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According to a preprint abstract, researchers have discovered that the metastasis of colon cancer requires a protein called Dickkopf-2 (DKK2) to generate cancer cells with properties similar to Paneth cells. Paneth cells are known to provide stem cell niche factors in normal conditions, but their role in cancer stem cell niche development was previously unclear. The study found that DKK2 is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. This research has not yet undergone peer review. [Extracted from the article]

According to a preprint abstract, researchers have discovered that the metastasis of colon cancer requires a protein called Dickkopf-2 (DKK2) to generate cancer cells with Paneth cell properties. Paneth cells are known to provide stem cell niche factors in normal conditions, but their role in cancer stem cell niche development was previously unclear. The study found that DKK2 is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. The researchers used knockout cancer organoids and mouse models to demonstrate the role of DKK2 and its downstream target, Hepatocyte nuclear factor 4-alpha (HNF4A), in promoting the generation of cancer cells with Paneth cell properties. This research provides new insights into the mechanisms of colon cancer metastasis and may have implications for future treatment strategies. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A recent study conducted by researchers at Washington University School of Medicine has found that the phenotype of ileal Paneth cells (PCP) can serve as a cellular biomarker for pouch complications in ulcerative colitis (UC). The study aimed to identify biomarkers that can predict outcomes in complex immune diseases like inflammatory bowel disease (IBD). The researchers discovered that abnormal PCP was associated with transcriptomic pathways of secretory granule maturation and polymorphisms in innate immunity genes. This finding suggests that ileal PCP can be used as a biomarker in IBD. [Extracted from the article]

A report from the Government Medical College in Thiruvananthapuram, India, discusses the link between obesity, metabolic associated steatohepatitis (MASH), and portal hypertension. The researchers suggest that Paneth cells in the intestinal epithelium play a role in the pathophysiology of portal hypertension and obesity. Dysfunction of these cells can lead to changes in the intestinal microbiota and increased intestinal permeability, potentially triggering systemic inflammation. The study concludes that understanding the role of Paneth cells could provide opportunities for intervention strategies in portal hypertension. [Extracted from the article]

A recent study conducted at the University of Illinois Chicago investigated the ion transport basis of diarrhea and other mucosal pathways in an animal model of colitis. The researchers found that anti-CD40-induced colitis in mice exhibited key features of inflammatory bowel disease (IBD), including diarrhea and gut inflammation. They also observed changes in Paneth cells, key transporters, and stem cell markers, as well as upregulation of the mechanosensory pathway. The study suggests that this animal model could be useful for further understanding the pathophysiology of ulcerative colitis. [Extracted from the article]

A recent report from the Medical University of Innsbruck in Austria explores the role of polyunsaturated fatty acids (PUFA) in driving gut inflammation, specifically in relation to enteritis. The study found that PUFA binding to the retinoid X receptor alpha (RXRa) in Paneth cells regulates the transcription of cytokines and is crucially involved in the development of diet-induced metabolic gut inflammation. The researchers suggest that RXRa could be a potential target for future drug development in the treatment of inflammatory bowel diseases. Further studies are needed to confirm these findings in human patients. [Extracted from the article]

A recent study conducted by researchers at Shanghai Jiao Tong University has investigated the role of mucosal pentraxin 2 (Mptx2) in Paneth cells, which are found in the small intestines of mice. The study found that Mptx2 is selectively expressed in Paneth cells and is essential for maintaining intestinal homeostasis. Mice lacking Mptx2 showed increased susceptibility to intestinal inflammation and injury, as well as altered intestinal bacteria composition. The researchers concluded that Mptx2 plays a crucial role in regulating autophagy in Paneth cells and maintaining intestinal health. This research provides valuable insights into potential therapeutic targets for intestinal disorders. [Extracted from the article]

Keywords: Newark; State:New Jersey; United States; North and Central America; Disease Attributes; Disease Progression; Health and Medicine; Inflammation; Intestinal Mucosa; Paneth Cells EN Newark State:New Jersey United States North and Central America Disease Attributes Disease Progression Health and Medicine Inflammation Intestinal Mucosa Paneth Cells 1375 1375 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Disease Attributes - Disease Progression. For more information on this research see: Infection and Inflammation Stimulate Expansion of a Cd74 SP + sp Paneth Cell Subset To Regulate Disease Progression. [Extracted from the article]

A recent study conducted by the Cancer Institute has revealed new findings in colon cancer research. The study focused on the cell fate determination program of tumor tissues, which originate from stem cells. Using patient-derived organoids, the researchers found that olfactomedin 4 (OLFM4)+ stem cells have the potential to produce a bifurcated lineage of progenies with absorptive and secretory properties. They also discovered the presence of Paneth-like cells, induced by Notch signaling inhibition, which contribute to tumor formation by providing niche factors. The study highlights the importance of understanding the cell fate specification program for developing targeted therapeutics. [Extracted from the article]

A recent study conducted at the Animal Experiment Center has found that inducible nitric oxide synthase (iNOS), which is expressed in Paneth cells, plays a crucial role in maintaining the intestinal stem cell (ISC) niche. The researchers used knockout mice to investigate the effects of iNOS ablation on ISC proliferation and differentiation. They found that the loss of iNOS led to morphological changes in the intestine, decreased ISC proliferation, and inhibited ISC differentiation and migration. The study suggests that iNOS could be a potential target for the development of new drugs and therapies for intestinal disorders. [Extracted from the article]

Keywords: Intestinal Mucosa; Life Sciences; Paneth Cells; Stem Cell Research EN Intestinal Mucosa Life Sciences Paneth Cells Stem Cell Research 55 55 1 10/03/23 20231005 NES 231005 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on life sciences is now available. These results indicate that HuR is essential for maintaining the integrity of the PC/ISC niche and highlight a novel role for a defective PC/ISC niche in the pathogenesis of intestinal mucosa atrophy.". [Extracted from the article]

Keywords: Chicago; State:Illinois; United States; North and Central America; Diet and Nutrition; Health and Medicine; Intestinal Mucosa; Paneth Cells; Vitamin D; Vitamins EN Chicago State:Illinois United States North and Central America Diet and Nutrition Health and Medicine Intestinal Mucosa Paneth Cells Vitamin D Vitamins 6271 6271 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Intestinal Mucosa - Paneth Cells is now available. For more information on this research see: Myeloid Vitamin D Receptor Regulates Paneth Cells and Microbial Homeostasis. [Extracted from the article]

For more information on this research see: Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Keywords: Goblet Cells; Intestinal Mucosa; Paneth Cells; Science EN Goblet Cells Intestinal Mucosa Paneth Cells Science 1919 1919 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New research on science is the subject of a new report. [Extracted from the article]

Diabetes Mellitus, Endocrine System Diseases and Conditions, Endocrinology, Glucose Metabolism Disorders, Health and Medicine, Intestinal Mucosa, Metabolic Diseases and Conditions, Nutritional and Metabolic Diseases and Conditions, Paneth Cells Keywords for this news article include: University of the Witwatersrand, Johannesburg, South Africa, Africa, Paneth Cells, Endocrinology, Diabetes Mellitus, Intestinal Mucosa, Health and Medicine, Glucose Metabolism Disorders, Endocrine System Diseases and Conditions, Nutritional and Metabolic Diseases and Conditions. Keywords: Diabetes Mellitus; Endocrine System Diseases and Conditions; Endocrinology; Glucose Metabolism Disorders; Health and Medicine; Intestinal Mucosa; Metabolic Diseases and Conditions; Nutritional and Metabolic Diseases and Conditions; Paneth Cells EN Diabetes Mellitus Endocrine System Diseases and Conditions Endocrinology Glucose Metabolism Disorders Health and Medicine Intestinal Mucosa Metabolic Diseases and Conditions Nutritional and Metabolic Diseases and Conditions Paneth Cells 220 220 1 06/26/23 20230626 NES 230626 2023 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Investigators publish new report on diabetes mellitus. [Extracted from the article]

Keywords: Sapporo; Japan; Asia; Amino Acids; Antimicrobial Cationic Peptides; Choline; Defensins; Diet and Nutrition; Health and Medicine; Intestinal Mucosa; Membrane Proteins; Micronutrient; Paneth Cells; Peptides; Pore Forming Cytotoxic Proteins; Proteins; alpha-Defensins EN Sapporo Japan Asia Amino Acids Antimicrobial Cationic Peptides Choline Defensins Diet and Nutrition Health and Medicine Intestinal Mucosa Membrane Proteins Micronutrient Paneth Cells Peptides Pore Forming Cytotoxic Proteins Proteins alpha-Defensins 2789 2789 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Membrane Proteins - Antimicrobial Cationic Peptides have been published. When alpha-defensin levels in the intestinal lumen are restored by intravenous administration of R-Spondin1 to induce Paneth cell regeneration or by oral administration of alpha-defensins, liver fibrosis is ameliorated with dissolving dysbiosis. [Extracted from the article]

Keywords: Intestinal Mucosa; Paneth Cells; Stem Cell Research EN Intestinal Mucosa Paneth Cells Stem Cell Research 59 59 1 03/27/23 20230331 NES 230331 2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Data detailed on Paneth cells have been presented. At the origin of Paneth cell life, several pathways such as Wnt, Notch, and BMP signaling, affect the differentiation of Paneth cells.". [Extracted from the article]

According to the news reporters, the research concluded: "Therapeutic strategies targeting PCs mainly include PC protection, PC-derived inflammatory cytokine elimination, and substituting AMP treatment. Keywords: Graft-Versus-Host Disease; Health and Medicine; Immune System Diseases and Conditions; Immunology; Intestinal Mucosa; Paneth Cells; Risk and Prevention EN Graft-Versus-Host Disease Health and Medicine Immune System Diseases and Conditions Immunology Intestinal Mucosa Paneth Cells Risk and Prevention 2631 2631 1 03/27/23 20230331 NES 230331 2023 MAR 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on graft-versus-host disease have been presented. [Extracted from the article]

Differentiated Paneth cells are the main source of epithelial-derived niche factor supplies and produce Wnt3 as an essential factor in supporting Lgr5 thorn stem cell activity in the absence of redundant mesenchymal Wnts." Keywords: Sherbrooke; Canada; North and Central America; Gastroenterology and Hepatology; Health and Medicine; Cell Differentiation; Intestinal Mucosa; Paneth Cells; Stem Cell Research EN Sherbrooke Canada North and Central America Gastroenterology and Hepatology Health and Medicine Cell Differentiation Intestinal Mucosa Paneth Cells Stem Cell Research 48 48 1 03/27/23 20230331 NES 230331 2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on Health and Medicine - Gastroenterology and Hepatology is now available. [Extracted from the article]

Keywords: Digestive System Diseases and Conditions; Enteritis; Gastroenteritis; Gastrointestinal Diseases and Conditions; Health and Medicine; Intestinal Mucosa; Paneth Cells; Stem Cell Research EN Digestive System Diseases and Conditions Enteritis Gastroenteritis Gastrointestinal Diseases and Conditions Health and Medicine Intestinal Mucosa Paneth Cells Stem Cell Research 900 900 1 03/27/23 20230331 NES 230331 2023 MAR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on enteritis is now available. Severe acute and chronic radiation enteritis result from the damage to the crypt-based intestinal stem cells and their derivatives, which include the Paneth cells. [Extracted from the article]

Keywords: Genetics; Intestinal Mucosa; Paneth Cells; Stem Cell Research EN Genetics Intestinal Mucosa Paneth Cells Stem Cell Research 143 143 1 03/24/23 20230302 NES 230302 2023 FEB 27 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Paneth cells. Moreover, PTBP1 inhibits the expression of an AKT inhibitor PHLDA3 in Paneth cells and permits AKT activation, which presumably maintains Paneth cell plasticity and function in supporting intestinal stem cell niche.". [Extracted from the article]

Keywords: Cell Differentiation; Gastroenterology and Hepatology; Health and Medicine; Intestinal Mucosa; Paneth Cells; Stem Cell Research EN Cell Differentiation Gastroenterology and Hepatology Health and Medicine Intestinal Mucosa Paneth Cells Stem Cell Research 2023 FEB 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators discuss new findings in gastroenterology and hepatology. Cell Differentiation, Gastroenterology and Hepatology, Health and Medicine, Intestinal Mucosa, Paneth Cells, Stem Cell Research. [Extracted from the article]

Keywords for this news article include: Zhejiang University School of Medicine, Actinobacteria, Bifidobacterium, Gram-Positive Rods, Stem Cell Research, Gram-Positive Bacteria, Gram-Positive Asporogenous Rods. Keywords: Actinobacteria; Bifidobacterium; Gram-Positive Asporogenous Rods; Gram-Positive Bacteria; Gram-Positive Rods; Stem Cell Research EN Actinobacteria Bifidobacterium Gram-Positive Asporogenous Rods Gram-Positive Bacteria Gram-Positive Rods Stem Cell Research 160 160 1 10/16/23 20231016 NES 231016 2023 OCT 16 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on bifidobacterium. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of the Wnt signaling pathway in the renewal and development of the gastrointestinal tract. The study used a mouse model to investigate the effects of partially inactivating the transcription factor Tcf4, a key effector of the Wnt signaling pathway. The results suggest that the damaged epithelium is restored through a standard homeostatic renewal pathway rather than a specific regeneration program. Additionally, disruption of Tcf4 led to a shift in cell lineage from Paneth cells to goblet cells, and the hyperactivation of the Wnt signaling pathway in colon adenomas correlated with the upregulation of genes typical of Paneth cells. The study highlights the critical role of Tcf4 in controlling cell lineage decisions in the intestinal epithelium and colon tumors. [Extracted from the article]

According to a preprint abstract, researchers have discovered that the bacterial metabolite ADP-heptose (ADP-Hep) plays a role in initiating a stem cell program in the intestinal epithelium. The study found that ADP-Hep induced the ablation of the homeostatic intestinal stem cell (ISC) pool, leading to the dedifferentiation of Paneth cells and the emergence of revival stem cells (revSCs) with fetal-like characteristics. The researchers also found that the detection of ADP-Hep by the ALPK1-TIFA pathway was necessary for efficient epithelial regeneration. This research suggests that Paneth cells can serve as the cell of origin for revSC induction in response to microbial stimulation. [Extracted from the article]

A recent study conducted at Cincinnati Children's Hospital Medical Center focused on a case of Mirage Syndrome with a samd9 mutation and refractory infantile diarrhea. The research highlighted complex light and electron microscopic abnormalities in the duodenum of an infant with intractable diarrhea. The findings suggest that the SAMD9 mutation may alter mucosal growth and the processing of mucin, Paneth, and neurosecretory granules, leading to specific granule degradation in enterocyte lysosomes. The study concluded that the multisystem manifestations of Mirage Syndrome may be attributed to a primary disorder of microsomal trafficking. [Extracted from the article]

A patent application titled "Methods And Compositions For Modulating Goblet Cells And For Muco-Obstructive Diseases" was published online by inventors from various locations. The application focuses on methods for directing changes in the cell state of progenitor cells, particularly intestinal stem cells, to potentially treat diseases related to abnormal cell types in the goblet cell lineage. The application outlines specific perturbagens and gene signatures that can alter the development of goblet cells, Paneth cells, and enteroendocrine cells, providing potential insights into treating muco-obstructive diseases. [Extracted from the article]

This article discusses a study that explores the response of intestinal stem cells (ISCs) to bacterial infection. The researchers focused on the early stages of infection and found that Salmonella enterica targets differentiated cells in the gut, including Paneth cells, enterocytes, and stem/progenitor cells. The study also revealed a defense mechanism employed by Lgr5+ ISCs, where they initiate cellular remodeling to combat the infection and protect the gut epithelium. This research provides insights into the innate immune response and tissue regeneration in the gut. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

The research team analyzed Axin1 expression in human inflammatory bowel disease datasets and found increased Axin1 expression in the colonic epithelium of IBD patients. Keywords: Bowel Diseases and Conditions; Colitis; Colonic Diseases and Conditions; Digestive System Diseases and Conditions; Drugs and Therapies; Engineering; Gastroenteritis; Gastroenterology; Gastrointestinal Diseases and Conditions; Health and Medicine; Inflammatory Bowel Disease; Intestinal Mucosa; Paneth Cells; Therapeutics; Therapy EN Bowel Diseases and Conditions Colitis Colonic Diseases and Conditions Digestive System Diseases and Conditions Drugs and Therapies Engineering Gastroenteritis Gastroenterology Gastrointestinal Diseases and Conditions Health and Medicine Inflammatory Bowel Disease Intestinal Mucosa Paneth Cells Therapeutics Therapy 1501 1501 1 10/09/23 20231009 NES 231009 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A groundbreaking study conducted by Jun Sun's research team at the University of Illinois Chicago has revealed a new and critical role of Axin1 in regulating intestinal epithelial development and microbial homeostasis. [Extracted from the article]

A study conducted by researchers from the University of Illinois explores the role of Axin1 in maintaining intestinal homeostasis and its impact on colitis. The study found increased Axin1 expression in the colonic epithelium of human inflammatory bowel disease (IBD) patients. Mouse models with Axin1 deficiency in intestinal epithelial cells and Paneth cells showed reduced susceptibility to colitis and alterations in gut microbiota. The findings suggest that Axin1 plays a crucial role in mediating intestinal homeostasis and the microbiota, providing potential therapeutic strategies for IBD. [Extracted from the article]

Keywords: Antibiotics; Antimicrobials; Bioengineering; Biomarkers; Biomedical Engineering; Biomedicine; Biotechnology; Crohn's Disease; Diagnostics and Screening; Digestive System Diseases and Conditions; Drugs and Therapies; Enterobacteriaceae; Epithelial Cells; Escherichia coli; Gastroenteritis; Gastroenterology; Gastrointestinal; Gastrointestinal Diseases and Conditions; Gram-Negative Bacteria; Health and Medicine; Inflammation; Inflammatory Bowel Diseases and Conditions; Intestinal Mucosa; Paneth Cells; Personalized Medicine; Personalized Therapy; Proteobacteria; Regenerative Medicine; Ulcerative Colitis; University of California - Riverside EN Antibiotics Antimicrobials Bioengineering Biomarkers Biomedical Engineering Biomedicine Biotechnology Crohn's Disease Diagnostics and Screening Digestive System Diseases and Conditions Drugs and Therapies Enterobacteriaceae Epithelial Cells Escherichia coli Gastroenteritis Gastroenterology Gastrointestinal Gastrointestinal Diseases and Conditions Gram-Negative Bacteria Health and Medicine Inflammation Inflammatory Bowel Diseases and Conditions Intestinal Mucosa Paneth Cells Personalized Medicine Personalized Therapy Proteobacteria Regenerative Medicine Ulcerative Colitis University of California - Riverside 380 380 1 04/24/23 20230427 NES 230427 2023 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- RIVERSIDE, Calif. -- Inflammatory bowel disease, or IBD, describes Crohn's disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. These structural changes in the appearance of Paneth cells can also serve as a marker of disease in IBD, especially Crohn's disease.". [Extracted from the article]

Amino Acids, Basic Amino Acids, Demethylase, Diamino Amino Acids, Enzymes and Coenzymes, Essential Amino Acids, Gastroenterology and Hepatology, Genetics, Health and Medicine, Lysine, Paneth Cells, Intestinal Mucosa Keywords: Amino Acids; Basic Amino Acids; Demethylase; Diamino Amino Acids; Enzymes and Coenzymes; Essential Amino Acids; Gastroenterology and Hepatology; Genetics; Health and Medicine; Intestinal Mucosa; Lysine; Paneth Cells EN Amino Acids Basic Amino Acids Demethylase Diamino Amino Acids Enzymes and Coenzymes Essential Amino Acids Gastroenterology and Hepatology Genetics Health and Medicine Intestinal Mucosa Lysine Paneth Cells 6918 6918 1 03/23/23 20230310 NES 230310 2023 MAR 10 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on gastroenterology and hepatology are presented in a new report. [Extracted from the article]

The stem and/or the progenitor cells may be adult stem cells, embryonic stem cells, or cancer stem cells. Keywords: Amino Acids; Cancer; Chemotherapy; Diarrhea; Digestive System Diseases and Conditions; Drugs and Therapies; Enteritis; Epithelial Cells; Gastroenteritis; Gastroenterology; Gastrointestinal Diseases and Conditions; Health and Medicine; Inflammation; Intestinal Mucosa; Oncology; Paneth Cells; Peptides; Proteins; Radiotherapy; Stem Cell Research; Therapy; University of Florida Research Foundation Inc EN Amino Acids Cancer Chemotherapy Diarrhea Digestive System Diseases and Conditions Drugs and Therapies Enteritis Epithelial Cells Gastroenteritis Gastroenterology Gastrointestinal Diseases and Conditions Health and Medicine Inflammation Intestinal Mucosa Oncology Paneth Cells Peptides Proteins Radiotherapy Stem Cell Research Therapy University of Florida Research Foundation Inc 2023 MAR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- A patent by the inventors Dennison, Daniel (Tallahassee, FL, US), Gatto, Stephen (Norwood, MA, US), Grosche, Astrid (Gainesville, FL, US), Gupta, Reshu (Gainesville, FL, US), Okunieff, Paul Gerson (Gainesville, FL, US), Vidyasagar, Sadasivan (Gainesville, FL, US), Yin, Liangjie (Gainesville, FL, US), filed on October 4, 2017, was published online on February 14, 2023, according to news reporting originating from Alexandria, Virginia, by NewsRx correspondents. "This cell proliferation and/or development can be used to improve proliferation and function of stem cells and progenitor cells located in various organ systems and places in the body. Radiation and/or chemotherapy therapy destroys not only the existing villous cells, but also stem cell and/or progenitor cells from which new villous cells form, and thus, can deplete almost the entire villous epithelium even at moderate doses. [Extracted from the article]

Researchers from Nanjing Agricultural University in China have conducted a study on the beneficial effects of postbiotics from Lactobacillus delbrueckii on intestinal health. The study found that postbiotics from L. delbrueckii alleviated intestinal inflammation in mice by increasing the survival rate and body weight, reducing inflammatory markers, improving intestinal barrier function, and modulating gut microbial diversity. Additionally, the postbiotics promoted the expansion of intestinal stem cells and increased the numbers of Paneth and Goblet cells. This research provides valuable insights into the potential therapeutic applications of postbiotics in protecting against intestinal inflammation. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the regulation of necroptosis, a form of cell death, for intestinal homeostasis. The study found that mice lacking a protein called Prmt5 in intestinal epithelial cells experienced premature death, necroptosis, villus atrophy, and loss of Paneth cells. The pathology could be partially rescued by antibiotic treatment, germ-free breeding conditions, and pharmaceutical inhibition of certain proteins. The researchers also identified a specific residue of a protein called RIPK3 that is involved in necroptosis and suggested that targeting this protein could be a potential treatment for necroptosis-related diseases. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at the IMBA and the Institute for Basic Science has identified a new gene, Daam1, that plays a crucial role in the development of secretory cells in the intestine. The researchers used intestinal organoids to investigate how tissue-specific stem cells determine which cell type to become. They found that Daam1 is required for the efficient formation of Paneth cells, which secrete growth factors that stimulate cell division. The study also suggests that tumor cells can modify their microenvironment to promote their own growth. This research provides new insights into stem cell differentiation and its implications for cancer research. [Extracted from the article]

A recent report from Chiba University in Japan discusses the role of angiogenin-4 (Ang4) in maintaining intestinal stem cells (ISCs) and inducing apoptosis in intestinal epithelial cells (IECs). The study found that Ang4, which is produced by Paneth cells in the small intestine and goblet cells in the colon, promotes the expansion of Lgr5+ ISCs and organoid growth through Wnt and Notch signaling. However, high concentrations of Ang4 also induce apoptosis in IECs. These findings suggest that Ang4 has a dual function in the crypt niche, both promoting ISC expansion and inducing apoptosis. [Extracted from the article]