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Consistency is a significant indicator to measure the correctness of a software system in its lifecycle. It is inevitable to introduce inconsistencies between different software artifacts in the software development process. In practice, developers perform consistency checking to detect inconsistencies, and apply their corresponding repairs to restore consistencies. Even if all inconsistencies can be repaired, how to preserve consistencies in the subsequent evolution should be considered. Consistency management (consistency checking and consistency preservation) is a challenging task, especially in the multi-view model-driven software development process. Although there are some efforts to discuss consistency management, most of them lack the support of formal methods. Our work aims to provide a framework for formal consistency management, which may be used in the practical software development process. A formal model, called a Structure model, is first presented for specifying the overall model-based structure of the software system. Next, the definition of consistency is given based on consistency rules. We then investigate consistency preservation under the following two situations. One is that if the initial system is inconsistent, then the consistency can be restored through repairs. The other is that if the initial system is consistent, then the consistency can be maintained through update propagation. To demonstrate the effectiveness of our approach, we finally present a case study with a prototype tool.

This is the first time to explore the self-assembly process of double butterfly-shaped lanthanide high-nucleus clusters and propose their possible assembly mechanism.

Widespread concern has been raised over the synthesis of highly nucleated lanthanide clusters with special shapes and/or specific linkages. Construction of lanthanide clusters with specific shapes and/or linkages can be achieved by carefully regulating the hydrolysis of lanthanide metal ions and the resulting hydrolysis products. However, studies on the manipulation of lanthanide-ion hydrolysis to obtain giant lanthanide-oxo clusters have been few. In this study, we obtained a tetraicosa lanthanide cluster (

Wireless positioning and tracking technology are key technologies in applying wireless sensor networks and have vital research significance and application value. In this paper, in terms of positioning multiple non-coincident dynamic targets, aiming at the problem of low precision and large computational complexity when locating multiple dynamic targets by the two-step least squares algorithm and the constrained total least squares algorithm, an improved constrained total least squares algorithm is proposed. This algorithm fully considers the constraints, introduces the Lagrangian multiplier technology and the quasi-Newton BFGS iterative formula, avoids the calculation of the Hessian matrix, reduces the amount of calculation, and improves the positioning accuracy. Simulation experiments show that when the measurement error and sensor position error are moderate, the ICTLS positioning algorithm has a smaller RMSE than the TSWLS and CTLS positioning algorithms, showing higher positioning accuracy and stronger robustness. Secondly, aiming at the problem that the target is close to the reference node or any coordinate axis causes the positioning error of the traditional positioning algorithm to increase sharply, an optimized two-step least squares algorithm is proposed. This algorithm corrects the defects of the TSWLS algorithm by selecting the reference station and rotating the coordinate system again, and improves the positioning performance of the algorithm while reducing the amount of calculation.

Background: Human adipose-derived stem cells (hASCs) play an important role in regenerative medicine. Objective: Exploring the mechanism of Rg1 in the promotion of the proliferation and adipogenic differentiation of hASCs is important in regenerative medicine research. Methods: To observe ginsenoside Rg1 in promoting the proliferation and adipogenic differentiation of hASCs, Rg1 medium at different concentrations was established and tested using the cell counting kit-8 (CCK-8) assay, oil red O staining, alizarin red, and alcian blue. Compared to the control, differentially expressed genes (DEGs) were screened via DEG analysis, which was carried out in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. To explore the relationship among mRNA, long non-coding RNA (lncRNA) and microRNA (miRNA), we constructed a competing endogenous RNA (ceRNA) network. Results: In this study, Rg1 was observed to promote the proliferation and adipogenic differentiation of hASCs. Additionally, enriched BPs and KEGG pathways may be involved in the promotion process, where FXR1 and Lnc-GAS5-AS1 were found to be regulatory factors. The regulatory network suggested that Rg1 could regulate the adipocytokine signaling pathway and IL−17 signaling pathway via FXR1 and Lnc-GAS5-AS1, which served as the mechanism encompassing the promotion of Rg1 on the proliferation and adipogenic differentiation of hASCs. Conclusion: A comprehensive transcriptional regulatory network related to the promotion ability of Rg1 was constructed, revealing mechanisms regarding Rg1’s promotion of the proliferation and adipogenic differentiation of hASCs. The present study provides a theoretical basis for optimizing the function of hASCs.

The Tauc plot method is widely used to determine the bandgap of semiconductors via UV-visible optical spectroscopy due to its simplicity and perceived accuracy. However, the actual Tauc plot often exhibits significant baseline absorption below the expected bandgap, leading to discrepancies in the calculated bandgap depending on whether the linear fit is extrapolated to zero or non-zero baseline. In this study, we show that both extrapolation methods can produce significant errors by simulating Tauc plots with varying levels of baseline absorption. To address this issue, we propose a new method that involves idealizing the absorption spectrum by removing its baseline before constructing the Tauc plot. Experimental verification of this method using a gallium phosphide (GaP) wafer with intentionally introduced baseline absorptions shows promising results. Furthermore, we apply this new method to cubic boron arsenide (c-BAs) and resolve discrepancies in c-BAs bandgap values reported by different groups, obtaining a converging bandgap of 1.835 eV based on both previous and new transmission spectra. The method is applicable to both indirect and direct bandgap semiconductors, regardless of whether the absorption spectrum is measured via transmission or diffuse reflectance, will become essential to obtain accurate values of their bandgaps.

To guarantee the safety and security of a real-time mobile system such as an intelligent transportation system, it is necessary to model and analyze its behaviors prior to actual development. In particular, the mobile objects in such systems must be isolated from each other so that they do not collide with each other. Since isolation means two or more mobile objects must not be located in the same place at the same time, a scheduling policy is required to control and coordinate the movement of such objects. However, traditional scheduling theories are based on task scheduling which is coarse-grained and cannot be directly used for fine-grained isolation controls. In this article, we first propose a fine-grained event-based formal model called a time dependency structure and use it to model and analyze real-time mobile systems. Next, an event-based schedule is defined and the composition of schedules is discussed. Then, we investigate the schedulability of isolation—that is, checking whether a given schedule ensures the isolation relationship among mobile objects or not. After that, we present an automation approach for scheduling generation to guarantee isolation controls in real-time mobile systems. Finally, case studies and simulation experiments demonstrate the usability and effectiveness of our approach.

Although progress has been made in the design and synthesis of chiral lanthanide clusters with pleasing structural connections and special shapes, assembly rules that guide their directional construction are still lacking. We reacted R/S-mandelic acid hydrazide, 2,3-dihydroxybenzaldehyde and DyCl

This study is devoted to the evaluation of dynamic impedance of the arch dam foundation embedded in a complex layered half-space. For this purpose, a modified scaled boundary finite element method (SBFEM) is developed for modeling the far field. In order to overcome the limits of scaling requirements of the original SBFEM, a scaled boundary transformation based on a scaling surface is developed, which can model the geometry of an infinitely long canyon exactly. Besides, the complex material portions of half-space can also be easily and exactly simulated using the modified scaled boundary transformation. Corresponding to the novel scaled boundary transformation, the governing equations of the modified SBFEM in terms of the displacement and dynamic stiffness are derived based on the frame work of Hamiltonian system. Comparison with existing solutions for a foundation supported on a semi-circular canyon in a homogeneous half-space confirms the accuracy and efficiency of the proposed approach. The effects of horizontal layers, shape of cross-section and the curved axis of canyon are investigated. The results show that the layers of half-space may have a significant effect on the dynamic stiffness of the canyon foundation.

We are the first to achieve the directional construction of chiral lanthanide clusters by regulating the hydroxyl coordination sites at different positions on the ligands by manipulating the annular growth mechanism.

China has achieved great economic and technological development, with the internet emerging as a further significant factor. Chinese millennials have grown up with the internet, which has shaped their ideas and behaviors. According to social change and human development theory, rapid development and popularization of communication technologies drive human change. Compared with traditional media, social media has become more integrated into people’s daily lives, which makes the effects of social media more potent. The current study tested the mediating role of desire for fame in relation to the connection between active WeChat use and future goals, including intrinsic and extrinsic goals. A sample of 422 Chinese university students completed a survey measuring active WeChat use, future goals, desire for fame, and narcissism. Results indicated that active WeChat use was associated with both extrinsic and intrinsic goals. Moreover, desire for fame mediated the association between active WeChat use and external and intrinsic goals. The mediation path linking active social media use to intrinsic goals differed from that linking active social media use to external goals. Compared with individuals with low-level narcissism, individuals with high-level narcissism who actively use WeChat were more likely to desire fame, which further drives them to pursue external goals. These findings advance understanding of how and when active WeChat use is associated with future goals for millennials, thus providing more empirical data at an individual level to enrich theory in the Chinese context.

The construction of the Yangtze River Economic Belt (YEB) is a great national economic development strategy in China. As the YEB covers most endemic provinces of schistosomiasis japonica featured by low endemicity, this study aimed to investigate the spatiotemporal distribution pattern of Oncomelania hupensis (O. hupensis), which serves as the only intermediate host of Schistosoma japonicum in the YEB. Annual data reflecting the distribution of O. hupensis from 2015 to 2021 were collected from the National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention. Spatial autocorrelation analysis, hotspot analysis and space–time scan analysis were performed to explore the aggregation features and spatiotemporal dynamics of the snail distribution. The distribution of both total snail habitats (during 2015–2021) and emerging snail habitats (in 2016, 2018 and 2020) showed spatial autocorrelation (Z = 15.8~16.1, p < 0.05; Z = 2.3~7.5, p < 0.05). Hotspot (high-value areas in space) counties were mainly clustered in the alluvial plain of the middle and lower reaches of the YEB. Eight spatial and temporal clusters of snail habitats were scanned and were mainly concentrated in the counties of Anhui, Jiangxi, Hubei, Hunan and Jiangsu provinces along the Yangtze River. The YEB carries a tremendous burden of O. hupensis. Surveillance and risk identification based on the snail presence should be strengthened to provide reference for protecting humans and public health security in the YEB.

Supplemental material, sj-docx-1-oag-10.1177_00307270231173137 for Use of “demonstration farm” videos to affect attitude change toward animal welfare on beef, egg, and fish farms in China by Yifei Yang, Tianxu Liu, Danielle Nilsson, Kate Hartcher, Hao-Yu Shih, Zhong-Hong Wu, Zhong-Ying Liu, Michelle Sinclair, Xochitl Samayoa, Kate Henning and Kris Descovich in Outlook on Agriculture

Microalgae-based antibiotic removal treatment has attracted attention because of its low carbon and sustainable advantages. The microalgal co-metabolism system with a suitable carbon source leads to enhanced performance of pollutant removal. However, currently, limited knowledge is available for the removal of fluoroquinolone using a microalgae-mediated co-metabolism system. In this study, we first investigated that the biotic processes by alga Haematococcus lacustris in the co-metabolism system by adding glycerol would be the main contributors responsible for the removal of 10 mg/L ofloxacin (OFL) with the efficiency of 79.73% and the removal of 10 mg/ L enrofloxacin (ENR) with the efficiency of 54.10%, respectively. Furthermore, we found that pyruvate from glycerol was converted into substrates and precursors, thereby resulting in the significant accumulations of microalgal astaxanthin and lipid. The astaxanthin content of H. lacustris was achieved at 4.81% and 4.69% treated with OFL and ENR in the presence of glycerol, with 16.04% and 14.55% of lipid content, respectively. The proposed metabolites and pathways were identified to plausibly explain the biodegradation of fluoroquinolone by H. lacustris. The molecular analyses demonstrated that cytochrome P450 (CYP450) enzymes are responsible for the biodegradation of fluoroquinolone, and it was further verified that fluoroquinolones might insert into CYP450 to finally form an efficient and tight binding conformation by molecular dynamic simulation. These findings provide a microalgae-based route for feasible and sustainable biodegradation of antibiotics using a co-metabolism strategy comprising glycerol as a carbon source, with the synergistic accumulation of valuable products., peer-reviewed

Water treatment is crucial to improve the water quality and reduce diarrheal and chronological diseases caused by excessive discharge of organic dyes and other waste. The development and expansion of efficient catalysts for the degradation and sterilization of organic dyes has attracted widespread attention. Herein, we report an example of a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) and its efficient sono-/photocatalytic degradation of organic dyes and bactericidal activity. The dislocated layers effectively avoid close π-π stacking and provide a porous space for oxygen/water/dye contact. The introduction of Zn ions increases the spin orbital coupling through the heavy atom effect and promotes the intersystem crossing process for singlet oxygen generation. The effective ligand-to-metal charge transfer and the excessive open Zn catalytic sites also facilitate water splitting for hydroxyl radical generation. These features together promote the reactive oxygen species (ROS) generation of 2DZnTcpp under light illumination or ultrasound sonication. It is worth noting that the 2DZnTcpp with a high specific surface area and porosity shows efficient sono-/photocatalytic degradation of organic dye waste. Moreover, 2DZnTcpp could also largely inactivate

As a safety-critical issue in complex mobile systems, isolation requires two or more mobile objects not to appear in the same place simultaneously. To ensure such isolation, a scheduling policy is needed to control and coordinate the movement of mobile objects. Unfortunately, existing task scheduling theories fails in providing effective solutions, because it is hardly possible to decompose a complex mobile system into multiple independent tasks. To solve this problem, a more fine-grained event scheduling is proposed in this paper to generate scheduling policies which can ensure the isolation of mobile objects. After defining event scheduling based on event-based formal models called dependency structures, a new event scheduling theory for mobile systems is developed accordingly. Then an algorithm for generating an event scheduling policy is proposed to implement the required isolation. Simulation experiments are conducted to prove the result of our theoretical analysis and show the effectiveness and scalability of the approach.

By changing the coordination anions (OAc

The established human health benefits of carotenoids along with the contemporary consumption of natural carotenoids bring the necessity to sustainable production of carotenoids. Among, marine diatoms have emerged as the potential biological resources for carotenoid production; however, their relatively lower yield in native strains provides the impetus to genetically improve the diatoms to cope with the burgeoning demand. In this study, we genetically improved the diatom Phaeodactylum tricornutum by overexpressing key carotenogenic genes involved in methylerythritol phosphate (MEP) pathway. The genes with lower relative transcript level under optimum conditions such as CMK and CMS were selected and overexpressed in P. tricornutum individually. Both CMK and CMS overexpressing lines exhibited elevated growth and photosynthesis. The expression of key carotenogenic genes such as PSY, PDS, ZDS, CRT, and LCYB was significantly upregulated. Furthermore, total carotenoid content was significantly increased; particularly, fucoxanthin content was increased by 1.83- and 1.82-fold in engineered lines CMK and CMS, respectively. Together, the results identify the potential metabolic targets and also uncover the crucial role of MEP pathway in redirecting metabolic precursors towards carotenogenesis. KEY POINTS: • Low abundant genes CMS and CMK of MEP pathway were overexpressed in the diatom • Total carotenoid content was increased, particularly fucoxanthin • Critical metabolic nodes were uncovered to accelerate fucoxanthin biosynthesis.

Two Dy4 complexes, namely, [Dy4(L1)4(NO3)2(μ3-OH)2]·2C2H5OH·3H2O (1) and [Dy4(L2)4(NO3)2(μ3-OH)2]·3C2H5OH·8H2O (2), were successfully designed and synthesized under solvothermal conditions. X-ray d...

Although various lanthanide clusters with different shapes and connections have been synthesised, more rules are still needed to guide their further serial expansion and directed structural modific...

Objective: To investigate the prevalence of myopia among children and adolescents in a local area (Liyang City) of China and analyze the influencing factors, so as to formulate corresponding preventive measures. Methods: A questionnaire survey was conducted, mainly investigating subjects’ age, gender, residence (urban/rural areas), parental myopia, daily time spent outdoors, daily sleep time, distance between computer screen and eyes, less than one punch (10 cm) from the chest to the edge of the desk when reading and writing, one inch (3 cm) between finger and pen tip when writing, number of in-school physical education (PE) classes, length of TV watching, and size of TV. The myopia of all participants was recorded. Results: This study enrolled 7,948 children and adolescents, including 4,733 (59.55%) cases of myopia, 1,025 (12.90%) of astigmatism, 251 (3.16%) of hyperopia, and 699 (8.79%) of anisometropia respectively. There were 2,519 (53.22%) cases of myopia in the left eye and 2,214 (46.78%) in the right eye. Low, moderate, and high myopia were determined in 2,682 (56.67%), 1,583 (33.45%), and 468 (9.89%), respectively. In terms of spherical equivalent (SEQ), a statistically lower SEQ was observed in urban areas (-1.56±0.46 d) versus suburban counties (-1.17±0.33 d), and in females (-1.68±0.30 d) compared with males (-1.17±0.44 d). The mean SEQ gradually decreased with age. The prevalence of myopia was 63.84% (2,436/3,816) in females, statistically higher than that of 55.59% (2,197/4,132) in males (χ(2)=56.00, P < 0.0001). The incidence of myopia was statistically higher in urban areas (67.93% [3,321/4,889]) versus rural areas (46.16% [1,412/3,059]). Parental myopia, one inch between finger and pen tip when writing, daily time spent outdoors, daily sleep time, distance between computer screen and eyes, less than one punch from the chest to the edge of the desk when reading and writing, number of in-school PE classes, and daily length of TV watching were significantly correlated with the occurrence of myopia. Conclusions: Parents are advised to pay attention to daily time spent outdoors, sleep time, distance between the computer screen and the eyes, distance between the chest and the edge of the table when reading and writing, and length of TV watching of their children. As far as schools are concerned, PE activity time should be properly maintained to ensure that children have enough outdoor exercise time to reduce eye fatigue.

We present a novel generating function (GF) method for the self-condensing vinyl polymerization (SCVP) system with any initial distribution of preexisted polymers. Such a method was proven to be especially useful to investigate the semi-batch SCVP system allowing a sequence of feeding operations during the polymerization. Consequently, the number-, weight-, and z-average molecular weights as well as polydispersity index of hyperbranched polymers can be explicitly given, which are determined by predetermined feeding details and conversions in each polymerization step. These analytical results are further confirmed by the corresponding Monte Carlo simulation. Therefore the present GF method has provided a unified treatment on the semi-batch SCVP system. Accordingly, hyperbranched polymers with desired properties can be prepared by designing feeding details and presetting conversions at each step based on the present GF method.

The metallic central magnetic axes in high-nucleation clusters with complex structural connections tend to be disorganized and cancel each other out. Therefore, high-nucleation clusters cannot easily exhibit single-molecule magnets (SMMs) behaviors. Herein, we select a triple-core building block (Dy

Lanthanoid metal ions have large ionic radii, complex coordination modes, and easy distortion of coordination spheres, but the design and synthesis of high-nucleation lanthanoid clusters with high stability in solution (especially aqueous solution) are challenging. Herein, a diacylhydrazone ligand (H

Zerovalent iron (ZVI) has been a major focus of research and has attracted great attention during the last 2 decades by international researchers because of its excellent pollutant removal performance and several other merits in environmental remediation. Based on Web of Science Core Collection data, we present a comprehensive bibliometric analysis of ZVI research from 2000 to 2019. We analyze 4472 publications assuming three stages of growth trend of annual publication totals. We find that “The Chemical Engineering Journal” has been the most productive journal; Noubactep C is identified as the most productive author; China has been the most active country in this field and the Chinese Academy of Science the most productive institution. The timeline of keywords shows seven distinct co-citation clusters. In addition, the top 38 keywords with strong citation bursts are also detected, suggesting that the innovation of green composite synthesis of ZVI and nanoscale ZVI and its efficient removal capacity might be the prevailing research directions in the future.

In the past two decades, tremendous progress has been made in the field of single-molecule magnets (SMMs), which not only achieves breakthroughs in various key indicators (flipping energy barrier and hysteresis temperature), but also expands SMMs of various types (3d, 4f, 3d–4f and 5f) and different connection methods. Among the many different types of SMM mentioned above, the SMM based on the 4f metal center has made the biggest breakthrough. Introducing 3d metal ions into lanthanide complexes to form 3d–4f heterometallic complexes can promote strong magnetic exchange between multiple metal centers, resulting in magnetic properties different from 3d and 4f complexes. Therefore, the expansion of the structure and magnetic properties of 3d–4f heterometallic complexes can promote the progress in the field of SMM. In this review, we summarize the structure and magnetic properties of 3d–4f heterometallic complexes formed by different types of organic ligands.

Background Schistosomiasis japonica remains an important public health concern due to its potential to cause severe outcomes and long-term sequelae. An integrated control strategy implemented in the Peoples’ Republic of China has been shown to be effective to control or interrupt the transmission of schistosomiasis. The objective of this study is to estimate the disease burden of schistosomiasis and assess the cost-effectiveness of the integrated control strategy focused on different major interventions at three stages for schistosomiasis control in a lake setting, to provide reference for policy making or planning. Methods Annual cost data of schistosomiasis control during 2009–2019 were obtained from the control program implementers in Jiangling County, Hubei Province, China. Economic costs are provided in constant 2009 Chinese Yuan (CNY). Epidemiological data of schistosomiasis were collected from the Jiangling county station for schistosomiasis control. Disease burden of schistosomiasis was assessed by calculating years of life lost (YLLs) owing to premature death, years lived with disability (YLDs) and disability-adjusted life years (DALYs). DALYs were calculated as the sum of YLLs and YLDs. We then conducted a rudimentary cost-effectiveness analysis by determining the ratio by dividing the difference between the average cost of integrated control strategy at transmission control (2013–2016) or transmission interruption (2017–2019) and the average cost at stage of infection control (2009–2012) with the difference between the DALYs of schistosomiasis at different control stages. Descriptive statistics on the costs and DALYs were used in the analysis. Results The total economic costs for schistosomiasis control in Jiangling County from 2009 to 2019 were approximately CNY 606.88 million. The average annual economic costs for schistosomiasis prevention and control at stages of infection control (2009–2012), transmission control (2013–2016), and transmission interruption (2017–2019) were approximately CNY 41.98 million, CNY 90.19 million and CNY 26.06 million respectively. The overall disease burden caused by schistosomiasis presented a downward trend. Meanwhile, the disease burden of advanced cases showed an upward trend with the DALY increased from 943.72 to 1031.59 person-years. Most disease burden occurred in the age group over 45 years old (especially the elderly over 60 years old). Taking the infection control stage as the control, the incremental cost-effectiveness ratio of integrated control strategy was CNY 8505.5 per case averted, CNY 60 131.6 per DALY decreased at transmission control stage and CNY −2217.6 per case averted, CNY −18 116.0 per DALY decreased at transmission interruption stage. Conclusions The disease burden of schistosomiasis decreased significantly with the implementation of the integrated prevention and control strategy. Surveillance and management on elder population should be strengthened to decrease diseases burden. There remains a need for well-conducted studies that examine the long-term cost-effectiveness of the integrated control strategy for schistosomiasis. Graphic Abstarct

The traditional constant time window-based waveform classification method is a robust tool for seismic facies analysis. However, when the interval thickness is seismically variable, the fixed time window is not able to contain the complete geologic information of interest. Therefore, the constant time window-based waveform classification method is inapplicable to conduct seismic facies analysis. To expand the application scope of seismic waveform classification in the strata with varying thickness, we have proposed a novel scheme for unsupervised seismic facies analysis of variable window length. The input of the top and bottom horizons can guarantee the comprehensive geologic information of the target interval. Throughout the whole workflow, we use the dynamic time warping (DTW) distance to measure the similarities between seismic waveforms of different lengths. First, we improve the traditional spectral clustering algorithm by replacing the Euclidean distance with the DTW distance. Therefore, it can be applicable in the interval of variable thickness. Second, to solve the problem of large computation when applying the improved spectral clustering approach, we adopt the method of seismic data thinning based on the technology of the superpixel. We combine these two algorithms and perform the integrated workflow of improved spectral clustering. The experiments on synthetic data show that the proposed workflow outperforms the traditional fixed time window-based clustering algorithm in recognizing the boundaries of different lithologies and lithologic associations with varying thickness. The practical application shows great promise for reservoir characterization of interval with varying thickness. The plane map of waveform classification provides convincing reference to delineate reservoir distribution of the data set.

The aggregation and formation of heterometallic nanoclusters usually involves a variety of complex self-assembly processes; thus, the exploration of their assembly mechanisms through process tracking is more challenging than that for homometallic nanoclusters. We explored here the effect of solvent on the formation of heterometallic clusters, which gave two heterometallic nanoclusters, [Dy2Co8(μ3-OCH3)2(L)4(HL)2(OAc)2(NO3)2(CH3CN)2]·CH3CN·H2O (1) and [Dy4Co6(L)4(HL)2(OAc)6(OCH2CH2OH)2(HOCH2CH2OH)(H2O)]·9CH3CN (2), with the H3L ligand formed from the in situ condensation reaction of 3-amino-1,2-propanediol with 2-hydroxy-1-naphthaldehyde in the presence of Co(OAc)2·4H2O and Dy(NO)3·6H2O. It is worth noting that the skeleton of cluster 1 has a high stability under high-resolution electrospray ionization mass spectrometry (HRESI-MS) conditions with a gradually increasing energy of the ion source. Cluster 2 underwent a multistep fragmentation even under a zero ion-source voltage for the measurement of HRESI-MS. Further analysis showed that cluster 2 underwent a possible fragmentation mechanism of Dy4Co6L6 → Dy2Co6L5/DyL → DyCo2L3/DyCo2L → DyL/Co2L2. Most notably, the species emerging in the formation process of cluster 1 were tracked using time-dependent HRESI-MS, from which we proposed its possible formation mechanism of H2L → Co2L2 → Co2DyL2/Co3L2 → Co3DyL2 → Co4DyL2 → Co5Dy2L4 → Co8Dy2L6. As far as we know, it is the first time to track the formation process of Dy-Co heterometallic clusters through HRESI-MS with the proposed assembly mechanism. The magnetic properties of the two titled DyIIIxCoII10-x (x = 2, 4) clusters were studied. Both of them exhibit slow magnetic relaxation, and 1 is a single-molecule magnet at zero direct-current field.

“Demonstration farms” can disseminate knowledge on farming practices and help to promote animal welfare. When on-farm visits are impractical, remote demonstrations are a feasible alternative. This study used videos of higher welfare beef, fish and free-range egg farms in China. It aimed to determine whether the videos affected attitudes and intentions toward animal welfare and whether such videos are useful training tools. Participants indicated a high acceptability of demonstration farm videos for learning about their industry and the needs of animals. Videos shifted participant attitudes toward animal welfare, but only when actively engaged in rating the farm on specific characteristics. Attitude changes suggested participants gained a greater understanding of animal welfare, a greater intention to improve on-farm welfare, and more confidence in peer support for welfare innovations after viewing the video. The findings indicate videos of demonstration farms are useful for remote training but passive viewing may be insufficient to create change, and outcomes should be monitored for success.

Nodular glomerulosclerosis, typically diagnosed in patients with diabetes mellitus, has been reported in native kidneys of pre-diabetic patients but similar cases in kidney transplant recipients are lacking. We describe a case of nodular glomerulosclerosis in a kidney transplant recipient who had not been found to be diabetic despite regular screening and discuss the implications for the pathogenesis and diagnosis of nodular glomerulosclerosis and screening of post-transplant diabetes mellitus. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13730-020-00546-x) contains supplementary material, which is available to authorized users.

Although the design and synthesis of high-nuclear lanthanide clusters with specific shapes and functions have been an active area of research, effective experience and rules to guide further systematic expansion of lanthanide clusters with different connections are lacking. Herein, we adjusted the steric hindrance effects on the substituents of diacylhydrazone ligands (H4L1, N′2,N′9-bis((E)-2-hydroxybenzylidene)-1,10-phenanthroline-2,9-dicarbohydrazide; H4L2, N′2,N′9-bis((E)-2-hydroxy-3-methylbenzylidene)-1,10-phenanthroline-2,9-dicarbohydrazide; H4L3, N′2,N′9-bis((E)-3-(tert-butyl)-2-hydroxybenzylidene)-1,10-phenanthroline-2,9-dicarbohydrazide) and reacted them with Dy(NO3)3·6H2O under solvothermal conditions to obtain three dysprosium clusters (1–3) with different shapes. The molecular formulas of the abovementioned clusters are [Dy16(L1)3(μ3-OH)25(NO3)11(H2O)10]·4CH3CN·8CH3OH, [Dy10(L2)4(μ2-OH)2(μ3-O)4(NO3)4(CH3CN)2(CH3OH)4(H2O)8]·CH3OH·8H2O, and [Dy5(L3)2(μ2-CH3O)(μ2-OH)2(μ4-O)(NO3)2(CH3OH)2]·6CH3OH·2CH3CN. Cluster 1 with a brucite-like planar structure crystallizes in the P21/n space group of the monoclinic system. The Dy(III) ions in the cluster 1 structure are bridged by μ3-OH− to form a plane triangle shape. In addition, the structure of cluster 1 contains three layers of Dy(III) ions (1 + 6 + 9) with different coordination environments. Cluster 2 crystallizes in the P space group of the triclinic system. The cluster core in cluster 2 is composed of two molecules of missing cubane Dy4O6 and two Dy(III) ions. The ligand (L2)4− adopts two coordination modes (μ3-η1:η1:η2:η1:η1:η2:η1:η1 and μ5-η2:η1:η1:η1:η1:η1:η1:η1:η1:η2) to chelate Dy(III) ions. In addition, Dy(III) ions in Dy4O6 are connected by μ2-OH− and μ3-OH−. Two molecules of planar Dy3L3 intersect to form cluster 3, and it crystallizes in the I2/a space group of the monoclinic system. The analysis of the structure of clusters 1–3 shows that they are formed by a stepwise assembly process from outside to inside. To the best of our knowledge, a very small number of examples have reported that a series of differently connected dysprosium clusters were obtained through the regulation of substitution effects. Notably, we are the first to propose the out-to-in growth mechanism of planar high-nucleus dysprosium clusters. The results of the variable temperature AC susceptibility test show that clusters 1, 2, and 3 exhibit single-molecule magnet-like behavior under zero-field conditions.

BACKGROUND AND AIMS Patients with glomerulonephritis may have an increased risk of influenza infection and morbidity, but vaccine coverage remained low with little data on acceptance in glomerulonephritis. We aimed to assess influenza vaccine awareness among patients with glomerulonephritis and identify determinants of vaccine acceptance. METHOD Single-center cross-sectional study of patients with glomerulonephritis who completed a survey in the clinic or over the telephone between June and August 2021. Sociodemographic data, health literacy measured by HLS-EU-47 questionnaire, influenza and the coronavirus disease (COVID-19) vaccine awareness and determinants of vaccine acceptance according to the World Health Organization framework. RESULTS Among 86 patients who completed the survey, influenza vaccine awareness was lower than COVID-19 vaccine awareness (75.6% versus 100%). After adjusting for the survey type, use of English language at home and at healthcare settings, higher income and professional or executive occupation were significantly associated with influenza vaccine awareness, while older age and lower education level were associated with reduced awareness. The healthcare provider was the most frequent information source and > 90% trusted that healthcare providers and the government considered the patients’ best interests and gave correct information. Only half thought their medical condition and medications would affect their vaccine decision while a quarter to half did not understand how the vaccine worked and thought there were better ways to protect against infection. CONCLUSION Healthcare providers can actively identify and advocate influenza vaccines to the unaware and overcome potential barriers to reduce influenza infections and morbidity in glomerulonephritis.