34 results on '"Greiter-Wilke, Andrea"'
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2. Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory
3. Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As
4. Unexpected neurotoxicity in chronic toxicity studies with a HBV viral expression inhibitor
5. The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis
6. Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute
7. Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species
8. Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa
9. The Safety Pharmacology Society salary survey
10. Human ex-vivo action potential model for pro-arrhythmia risk assessment
11. Cardiovascular safety assessments in the cynomolgus monkey: Unmasking potential background arrhythmias in general toxicity studies
12. Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies
13. Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development
14. Preclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortium
15. Rodent respiratory findings with mGlu5 positive allosteric modulator RG7342, translation to non-rodent and man
16. Current nonclinical in vivo safety pharmacology testing enables safe entry to first-in-human clinical trials: The IQ consortium nonclinical to clinical translational database
17. Cardiovascular effects of RTR2996, a single stranded oligonucleotide, in the minipig
18. Feasibility studies to investigate the use of jacketed telemetry in the Göttingen minipig for the assessment of ECG and respiration
19. Cardiovascular effects of verapamil in the Göttingen minipig
20. JTp and Tpe as Biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortium
21. An Overview of the Safety Pharmacology Society (SPS) Strategic Plan (2016-2018)
22. CiPA-like Cardiovascular In Silico Modeling—Two Case Reports
23. Assessing Cardiotoxicity In Vitro: A Comparison of Complexity
24. The electromechanical window (EMw): A heart-rate independent biomarker for delayed repolarization of the heart
25. Human ex-vivo action potential model for pro-arrhythmia risk assessment
26. Using a new implantable telemetry device to examine the effects of L-NAME on cardiovascular parameters in the Göttingen minipig
27. Atrioventricular block in the Mauritian cynomolgus monkey—A not so uncommon arrhythmia?
28. Applying the audiogenic seizure model to evaluate the interaction with anticonvulsant treatment
29. How do large pharmaceutical companies mitigate concerns of drug-induced QT prolongation in drug discovery?
30. Thioridazine-induced QTc prolongation: Minipig is more sensitive than the dog
31. Evaluation of a CNS compound in two species: Differential pharmacological responses in dogs and minipigs
32. Assessment of the relationship between core body temperature and QT/QTc in the minipig using Dihydrocapsaicin
33. Comparison of high definition oscillometry and telemetry for blood pressure measurements in conscious dogs: Effects of torcetrapib
34. Application of the probabilistic method for QT rate-correction in telemetered beagles: Effects of moxifloxacin
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