38 results on '"Mori, Mattia"'
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2. Inhibitors of UHRF1 base flipping activity showing cytotoxicity against cancer cells
3. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors
4. Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment
5. Thienoguanosine, a unique non-perturbing reporter for investigating rotational dynamics of DNA duplexes and their complexes with proteins
6. Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity
7. SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
8. Conformational insights into the C-terminal mutations of human rhodopsin in retinitispigmentosa
9. Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
10. Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma
11. Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro
12. Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines
13. Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1
14. Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors
15. Current trends in Hedgehog signaling pathway inhibition by small molecules
16. Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold
17. A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
18. Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein
19. Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
20. Natural modulators of nonalcoholic fatty liver disease: Mode of action analysis and in silico ADME-Tox prediction
21. Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells
22. Chapter 2.1 - DNA and RNA polymerases
23. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro
24. Discovery of in vitro antitubercular agents through in silico ligand-based approaches
25. Targeting GLI factors to inhibit the Hedgehog pathway
26. Small molecules modulation of 14-3-3 protein–protein interactions
27. Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein
28. Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP
29. Contributors
30. Probing the Pore Drug Binding Site of Microtubules with Fluorescent Taxanes: Evidence of Two Binding Poses
31. 2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4- d]pyrimidines Src-Abl dual inhibitors
32. A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia
33. Hetero Diels–Alder reactions (HDAR) of α,α′-dioxothiones on solid support
34. SAT002 - Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
35. Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1
36. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein–protein interactions
37. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor
38. Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case
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