44 results on '"Commandeur, Jan N.M."'
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2. Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment
3. Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis
4. High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions
5. A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants
6. Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium
7. Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism
8. Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
9. Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity
10. Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer
11. Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants
12. Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants
13. Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites
14. Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs
15. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen
16. Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast
17. Application of a Fluorescence-Based Continuous-Flow Bioassay to Screen for Diversity of Cytochrome P450 BM3 Mutant Libraries
18. Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR
19. Structure–activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues
20. Online Biochemical Detection of Glutathione-S-Transferase P1-Specific Inhibitors in Complex Mixtures
21. Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography–mass spectrometry
22. Cytochrome P450 bio-affinity detection coupled to gradient HPLC: On-line screening of affinities to cytochrome P4501A2 and 2D6
23. Development of a Novel Cytochrome P450 Bioaffinity Detection System Coupled Online to Gradient Reversed-Phase High-Performance Liquid Chromatography
24. Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
25. Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate β-lyase
26. The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene
27. Corrigendum to “Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment” [Toxicol. Lett. 341 (2021) 94–106]
28. Biomarkers of free radical damage: Applications in experimental animals and in humans
29. Effect of polymorphism of CYP2C8 on hydroxylation of diclofenac acyl-glucuronide
30. Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection
31. Identification and quantitative determination of 3-chloro-2-hydroxypropylmercapturic acid and α-chlorohydrin in urine of rats treated with epichlorohydrin
32. Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes
33. 3-Chloro-2-hydroxypropylmercapturic acid and α-chlorohydrin as biomarkers of occupational exposure to epichlorohydrin
34. Protective effects of lobenzarit against allyl alcohol-induced hepatotoxicity in mice and rats
35. Novel piperidine derivatives: inhibitory properties towards cytochrome P450 isoforms, and cytoprotective and cytotoxic characteristics
36. Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study
37. Comparative cytotoxicity of 14 novel selenocysteine Se-conjugatesin rat renal proximal tubular cells
38. Evaluation of Urinary Biomarkers for Radical-Induced Liver Damage in Rats Treated with Carbon Tetrachloride
39. The Use of Humanin VitroMetabolic Parameters to Explore the Risk Assessment of Hazardous Compounds: The Case of Ethylene Dibromide
40. Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes
41. In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
42. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver
43. P2A236 - Activation of microsomal glutathione S-transferase as a tool in environmental and molecular toxicology
44. Cytochrome P-450-catalysed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats
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