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The outbreak of the COVID-19 in 2020 has a severe impact on all countries. This paper first studies the impact of the epidemic on the macro-economy in China, which is one of the countries with early epidemic situation, in the rapid development stage of the epidemic situation, and the specific performance in macro-economy aspects. On this basis, study the development trend and macroeconomic performance of the United States as one of the most serious countries, and the relationship between the epidemic development and macro-economy in the United States. As for the differences in epidemic control measures between China and the US, China's indicators are significant in terms of sentiment factors, but the impact of COVID-19 on the sentiment factors in the US is different. The Chinese government has not adopted unlimited easing and maintained consistent policies. At present, the economic impact of COVID-19 on the US is far greater than that of China. [ABSTRACT FROM AUTHOR]