43 results on '"Villeval, Jean-Luc"'
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2. Exacerbation of thromboinflammation by JAK2V617F mutation worsens the prognosis of cerebral venous sinus thrombosis
3. Comparison of endothelial promoter efficiency and specificity in mice reveals a subset of Pdgfb‐positive hematopoietic cells
4. Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis
5. Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes
6. The cell cycle regulator CDC25A is a target for JAK2V617F oncogene
7. Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation
8. Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines
9. Activating mutations in human acute megakaryoblastic leukemia
10. JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders
11. Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells
12. Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen
13. Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease
14. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily
15. Hematopoietic-specific β1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2
16. Pathophysiology of Thrombocytopenia and Anemia in Mice Lacking Transcription Factor NF-E2
17. Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis
18. 1017 – INVESTIGATING THE MECHANISMS OF IFNALPHA THERAPY IN JAK2V617F AND CALR MUTATED MYELOPROLIFERATIVE NEOPLASMS
19. Differential Impact of Interferon Alpha on JAK2V617F and Calr Mutated Hematopoietic Stem and Progenitor Cells in Classical MPN
20. Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis
21. Following the in vivo expansion of a myeloproliferative disease
22. Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice
23. Complete Inhibition of STAT5 Phosphorylation Is Achieved By Combination of JAK1/2 and PI3K/mTOR Inhibitors in in Vitro and In Vivo MPN Models
24. Use Of 46/1 Haplotype Permits To Follow JAK2V617F Clonal Architecture In PV Patients: Clonal Evolution and Impact Of IFNα Treatment
25. Effect Of The JAK1/2 Inhibitor GS-0387 (momelotinib) On The Anemia Associated With a Preclinical Murine Model Of Human Primary Myelofibrosis
26. 46/1 Haplotype Permits to Follow JAK2 Homologous Recombination: Modeling JAK2V617F clonal Architecture in PV Patients
27. Combined Inhibition of JAK2 and mTOR Signaling Results in Enhanced Efficacy in in-Vitro and Preclinical Mouse Models of JAK2V617F-Driven Myeloproliferative Disease
28. Combination Treatment with JAK2 and PI3K Inhibitors in Myeloproliferative Neoplasms
29. The Cell Cycle Regulator CDC25A Is a Target for JAK2V617F Oncogene
30. Platelet Phenotype and Thrombosis In JAK2V617F Mice
31. JAK2V617F Promotes Stem Cell Amplification Driving MPN Clonal Dominance in Mice and Treatment by IFNa Prevents This Effect
32. Novel Mutations: Dissecting Pathogenetic Contribution
33. Ligand-Independent MPLW515L Activity Requires Cell Surface Localization
34. Increased Myelofibrosis in Thrombospondin-1-Null Mice Is Associated with Enhanced TGF-β1-Mediated Response by Bone Marrow Fibroblasts
35. JAK2 Activation Stimulates Homologous Recombination and Genetic Instability.
36. Human Platelet Glycoprotein VI: Identification of Residues Involved in the Binding to Collagen.
37. Regulation of megakaryocytopoiesis and platelet production: Lessons from animal models
38. Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to Megakaryocytes
39. Thrombopoietin Does Not Induce Lineage-Restricted Commitment of Mpl-R Expressing Pluripotent Progenitors But Permits Their Complete Erythroid and Megakaryocytic Differentiation
40. Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on Hematopoietic Progenitor Cells in Cancer Patients
41. Missense Mutation of the Erythropoietin Receptor Is a Rare Event in Human Erythroid Malignancies
42. High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice
43. Autocrine Stimulation by Erythropoietin (Epo) Requires Epo Secretion
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