1. New drug-strategies to tackle viral-host interactions for the treatment of influenza virus infections
- Author
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van de Wakker, Simonides I, Fischer, Marcel J E, Oosting, Ronald S, Pharmacology, Chemical Biology and Drug Discovery, Afd Chemical Biology and Drug Discovery, Pharmacology, Chemical Biology and Drug Discovery, and Afd Chemical Biology and Drug Discovery
- Subjects
0301 basic medicine ,Population ,Hyper immune reaction ,Drug development ,Biology ,medicine.disease_cause ,Antiviral Agents ,Virus ,03 medical and health sciences ,Pandemic ,Influenza, Human ,Influenza A virus ,medicine ,Animals ,Humans ,Drug Interactions ,Host targets ,education ,Pharmacology ,education.field_of_study ,Outbreak ,H5N1 ,World population ,Orthomyxoviridae ,Virology ,Influenza A virus subtype H5N1 ,030104 developmental biology ,Host-Pathogen Interactions - Abstract
The influenza virus (IV) is a highly contagious virus causing seasonal global outbreaks affecting annually up to 20% of the world's population and leading to 250,000-500,000 deaths worldwide. Current vaccines have variable effectiveness, and, in particular during a pandemic outbreak, they are probably not available in the amounts needed to protect the world population. Therefore we need effective small molecule drugs to combat an IV infection and that can be produced, in case of pandemic, rapidly and in large quantities. Unfortunately, natural occurring IV becomes more and more resistant to current anti-IV drugs. And thus, there is an urgent need for development of alternative agents with new mechanisms of action. This review provides an overview of the pharmacology and effectiveness of new anti-IV agents, focusing on inhibition mechanisms directed against virus-host interactions.
- Published
- 2017