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Additional file 2. Supplementary Tables incuding Table S1, Table S2 and Table S3.

Additional file 1. Supplementary Figure S1. A schematic illustrating the inclusion/exclusion of the participants.

Supplemental material, sj-docx-4-dhj-10.1177_20552076221113393 for Use of handheld electrocardiograph (SnapECG) for the remote monitoring of arrhythmias by Qian Gu, Zengguang Chen, Jiazheng Ma, Yaqing Zhou, Jinshuang Li, Lianghong Ying, Rui Hua, Wenhao Zhang, Ran Li, Fengwei Zou, Xiaoxuan Gong, Yiyang Zhan and Chunjian Li in Digital Health

Additional file 2: Table S1. Interaction analyses between BTBD7_hsa_circ_0000563 and 7 proteins Table S2. Baseline characteristics of the subjects undergoing western blot.

Additional file 1: Figure S1 PSM score distribution. (a) Distribution of peptide score. (b) Scatterplot of peptide score versus precursor mass error. Decoy represented error spectrums and Target represented target spectrums. The vertical dotted line represented the threshold of PSM score which was set as filter criteria.

Objective: To explore the efficacy of Jianpiyangxue granules on gastrointestinal autonomic nerve dysfunction and their impact on adverse reactions. Methods: From September 2016 to September 2020, 120 patients with gastrointestinal autonomic nerve dysfunction treated in our hospital were retrospectively selected and randomly assigned to a treatment group (TG) which was administered Jianpiyangxue granules prepared by our hospital and a control group (CG) which was administered routine Western medicine treatment (B vitamins + oryzanol). There were 60 patients in each group. The clinical efficacy and incidences of adverse effects were compared between the groups. The gastrointestinal hormone indexes, the inflammatory cytokines, and the immune indexes were analyzed before and after the therapy. The gastrin (GAS) and motilin (MTL) levels were measured using the motilin stimulating method, and the somatostatin (SS) levels were measured using ELISA for comparison. The autonomic nerve dysfunction symptoms were used for the evaluation. The degree of neurological functional defects scale (NIHSS) was used to assess the neurological functional defect levels. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores were used to assess the patients’ psychological statuses. Results: After the therapy, the GAS, MTL, and SS expressions in the TG were remarkably higher than they were in the CG. The CRP and IL-6 expressions in the TG were significantly lower than they were in the CG. The TG had higher IgG, IgM, and IgA levels as compared with the CG, higher grade 0 and grade 1 scores on the gastrointestinal autonomic nerve dysfunction, but lower grade 2 and 3 scores were observed compared to the CG. Significantly lower NIHSS, SAS, and SDS scores were recorded in the TG compared with the CG. The TG yielded more promising outcomes in terms of the total effective rate and the incidences of adverse reactions than the CG. Conclusion: Jianpiyangxue granules contribute to enhancing the clinical efficacy, reducing the incidence of adverse reactions, and improving the gastrin, somatostatin, and other indicators in treating gastrointestinal autonomic nerve dysfunction.

Black carbon (BC) aerosol plays an important role in the Earth's radiative balance. An intensive measurement campaign was conducted at Xi'an, China, from December 2012 to January 2013 to investigate the sources and physicochemical characteristics of refractory BC (rBC) and its direct radiative forcing at the surface. The overall average rBC concentration for the campaign was 8.0 ± 7.1 µg m−3. Source apportionment based on positive matrix factorization showed that traffic was the dominant rBC source (46.0%), followed by coal burning (33.9%) and biomass burning (20.1%). The rBC mass size distributions were monomodal and lognormal with larger mass median diameters for coal burning source (215 nm) compared with the traffic source (189 nm). Coal burning rBC was more strongly associated with sulfate than traffic rBC, suggesting a higher cloud condensation nuclei activity. The slope of a robust linear regression between rBC and carbon monoxide (CO) for all samples was 5.9 µg m−3 ppm−1, and the slope for the coal burning source (4.5 µg m−3 ppm−1) was larger than that for the traffic source (2.7 µg m−3 ppm−1). The net rBC emission during winter of 2009 was estimated to be 4.5 Gg based on the relationship between rBC and CO. A Tropospheric Ultraviolet and Visible radiation model showed that the average daytime value for the clear-sky direct radiative forcing due to rBC from 23 December 2012 to 31 January 2013 was −47.7 ± 28.9 W m−2, which amounted to an average of 45.7% of the total surface atmospheric aerosol forcing.

Reactive oxygen species (ROS) are believed to contribute to the adverse health effects of aerosols. This may happen by inhaled particle-bound (exogenic) ROS (PBROS) or by ROS formed within the respiratory tract by certain aerosol components (endogenic ROS). We investigated the chemical composition of aerosols and their exogenic ROS content at the two contrasting locations Beijing (China) and Bern (Switzerland). We apportioned the ambient organic aerosol to different sources and attributed the observed water-soluble PB-ROS to them. The oxygenated organic aerosol (OOA, a proxy for secondary organic aerosol, SOA) explained the highest fraction of the exogenic ROS concentration variance at both locations. We also characterized primary and secondary aerosol emissions generated from different biogenic and anthropogenic sources in smog chamber experiments. The exogenic PB-ROS content in the OOA from these emission sources was comparable to that in the ambient measurements. Our results imply that SOA from gaseous precursors of different anthropogenic emission sources is a crucial source of water-soluble PB-ROS and should be additionally considered in toxicological and epidemiological studies in an adequate way besides primary emissions. The importance of PB-ROS may be connected to the seasonal trends in health effects of PM reported by epidemiological studies, with elevated incidences of adverse effects in warmer seasons, which are accompanied by moreintense atmospheric oxidation processes.

Reactive oxygen species (ROS) are believed to contribute to the adverse health effects of aerosols. This may happen by inhaled particle-bound (exogenic) ROS (PB-ROS) or by ROS formed within the respiratory tract by certain aerosol components (endogenic ROS). We investigated the chemical composition of aerosols and their exogenic ROS content at the two contrasting locations Beijing (China) and Bern (Switzerland). We apportioned the ambient organic aerosol to different sources and attributed the observed water-soluble PB-ROS to them. The oxygenated organic aerosol (OOA, a proxy for secondary organic aerosol, SOA) explained the highest fraction of the exogenic ROS concentration variance at both locations. We also characterized primary and secondary aerosol emissions generated from different biogenic and anthropogenic sources in smog chamber experiments. The exogenic PB-ROS content in the OOA from these emission sources was comparable to that in the ambient measurements. Our results imply that SOA from gaseous precursors of different anthropogenic emission sources is a crucial source of water-soluble PB-ROS and should be additionally considered in toxicological and epidemiological studies in an adequate way besides primary emissions. The importance of PB-ROS may be connected to the seasonal trends in health effects of PM reported by epidemiological studies, with elevated incidences of adverse effects in warmer seasons, which are accompanied by more-intense atmospheric oxidation processes., Atmospheric Chemistry and Physics, 19 (23), ISSN:1680-7375, ISSN:1680-7367