42 results on '"Shen, Jingkang"'
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2. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors
3. Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction
4. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
5. Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
6. Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site
7. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
8. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
9. Stereoselective addition of Grignard reagents to (2-methyl-5-tert-butyl)phenyl 1-thio-β-D-ribopentodialdo-1,4-furanoside derivative
10. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity
11. Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic
12. Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design
13. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors
14. Synthesis and biological evaluation of 6H-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization
15. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
16. Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors
17. Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors
18. (N,N-Diisopropylcarbamoyloxy)-methyl p-tolyl sulfone: preparation and application for the syntheses of 1,2-diols
19. Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists
20. Discovery of benzhydrylpiperazine derivatives as CB 1 receptor inverse agonists via privileged structure-based approach
21. Aromatic β-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists
22. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
23. Illudalic acid as a potential LAR inhibitor: Synthesis, SAR, and preliminary studies on the mechanism of action
24. Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates
25. One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation
26. Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors
27. Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor
28. Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L
29. Preparation of 5′-deoxy-5′-amino-5′-C-methyl adenosine derivatives and their activity against DOT1L
30. Design and synthesis of benzylpiperidine inhibitors targeting the menin–MLL1 interface
31. Formation of 1,3-diazocine by palladium catalyzed C–H arylation
32. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
33. Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors
34. 1,2-trans-1-Dihydroxyboryl benzyl S-glycoside as glycosyl donor
35. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
36. CCLab—a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design
37. Potent and novel 11β-HSD1 inhibitors identified from shape and docking based virtual screening
38. A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate
39. Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors
40. Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones
41. Synthesis of pyrrolidine analogues of solamin
42. WITHDRAWN: Design, synthesis and biological evaluation of 3-substituted-4-anilinequinoline as EGFR tyrosine kinase inhibitors
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