1. Early life peer victimization : associated neural structure and reactivity to social-emotional stimuli, drinking motives, and alcohol use in young adulthood
- Author
-
Tretyak, Valeria
- Subjects
- Peer victimization, Adolescent, Young adult, Neurobiology, Drinking motives, Alcohol use
- Abstract
Peer victimization—otherwise known as bullying victimization—is a known risk factor for increased alcohol use, however the neural correlates of this association remain unknown. Early life peer victimization may impact neural affect reactivity, which may contribute to alcohol use as a maladaptive coping mechanism later in life. Peer victimization has been associated with differential structure and/or function of the orbitofrontal, anterior cingulate and insula cortices, and amygdala. These neural networks have also been implicated in affect reactivity and regulation, heavy drinking, and addiction. Whether differential structure and/or function of these neural regions is associated with greater alcohol use in young adults with history of peer victimization has not been directly investigated. This dissertation comprised a secondary data analysis in IMAGEN—a multinational European research project. This study aimed to investigate whether greater early life peer victimization (ages:14-22) is associated with differential structure and function (Angry-Neutral-Faces Task) in orbitofrontal, anterior cingulate and insula cortices, and amygdala in 674 young adults (53% female, mean age:22 [SD:1]). Additionally, this study investigated whether increased alcohol use associated with peer victimization is mediated by greater endorsement of coping anxiety and depression drinking motives, and whether this mediation is, in turn, moderated by differences in gray matter volume and/or functional activation in a priori regions of interest. Higher peer victimization scores were associated with greater gray matter volume in left anterior insula, and lower functional activation in left orbitofrontal cortex when viewing angry compared to neutral faces. Coping anxiety and depression drinking motives fully mediated relations between most severe peer victimization scores and greater frequency and quantity of recent alcohol use. Additionally, most severe peer victimization scores were associated with greater coping depression drinking motives in participants with lower gray matter volume in left anterior insula, and in young adult females with lower functional activation in left orbitofrontal cortex. Follow-up studies are needed to replicate—and expand upon—these findings. Identifying biomarkers of greater alcohol use in young adults with history of peer victimization may provide the foundation for future clinical trials and development of prevention initiatives aimed at decreasing risk of alcohol misuse.
- Published
- 2023