1. Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
- Author
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Ronald C. McGarry, Bhaswanth Dhanireddy, J Molloy, Damodar Pokhrel, Marcus E. Randall, and Lana Sanford
- Subjects
Lung Neoplasms ,stereotactic lung treatment ,VMAT ,Dose distribution ,outcomes ,Radiosurgery ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Lung lesion ,Carcinoma, Non-Small-Cell Lung ,medicine ,Effective treatment ,Radiation Oncology Physics ,Humans ,Radiology, Nuclear Medicine and imaging ,Four-Dimensional Computed Tomography ,Radiometry ,Instrumentation ,Patient comfort ,beam‐on time ,Radiation ,Flattening filter free ,Lung ,business.industry ,Radiotherapy Planning, Computer-Assisted ,FFF‐beam ,Cone-Beam Computed Tomography ,Volumetric modulated arc therapy ,medicine.anatomical_structure ,single dose ,030220 oncology & carcinogenesis ,Radiotherapy, Intensity-Modulated ,Ct imaging ,business ,Nuclear medicine ,Algorithms ,Follow-Up Studies - Abstract
Cone‐beam CT‐guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four‐dimensional (4D) CT‐based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X‐FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow‐up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow‐up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.
- Published
- 2020