1. Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
- Author
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William H. Gerwick, Hua Tang, Hui-ming Hua, Jiao Li, Baoshu Liu, Wen Zhang, Wei Zhou, and Heng-Chao E
- Subjects
China ,South china ,Oceans and Seas ,Medicinal & Biomolecular Chemistry ,Coral ,diterpenoid ,Pharmaceutical Science ,Antineoplastic Agents ,Junceella gemmacea ,junceellolide ,Growth inhibitory ,Drug Screening Assays ,Physical Chemistry ,Article ,Cell Line ,Cell Line, Tumor ,Neoplasms ,Anthozoa ,Drug Discovery ,Botany ,Animals ,Humans ,Bioassay ,lcsh:QH301-705.5 ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Tumor ,biology ,Spectrum Analysis ,Absolute configuration ,Antitumor ,Pharmacology and Pharmaceutical Sciences ,biology.organism_classification ,Terpenoid ,Gorgonian ,lcsh:Biology (General) ,briarane ,Drug Screening Assays, Antitumor ,Diterpenes ,Physical Chemistry (incl. Structural) - Abstract
Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1–3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.
- Published
- 2014