1. A method of knowledge modeling and its application to gene function analysis.
- Author
-
Matsunaga, Tsutomu
- Subjects
INFORMATION retrieval ,ARTIFICIAL intelligence ,INFORMATION science ,ELECTRONIC data processing ,COMPUTER systems - Abstract
This paper proposes a knowledge model for large-scale knowledge structurization of documents. When an elementary concept such as input for information retrieval is handled as an object, generally a structure composed of the relations in the set of objects is observed. The proposed model generates objects by statistical machine learning of the occurrence patterns of words in the word set and quantifies the relations among the objects by matching to the occurrence patterns. The idea is to approach knowledge structurization in order to achieve systematic understanding by relating pieces of existing knowledge by quantifying the relations among objects as elementary concepts. In this paper, the proposed model is applied to problems in the life science field, where there is a strong requirement for new knowledge with a comprehensive overview, and its application to gene function analysis is discussed. Experimental results on the extraction of disease-related genes as relations between genes and a disease, and on the estimation of gene functions combined with knowledge about organs, are presented and the effectiveness of the approach is demonstrated. © 2004 Wiley Periodicals, Inc. Syst Comp Jpn, 35(8): 21–30, 2004; Published online in Wiley InterScience (
www.interscience.wiley.com ). DOI 10.1002/scj.10670 [ABSTRACT FROM AUTHOR]- Published
- 2004
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