and Meisel, Simcha
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- 2012
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41. Short and Long-Term Outcome of Impedance-Guided Preemptive Therapy Provided To Prevent Acute Heart Failure in the Course of Acute Myocardial Infarction.
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Shochat, Michael, Shotan, Avraham, Shochat, Ilia, Dahan, Iris, Asif, Aya, Blomdhaim, David, and Meisel, Simcha
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- 2011
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42. NT-proBNP-Guided Preemptive Treatment of Outpatients with Chronic Heart Failure Followed in a Out Hospital Clinic.
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Shochat, Michael, Shotan, Avraham, Dahan, Iris, Shochat, Ilia, Levy, Yaniv, Asif, Aya, Kazatsker, Mark, Blondheim, David, and Meisel, Simcha
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- 2011
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43. Role of Lung Impedance Monitoring in the Outpatient Clinic for Predicting and Preventing of Hospitalizations Patients with Chronic Heart Failure.
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Shochat, Michael, Shotan, Avraham, Asif, Aya, Levy, Yaniv, Shochat, Ilia, Dahan, Iris, Blonheim, David, and Meisel, Simcha
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- 2011
- Full Text
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44. Transient ST-segment elevation myocardial infarction.
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Meisel, Simcha R., Shotan, Avraham, and Jolobe, Oscar M P
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- 2008
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45. Prosthetic Valve Endocarditis In Pregnancy
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Zimmerman, Joseph and Shotan, Avraham
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A case of prosthetic valve endocarditis is described, caused by Streptorcoccus viridans in the third trimester of pregnancy. During her illness, the patient gave birth to a normal baby in an uncomplicated vaginal delivery. She had recurrent post-partum vaginal bleeding. Aspects relevant to the management of the case are discussed.
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- 1984
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46. Abstract 190
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Topaz, Moris, Kazatsker, M, Oron, Y, Keren, G, Silberman, A, Carmel, NN, Topaz, G, Meisel, SR, Frimerman, A, Blondheim, DS, and Shotan, A
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- 2013
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47. Abstracts
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Barthelemy, O., Silvain, J., Brieger, D., Bellemain-Appaix, A., Cayla, G., Beygui, F., Lancar, R., Collet, J.P., Mercadier, A., Montalescot, G., Cha, K.S., Nam, Y.H., Kim, J.H., Park, S.Y., Park, T.H., Kim, M.H., Kim, Y.D., Lee, H.C., Ahn, M.S., Hong, T.J., Blanco, R., Blanco, F., Szarfer, J., Garcia Escudero, A., Gigena, G., Gagliardi, J., Rodriguez, A., Sarmiento, R., Affatatto, S., Riccitelli, M., Petris, A., Datcu, M.D., Pop, C., Radoi, M., Arsenescu-Georgescu, C., Petrescu, I., Petrescu, L., Serban, L., Nechita, E., Tatu-Chitoiu, G., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, C., Ionescu, D.D., Radoi, M., Pop, C., Ginghina, C., Minescu, B., Izzo, A., Mantovani, P., Tomasi, L., Dalloglio, L., Bonatti, S., Rosiello, R., Romano, M., Agostini, F., Zanini, R., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yany, Y.J., Qian, H.Y., Tang, Y.D., Timoteo, A.T., Toste, A., Lousinha, A., Ramos, R., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Cabades, C., Diez Gil, J.L., Aguar, P., Sanmiguel, D., Lopez-March, A., Marmol, R., Guerra, L., Girbes, V., Ferrando, J., Rincon De Arellano, A., Timoteo, A.T., Ramos, R., Toste, A., Oliveira, J.A., Patricio, L., Ferreira, M.L., Ferreira, R.C., Blondal, M., Ainla, T., Marandi, T., Eha, J., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Cunha, P.S., Feliciano, J., Silva, S., Ferreira, R.C., Kanovsky, J., Kala, P., Parenica, J., Poloczek, M., Prymusova, K., Kubkova, L., Spinar, J., Olinic, D., Homorodean, C., Ober, M., Olinic, M., Andrioaia, C., Condac, A., Masmoudi, M., Berdaoui, B., Labidi, S., Tapia Ballesteros, C., Hernandez Luis, C., Sandin, M.G., Vegas, J.M., Andion, R., Martinez, N., Gonzalez, I.A., Alvarado, M., Amat, I.J., San Roman, J.A., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Dorta Martin, M., Marrero Rodriguez, F., Dragu, R., Kapeliovich, M., Hammerman, H., Silva, D., Cortez-Dias, N., Jorge, C., Silva Marques, J., Carilho Ferreira, P., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Fiuza, M., Lopes, M.G., Milicevic, P., Panic, M., Stankovic, I., Milicevic, D., Kalezic, T., Kafedzic, S., Ilic, I., Cerovic, M., Putnikovic, B., Neskovic, A., Rott, D., Leibowitz, D., Monhart, Z., Reissigova, J., Grunfeldova, H., Jansky, P., Timoteo, A.T., Valente, B., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Villanueva Benito, I., Solla, I., Paredes, E., Diaz Castro, O., Calvo, F., Baz, J.A., Iniguez, A., Aleksova, A., Gerloni, R., Belfiore, R., Carriere, C., Barbati, G., Fabris, E., Possa, F., Nait, D., Milo, M., Sinagra, G., Marques, N., Mimoso, J., Gomes, V., Agra Bermejo, R.M., Emad Abu Assi, E.A.A., Sergio Raposeiras Roubin, S.R.R., Pilar Cabanas Grandio, P.C.G., Carlos Pena Gil, C.P.G., Jose Maria Garcia Acuna, J.M.G.A., Jose Ramon Gonzalez Juanatey, J.R.G.J., Daly, M.J., Scott, P., Owens, C.G., Tomlin, A., Smith, B., Adgey, A.A.J., Alvarez-Contreras, L.R., Juarez, U., Altamirano, A., Arias, A., Alvarez-San Gabriel, A., Gonzalez-Pacheco, H., Martinez-Sanchez, C., Rahnavardi, M., Keshtkar-Jahromi, M., Vakili, H., Gholamin, S., Razavi, S.M., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Koerfer, J., Horstkotte, D., Vrsalovic, M., Getaldic, B., Vrkic, N., Pintaric, H., Khan, S., Wasan, B., Moretti, L., Grossi, P., Silenzi, S., Testa, M., Candelori, L., Clementi, L.N., Forlini, M., Lando, L., Pezzuoli, M.L., Corradetti, P., Leurent, G., Pennec, P.Y., Filippi, E., Moquet, B., Hacot, J.P., Druelles, P., Rialan, A., Rouault, G., Coudert, I., Le Breton, H., Gevaert, S., Tromp, F., Vandecasteele, E., De Somer, F., Van Belleghem, Y., Bouchez, S., Martens, F., Herck, I., De Pauw, M., Spinar, J., Ludka, O., Sepsi, M., Miklik, R., Dusek, L., Tomcikova, D., Marques, N., Mimoso, J., Gomes, V., Garcia-Acuna, J.M., Aguiar-Souto, P., Raposeiras Roubin, S., Agra-Bermejo, R., Jacquet, M., Abu-Assi, E., Gonzalez-Juanatey, J.R., Ibatov, A., Labrova, R., Spinar, J., Karlik, R., Kanovsky, J., Lokaj, P., She, Q., Deng, S.B., Huang, S.H., Gu, L.J., Rong, J.I.A.N., Wu, Z.K., Li, Y., Zhang, J., Parascan, L., Campanile, A., Spinelli, L., Santulli, G., Ciccarelli, M., De Gennaro, S., Assante Di Panzillo, E., Trimarco, B., Iaccarino, G., Bobescu, E., Radoi, M., Datcu, G., Dobreanu, D., Doka, B., Charniot, J.-C., Cosson, C., Albertini, J.P., Bittar, R., Giral, P., Cherfils, C., Guillerm, E., Bonnefont-Rousselot, D., Craiu, E., Rusali, A., Cojocaru, L., Parepa, I., Koizumi, T., Iida, S., Sato, J., Kikutani, T., Muramatsu, T., Nishimura, S., Komiyama, N., Lee, W.P., Ong, B.B., Haralambos, K., Townsend, D., Rees, J.A.E., Williams, E.J., Halcox, J.P., Mcdowell, I., Damjanovic, M., Koracevic, G., Djordjevic-Radojkovic, D., Pavlovic, M., Krstic, N., Ciric-Zdravkovic, S., Stojkovic, A., Perisic, Z., Apostolovic, S., Faustino, A., Seca, L., Barra, S., Caetano, F., Providencia, R., Silva, J., Gomes, P., Costa, G., Costa, M., Leitao-Marques, A., Volkova, A.L., Arutyunov, G.P., Bylova, N.A., Dayter, I.I., Jao, Y.T.F.N., Fang, C.C., Chen, Y., Yu, C.L., Wang, S.P., Valencia, J., Perez-Berbel, P., Ruiz-Nodar, J.M., Pineda, J., Bordes, P., Quintanilla, M., Mainar, V., Sogorb, F., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Providencia, R.A., Gomes, P.L., Seca, L., Barra, S., Silva, J., Faustino, A., Caetano, F., Pais, J.R., Mota, P., Leitao-Marques, A.M., Farhan, S., Jarai, R., Tentzeris, I., Vogel, B., Freynhofer, M.K., Wojta, J., Huber, K., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Lettino, M., Casella, G., Conte, M.R., De Luca, L., Geraci, G., Ceravolo, R., Milo, M., Pani, A., Trambaiolo, P., Fradella, G., Schratter, A., Thiele, H., Klemm, T., Demmin, K., Lehmann, D., Mende, M., Schuler, G., Pittl, U., Chernova, A., Nikulina, S.U., Naruke, T., Inomata, T., Yanagisawa, T., Maekawa, E., Mizutani, T., Shinagawa, H., Nishii, M., Takeuchi, I., Takehana, H., Izumi, T., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Nardai, S., Szabo, G.Y., Berta, B., Edes, I., Merkely, B., Delgado Silva, J., Seca, L., Baptista, R., Providencia, R., Mota, P., Costa, M., Leitao-Marques, A., Faria, R., Trigo, J., Gago, P., Mimoso, J., Marques, N., Gomes, V., Gheorghe, G., Nanea, I.T., Cristea, A., Almarichi, S., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Nanea, T., Gheorghe, G.S., Visan, S., Paun, N., Gaber, R., Gaber, R., Delewi, R., Nijveldt, R., De Bruin, H.A., Hirsch, A., Van Der Laan, A., Bouma, B.J., Tijssen, J.P.G., Van Rossum, A.C., Zijlstra, F., Piek, J.J., Rus, H., Radoi, M., Donea, M., Ciurea, C., Ifteni, G., Casolo, G., Chioccioli, M., Magnacca, M., Del Meglio, J., Comella, A., Baratto, M., Lera, J., Salvadori, L., Tessa, C., Vignali, C., Keca, Z., Momcilov Popin, T., Panic, G., White, R., Mateen, F., Weaver, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Timoteo, A.T., Lousinha, A., Santos, N., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Okisheva, E., Tsaregorodtsev, D., Sulimov, V., Amat Santos, I.J., Gonzalez, I.A., Hernandez, C., Sandin, M.G., Tapia, C., Andion, R., Alvarado, M., Campo, A., San Roman, J.A., Fredman, D., Svensson, L., Rosenqvist, M., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Zima, E., Jenei, Z.S., Kovacs, E., Osztheimer, I., Szabo, G.Y., Molnar, L., Horvath, A., Becker, D., Geller, L., Merkely, B., Maggi, R., Furukawa, T., Viscardi, V., Brignole, M., Leal, S.R.N., Dores, H., Rosario, I., Monge, J., Carvalho, M.J., Arroja, I., Leitao, A., Fonseca, C., Aleixo, A., Silva, A., Keuleers, S., Herijgers, P., Herregods, M.C., Budts, W., Dubois, C., Meuris, B., Verhamme, P., Flameng, W., Van De Werf, F., Adriaenssens, T., Badran, H., Elnoamany, M., Lolah, T., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, CRINA., Ionescu, D.D., Olariu, C., Radoi, M., Pop, C., Macarie, C., Mollik, M.A.H., Hassan, A.I., Paul, T.K., Haque, M.Z., Jahan, R., Rahmatullah, M., Khatun, M.A., Rahman, M.T., Chowdhury, M.H., Bustamante Munguira, J., Tamayo, E., Garcia-Cuenca, I., Bustamante, E., Gualis, J., Gomez-Martinez, M.L., Florez, S., Gomez-Herreras, J.I., Ramirez Rodriguez, R., Ramirez Rodriguez, A.M., Garcia-Bello, M.A., Hernadez Ortega, E., Caballero Dorta, E., Garcia Quintana, A., Piro Mastraccio, V., Medina Fernandez Aceytuno, A., Assanelli, E., De Metrio, M., Rubino, M., Lauri, G., Cabiati, A., Campodonico, J., Grazi, M., Moltrasio, M., Marana, I., Marenzi, G., Lovlien, M., Schei, B., Picon-Heras, R., Acebal, C., Garcia Rubira, J.C., Vivas Balcones, D., Nunez-Gil, I., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Vintila, V.D., Enescu, O.A., Stoicescu, C.I., Udroiu, C., Cinteza, M., Tatu – Chitoiu, G., Vinereanu, D., Fresco, C., De Biasio, M., Muser, D., Sappa, R., Morocutti, G., Bernardi, G., Proclemer, A., Fontanella, B., Affatato, A., Ciccarese, C., Sacchini, M., Volpini, M., Bianchetti, F., Verzura, G., Dei Cas, L., Pudil, R., Blaha, V., Vojacek, J., Paraskevaidis, I., Ikonomidis, I., Parissis, J., Papadopoulos, C., Stasinos, V., Bistola, V., Anastasiou-Nana, M., Shochat, M., Shotan, A., Kazatsker, M., Gurovich, V., Asif, A., Noiman, E., Levy, Y., Blondhaim, D., Rabinovich, P., Meisel, S., Koracevic, G., Stojkovic, A., Petrovic, S., Pavlovic, M., Glasnovic, J., Tomasevic, M., Krstic, N., Djordjevic-Radojkovic, D., Sakac, D., Obradovic, S., Londono Sanchez, O., Pacreu, S., Torres, L., Mihaylov, G., Shaban, G.M., Trendafilova, E., Krasteva, V., Mudrov, T.S., Didon, J.P., Panageas, V., Vlachos, N., Pernat, A., Radan, I., Mozina, H., Izzo, A., Tomasi, L., Mantovani, P., Dalloglio, L., Pepi, P., Romano, M., Cionini, F., Baccaglioni, N., Zanini, R., Viertel, A., Havers, J., Ballard, G., Groenefeld, G., Santos, N., Branco, L.M., Oliveira, J.A., Ferreira, L., Timoteo, A.T., Fiarresga, A., Feliciano, J., Ramos, R., Ferreira, R.C., Izzo, A., Tomasi, L., Mantovani, P., Pepi, P., Lettieri, L., Dalloglio, L., Reggiani, A., Zanini, R., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Juarez Prera, R., Blanco Palacios, G., Dorta Martin, M., Marrero Rodriguez, F., Martin, A.-C., Manzo Silberman, S., Chaib, A., Varenne, O., Allouch, P., Salengro, E., Jegou, A., Margot, O., Spaulding, C., Diego, A., De Miguel, A., Cuellas, C., Fraile, E., Martin, J., Vega, B., Bangueses, R., Fernandez-Vazquez, F., Perez De Prado, A., Rosario, I., Dores, H., Leal, S., Correia, M.J., Monge, J.C., Arroja, I., Abecasis, J., Aleixo, A., Silva, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Garcia-Garcia, C., Subirana, I., Sala, J., Bruguera, J., Valle, V., Sanz, G., Fiol, M., Aros, F., Marrugat, J., Elosua, R., Barra, S.N.C., Silva, J., Gomes, P., Providencia, R., Seca, L., Leitao Marques, A., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yang, Y.J., Xu, B., Tang, Y.D., Song, G.Y., G, R.L., Panic, M., Milicevic, P., Stankovic, I., Ilic, I., Kafedzic, S., Kalezic, T., Milicevic, D., Aleksic, A., Putnikovic, B., Neskovic, A., Serpytis, P., Rucinskas, K., Kalinauskas, A., Karvelyte, N., Santos De Sousa, C.I., Ferreira, S., Calaca, J., Lousada, N., Palma Reis, R., Gualandro, D.M., Seguro, L.F.B.C., Braga, F.G.M., Silvestre, O.M., Lage, R.L., Fabri, J., Oliveira, M.T., Urbano Moral, J.A., Torres Llergo, J., Solanilla Rodriguez, R., Sanchez Gonzalez, A., Martinez Martinez, A., Den Uil, C.A., Lagrand, W.K., Van Der Ent, M., Jewbali, L.S.D., Cheng, J.M., Spronk, P.E., Simoons, M.L., Mornos, C., Petrescu, L., Dragulescu, D., Ionac, A., Guardado, J., Azevedo, O., Fernandes, M., Canario-Almeida, F., Sanfins, V., Pereira, A., Almeida, J., Kaplunova, V.U., Belenkov, Y.N., Privalova, E.V., Fomin, A.A., Suvorov, A.Y., Goodkova, A., Rubakova, M.G., Kuznetsova, I.A., Semernin, E.N., Keshavarzi, F., Kojuri, J., Mikhailov, V.M., Vezhenkova, I.V., Goodkova, A.Y.A., Jarai, R., Pavlovic, I., Farhan, S., Schwarz, M., Jakl, G., Huber, K., Jarai, R., Schwarz, M., Smetana, P., Jakl, G., Perkmann, T., Farhan, S., Huber, K., Mayr, A., Mair, J., Klug, G., Schocke, M., Trieb, T., Jaschke, W., Pachinger, O., Metzler, B., Bronze Carvalho, L., Azevedo, J., Andrade, M.L., Arroja, I., Relvas, M.J., Coucello, J., Monge, J., Morais, G., Seabra, M., Aleixo, A., Afamefule, F., Luaces Mendez, M., Teijeiro-Mestre, R., Nunez-Gil, I.J., Leco-Gil, N., Madronal-Cerezo, E., Zannin, I., Ruiz, J., Orynchak, M.A., Vakalyuk, I.I., Vakalyuk, I.P., Berezin, A., Panasenko, T., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Gorenek, B., Unalacak, M., Birdane, A., Yuksel, F., Ata, N., Lee, W.P., Halcox, J.P.J., Cavusoglu, Y., Beyaztas, A., Entok, E., Demirustu, C., Uslu, I., Birdane, A., Gorenek, B., Ata, N., Schaefer, A., Flierl, U., Seydelmann, N., Bauersachs, J., Calmac, L., Craiu, E., Ionescu, D.D., Nanea, T., Pop, C., Marinescu, S., Macarie, C., Tatu Chitoiu, G., Fruntelata, A.G., Dorobantu, M., Hamdi, S., Maazoun, Y., Neji, A., Farhat, O., Majdoub, M., Ben Hamda, K., Maatouk, F., Balanescu, S.M., Benedek, I., Nedelciuc, I., Deleanu, D., Dobreanu, D., Olinic, D., Petrescu, L., Ortan, F., Mot, S., Tatu Chitoiu, G., Sinnaeve, P.R., Moreels, S., Adriaenssens, T., Dubois, C., Coosemans, M., Vydt, T., Desmet, W., Sinnaeve, P.R., Moreels, S., Vydt, T., Dubois, C., Adriaenssens, T., Coosemans, M., Desmet, W., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Tobing, D., Rifnaldi, R., Juzar, D., Firdaus, I., Dharma, S., Irmalita, I., Kalim, H., Bejiqi, R., Retkoceri, R., Bejiqi, H., Kryeziu, L., Kelmendi, M., Borovci, S.H., Victor, S.M., Gnanaraj, A., Deshmukh, R., Mullasari, A.S., Yahalom, M., Kaiyal, R.S., Roguin, N., Bornstein, J., Atar, S., Farah, R., Seca, L.F., Faustino, A., Silva, J., Providencia, R., Gomes, P., Barra, S., Caetano, F., Costa, M., Leitao Marques, A.M., Margato, R., Sousa, P., Ribeiro, H., Rocha, L., Correia, A., Moreira, J.I., Carvalho, H.C., Afifi, M., Abed, N., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Suarez-Barrientos, A., Vivas, D., Castro-Ferreira, F., Nunez-Gil, I., Franco, E., Garcia-Rubira, J.C., Fernandez-Ortiz, A., Fuster, V., Macaya, C., Ibanez Cabeza, B., Salinger, S., Perisic, Z., Milic, D., Stanojlovic, T., Apostolovic, S., Obradovic, S., Djordjevic-Radojkovic, D., Damjanovic, M., Koracevic, G., Kostic, T., Khan, M.A., Vrapi, F., Naeem, K., Davar, J., Hristova, K., Hristova, K., Pencheva, G., Radeva, R., Milanov, S., Trambaiolo, P., Poli, M., De Luca, M., Lukic, V., Mustilli, M., Corsi, F., Simonetti, M., Ferraiuolo, G., Fareed, A., Oraby, M., Nasr, G.M., Maklady, F., Dupouy, P., Sorensen, J.T., Terkelsen, C.J., Lassen, J.F., Trautner, S., Christensen, E.F., Nielsen, T.T., Botker, H.E., Andersen, H.R., Thygesen, K.A., Checco, L., Usmiani, T., Sbarra, P.L., Boffini, M., Saviolo, R., Grasso, C., Conrotto, F., Marchetti, M., Rinaldi, M., Marra, S., Moscoso Costa, F., Ferreira, J., Raposo, L., Aguiar, C., Trabulo, M., Silva, J.A., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Swiatkowski, A., Kowalczyk, J., Lenarczyk, R., Chodor, P., Honisz, G., Was, T., Swierad, M., Sredniawa, B., Polonski, L., Kalarus, Z., Postadzhiyan, A.S., Velinov, H., Velchev, V., Hazarbasanov, D., Apostolova, M., Finkov, B., Petrovic, M., Panic, G., Jovelic, A., Canji, T., Srdanovic, I., Popov, T., Golubovic, M., Pavlovic, K., Cemerlic-Adjic, N., Bro-Jeppesen, J., Kjaergaard, J., Wanscher, M.C., Nielsen, S.L., Rasmussen, L.S., Hassager, C., Bro-Jeppesen, J., Kjaergaard, J., Wanscher, M.C., Rasmussen, L.S., Hassager, C., Khan, M., Crolla, E., Morley, H., Akeroyd, L., Beaini, Y., Morley, C., Dores, H., Leal, S., Rosario, I., Abecasis, J., Monge, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Bekeredjian, R.H., Krumsdorf, U., Rottbauer, W., Katus, H.A., Pleger, S., Providencia, R.A., Silva, J., Barra, S., Gomes, P.L., Seca, L., Botelho, A., Quintal, N., Mota, P., Leitao-Marques, A.M., Silva, B., Santos, N., Cafe, H., Faria, P., Serrao, M., Gomes, S., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Roussel, J.C., Senage, T., Perigaud, C., Habash, O., Michel, M., Treilhaud, M., Despins, P., Trochu, J.N., Baron, O., Duveau, D., Kitsiou, A.N., Giannakopoulos, K., Papadimitriou, G., Karas, S., Babic, Z., Nikolic Heitzler, V., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Freynhofer, M., Brozovic, I., Bruno, V., Leherbauer, L., Djurkovic, M., Jarai, R., Willheim, M., Huebl, W., Wojta, J., Huber, K., Vogel, B., Hahne, S., Kozanli, I., Kalla, K., Jarai, R., Freynhofer, M., Smetana, P., Geppert, A., Unger, G., Huber, K., Simoes Marques Assuncao Caetano, A.F., Barra, S., Silva, J., Providencia, R., Faustino, C., Botelho, A., Mota, P., Leitao Marques, A., Ariza Sole, A., Sanchez Salado, J.C., Lorente Tordera, V., Martinez Garcia, V., Salazar Mendiguchia Y Garcia, J., Gomez Hospital, J.A., Maristany Daunert, J., Berdejo Gago, F.J., Esplugas Oliveras, E., Brzozowska-Czarnek, A., Urbanik, A., Kakouros, N., Kakouros, S., Lekakis, J., Rizos, J., Kokkinos, D., Venevtseva, J., Melnikov, A., Valiahmetov, M., Gomova, T., Perelomova, I., Ferrer Hita, J.J., Bosa-Ojeda, F., Sanchez-Grande-Flecha, A., Yanes-Bowden, G., Vargas-Torres, M.J., Rodriguez-Gonzalez, A., Rubio-Iglesias-Garcia, C., Dominguez-Rodriguez, A., Enjuanes-Grau, C., Marrero-Rodriguez, F., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Alexandrescu, L., Dumitru, E., Miu, V., Jitari, V., Craiu, E., Voinea, F.L., Balachandran, K.P., Schofield, R., Sankaranarayanan, R., Helm, K., Crowe, C., Singh, R., Mcdonald, J., Chuen, M.J., Kobusiak-Prokopowicz, M., Preglowska, M., Mysiak, A., Doi, T., Sakoda, T., Akagami, T., Naka, T., Tsujino, T., Masuyama, T., Ohyanagi, M., Kume, N., Mitsuoka, H., Hayashida, K., Tanaka, M., Biasucci, L.M., Della Bona, R., Biasillo, G., Leo, M., Zaninotto, M., Plebani, M., Crea, F., Biasucci, L.M., Dellabona, R., Leo, M., Biasillo, G., Zaninotto, M., Plebani, M., Crea, F., Cavusoglu, Y., Gok, B., Birdane, A., Demirustu, C., Gorenek, B., Unalir, A., Ata, N., Timuralp, B., Nikulina, N., Yakushin, S.S., Nikulina, N., Yakushin, S.S., Furmenko, G.I., Akinina, S.A., Dores, H., Ingrid, R., Leal, S., Correia, M.J., Bronze, L., Monge, J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Djambazov, S., Zhivkov, A., Maznev, I., Ingeliev, M., Slavov, R., Cvetkova, N., Patarinski, V., Groch, L., Horak, J., Dimitrov, N., Hayrapetyan, H.G., Raposeiras Roubin, S., Abu-Assi, E., Cabanas-Grandio, P., Agra-Bermejo, R., Garcia-Acuna, J.M., Pena-Gil, C., Gonzalez-Juanatey, J.R., Barra, S.N.C., Silva, J., Providencia, R., Seca, L., Gomes, P., Leitao Marques, A., Daly, M.J., Mc Keag, N.A., Mc Cann, C.J., Cardwell, C., Young, I.S., Adgey, A.A.J., Mikhalchikova, N., Burova, N., Zaccaria, M., Palmisano, P., Palumbo, V., Ciccone, M.M., Favale, S., Chen, K.C., Yin, W.H., Liu, J.H., Goncalves, S., Santos, J.F., Amador, P., Soares, L.N., Zahidova, K., Guliyev, F., Zahidov, N., Carrilho-Ferreira, P., Cortez-Dias, N., Marques, J.S., Silva, D., Jorge, C., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Carvalho De Sousa, J., Lopes, M.G., Cortez-Dias, N., Calisto, C., Silva, D., Jorge, C., Carrilho-Ferreira, P., Silva Marques, J., Robalo Martins, S., Correia, M.J., Carvalho De Sousa, J., Lopes, M.G., Uthoff, H., Thalhammer, C., Potocki, M., Reichlin, T., Noveanu, M., Aschwanden, M., Staub, D., Arenja, N., Socrates, T., Mueller, C., Zhao, Y., Wu, X., Xue, Q., Gao, L., Lin, H., Wang, S., Watanabe, K., Kawamura, A., Seko, T., Omura, A., Sakabe, S., Kasai, A., Starodubova, A.V., Storozhakov, G., Kisliak, O., Hautieva, F., Tursheva, M., Fedotova, N., Di Maio, R.C., Mclaughlin, J., Allen, J.D., Anderson, J.M.C., Adgey, A.A.J., Khaled Nagi, H., Abed, N., Tayeh, O., Farok, W., Mousa, A., Neuzil, P., Skoda, J., Petru, J., Sediva, L., Kralovec, S., Holy, F., Holdova, K., Jehlicka, P., Plasil, P., Reddy, V.Y., Alabakovska, S., Labudovic, D., Jovanova, S., Tosheska, K., Alabakovski, M., Jeevaratnam, K., Tee, S.P., Zhang, Y., Guzadhur, L., Gurung, I.S., Duehmke, R., Grace, A.A., Lei, M., Huang, C.L., Ishibashi, Y., Yamauchi, M., Akashi, Y., Musha, H., Miyake, F., Hnatek, T., Kamenik, L., Sedlon, P., Luxova, J., Steuerova, B., Skvaril, J., Cernohous, M., Zavoral, M., Ratkovic, N., Nemanja Djenic, N.R., Aleksandra Jovelic, A.J., Slobodan Obradovic, S.O., Branko Gligic, B.G., Kletsiou, E., Giannakopoulou, M., Bozas, E., Iliodromitis, E.K., Anastasiou-Nana, M., Papathanassoglou, E.D.E., Anton, M., Anton, G., Muraru, M., Stanojlovic, T., Salinger Martinovic, S., Radosavljevic, M., Glasnovic, J., Stanojevic, D., Zivkovic, M., Cortez-Dias, N., Jorge, C., Calisto, C., Silva, D., Carrilho-Ferreira, P., Silva Marques, J., Robalo Martins, S., Pessoa, T., Fiuza, M., Lopes, M.G., Aspromonte, N., Ronco, C., Tubaro, M., Santini, M., Colivicchi, F., Aiello, A., Cruz, D., Anzoletti Boscolo, A., Vianello, G., Valle, R., Cavusoglu, Y., Parspour, A., Birdane, A., Tek, M., Gorenek, B., Unalir, A., Ata, N., Lee, W.P., Ong, B.B., Watkins, S., Datta, D., Halcox, J.P.J., Providencia, R.A., Barra, S., Gomes, P.L., Seca, L., Silva, J., Botelho, A., Quintal, N., Pais, J.R., Mota, P., Leitao-Marques, A.M., Nikishin, A.G., Pirnazarov, M.M., Nurbaev, T.A., Motovska, Z., Fischerova, M., Osmancik, P., Maly, M., Widimsky, P., Pavli, E., Dibra, A., Mehilli, J., Dibra, L., Schoemig, A., Kastrati, A., Carmo, P., Ferreira, J., Aguiar, C., Almeida, M., Raposo, L., Teles, R., Goncalves, P., Brito, J., Silva, A., Dascenzo, F., Gonella, A., Longo, G., Pullara, A., Moretti, C., Sciuto, F., Omede, P., Biondi Zoccai, G., Trevi, G.P., Sheiban, I., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Cafe, H.M., Silva, B., Santos, N., Faria, P., Oliveira, R., Pereira, A., Caires, G., Pereira, D., Freitas, D., Araujo, J., Pittl, U., Schratter, A., Klemm, T., Lehmann, D., Demmin, K., Mende, M., Schuler, G., Thiele, H., Salazar Mendiguchia Y Garcia, J., Ariza Sole, A., Martinez Garcia, V., Sanchez Salado, J.C., Lorente Tordera, V., Ortiz Berbel, D., Rabasa Baraibar, J.M., Esplugas Oliveras, E., Monge, J., Leal, S., Dores, H., Bronze Carvalho, L., Rosario, I., Abecasis, J., Correia, M.J., Leitao, A., Aleixo, A., Silva, A., Leone, A.M., De Caterina, A., Aurelio, A., Sciahbasi, A., Lioy, E., Trani, C., Burzotta, F., Porto, I., Rebuzzi, A.G., Crea, F., Trusinskis, K., Juhnevica, D., Strenge, K., Sondore, D., Kumsars, I., Jegere, S., Narbute, I., Grave, A., Zakke, I., Erglis, A., Mihaylov, G., Marenzi, G., Assanelli, E., Ferrari, C., Marana, I., Lauri, G., De Metrio, M., Grazi, M., Campodonico, J., Moltrasio, M., Bartorelli, A.L., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Saeed, M., Gaber, R., Mornos, C., Cozma, D., Pescariu, S., Dragulescu, S.I., Kamal, H.S., Abdelfattah, A., Abdelbary, A.M., Elassar, H., Naggar, A., Khaled, M., Fareed, A.M., Pernes, J.M., Gaux, J.C., Oraby, M., Nasr, G.M., Maklady, F., Dupouy, P., Prull, M.W., Sasko, B., Wirdemann, H., Bittlinsky, A., Butz, T., Trappe, H.J., Perazzolo Marra, M., Cacciavillani, L., Marzari, A., De Lazzari, M., Turri, R., China, P., Corbetti, F., Iliceto, S., Stazhadze, L.L., Spiridonova, E.A., Bulanova, N.A., Ermolaev, A.A., Savic, L., Mrdovic, I., Krljanac, G., Perunicic, J., Asanin, M., Lasica, R., Matic, M., Vasiljevic, Z., Ostojic, M., Pudil, R., Tichy, M., Blaha, V., Andrys, C., Vojacek, J., Conti, A., Poggioni, C., Viviani, G., Bulletti, F., Boni, V., Luzzi, M., Vicidomini, S., Donati, M., Del Taglia, B., Pini, R., Sousa, O., Fontes-Carvalho, R., Caeiro, D., Dias Ferreira, N., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Murai, M., Takeda, Y., Shinmyo, T., Tanigawa, J., Hazui, H., Nakakohji, T., Ohishi, Y., Hoshiga, M., Ishihara, T., Hanafusa, T., Belohlavek, J., Rohn, V., Kunstyr, J., Lips, M., Semrad, M., Horak, J., Mlejnsky, F., Tosovsky, J., Linhart, A., Lindner, J., Sablik, Z., Samborska-Sablik, A., Drozdz, J., Gaszynski, W., Ferrer Hita, J.J., Rodriguez-Gonzalez, A., Izquierdo-Gomez, M.M., Enjuanes-Grau, C., Rubio-Iglesias-Garcia, C., Sanchez-Grande-Flecha, A., Juarez-Prera, R., Blanco-Palacios, G., Bosa-Ojeda, F., Marrero-Rodriguez, F., Lakhdar, R., Drissa, M., Drissa, M., Jedaida, B., Drissa, H., Sousa, O., Dias Ferreira, N., Sampaio, F., Caeiro, D., Fontes-Carvalho, R., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Hsin, H.-T., Huang, J.-H., Chiu, K.-M., Chen, Z.-S., Lin, P.-C., Chen, L.-Y., Chu, S.-H., Efthimiadis, I., Skendros, P., Sarantopoulos, A., Boura, P., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Backus, B.E., Six, A.J., Kelder, J.H., Mosterd, A., Mast, E.G., Mast, T.P., Braam, R., Tio, R., Veldkamp, R., Doevendans, P.A., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Paarup Dridi, N., Holmvang, L., Engstroem, T., Rekik, S., Brunet, J., Hager, F.X., Bayet, G., Meille, L., Quatre, J.M., Sainsous, J., Chu, P.-H., Tang, C.-H., Ibatov, A., Pogosova, N., Koltunov, I.E., Sapunova, I.D., Vigodin, V.A., Uhliar, R., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Schmidt, A., Brockmeyer, B., Horstkotte, D., Suzuki, A., Eki, Y., Higuchi, H., Yukawa, A., Yamauchi, R., Sato, Y., Endo, Y., Martinez Garcia, V., Salazar Mendigucha Garcia, J., Ariza Sole, A., Sanchez Salado, J.C., Lorente Tordera, V., Homs Vila, S., Gomez Hospital, J.A., Cequier Fillat, A., Esplugas Oliveras, E., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M., Tapia Ballesteros, C., Vegas Valle, J.M., Gonzalez Garcia, I.A., Duro Aguado, I.A., Palomino Doza, A.J., Gomez Salvador, I., San Roman Calvar, J.A., Nikishin, A.G., Mamarasulov, T.M., Pirnazarov, M.M., Koracevic, G., Pavlovic, M., Glasnovic, J., Damjanovic, M., Stojkovic, A., Kostic, T., Todorovic, L., Petrovic, S., Zivkovic, M., Djordjevic-Radojkovic, D., Cherneva, Z.C.H., Denchev, S.D., Heltai, K., Becker, D., Merkely, B., Nikulina, N., Yakushin, S.S., Akinina, S.A., Furmenko, G.I., Boytsov, A., Yakushin, S.S., Nikulina, N.N., Furmenko, G.I., Akinina, S.A., Dores, H., Leal, S., Rosario, I., Bronze, L., Abecasis, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Dores, H., Leal, S., Rosario, I., Monge, J., Abecasis, J., Correia, M.J., Bronze, L., Arroja, I., Aleixo, A., Silva, A., Rosario, I., Leal, S., Dores, H., Correia, M.J., Monge, J.C., Abecasis, J., Arroja, I., Aleixo, A., Silva, A., Palmisano, P., Zaccaria, M., Zanna, D., Marangelli, V., Caiati, C., Ciccone, M.M., Favale, S., Picon Heras, R., Loureiro, M.J., Nunez-Gil, I., Garcia Rubira, J.C., Acebal, C., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Macaya, C., Rosario, I., Dores, H., Leal, S., Monge, J.C., Correia, M.J., Bronze Carvalho, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Urazovskaya, I., Vinogradova, D., Vasilieva, E., Shpektor, A., Faustino, A., Seca, L., Barra, S., Providencia, R., Silva, J., Gomes, P., Costa, G., Caetano, F., Costa, M., Leitao-Marques, A., Conti, E., Musumeci, M.B., Lauri, F.M., Dito, E., De Giusti, M., Lallo, A., Fusco, D., Davoli, M., Volpe, M., Autore, C., Gamra, H., Dridi, Z., Hassine, M., Addad, F., Gherissi, I., Reda, A., Mahjoub, M., Bouraoui, S., Abdennadher, M., Betbout, F., Mota, P.M.F.P., Silva, J.D., Providencia, R.A., Leitao-Marques, A., Nikolic Heitzler, V., Babic, Z., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Stanojevic, D., Apostolovic, S., Jankovic Tomasevic, R., Pavlovic, M., Djordjevic, V., Djordjevic Radojkovic, D., Salinger Martinovic, S., Koracevic, G., Damjanovic, M., Ilic, I., Scafa Udriste, A., Fruntelata, A., Gainoiu, E., Bogdan, S., Calmac, L., Zamfir, D., Teodorescu, C., Guran, M., Constantinescu, D., Dorobantu, M., Rosario, I., Dores, H., Leal, S., Abecasis, J., Monge, J.C., Bronze, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Konopka, A., Banaszewski, M., Wojtkowska, I., Stepinska, J., Vidergold, J.V., Osipova, I.V., Tavrovskaya, T.V., Galkina, J.V., Timofeev, A.V., Vorobyov, R.I., Vorobyova, E.N., Matos, L., Carvalho, A.C.C., Oliveira, W., Cintra, F., Poyares, D., Andersen, M., Martins, R., Tufik, S., Neuzil, P., Ostadal, P., Skoda, J., Holy, F., Holdova, K., Brada, J., Horakova, S., Mlcek, M., Hrachovina, V., Kittnar, O., Gorudko, I.V., Buko, I.V., Cherenkevich, S.N., Polonetsky, L.Z., Plotkin, V.Y., Timoshina, M.A., Azanchevskaya, S.V., Chromov-Borisov, N.N., Vorlat, A., Snoep, L., Claeys, M.J., Vrints, C.J., Palazzuoli, A., Caputo, M., Quatrini, I., Calabro, A., Antonelli, G., Campagna, M.S., Franci, B., Nuti, R., Maisel, A., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Negrini, M., Minora, T., Marino, P., Seregni, R., Tavlueva, E., Barbarash, O., Barbarash, L., Janota, T., Kudlicka, J., Malik, K., Wichterle, D., Hradec, J., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Body, R., Carley, S.D., Mcdowell, G., Nuttall, M., Wibberley, C., France, M., Cruickshank, J.K., Mackway-Jones, K., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Unalacak, M., Gorenek, B., Birdane, A., Yuksel, F., Ata, N., Leon, M., Cozma, C., Mitu, F., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Barra, S.N.C., Gomes, P., Silva, J., Providencia, R., Seca, L., Leitao Marques, A., Burazor, I., Burazor, M., Krstic, M., Lazovic, M., Stojkovic, A., Vukmanovic, M., Djordjevic, J., Radovanovic, Z., Ilic, D., Bosnjakovic, P., Margato, R., Ferreira, A.C., Mateus, P.S., Ribeiro, H., Fontes, P., Moreira, J.I., Teixeira, T., Silva, J.D., Costa, M., Leitao-Marques, A., Conte, G., Menozzi, A., Solinas, E., Bolognesi, M.G., Tadonio, I., Mantovani, F., Cattabiani, A., Vignali, L., Ardissino, D., Scafa Udriste, A., Fruntelata, A., Tautu, O., Calmac, L., Alexandrescu, A., Niculescu, R., Tatu-Chitoiu, G., Dorobantu, M., Djordjevic Radojkovic, D., Apostolovic, S., Perisic, Z., Damjanovic, M., Jankovic, R., Salinger Martinovic, S., Koracevic, G., Todorovic, L., Bozinovic, N., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Santos, C., Ferreira, J., Carmo, P., Costa, F., Brito, J., Sousa, P., Cardoso, G., Correia, I., Aguiar, C., Silva, A., Fountoulaki, K., Kastellanos, S., Voltirakis, E., Kokotos, A., Michalakeas, C., Kontsas, K., Hasioti, K., Iliodromitis, E.T., Anastasiou-Nana, M., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M.G., Tapia Ballesteros, C., Vegas Valle, J.M., Zatarain Nicolas, E., Amat Santos, I.J., Martinez Uruena, N., Alvarado Montes De Oca, M., San Roman Calvar, J.A., Belohlavek, J., Dytrych, V., Kovarnik, T., Smid, O., Kral, A., Linhart, A., Aroutunov, A.G., Intwala, S., Sondore, D., Juhnevica, D., Trusinskis, K., Strenge, K., Jegere, I., Narbute, I., Grave, A., Erglis, A., Shaalan, H.S.H., Pagava, Z., Agladze, R., Shakarishvili, R., Sharashidze, N., Gujejiani, L., Saatashvili, G., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Gaber, R., Gaber, R., Hristova, K., Katova, T.Z., Kostova, V., Simova, Y., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Voinea, F.L., Craiu, E., Obradovic, S., Salinger, S., Vukotic, S., Rafajlovski, S., Romanovic, R., Koracevic, G., Antonijevic, N., Gligic, B., Hutyra, M., Skala, T., Horak, D., Vindis, D., Taborsky, M., Contine, A., Del Pinto, M., Angeli, F., Verdecchia, P., Borgognoni, F., Grikstaite, E., Pantano, P., Ambrosio, G., Cavallini, C., Bonanad, C., Sanchis, J., Bodi, V., Nunez, J., Bosch, X., Heras, M., Pellicer, M., Llacer, A., Seca, L.F., Fontes-Carvalho, R., Caeiro, D., Adao, L., Oliveira, M., Goncalves, H., Primo, J., Gama, V., Fresco, C., De Biasio, M., Sappa, R., Muser, D., Morocutti, G., Bernardi, G., Proclemer, A., Lombardi, C., Metra, M., Bugatti, S., Pasotti, E., Quinzani, F., Adamo, M., Villa, C., Rovetta, R., Manerba, A., Dei Cas, L., Mariani, M., Dushpanova, A., Baroni, M., Cerone, E., Nardelli, A., Gianetti, J., Berti, S., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Toste, A., Ramos, R., Cunha, P.S., Feliciano, F., Soares, R., Santos, S., Ferreira, R.C., Ostadal, P., Kruger, A., Vondrakova, D., Herget, J., Di Maio, R.C., Navarro, C., Cromie, N.A., Anderson, J.M.C., Adgey, J.A.A., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Caeiro Pereira, D., Braga, P., Fontes Carvalho, R., Sousa, O., Rodrigues, A., Goncalves, H., Ribeiro, J., Goncalves, M., Simoes, L., Gama, V., and Borisov, K.V.
- Abstract
Background: Radial access for PCI is increasing but its use in emergency still remains confidential. We report our single center experience where all interventional cardiologists use the radial access as default strategy for primary PCI. Methods and Results: STEMI patients (n = 671) were evaluated for bleeding complications using a web-based registry (e-PARIS). In-hospital bleeding was adjudicated using various definitions (TIMI, GUSTO, STEEPLE). MACE was the composite of death, MI and stroke. In this non-selected, high risk population, 6.1% had cardiogenic shock on admission, 3.9% out-of-hospital cardiac arrest and 51.2% multivessel disease. Radial access (88%) was the default strategy as was abciximab (78%). Clopidogrel loading dose ranged from 300 to 900 mg. Pre-hospital fibrinolysis was used in 7.1%. Hemodynamic support devices (IABP, ECMO, Tandem Heart) were needed in 7.0%. In-hospital bleeding rates varied widely according to the definitions used: 2.5%, 1.5%, 5.7%, 9.2% and 10.9% with TIMI Major, GUSTO Severe, TIMI Major/minor, GUSTO Severe/moderate or STEEPLE Major, respectively. In-hospital death rate was 5.5%. One-year mortality (8.2%) was seriously impacted by in-hospital bleeding (31.6% vs 6.8%, p < 0.001). The most frequent bleeding site was gastro-intestinal (figure). GUSTO Severe/moderate bleeding was independently correlated with MACE (OR 2.60; 95%CI 1.21–5.59; p = 0.01) and radial access was a strong predictor of survival (OR 0.33; 95%CI 0.17–0.56; p = 0.002). Conclusions: The gastro-intestinal tract is the most frequent site of bleeding when the radial artery is the predominant vascular access site for primary PCI. GUSTO Severe/moderate bleeding is an independent predictor of MACE while radial access predicts survival.
- Published
- 2010
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48. 901–86 Low Total Cholesterol is Associated with Higher Mortality in Patients with Coronary Heart Disease
- Author
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Behar, Solomon, Goldbourt, Uri, Graff, Eran, Reicher-Reiss, Henrietta, Boyko, Valentina, Benderly, Michal, Shotan, Avi, and Brunner, Daniel
- Abstract
Several studies have shown an association between low total cholesterol (TC) and increased mortality. Among 13,753 patients (pts) of both genders with coronary artery disease (CAD) aged 45–70 yrs (mean 61 yrs) screened for the Bezafibrate Infarction Prevention (BIP) Study, 554 pts (4.0%) had low TC(≤160mg/dl) mean (147±12mg/dl). Age, clinical findings and medical treatments were similar in pts with low TC and pts with TC > 160mg/dl (mean 222±36mg/dl). The former had lower mean HDL-C (32.5±8.6mg/dl) and triglyceride levels (119 ±66mg/dl) in comparison to pts with TC> 160mg/dl (37.9±10.0mg/dl and 164±93mg/dl respectively). Three year mortality rates after screening were as follows for both groups:Pts groupMortalityTotalCardiacNon-cardiacLow T-C (n=554)3.8*4.3*8.1*Others (n=13199)2.71.94.6*p<0.001
- Published
- 1995
- Full Text
- View/download PDF
49. Prognostic significance of history of stroke among 11507 patients with coronary artery disease
- Author
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Reicher-Reiss, Henrietta, Goldbourt, Uri, Tanne, David, Boyko, Valentina, Shotan, Avraham, Jonas, Michael, and Behar, Solomon
- Published
- 1996
- Full Text
- View/download PDF
50. Global ischemia-induced alterations in the eicosanoid synthesis of the endocardial explants obtained from the working isolated rat heart
- Author
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Shotan, Avraham, Arad, Michael, Elazar, Ella, Klein, Rodica, Horowitz, Liana, Kaplinsky, Elieser, and Rabinowitz, Babeth
- Published
- 1990
- Full Text
- View/download PDF
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