78 results on '"Kirk, Christopher"'
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2. Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation
3. Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen–Disparate Murine Model
4. Anti-leukemic activity and mechanisms underlying resistance to the novel immunoproteasome inhibitor PR-924
5. Chapter 18 - Kyprolis (carfilzomib) (approved): a covalent drug with high extrahepatic clearance via peptidase cleavage and epoxide hydrolysis
6. The immunoproteasome in antigen processing and other immunological functions
7. Validation of the Proteasome as a Therapeutic Target in Plasmodium Using an Epoxyketone Inhibitor with Parasite-Specific Toxicity
8. Discovery and Development of Second-Generation Proteasome Inhibitors
9. Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
10. Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer
11. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
12. N-terminal Domains of DELLA Proteins Are Intrinsically Unstructured in the Absence of Interaction with GID1/Gibberellic Acid Receptors
13. An E. coli expression system optimized for DELLA proteins
14. Endocrine disrupting alkylphenols: Structural requirements for their adverse effects on Ca 2+pumps, Ca 2+ homeostasis & Sertoli TM4 cell viability
15. Expression in Escherichia coli and in vitro refolding of the plant transcription factor Arabidopsis thaliana RGL3
16. A novel peptide tag for detection and purification of recombinant expressed proteins
17. Impact of Immunoproteasome Inhibition in Preclinical Studies of Hemophagocytic Lymphohistiocytosis
18. Environmental endocrine disrupters dysregulate estrogen metabolism and Ca 2+ homeostasis in fish and mammals via receptor-independent mechanisms
19. Alkylphenol endocrine disrupters inhibit IP 3-sensitive Ca 2+ channels
20. 3112 – IMPACT OF IMMUNOPROTEASOME INHIBITION IN MOUSE MODEL OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
21. Immune Evasion by Muscle-Specific Gene Expression in Dystrophic Muscle
22. Analysis of Muscle Creatine Kinase Regulatory Elements in Recombinant Adenoviral Vectors
23. Sulfation of “Estrogenic” Alkylphenols and 17β-Estradiol by Human Platelet Phenol Sulfotransferases
24. Binding of human immunodeficiency virus type 1 nucleocapsid protein to Ψ-RNA-SL3
25. Age-Related Decline in Activation of JNK by TCR- and CD28-Mediated Signals in Murine T-Lymphocytes
26. Age-Sensitive and -Insensitive Pathways Leading to JNK Activation in Mouse CD4+ T-Cells
27. Protein Translocation Inhibitors Overcome Cytokine-Induced Glucocorticoid Resistance in T-Cell Acute Lymphoblastic Leukemia
28. Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies
29. Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61
30. Contributors
31. Development Of Methods To Perform Next Generation Sequencing (NGS)-Based Genomics Studies On Multiple Myeloma Clinical Samples
32. Selective Inhibitor Of Nuclear Exports (SINE) KPT-330 In Combination With The Novel Proteasome Inhibitor Carfilzomib As a Novel Therapeutic Regimen For Treating Aggressive B-Cell Lymphomas
33. A Method To Identify Copy Number Aberrations (CNAs) From Whole Exome Sequence (WES) Data and Its Application To Multiple Myeloma Cell Lines and Patient Samples
34. Inhibition Of The Immunoproteasome Subunit LMP7 Decreases Alloresponses In Both MHC-Mismatched and miHA-Disparate Murine Models Of Graft Versus Host Disease
35. Blocking Protein Secretion and Degradation Is a Novel Treatment Strategy For Malignant Cells With High Protein Load
36. Survival Pathways Stabilized By Proteasome Inhibition Reveal PIM2 As a Novel Target For Potentiating The Anti-Myeloma Activity Of Carfilzomib
37. Inhibition Of Autophagy By ACY-1215, a Selective HDAC6 Inhibitor Accelerates Carfilzomib-Induced Cell Death In Multiple Myeloma
38. The Novel Immunoproteasome Inhibitor PR-924: Anti-Leukemic Activity and Mechanisms Of Resistance
39. Immunoglobulin Expression Is a Major Determinant Of Patient Sensitivity To Proteasome Inhibitors
40. Carfilzomib, a Second-Generation Proteasome Inhibitor, In Combination With The Btk Inhibitor Ibrutinib As a Novel Therapeutic Regimen For Treating Double Hit DLBCL
41. A Novel Bruton′s Tyrosine Kinase Inhibitor CC-292 In Combination With The Proteasome Inhibitor Carfilzomib Iimpacts Multiple Myeloma Bone Microenviroment With Resultant Anti-Myeloma Activity
42. Use of the Immunoproteasome Subunit LMP7 Inhibitor to Ameliorate Gvhd in an MHC-Matched miHA-Disparate Murine Model
43. Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutive PSMB5
44. Constitutive and immunoproteasome crystal structures reveal differences in substrate and inhibitor specificity
45. Potent Inhibition of Multiple Proteasome Subunits by Carfilzomib in Multiple Myeloma and Solid Tumor Patients
46. Carfilzomib, An Irreversible Proteasome Inhibitor, Induces Long-Term Growth Inhibition of Mantle Cell Lymphoma In Vivo,
47. Epoxyketone-Based Proteasome Inhibitors Carfilzomib and Orally Bioavailable ONX 0912 Have Anti-Resorptive and Bone-Anabolic Activity in Addition to Anti-Myeloma Effects
48. Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression
49. Induction of Metabolic Impairment In Prolonged Early G1 Arrest Induced by CDK4/CDK6 Inhibition Sensitizes Myeloma Cells for Proteasome Inhibitor Killing During Subsequent S Phase Synchronization
50. Dose Intensive Administration of PR-047, a Novel Orally Bioavailable Inhibitor of the 20S Proteasome, Is Well Tolerated in Experimental Animals.
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