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9. Rolling Circle Amplification-Based DNA Nano-Assembly for Targeted Drug Delivery and Gene Therapy

Author

Zhiqing Zhang, Dongyan Xu, Jiawei Wang, Ruyan Zhang, Huan Du, Ting Zhou, Xiufeng Wang, and Fang Wang

Subjects
Biomaterials, Polymers and Plastics, Materials Chemistry, Bioengineering
Abstract

Combining the killing ability of chemotherapy drugs on tumor cells with the inhibiting ability of genetic drugs on tumor cell growth, a dual drug delivery system loaded with therapy drugs and siRNA has gradually received more and more research and extensive attention. In this paper, we designed a DNA nano-assembly based on rolling circle amplification that can co-deliver doxorubicin (Dox) and siRNA simultaneously. In order to fully exploit the potential of the dual loading system in cancer treatment, we selected STAT3 gene as a target and used siRNA to target STAT3 of mRNA and reduce the STAT3 expression in mouse melanoma cell line (B16); meanwhile, Dox as a chemotherapy drug was combined with multivalent aptamers specifically targeting B16 to achieve efficient delivery of siRNA and Dox. The results showed that the synergistic delivery system could achieve high efficiency in targeting and inhibiting proliferation in mouse melanoma cells. In addition, the synergistic effect of the dual delivery system on apoptosis of cancer cells was significantly better than that of single drug delivery systems.

Published
2022
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11. 'Willow Branch' DNA Self-Assembly for Cancer Dual-Target and Proliferation Inhibition

Author

Jiawei Wang, Zhiqing Zhang, Ruyan Zhang, Huan Du, Ting Zhou, and Fang Wang

Subjects
Oligonucleotides, DNA, Single-Stranded, Salix, DNA, Surfaces and Interfaces, Aptamers, Nucleotide, Condensed Matter Physics, Antibodies, Neoplasms, Electrochemistry, Humans, General Materials Science, beta Catenin, Spectroscopy, Cell Proliferation
Abstract

DNA nanotechnology is beginning to yield unique advantages in the area of drug delivery. For the dual-targeting and proliferation suppression of cancer cells, a "willow branch" DNA assembly based on rolling circle amplification (RCA) was built. Three single-stranded DNAs, including antibody modified cDNAs, aptamer cDNAs, and simple cDNAs, were employed in the DNA self-assembly, along with the RCA scaffolds (every 63 bases is a repeat unit). "Willow branch" DNA (WB DNA) assembly successfully linked multiple antibodies and aptamers together to achieve dual targeting of cancer cells. Binding of CD44 antibodies and S2.2 aptamers to receptors on the cell membrane inhibits both pathways, β-catenin signaling and nuclear factor-kappa B-specific transcription activity, through feedback regulation. Results demonstrated that WB DNA assembly could effectively exert multivalency clustering cell-surface receptors, modulating signal pathways and inhibiting proliferation. This study proposes a new approach for cancer dual-target and proliferation inhibition by clustering multivalent receptors.

Published
2022
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14. Effect of Sealing Treatment on Corrosion Resistance of Arc-Sprayed Zn and Zn85-Al15 Coatings

Author

Liu, Bo Li, Zhuoyi Liu, Jinhang He, Jie Bai, Haibo Jiang, Ye Tian, Zhiqing Zhang, and Shifeng

Subjects
corrosion resistance, Zn and Zn85-Al15 coatings, electrochemical corrosion, salt spray
Abstract

This study investigated the corrosion morphology of arc-sprayed Zn and Zn85-Al15 coatings with and without sealing treatment under simulated defect conditions. The hole sealing treatment was carried out by Conventional Impregnation Sealing (CIS). The performance of two coatings was assessed by employing morphological analysis, chemical composition, and electrochemical studies. The results showed that the corrosion performance of two coatings with sealing treatments was better than that of the un-sealing coating. Through the double protection of coating and sealing treatment, the defect-free material has excellent anti-corrosion performance in the salt spray experiment. In the simulated defect environment, the Zn-Al coating has better corrosion resistance, and the corrosion products are denser and more stable near the defects, which reduces the overall corrosion rate of the coating. The electrochemical experiment results demonstrated that the Zn-Al coating exhibited a three times lower corrosion rate compared to the Zn coating in the immersion experiment, and the corrosion rate did not change with the thickness of the coating. The average adhesion values of the two different methods (chilled iron and alumina) were similar (~8 MPa), but after the salt spray test, the adhesion strength increased. The corrosion mechanisms of Zn coating and Zn-Al coating are analyzed and compared. In general, it was indicated that the Zn85/Al15 coating prepared by sealing treatment has better corrosion resistance than the matrix steel. This study can provide some reference for corrosion behavior in defect environments.

Published
2023
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18. Risk factors for breakthrough urinary tract infection in children with vesicoureteral reflux receiving continuous antibiotic prophylaxis

Author

Dequan Su, Qian Shen, Yihui Zhai, Jing Chen, Jia Rao, Qianfan Miao, Xiaoshan Tang, Zhiqing Zhang, Jiaojiao Liu, Jialu Liu, Hong Xu, and Xiaoyan Fang

Subjects
Pediatrics, Perinatology and Child Health, Original Article, urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

BACKGROUND: To investigate the risk factors for breakthrough urinary tract infection (BT-UTI) in children with vesicoureteral reflux (VUR) receiving continuous antibiotic prophylaxis (CAP). METHODS: This was a single-centre cohort study (January 2016 to December 2019). The clinical data of 256 children with grade I–V VUR receiving CAP were analysed. In this study, exposure variables were sex, younger age at the initial diagnosis of UTI ≤12 months, high-grade VUR, bilateral VUR, aetiology, presence of renal scarring at the initial diagnosis, presence of renal function impairment at the initial diagnosis, ultrasound abnormalities, antibiotic used and bladder and bowel dysfunction (BBD). Outcome was BT-UTI. RESULTS: BT-UTI occurred in 81 out of 256 children with grade I–V VUR who received CAP, an incidence of 31.64%. Univariate analysis showed that younger age at the initial diagnosis of UTI (≤12 months), bilateral VUR, renal scarring on the dimercaptosuccinic acid (DMSA) scan at the initial diagnosis of UTI and BBD were correlated with the occurrence of BT-UTI. Multivariate analysis showed that younger age at the initial diagnosis of UTI (≤12 months) [hazard ratio (HR): 4.629; 95% confidence interval (CI): 1.302–16.462], bilateral VUR (HR: 2.078; 95% CI: 1.084–4.022) and BBD (HR: 3.194; 95% CI: 1.243–8.206) were independent risk factors for the occurrence of BT-UTI. CONCLUSIONS: For VUR children receiving CAP, younger age at the initial diagnosis of UTI (≤12 months), bilateral VUR, and BBD were independent risk factors for the occurrence of BT-UTI.

Published
2022
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19. Study on Association Behavior and Solution Properties of Poly(Acrylic Acid-Alkyl Polyoxyethylene Acrylate) Amphiphilic Copolymers

Author

Xiqiu Wang, Zhiqing Zhang, Yukun Zhang, Guodong Zhang, and Fang Wang

Abstract

The hydrophobically associating water-soluble polymers (HAWSPs), which possess both surfactant and polymer properties, have been the subject of considerable research. In this study, a novel HAWSP, poly(acrylic acid-alkyl polyoxyethylene acrylate) (P(AA-AAEOn)), was synthesized via aqueous polymerization of acrylic acid andalkyl polyoxyethylene acrylate (AAEOn) with different ethoxy groups. The structure of P(AA-AAEOn) was characterized by Fourier Transform Infrared spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR). Additionally, its association behavior in solution was evaluated by surface tension, dynamic light scattering, and rheology. The results indicated that P(AA-AAEOn) exhibited excellent surface activity, and its ability to reduce the water surface tension increased with the increase in the proportion of the hydrophobic group. When the concentration reached 0.01%, P(AA-AAEOn) in the solution changed from intramolecular association to intermolecular association. Furthermore, P(AA-AAEOn) also displayed remarkable shear resistance, shear recovery, and viscoelasticity, with a transition from energy elasticity to entropy elasticity in P(AA-AAEOn) molecules between 25℃ and 35℃.

Published
2023
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22. Application of rivaroxaban in patients with non-valvular atrial fibrillation and end-stage kidney disease: A systematic review and meta-analysis

Author

Zhenzhen Yang, Jieya Wang, Ye Yuan, Tian Cheng, Feifei Ren, Songsong Wang, and Zhiqing Zhang

Subjects
Cardiology and Cardiovascular Medicine
Abstract

BackgroundNowadays, the number of patients with non-valvular atrial fibrillation (NVAF) complicated by end-stage renal disease (ESKD) is increasing. There are significant challenges in anticoagulation with prescription drugs because of the high risk of bleeding and embolism among these patients. However, no randomized controlled trials (RCTs) of warfarin in combination with any non-vitamin K oral anticoagulant (NOACs) have been performed in patients with baseline creatinine clearance (CrCl) MethodsThe present systematic review and meta-analysis searched the databases of PubMed, Embase, the Cochrane Library, CNKI, CBM, and Google Scholar for relevant studies from inception to 1 June 2022, with the restriction of English and Chinese. Eligible cohort studies and RCTs that reported efficacy outcomes [composite of stroke and systemic embolism (SSE), ischemic stroke (ICS), and systemic embolization] or safety outcomes [major bleeding, intracranial hemorrhage (ICH), and gastrointestinal bleeding (GIB)] of rivaroxaban in NVAF patients with ESKD were enrolled. Two authors completed the data extraction and quality assessment work, respectively. The Cochrane Collaboration tool for assessing the risk of bias was used for RCTs, and the NEW-Castle Ottawa scale was used for study quality assessment for cohort studies. Dichotomous variables were calculated as risk factors with 95% confidence intervals (CIs), and meta-analysis was performed to probe the effect of research design, rivaroxaban dose, and controlled drug factors on outcomes.ResultsIn total, three studies were included for meta-analysis, involving 6,071 NVAF patients with ESKD, and two studies were included for qualitative analysis. All included studies were at low risk of bias. A meta-analysis demonstrated that mix-dose rivaroxaban caused no statistical discrepancy in the occurrence of thrombotic and bleeding events when compared to the control group (embolism, LogOR: −0.64, 95% CI: −1.05 to −0.23, P:0.25; bleeding, LogOR: −0.33, 95% CI: −0.63 to −0.03, P:0.15), and low-dose rivaroxaban produced similar results (embolism, LogOR: −1.04, 95% CI: −2.15 to 0.07, P:0.61; bleeding, LogOR: −0.81, 95% CI: −1.19 to −0.44, P:0.93).ConclusionIn this study, low-dose rivaroxaban (10 mg, once a day) may benefit more than warfarin in patients with NVAF and ESKD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42022330973.

Published
2023
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24. Preliminary characteristics of non-starch polysaccharide from chayote (Sechium edule)

Author

Jingxuan KE, Xiaoting DENG, and Zhiqing ZHANG

Subjects
non-starch polysaccharide, physicochemical properties, Food Science, Biotechnology, conventional heating extraction
Abstract

Chayote is rich in non-starch polysaccharides. The physicochemical properties of non-starch polysaccharide from chayote were not study extensively. In the present research, non-starch polysaccharide of chayote (CP-CHE) extracted by conventional heating extraction method was obtained, and the preliminary physicochemical and functional properties of CP-CHE had been carried out. The results indicated that the CP-CHE was rich in galactan, glucoses and galacturonic acid. Also, CP-CHE had the negatively charged, a wide distribution of molecular weight and particle size. Additionally, CP-CHE solutions had shear thinned fluid property when the concentrations between 1% to 4%. The results of this study would be beneficial to the application of CP-CHE in food and improve the economic value of chayote.

Published
2023

25. Systematically uncovering the absorbed effective substances of Radix scutellaria-licorice drug pair in rat plasma against COVID-19 using a combined UHPLC-Q-TOF-MS analysis and target network pharmacology

Author

xuqing wen, weiwei xie, juan gao, dedong zhang, Mengxin Yang, Zhiqing Zhang, yiran jin, and Yingfeng Du

Abstract

Rationale: Radix scutellaria-Licorice drug pair (RSLDP), a frequently used herbal pair with the effect of clearing heat and detoxifying, is the commonly employed drug pair in TCM prescription for the treatment of COVID-19. Until now, the metabolism feature and anti-COVID-19 mechanism of RSLDP have not been fully elucidated. Methodology: In this study, a sensitive and rapid method was developed for the separation and identification of the absorbed constituents of RSLDP in the rat plasma by UHPLC-QTOF-MS. Besides, we optimized the conventional process ways of network pharmacology and proposed a new concept called target network pharmacology (T-NP). It used the absorbed constituents and the corresponding targets to generate compound-target network, and compare to the conventional network pharmacology, it could reduce the false positive results. Results: A total of 85 absorbed constituents were identified or tentatively characterized in dosed plasma,including 32 components in Radix Scutellaria,27 components in Licorice and 65 components in RSLDP. The results showed that the compatibility of Radix Scutellaria and Licorice increased the quantity of components in vivo. We found that 106 potential targets of 64 active compounds in RSLDP were related to COVID-19.And 12 targets (MAPK3,IL6,JUN,IL2,STAT3, AKT1,TNF,STAT1,EGFR,HSP9AA1,VEGFA,RELA) could be core targets for RSLDP in treating COVID-19. Conclusions: The metabolism feature of RSLDP in vivo was systematically uncovered. The combining use of the T-NP method could discover potential drug targets and disclose the biological processes of RSLDP, which will clarify the potential mechanisms of RSLDP in the treatment of COVID-19.

Published
2023
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26. Effect of Electroacupuncture on Reproductive Disorders and Insulin Resistance in a Murine Polycystic Ovary Syndrome Model

Author

Chang Ji, Wanling Xu, Zhiqing Zhang, Shuai Cui, and Wei Yi

Subjects
Other systems of medicine, endocrine system, Article Subject, Complementary and alternative medicine, RZ201-999, hormones, hormone substitutes, and hormone antagonists, Research Article
Abstract

Polycystic ovarian syndrome (PCOS) is a common, complex, and heterogeneous endocrine and metabolic disorder. There is no standardized treatment, and it therefore requires individualized therapies according to the symptoms and pathogenesis of each patient. The present study aimed to determine the effect of electroacupuncture at the acupoints Zusanli (ST36), Sanyinjiao (SP6), and Neiguan (PC6) on reproductive disorders and insulin resistance in a murine model of PCOS induced by dehydroepiandrosterone (DHEA). Vaginal smear analysis was used to determine mice estrous cycle; intraperitoneal glucose and insulin tolerance tests were adopted to analyze metabolic characteristics; enzyme-linked immunosorbent assay was used to measure hormone levels; gene expression was quantified with real-time PCR; hematoxylin and eosin staining was used to observe ovarian morphology. We observed disordered estrous cycle, polycystic ovarian morphology, and higher levels of homeostasis model assessment-insulin resistance (HOMA-IR) and testosterone (T), indicating successful modeling of PCOS. DHEA increased levels of estrogen (E2), progesterone (P), testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), and EA treatment restored them to levels seen in the control group. EA reduced the days in estrus caused by DHEA, improved the abnormal sex hormone receptor genes, and attenuated the DHEA-induced histomorphological changes in mouse ovaries. The average expressions of the androgen receptor (AR), estrogen receptor (ER), luteinizing hormone receptor (LHR), and follicle-stimulating hormone receptor (FSHR) genes in the ovary greatly increased after DHEA treatment and significantly decreased in the DHEA + EA group. After EA treatment, the cystic follicle (CF) number was reduced and corpora lutea (CL) increased in the DHEA + EA group compared to the DHEA group. EA improved glucose intolerance and insulin intolerance. Statistical analysis of intraperitoneal glucose tolerance test-area under curve (IPGTT-AUC) glucose levels revealed a significant decrease in DHEA group mice compared to the control and DHEA + EA groups. EA was found to restore fasting blood glucose, fasting serum insulin, and HOMA-IR. In summary, our study suggests that EA has a remarkable effect in the DHEA-induced murine PCOS model. Management of EA could improve estrous cycle, hormonal disorders, abnormal sex hormone receptors in ovaries, ovary morphology, and insulin resistance in PCOS mice.

Published
2021
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27. Consensus Sliding-Mode Fault-Tolerant Control for Second-Order Multi-Agent Systems

Author

Zixin Wang, Zhiqing Zhang, Huawei Technologies Co., Ltd. Ruanjian Avenue, Nanjing, Jiangsu , China, Hu Xukai, Pu Yang, Ben Ma, and Astronautics Jiangjun Road, Nanjing, Jiangsu , China

Subjects
Human-Computer Interaction, Computer Science::Systems and Control, Artificial Intelligence, Control theory, Computer science, Order (business), Multi-agent system, Control (management), Mode (statistics), Fault tolerance, Computer Vision and Pattern Recognition, Sliding mode control
Abstract

This study investigates the consensus problem of second-order nonlinear multi-agent systems (MASs) with actuator faults via a sliding mode control approach. The consensus error dynamic is given based on the relative states of the neighbors. Then, a sliding mode surface based on consensus errors is proposed, and the asymptotic stability of the sliding mode is proved using the Lyapunov theory. Furthermore, a sliding-mode fault-tolerant consensus protocol is proposed to compensate for actuator faults. According to the sliding mode control theory, the proposed sliding-mode fault-tolerant controller ensures that the consensus of the MASs can be reached in a finite time. Finally, a simulation example of a second-order multi-robot system is presented to demonstrate the effectiveness of the proposed controller.

Published
2021
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28. Ship engine detection based on wavelet neural network and FPGA image scanning

Author

Guanglin Lan, Yanhua Jiang, and Zhiqing Zhang

Subjects
Computer science, business.industry, 020209 energy, Circuit design, Feature extraction, General Engineering, Wavelet transform, Image processing, 02 engineering and technology, Fault (power engineering), Engineering (General). Civil engineering (General), 01 natural sciences, 010305 fluids & plasmas, Wavelet neural network, Wavelet, Data acquisition, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, FPGA image, Ship engine, TA1-2040, Field-programmable gate array, business, Computer hardware
Abstract

This paper uses wavelet neurons instead of traditional neurons, and uses wavelet multi-resolution analysis to decompose the FPGA image scan of the ship engine. Because the neural network has the approximation ability of arbitrary functions, the wavelet transform is connected to the neural network to form a wavelet neural network. To test ship engines. The hardware design of GigE image acquisition and processing system based on FPGA was started. FPGA was used as the main control chip and Gigabit Ethernet was used as the transmission medium. The hardware circuit of the image data acquisition and image processing system was designed. It mainly includes the FPGA main control circuit and the FPGA Peripheral circuits. The high-speed image acquisition, transmission, storage, and display module circuit design is realized. Real-time monitoring and fault analysis of the engine's condition is performed by the FPGA image scanning method, and data of the engine's running state is pre-processed with the help of step tracking technology to make it a standard signal. The data is transmitted to the computer through NI's data acquisition card. Combining feature extraction such as information entropy, Fourier transform, EMD and wavelet neural network technology. The accuracy of the diagnosis results and the actual fault state is improved. It can enable the staff to monitor the running status of the engine in real time, improve the efficiency of engine fault diagnosis, reduce labour costs and maintenance costs, and thus realize intelligent, real-time and accurate status monitoring of the engine.

Published
2021

29. Second-order Stokes wave-induced dynamic response and instantaneous liquefaction in a transversely isotropic and multilayered poroelastic seabed

Author

Zhiqing Zhang, Bohao Zhou, Xibin Li, and Zhe Wang

Subjects
Global and Planetary Change, Ocean Engineering, Aquatic Science, Oceanography, Water Science and Technology
Abstract

The ocean waves exhibit obvious non-linearity with asymmetric distribution of wave crests and troughs, which could induce significantly different effect on the seabed compared to the commonly used linear wave theory. In this paper, a semi-analytical solution for a transversely isotropic and multilayered poroelastic seabed under non-linear ocean wave is proposed by virtue of the dual variable and position (DVP) method. The ocean wave and seabed are, respectively, modelled using second-order Stokes theory and Biot’s complete poroelastodynamic theory. Then the established governing equations are decoupled and solved via the powerful scalar potential functions. Making use of the DVP scheme, the layered solutions are finally gained by combining the boundary conditions of the seabed. The developed solutions are verified by comparing with existing solutions. The selected numerical examples are presented to investigate the effect of main parameters on the dynamic response of the seabed and evaluate the corresponding liquefaction potential. The results show that the anisotropic stiffness and permeability, degree of saturation and stratification have remarkable influence on the dynamic response and liquefaction behavior of the seabed. The present solution is a useful tool to estimate the stability of transversely isotropic and layered seabed sediment in the range of non-linear ocean wave.

Published
2022
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30. A Multi-Scale Feature Pyramid Network for Detection and Instance Segmentation of Marine Ships in SAR Images

Author

Zequn Sun, Chunning Meng, Jierong Cheng, Zhiqing Zhang, and Shengjiang Chang

Subjects
General Earth and Planetary Sciences, multi-scale feature pyramid network (MS-FPN), multi-scale feature maps, ship detection, ship segmentation, synthetic aperture radar (SAR)
Abstract

In the remote sensing field, synthetic aperture radar (SAR) is a type of active microwave imaging sensor working in all-weather and all-day conditions, providing high-resolution SAR images of objects such as marine ships. Detection and instance segmentation of marine ships in SAR images has become an important question in remote sensing, but current deep learning models cannot accurately quantify marine ships because of the multi-scale property of marine ships in SAR images. In this paper, we propose a multi-scale feature pyramid network (MS-FPN) to achieve the simultaneous detection and instance segmentation of marine ships in SAR images. The proposed MS-FPN model uses a pyramid structure, and it is mainly composed of two proposed modules, namely the atrous convolutional pyramid (ACP) module and the multi-scale attention mechanism (MSAM) module. The ACP module is designed to extract both the shallow and deep feature maps, and these multi-scale feature maps are crucial for the description of multi-scale marine ships, especially the small ones. The MSAM module is designed to adaptively learn and select important feature maps obtained from different scales, leading to improved detection and segmentation accuracy. Quantitative comparison of the proposed MS-FPN model with several classical and recently developed deep learning models, using the high-resolution SAR images dataset (HRSID) that contains multi-scale marine ship SAR images, demonstrated the superior performance of MS-FPN over other models.

Published
2022
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31. Therapeutic drug monitoring of free vancomycin concentration in practice: A new analytical technique based on the HFCF-UF sample separation method

Author

Feifei Ren, Yixin Liu, Shan Li, Xiangchen Li, Xikun Wu, Yaqian Li, and Zhiqing Zhang

Subjects
Pharmacology, Clinical Biochemistry, Drug Discovery, General Medicine, Molecular Biology, Biochemistry, Analytical Chemistry
Abstract

The aim of this study was to establish a method for free vancomycin concentration determination in human plasma and apply it to clinical therapeutic drug monitoring (TDM). The unbound vancomycin in plasma was separated by the hollow fiber centrifugal ultrafiltration (HFCF-UF) technique and analyzed by HPLC. Chromatographic conditions were optimized, the specificity, linearity, precision, recovery and stability of the method were examined, and plasma samples of patients were measured. The standard curve for free vancomycin is y = 0.0277x - 0.0080 with good linearity within 0.25-50 μg·mL

Published
2022

33. Classifying directed and diffusive transport in short, noisy single-molecule trajectories with wMSD

Author

Noémie Danné, Zhiqing Zhang, and Erwin J. G. Peterman

Abstract

Fluorescence imaging in combination with single-particle tracking analysis has emerged as a powerful tool to study and characterize the motion of proteins moving in biological media. One of the main challenges in this approach is to reliably distinguish between directed and diffusive transport, especially for short and often noisy trajectories showing distinct, time- and place-dependent modes of motility. In this contribution, we present a windowed Mean-Square Displacements classifier (wMSDc) that is able to reliably (i) identify periods of diffusive and directed transport, (ii) extract position-dependent diffusion coefficients and velocities, and (iii) identify the location of switches in direction or motility mode in short (< 50 time points) and noisy single-molecule trajectories. We compare the performance of this approach to a Hidden Markov Model (HMM) method and a Moment Scaling Spectrum based method (DC-MSS) previously published and show that, in most cases, its performance is superior. We present a wide range of applications: from the movement of whole organisms and cells to protein-DNA interactionsin vitroand motor-protein dynamicsin vivo.Statement of SignificanceExtracting quantitative parameters from single-particle trajectories is a challenging task, especially in biological samples, which often show a high degree of heterogeneity. Trajectories can reveal switches between different types of motion; directed, diffusive and sub-diffusive motion. Usually, the length of these trajectories and their localization precision are limited by the experimental conditions. Here, we present a novel approach to analyse single molecule trajectories, windowed Mean-Square Displacement classifier (wMSDc) to reliably distinguish between directed and diffusive transport in the short trajectories with a finite precision of localization and integration time typically obtained when imaging single fluorescent proteins in living cells or organisms. We show that, using simulated and a wide range of experimental trajectories, wMSDc is a reliable method to extract motility parameters such as diffusion coefficient and velocity.

Published
2022
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34. Interface Engineering with Quaternary Ammonium-Based Ionic Liquids toward Efficient Blue Perovskite Light-Emitting Diodes

Author

Fanghao Ye, Huibo Yan, Siyang Liu, Baoxing Liu, Zhiqing Zhang, Mengyao Tian, Ting Zheng, Xi Lan, Jincheng Huang, Chunfeng Meng, Ping Xu, and Guijun Li

Subjects
General Materials Science
Abstract

Perovskite light-emitting diodes (PeLEDs) have become a hot research topic in recent years and can now achieve an external quantum efficiency (EQE) of over 22% for green and red devices. However, the efficiency of blue PeLEDs, which are essential for display applications, lags far behind their green and red counterparts. The interface of the PeLEDs has a critical influence on the carrier transport and exciton recombination dynamics, and interface engineering is considered to be an effective strategy to improve the device performance. Herein, quaternary ammonium-based ionic liquids serve as an interfacial modification layer to significantly improve the device efficiency and stability. The interaction of quaternary ammonium cations with Pb(Br/Cl)

Published
2022

35. Improving the tensile strength of non-keyhole friction stir lap welding joint of 2024-T4 Al alloy by radial basis function neural network and improved particle swarm optimization algorithm

Author

Yuting Li, Zelin Sun, Xin Qi, Peng Gong, Shude Ji, Baoguang Wang, Zhiqing Zhang, and Jiaqi Zhang

Subjects
Materials Science (miscellaneous)
Abstract

The non-keyhole friction stir lap welding (N-KFSLW) technology assisted by the outer stationary shoulder and the inner upper half-thread rotating pin was proposed to obtain the welding joint without keyhole through one-time process. Choosing 2024 aluminum alloys as the research object, the formation, microhardness and tensile strength of N-KFSLW joint were investigated. The improved particle swarm optimization (IPSO) algorithm was newly developed and had the advantages of large convergence speed and strong search ability, by which the radial basis function (RBF) neural network was optimized to enhance its prediction accuracy. After that, the RBF and IPSO (IPSO-RBF) system was used to predict the joint strength and optimize the process parameters combination. The results showed that the lap joint had not only the SZ with the thickness almost equal to the thickness of upper sheet but also the cold lap with a very small height, thereby leading to the high tensile strength of joint. The optimized parameters of welding speed, rotating speed and pin type by the IPSO-RBF system were respectively 612 rpm, 80 mm/min, and upper half-thread pin, and the tensile strength of lap joint reached 11.88 kN/mm. The N-KFSLW technology assisted by upper half-thread pin provides an effective way to obtain the lap joint with high performance, and the IPSO-RBF system can be used to maximize the strength of welding joint.

Published
2022
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38. Multi-objective optimization of the three-way catalytic converter on the combustion and emission characteristics for a gasoline engine

Author

Zhiqing Zhang, Jingyi Hu, Dongli Tan, Junming Li, Feng Jiang, Xiaoxue Yao, Dixin Yang, Yanshuai Ye, Ziheng Zhao, and Guanhua Yang

Subjects
General Energy, Mechanical Engineering, Building and Construction, Electrical and Electronic Engineering, Pollution, Industrial and Manufacturing Engineering, Civil and Structural Engineering
Published
2023
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40. Hydrogen peroxide-assisted and histidine-stabilized copper-containing nanozyme for efficient degradation of various organic dyes

Author

Siqi Wang, Xiufeng Wang, Bingyuan Du, Yao Jin, Wenhui Ai, Guodong Zhang, Ting Zhou, Fang Wang, and Zhiqing Zhang

Subjects
Histidine, Hydrogen Peroxide, Wastewater, Coloring Agents, Instrumentation, Spectroscopy, Atomic and Molecular Physics, and Optics, Copper, Analytical Chemistry
Abstract

Nanozymes have potential applications in many fields, and a novel copper-containing nanozyme with highly dispersity and uniformity was self-assembled for efficient degradation of various organic dyes in this work. In the nanozyme, histidine was used to coordinate with copper ions, and hydrogen peroxide was prone to Fenton-like reaction to generate hydroxylated copper oxide intermediates. The nanozyme showed good peroxidase-like activity, and also had the ability to catalyze the degradation of various organic dyes efficiently with good storage and recycling ability. Furthermore, the degradation kinetics and mechanism of nanozyme had been further studied, and found that hydroxyl radical and singlet oxygen play vital roles in the catalytic degradation process. Meanwhile, this nanozyme can efficiently degrade two organic compounds at the same time, and this system is capable of dealing with complex practical application scenarios where wastewater contains a variety of organic pollutants.

Published
2022

41. A Facile Strategy for Development of pH-Sensing Indicator Films Based on Red Cabbage Puree and Polyvinyl Alcohol for Monitoring Fish Freshness

Author

Hejun Wu, Chun Jiao, Shasha Li, Qingye Li, Zhiqing Zhang, Man Zhou, and Xiangyang Yuan

Subjects
Health (social science), red cabbage puree, anthocyanins, polyvinyl alcohol, pH sensitivity, intelligent packaging, fish freshness, Plant Science, Health Professions (miscellaneous), Microbiology, Food Science
Abstract

This study aimed to develop a novel pH-sensing biopolymer film based on red cabbage puree (RCP) incorporated with polyvinyl alcohol (PVA), which was utilized for monitoring fish freshness during storage at 25 °C. A homogenized RCP suspension with a mean particle size of 12.86 ± 0.03 μm and a total anthocyanin concentration of 292.17 ± 2.65 mg/L was directly used as a film-forming substance and anthocyanin source to blend with PVA, showing visual changes in color and ultraviolet-visible spectra within a pH of 2–12. Rheological and microstructural studies certified the strong interactions and good compatibility between the RCP and PVA, resulting in better mechanical properties and water resistance of the composite film than those of a pure RCP film, but without affecting its pH sensitivity. When used for fish freshness monitoring at 25 °C, the developed RCP/PVA film presented visible color differences from purple to yellow, which corresponded to the spoilage threshold of the total volatile basic nitrogen and the total viable count in fish samples. The study highlights that anthocyanin-rich purees of fruits and vegetables, in this case red cabbage puree, can be fully utilized to develop eco-friendly pH-sensing indicator films for intelligent food packaging.

Published
2022

42. Duration of initial prednisolone therapy for first episode of childhood nephrotic syndrome based on time to response

Author

Xiaoshan Tang, Qian Shen, Jia Rao, Jing Chen, Xiaoyan Fang, Zhiqing Zhang, Manpreet Grewal, Tej Mattoo, and Hong Xu

Subjects
Pediatrics, Perinatology and Child Health
Abstract

BackgroundThe duration of initial corticosteroid therapy in newly diagnosed Idiopathic nephrotic syndrome (INS) is about 3 months. Our study was designed to test the feasibility of a shorter duration of corticosteroid therapy in newly diagnosed INS who show a quicker response.MethodsPatients who responded within 10 days (Group A) received 8 weeks of corticosteroid therapy as compared to 12–14 weeks of standard therapy in those who responded between >10 days to 28 days (Group B), and follow up for 52 weeks. The primary endpoint is time to first relapse after treatment completion. (NCT03878914, March 18, 2019)ResultsA total of 33 children with INS were enrolled and the follow-up data were analyzed. The clinical and laboratory characteristics of patients in both groups were similar. No significant difference was found in time to first relapse [65(14.5, 159) days for Group A vs. 28(17, 61.5) days for Group B, P = 0.371], the incidence of frequently relapsing nephrotic syndrome [6/18 (33.3%) vs. 5/10(50%), P = 0.644] or requirement for alternative immunosuppressant [4/18 (22.2%) vs. 1/10 (10%), P = 0.769]. Group A received similar corticosteroid dose compare with Group B (3511 ± 2421 mg/m2 vs. 4117 ± 2556 mg/m2, P = 0.524). Frequency and severity of corticosteroid-related complications was similar in both groups.ConclusionsThe time to first relapse and the number of relapses per patient were comparable between the two groups. However, more patients in Group A relapsed and the mean total dose of prednisolone for the study period was very similar between the two groups.

Published
2022

43. Search for Higgs boson pair production in the two bottom quarks plus two photons final state in pp collisions at s=13 TeV with the ATLAS detector

Author

Kaili Zhang, Michel Vetterli, Zhiqing Zhang, Eleanor Jones, Renjie Wang, Christos Bakalis, Nico Madysa, Umberto De Sanctis, Fridolin Dittus, Christophe Roland, Aidan Robson, António Jacques Costa, Sergey Karpov, Christina Potter, Hassane Hamdaoui, Clara Troncon, Santosh Parajuli, Louis D'Eramo, Marta Czurylo, SERKANT ALİ ÇETİN, Ovidiu Miu, Wasikul Islam, Andrea Formica, Francois Corriveau, Joaquin Hoya, Zekeriya Uysal, Matt Zhang, Pawel Klimek, Deepak Kar, Alessandra Betti, Melissa Ridel, Andrey Kiryunin, Emily Anne Thompson, Juan Antonio Aguilar Saavedra, Aidan Grummer, Abdualazem Fadol, Yohei Yamaguchi, Philip Sommer, Stanislav Nemecek, Vladimir Cindro, Katherine Pachal, Artur Trofymov, Naryshkin Iurii, Pascal Pralavorio, Nello Bruscino, Evgenii Baldin, Jos Vermeulen, Arka Santra, Roberto Di Nardo, Sigve Haug, Yee Chinn Yap, Amanda Steinhebel, Lailin Xu, Chris Hays, Kunlin Han, Bobby Acharya, Vitaliano Chiarella, Dirk Sammel, Serena Palazzo, Gabriele D'Amen, Daniela Köck, Philipp Windischhofer, Lee Sawyer, Alessio Pizzini, Thu LH Pham, Andrew Haas, Alison Lister, Zuzana Rurikova, Fang-Ying Tsai, Xiangyang Ju, Amanda Cooper-Sarkar, Jonas Strandberg, Giuseppe Iacobucci, Riccardo Vari, Stephen Lloyd, Yann Coadou, AIMILIANOS KOULOURIS, Lorenzo Marcoccia, George Iakovidis, Sandro Palestini, Alberto Stabile, Dimitrii Krasnopevtsev, Ljiljana Morvaj, Tomas Komarek, Sylvain Tisserant, Trine Poulsen, Wendy Taylor, Ruggero Turra, Janet Dietrich, Baptiste Ravina, Eirik Gramstad, Iacopo Vivarelli, Anna Lipniacka, Pienpen Seema, Tal Van Daalen, Spyridon Argyropoulos, Lawrence Lee, Guillaume Unal, Joaquin Poveda, Wolfgang Walkowiak, Francesco Guescini, Hyungsuk Son, Jan-Hendrik Arling, Sergey Burdin, Ismet Siral, Allen Mincer, Lara Katharina Schildgen, Ewelina Maria Lobodzinska, Daniel Rauch, Hideyuki Oide, Andrea Dell’Acqua, Giovanni Darbo, Krzysztof Korcyl, Tatsumi Nitta, Carl Suster, Peter Berta, Carlo Dallapiccola, Giada Mancini, Fabian Becherer, Christian Scharf, Kuan-Yu Lin, Pedro Teixeira-Dias, Patrick Czodrowski, Nicola Orlando, John Raine, Johannes Junggeburth, Nadezda Proklova, Neelam Kumari, Masahiro Kuze, Klaus Moenig, Geoffrey Mullier, Cristobal Padilla, Samira Hassani, Alexandre Lebedev, Elisabetta Pianori, Jens Weingarten, Thomas Spieker, Vasiliki A. Mitsou, Roberto Iuppa, Evelyn Thomson, Annick Lleres, Krisztian Peters, Angel Abusleme, Oleg Brandt, Tibor Zenis, Sara Alderweireldt, Gonzalo Enrique Orellana, Mattias Ellert, Stefan Von Buddenbrock, Bakar Chargeishvili, Heather Gray, Ioan-Mihail Dinu, Farid Ould-Saada, Amir Farbin, Teng Jian Khoo, John Stupak III, Tamara Vazquez Schroeder, Marco Cristoforetti, Marino Romano, Oxana Smirnova, ERIC BALLABENE, Victor Solovyev, Hannah Herde, Peter Johannes Falke, Joern Lange, Hajime Nanjo, Kun Liu, Konstantinos Nikolopoulos, Julie Kirk, Jonathan David Long, Salvatore Loffredo, Valerio Dao, Philip Allport, Marjorie Shapiro, Takuya Nobe, Aaron Angerami, Deb Sankar Bhattacharya, Saskia Falke, William Murray, Thomas Charman, Tomasz Bold, Hans Peter Beck, Borut Kersevan, Vadim Bednyakov, Andrea Di Luca, JOAO VICTOR DA FONSECA PINTO, Andrea Matic, Andrew Pilkington, Antonio Policicchio, Javier Montejo Berlingen, José Ocariz, Michael Hank, Stefano Terzo, Alessandro Cerri, Jose Guillermo Panduro Vazquez, Alexander Bitadze, Ming-chung Chu, Paul Thompson, Jean-Baptiste De Vivie, Gianluca Alimonti, Humphry Tlou, Ivan Sykora, Vincent Alexander Croft, Thorsten Wengler, Jiri Kroll, George Redlinger, Martin Barisits, Mariusz Przybycien, Torre Wenaus, Cristinel Diaconu, Alexandros Marantis, Fabrice Hubaut, Robert McPherson, Ilija Vukotic, Tomas Davidek, Nabila Wahab Shaikh, Michel Lefebvre, Michael Nelson, Ivo Van Vulpen, Santiago Gonzalez de la Hoz, Anthony Doyle, Tomas Dado, Stephane JEZEQUEL, TROCME Benjamin, Marc Escalier, Lars Henkelmann, Polyneikis Tzanis, Norman Gee, Emanuel Gouveia, Anthony Affolder, Aleandro Nisati, Aurelio Juste, Emma Kuwertz, Dengfeng Zhang, Yusheng Wu, Georges Aad, Koji Terashi, Vincent Wai Sum Wong, Athanasios Manousos, Alena Loesle, Wladyslaw Dabrowski, Rahul Balasubramanian, Mazuza Ghneimat, Michele LIVAN, Wenhao Xu, Frank Filthaut, Yassine El Ghazali, Nuno Castro, Antoine Marzin, Christian Johnson, Luis Pascual Domínguez, Tommaso Lari, Laurent Schoeffel, Madhuranga Thilakasiri Madugoda Ralalage Don, Marco Rimoldi, Carolyn Gee, Bruce Yabsley, Jahred Adelman, Jana Faltova, Björn Wendland, Sebastian Grinstein, Ellis Kay, Michele Weber, Fabio Cardillo, Minghui Liu, Michal Svatos, Nicolas Berger, Carlos Escobar Ibáñez, Bartosz Mindur, Claire Gwenlan, Peter Van Gemmeren, Asma HADEF, Dominik Duda, Craig Buttar, Frank Winklmeier, Frederik Ruehr, Daniel Camarero Muñoz, Yoram Rozen, Thomas Koffas, Yohei Noguchi, Claude Leroy, Kyle Cranmer, Peter Onyisi, Thi Ngoc Loan Truong, LUCAS FLORES, Clara Leitgeb, Ali EL Moussaouy, Konstantinos Ntekas, Garabed Halladjian, Ryan Atkin, Elodie Resseguie, William Fawcett, Luc Goossens, Lydia Roos, Alexey Zhemchugov, Tatyana Kharlamova, Francisco Alonso, Paolo Gauzzi, Rebeca Gonzalez Suarez, Mario Giordani, Mario Grandi, Maria Josefina Alconada Verzini, Gaogalalwe Mokgatitswane, Julia Gonski, Lucia Masetti, Calin Alexa, Davide Pietro Mungo, Ana Paula Pereira Peixoto, Mateusz Dyndal, Georges Azuelos, Robert Astalos, Werner Wiedenmann, Marcos Vinicius Silva Oliveira, Lea Halser, Arnaud Lucotte, Lesya Horyn, Jesus Guerrero Rojas, Giancarlo Panizzo, Ning Zhou, Masahiro Morii, Wade Fisher, Theodore Georgio Zorbas, Petr Balek, Nicolas Ellis, Silvia Resconi, Oleg Meshkov, Christine Kourkoumelis, James Walder, Gianluca Introzzi, Murtaza Safdari, Cristiano Sebastiani, Evelina Bouhova-Thacker, Paola Giannetti, Trevor Vickey, Christos Vergis, MARCELLO FANTI, Harish Potti, Anna Kaczmarska, Alison Elliot, Alexey Anisenkov, Paolo Francavilla, Trisha Farooque, Jan Kretzschmar, Patrick Rieck, Eric Edward Corrigan, Farida Fassi, James Keaveney, James Mueller, Kendall Reeves, Song-Ming Wang, Jay Chan, Silvia Biondi, Roman Lysak, Daniela Marcella Rebuzzi, Minyu Feng, Hongbo Zhu, Stefio Yosse Andrean, Sau Lan Wu, Adrian Bevan, Andre Sopczak, Harold Evans, Craig Sawyer, Nikola Makovec, Costa Mezquita, Luis Roberto Flores Castillo, Christian Gutschow, Salah-eddine Dahbi, Tristan Beau, Ryu Sawada, Andre Rummler, Alexander Held, JUAN TERRON, Othmane Rifki, Danijela Bogavac, Eftychia Tzovara, Sinead Farrington, Calum Macdonald, Jörn Große-Knetter, Riccardo Maria Bianchi, Liron Barak, Frank Ellinghaus, Peter Kodyš, Fabrizio Trovato, Joany Manjarrés Ramos, Victor Maleev, Philipp Horn, Xin Wu, Alexandra Tudorache, Sukanya Sinha, Andrei-Alexandru Geanta, Bingxuan Liu, Alessandro Lapertosa, Chunhui Chen, Yury Smirnov, Benjamin Carlson, Hok-Chuen Cheng, Giuliano Gustavino, Susumu Oda, Eleni Myrto Asimakopoulou, Andrei Snesarev, Jonathan David Bossio Sola, Frederic Deliot, Markus Elsing, Alexandre Laurier, Benoit Roland, Marina Rotaru, Marcello Bindi, Ki Lie, Tim Adye, Evangelos Kourlitis, Marcin Wolter, Leigh Schaefer, William McCormack, Katharina E. Schleicher, Paolo Sabatini, Shawn McKee, Knut Oddvar Høie Vadla, Chen Yu-Heng, Arnaud Duperrin, Luigi Longo, Giuseppe Avolio, Pavel Řezníček, Stephane Willocq, Cristiano Alpigiani, Robert Les, Javier Llorente Merino, Matteo Franchini, Seth Zenz, Stefania Stucci, Matthias Saimpert, Juerg Beringer, Ester Ricci, Janusz Chwastowski, Chaowaroj Wanotayaroj, Soumya Mohapatra, Ferdinand Krieter, Manuella Vincter, Jianming Qian, Oana Vickey Boeriu, Laurent Chevalier, Stephen Hillier, Jordy Degens, Emily Takeva, Victor Araujo Ferraz, Dongshuo Du, Ondrej Penc, Laura Gonella, Archil Durglishvili, Salvador Marti-Garcia, Andrea Gabrielli, Bjarne Stugu, Muhammad Usman, Lorenzo Massa, Alexey Ezhilov, Iacopo Longarini, Melissa Franklin, James Heinlein, Jana Schaarschmidt, Remi Lafaye, Sabrina Groh, Nikolai Russakovich, Jeffrey Shahinian, Giacomo Artoni, Andreas Warburton, Konie Al khoury, Armin Ilg, Liang Li, Anthony Morley, Junpei Maeda, Miguel Villaplana Perez, Paul Gessinger, Jiri Chudoba, Marcella Bona, Steffen Stärz, Fernando Barreiro, Stefan Popa, Garrett Merz, Robert Kowalewski, Aliaksei Hrynevich, Jason Nielsen, Karel Smolek, Elizabeth Brost, Lorenzo Feligioni, Maximiliano Sioli, J. Katharina Behr, Yuri Kulchitsky, Murrough Landon, Krzysztof Cieśla, Nikolaos Konstantinidis, Knut Zoch, Mikhail Levchenko, Sergi Rodríguez Boscà, Peter Henrik Hansen, Elisabeth Schopf, Lidia Dell'Asta, ANNA GOUSSIOU, Kevin Varvell, Shyam Balaji, Stefania Xella, Yuji Yamazaki, Stephen Jiggins, Matei-Eugen Vasile, Jonathan Jamieson, Hucheng Chen, Vincent Goumarre, Sahal Yacoob, Matt LeBlanc, Nataliia Zakharchuk, Gideon Bella, Emmanuel Sauvan, Muhammad Alhroob, Lorenzo Bellagamba, Ole Myren Røhne, Ngoc Khanh Vu, Martin White, Paul Jackson, Rachik Soualah, Juan Pedro Ochoa-Ricoux, Zhiying Li, Anton Wolf, Lennart Adam, Antonio Ereditato, Vojtech Pleskot, Christian Schmitt, Domizia Orestano, Heather Russell, Leonid Kurchaninov, James Kendrick, Yifan Hu, Carl Gwilliam, Florencia Luciana Castillo, Pingchuan Zhao, Bernhard Meirose, Evgeny Khramov, Avik Roy, Supriya Sinha, Kunlin Ran, Jozsef Toth, Luigi Sabetta, Damiano Vannicola, Jay Sandesara, Eric Schanet, Micael Veríssimo de Araújo, Khalil Bouaouda, Carmen Garcia, Kevin Sedlaczek, Markus Cristinziani, Marie-Helene Genest, Emma Torro Pastor, Sergei Smirnov, Andrea Coccaro, Massimo Lazzaroni, Didier Ferrere, Edward Moyse, Daniel Kelsey, Dominik Derendarz, Federico Meloni, Hannes Mildner, Elizaveta Shabalina, Farès Djama, Walter Hopkins, Pablo Martinez-Agullo, Mark Oreglia, Konstantinos Bachas, Thomas G McCarthy, Caterina Doglioni, Javier Sanchez, Mario Lassnig, John Baines, Carlos Lacasta, Driss Benchekroun, Steven Schramm, Christos Leonidopoulos, Margherita Primavera, Elisabetta Barberio, Enrico Junior Schioppa, Beojan Stanislaus, Klaudia Maj, Fabien Jeanneau, Evgeny Shulga, Andy Buckley, Joseph Muse, Daniele Zanzi, Stefan Schmitt, Nihal BRAHIMI, Pierre-Antoine Delsart, Marco Sessa, Gunnar Jakel, Kamal Saoucha, Matthias Danninger, Louis-Guillaume Gagnon, Harald Fox, Katharine Leney, Khuram Tariq, William Leight, Francesco Giuli, Mukesh Kumar, Maximilian Swiatlowski, Matthew Heath, Djamel BOUMEDIENE, Anna Sfyrla, Yingjie Wei, Laura Barranco Navarro, Peter Loch, Ruth Pöttgen, Juan Antonio Garcia Pascual, Ana Rosario Cueto Gómez, Loïc Valéry, Marek Palka, Jyoti Prakash Biswal, Maximilian Hils, Christian Ohm, Susana Cabrera Urbán, Thomas Stevenson, Henri Bachacou, Liza Mijovic, Davide Costanzo, Monika Wielers, Madar Romain, Edoardo Maria Farina, Craig Wiglesworth, Hongtao Yang, Steven Worm, Cristóvão Da Cruz e Silva, Sinem Simsek, Kazunori Hanagaki, David Britton, Rosa Simoniello, Andrea Ventura, Michael Duehrssen-Debling, Javier Jiménez Peña, Noemi Cavalli, Jaroslav Guenther, Evelin Bakos, Paolo Camarri, Sergio Calvente Lopez, Marcel Weirich, Werner Spolidoro Freund, Andrea Knue, Christopher Gorham Lester, Yanlin Liu, Rickard Ström, Tigran Mkrtchyan, Blaž Leban, Shahzad Ali, Benedict Tobias Winter, Marc-André Pleier, David Sankey, Frederick Luehring, Johannes Erdmann, Soufiane Zerradi, Nicolas Morange, Scott Snyder, Hartmut Sadrozinski, Nikiforos Nikiforou, Valentina Tudorache, Florian Leitgeb, Guglielmo Frattari, Fabian Hügging, Zoya Karpova, Oliver Majersky, Tiago Vale, Michael Begel, Tamar Djobava, Marco Valente, Andrey Ryzhov, Abhishek Sharma, Siqi Yang, Sergio Grancagnolo, Francesca Ungaro, Richard Keeler, Stefano Camarda, Kathleen Whalen, Jose Enrique Garcia Navarro, Federico Sforza, Roman Müller, Hans-Christian Schultz-Coulon, Simone Francescato, Alvaro Lopez Solis, Justin Albert, Giuseppe Callea, Xiaotian Liu, Laura Pereira Sánchez, Philipp Mogg, Armin Nairz, Koji Sato, Takanori Kono, Jared Little, Jiangyong Jia, Mingyi Liu, Thomas Billoud, Matteo Mario Beretta, Torsten Akesson, Bartosz Dziedzic, Christopher Pollard, Patrawan Pasuwan, Yuta Okazaki, Valentina Maria Martina Cairo, Krzysztof Sliwa, Martine Bosman, Ioannis Maniatis, Artur Coimbra, Kohei Yorita, Veronica Fabiani, Fabrizio Napolitano, Panagiotis Bellos, Jean-Francois Arguin, Brian Moser, Shigeki Hirose, Masahiko Saito, Pavel Starovoitov, Jacopo Magro, Noam Tal Hod, Tomas Jakoubek, Andrew Blue, Nico Giangiacomi, Claire Antel, PHILLIP URQUIJO, Santu Mondal, Tobias Golling, Hector De la Torre Perez, Jacob Kempster, Louis Portales, Yuan-Tang Chou, Kayla McLean, Leszek Adamczyk, Giordon Stark, Arno Straessner, Anjishnu Bandyopadhyay, Jochen Jens Heinrich, María Moreno Llácer, Tatsuya Masubuchi, Yanjun Tu, Iwona Grabowska-Bold, Marija Vranjes Milosavljevic, Riccardo Poggi, Ahmed Bassalat, Alessia Murrone, Sophie Trincaz-Duvoid, Giuseppe Carratta, Aishik Ghosh, Joseph Carter, Nenad Vranjes, Jianhuan Xiang, Jonathan Butterworth, Francisca Munoz Sanchez, Guenter Duckeck, Masato Aoki, Sebastian Weber, Osamu Jinnouchi, Christian Weiser, Jean-François Grivaz, Flavia De Almeida Dias, Sarah Heim, Elena Freundlich, Liaoshan Shi, Claire David, Marcel Vos, Robin Newhouse, and Paul Dervan

Published
2022
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44. Measurements of jet observables sensitive to b -quark fragmentation in tt¯ events at the LHC with the ATLAS detector

Author

Kaili Zhang, Michel Vetterli, Zhiqing Zhang, Eleanor Jones, Nektarios Benekos, Renjie Wang, Swagato Banerjee, Christos Bakalis, Nico Madysa, Umberto De Sanctis, Fridolin Dittus, Christophe Roland, Aidan Robson, António Jacques Costa, Sergey Karpov, Alberto Valero, Christina Potter, Hassane Hamdaoui, Clara Troncon, Santosh Parajuli, Louis D'Eramo, Marta Czurylo, SERKANT ALİ ÇETİN, Ludovic Michel Scyboz, Ovidiu Miu, Wasikul Islam, Andrea Formica, Francois Corriveau, Joaquin Hoya, Zekeriya Uysal, Matt Zhang, Pawel Klimek, Deepak Kar, Alessandra Betti, Melissa Ridel, Andrey Kiryunin, Emily Anne Thompson, Juan Antonio Aguilar Saavedra, Aidan Grummer, Yohei Yamaguchi, Philip Sommer, Stanislav Nemecek, Vladimir Cindro, Katherine Pachal, Artur Trofymov, Naryshkin Iurii, Pascal Pralavorio, Nello Bruscino, Evgenii Baldin, Jos Vermeulen, Arka Santra, Roberto Di Nardo, Sigve Haug, Yee Chinn Yap, Amanda Steinhebel, Lailin Xu, Jeroen Schouwenberg, Chris Hays, Nathalie Besson, Kunlin Han, Bobby Acharya, Vitaliano Chiarella, Dirk Sammel, Vasiliki Kouskoura, Serena Palazzo, Gabriele D'Amen, Daniela Köck, Amal Vaidya, Philipp Windischhofer, Lee Sawyer, Alessio Pizzini, Thu LH Pham, Andrew Haas, Alison Lister, Zuzana Rurikova, Fang-Ying Tsai, Xiangyang Ju, Amanda Cooper-Sarkar, Jonas Strandberg, Giuseppe Iacobucci, Riccardo Vari, Stephen Lloyd, Adriaan König, Yann Coadou, AIMILIANOS KOULOURIS, Lorenzo Marcoccia, George Iakovidis, Sandro Palestini, Alberto Stabile, Dimitrii Krasnopevtsev, Ljiljana Morvaj, Tomas Komarek, Sylvain Tisserant, Trine Poulsen, Wendy Taylor, Ruggero Turra, Janet Dietrich, Baptiste Ravina, Eirik Gramstad, Iacopo Vivarelli, Anna Lipniacka, Pienpen Seema, Tal Van Daalen, Spyridon Argyropoulos, Lawrence Lee, Guillaume Unal, Joaquin Poveda, Wolfgang Walkowiak, Francesco Guescini, Hyungsuk Son, Jan-Hendrik Arling, Sergey Burdin, Ismet Siral, Allen Mincer, Lara Katharina Schildgen, Ewelina Maria Lobodzinska, Daniel Rauch, Hideyuki Oide, Andrea Dell’Acqua, Giovanni Darbo, Krzysztof Korcyl, Tatsumi Nitta, Carl Suster, Peter Berta, Carlo Dallapiccola, Giada Mancini, Fabian Becherer, Christian Scharf, Kuan-Yu Lin, Pedro Teixeira-Dias, Patrick Czodrowski, Nicola Orlando, John Raine, Johannes Junggeburth, Nadezda Proklova, Masahiro Kuze, Klaus Moenig, Geoffrey Mullier, Cristobal Padilla, Samira Hassani, Alexandre Lebedev, Elisabetta Pianori, Jens Weingarten, Thomas Spieker, Vasiliki A. Mitsou, Roberto Iuppa, Evelyn Thomson, Annick Lleres, Krisztian Peters, Paolo Morettini, Oleg Brandt, Tibor Zenis, Sara Alderweireldt, Gonzalo Enrique Orellana, Mattias Ellert, Stefan Von Buddenbrock, Bakar Chargeishvili, Heather Gray, Farid Ould-Saada, Amir Farbin, Teng Jian Khoo, John Stupak III, Tamara Vazquez Schroeder, Vassili Kazanin, Marco Cristoforetti, Marino Romano, Oxana Smirnova, Victor Solovyev, Hannah Herde, Peter Johannes Falke, Yasushi Nagasaka, Joern Lange, Hajime Nanjo, Kun Liu, Konstantinos Nikolopoulos, Julie Kirk, Jonathan David Long, Salvatore Loffredo, Valerio Dao, Philip Allport, Marjorie Shapiro, Takuya Nobe, Aaron Angerami, Deb Sankar Bhattacharya, Saskia Falke, William Murray, Thomas Charman, Tomasz Bold, Hans Peter Beck, Borut Kersevan, Vadim Bednyakov, Andrea Di Luca, JOAO VICTOR DA FONSECA PINTO, Andrea Matic, Andrew Pilkington, María Pilar Casado Lechuga, Antonio Policicchio, Javier Montejo Berlingen, José Ocariz, Michael Hank, Stefano Terzo, Alessandro Cerri, Jose Guillermo Panduro Vazquez, Alexander Bitadze, Ming-chung Chu, Paul Thompson, Jean-Baptiste De Vivie, Gianluca Alimonti, Ivan Sykora, Vincent Alexander Croft, Thorsten Wengler, Jiri Kroll, George Redlinger, Martin Barisits, Mariusz Przybycien, Torre Wenaus, Cristinel Diaconu, Alexandros Marantis, Fabrice Hubaut, Robert McPherson, Ilija Vukotic, Tomas Davidek, Nabila Wahab Shaikh, Michel Lefebvre, Michael Nelson, Ivo Van Vulpen, Santiago Gonzalez de la Hoz, Anthony Doyle, Tomas Dado, Stephane JEZEQUEL, TROCME Benjamin, Marc Escalier, Lars Henkelmann, Norman Gee, Emanuel Gouveia, Anthony Affolder, Aleandro Nisati, Aurelio Juste, Emma Kuwertz, Dengfeng Zhang, Yusheng Wu, Georges Aad, Koji Terashi, Vincent Wai Sum Wong, Athanasios Manousos, Korbinian Schmidt-Sommerfeld, Alena Loesle, Wladyslaw Dabrowski, Rahul Balasubramanian, Mazuza Ghneimat, Michele LIVAN, Wenhao Xu, Frank Filthaut, Nuno Castro, Antoine Marzin, Christian Johnson, Luis Pascual Domínguez, Tommaso Lari, Laurent Schoeffel, Madhuranga Thilakasiri Madugoda Ralalage Don, Marco Rimoldi, Carolyn Gee, Bruce Yabsley, Jahred Adelman, Jana Faltova, Björn Wendland, Sebastian Grinstein, Ellis Kay, Michele Weber, Fabio Cardillo, Minghui Liu, Michal Svatos, Nicolas Berger, Carlos Escobar Ibáñez, Bartosz Mindur, Claire Gwenlan, Peter Van Gemmeren, Asma HADEF, Akshat Puri, Dominik Duda, Craig Buttar, Frank Winklmeier, Frederik Ruehr, Daniel Camarero Muñoz, Yoram Rozen, Thomas Koffas, Yohei Noguchi, Claude Leroy, Kyle Cranmer, Peter Onyisi, Thi Ngoc Loan Truong, LUCAS FLORES, Clara Leitgeb, Arthur Eugen Bolz, Konstantinos Ntekas, Fenfen An, Garabed Halladjian, Ryan Atkin, Elodie Resseguie, William Fawcett, Luc Goossens, Lydia Roos, Alexey Zhemchugov, Tatyana Kharlamova, Francisco Alonso, Paolo Gauzzi, Rebeca Gonzalez Suarez, Mario Giordani, Lidija Zivkovic, Mario Grandi, Maria Josefina Alconada Verzini, Gaogalalwe Mokgatitswane, Julia Gonski, Lucia Masetti, Robert Hunter, Calin Alexa, Davide Pietro Mungo, Ana Paula Pereira Peixoto, Mateusz Dyndal, Georges Azuelos, Robert Astalos, Werner Wiedenmann, Marcos Vinicius Silva Oliveira, Arnaud Lucotte, Lesya Horyn, Jesus Guerrero Rojas, Giancarlo Panizzo, Ning Zhou, Matej Melo, Masahiro Morii, Wade Fisher, Theodore Georgio Zorbas, Petr Balek, Nicolas Ellis, Silvia Resconi, Oleg Meshkov, Christine Kourkoumelis, James Walder, Gianluca Introzzi, Murtaza Safdari, Cristiano Sebastiani, Evelina Bouhova-Thacker, Paola Giannetti, Trevor Vickey, Christos Vergis, MARCELLO FANTI, Harish Potti, Anna Kaczmarska, Alison Elliot, Alexey Anisenkov, Paolo Francavilla, Trisha Farooque, Makoto Shimojima, Jan Kretzschmar, Patrick Rieck, Eric Edward Corrigan, Farida Fassi, James Keaveney, James Mueller, Kendall Reeves, Song-Ming Wang, Jay Chan, Francesco Maria Follega, Silvia Biondi, Roman Lysak, Daniela Marcella Rebuzzi, Minyu Feng, Hongbo Zhu, Stefio Yosse Andrean, Sau Lan Wu, Adrian Bevan, Andre Sopczak, Harold Evans, Craig Sawyer, Nikola Makovec, Costa Mezquita, Luis Roberto Flores Castillo, Christian Gutschow, Paul Glaysher, Salah-eddine Dahbi, Tristan Beau, Ryu Sawada, Andre Rummler, Kristian Gregersen, Alexander Held, JUAN TERRON, Othmane Rifki, Danijela Bogavac, Eftychia Tzovara, Sinead Farrington, Calum Macdonald, Jörn Große-Knetter, Riccardo Maria Bianchi, Liron Barak, Frank Ellinghaus, Peter Kodyš, Fabrizio Trovato, Joany Manjarrés Ramos, Victor Maleev, Roland Jansky, Philipp Horn, Xin Wu, Alexandra Tudorache, Sukanya Sinha, Andrei-Alexandru Geanta, Bingxuan Liu, Alessandro Lapertosa, Chunhui Chen, Yury Smirnov, Benjamin Carlson, Hok-Chuen Cheng, Giuliano Gustavino, Susumu Oda, Eleni Myrto Asimakopoulou, Emma Winkels, Andrei Snesarev, Jonathan David Bossio Sola, Frederic Deliot, Markus Elsing, Alexandre Laurier, Benoit Roland, Marina Rotaru, Marcello Bindi, Ki Lie, Tim Adye, Evangelos Kourlitis, Marcin Wolter, Leigh Schaefer, William McCormack, Katharina E. Schleicher, Paolo Sabatini, Shawn McKee, Knut Oddvar Høie Vadla, Chen Yu-Heng, Arnaud Duperrin, Luigi Longo, Ziyu Guo, Giuseppe Avolio, Pavel Řezníček, Stephane Willocq, Cristiano Alpigiani, Robert Les, Javier Llorente Merino, Matteo Franchini, Seth Zenz, Stefania Stucci, Matthias Saimpert, Juerg Beringer, Ester Ricci, Janusz Chwastowski, Chaowaroj Wanotayaroj, Soumya Mohapatra, Ferdinand Krieter, Manuella Vincter, Jianming Qian, Oana Vickey Boeriu, Laurent Chevalier, Stephen Hillier, Emily Takeva, Victor Araujo Ferraz, Dongshuo Du, Ondrej Penc, Laura Gonella, Archil Durglishvili, Salvador Marti-Garcia, Andrea Gabrielli, Bjarne Stugu, Lorenzo Massa, Alexey Ezhilov, Iacopo Longarini, Melissa Franklin, James Heinlein, Jana Schaarschmidt, Remi Lafaye, Sabrina Groh, Nikolai Russakovich, Jeffrey Shahinian, Giacomo Artoni, Andreas Warburton, Konie Al khoury, Armin Ilg, Liang Li, Anthony Morley, Junpei Maeda, Miguel Villaplana Perez, Paul Gessinger, Jiri Chudoba, Marcella Bona, Steffen Stärz, Fernando Barreiro, Garrett Merz, Robert Kowalewski, Aliaksei Hrynevich, Jason Nielsen, Karel Smolek, Elizabeth Brost, Lorenzo Feligioni, Maximiliano Sioli, J. Katharina Behr, Yuri Kulchitsky, Murrough Landon, Krzysztof Cieśla, Nikolaos Konstantinidis, Knut Zoch, Mikhail Levchenko, Sergi Rodríguez Boscà, Peter Henrik Hansen, Elisabeth Schopf, Lidia Dell'Asta, ANNA GOUSSIOU, Kevin Varvell, Shyam Balaji, Stefania Xella, Yuji Yamazaki, Stephen Jiggins, Matei-Eugen Vasile, David Handl, Jonathan Jamieson, Hucheng Chen, Sahal Yacoob, Matt LeBlanc, Nataliia Zakharchuk, Alexey Buzykaev, Gideon Bella, Emmanuel Sauvan, Muhammad Alhroob, Lorenzo Bellagamba, Ole Myren Røhne, Ngoc Khanh Vu, Martin White, Paul Jackson, Rachik Soualah, Juan Pedro Ochoa-Ricoux, Zhiying Li, Anton Wolf, Lennart Adam, Samuel Jones, Antonio Ereditato, Vojtech Pleskot, Christian Schmitt, Domizia Orestano, Heather Russell, Leonid Kurchaninov, James Kendrick, Yifan Hu, Carl Gwilliam, Florencia Luciana Castillo, Pingchuan Zhao, Bernhard Meirose, Evgeny Khramov, Avik Roy, Kunlin Ran, Jozsef Toth, Luigi Sabetta, Damiano Vannicola, Eric Schanet, Khalil Bouaouda, Carmen Garcia, Kevin Sedlaczek, Markus Cristinziani, Marie-Helene Genest, Emma Torro Pastor, Sergei Smirnov, Simone Monzani, Andrea Coccaro, Massimo Lazzaroni, Didier Ferrere, Edward Moyse, Daniel Kelsey, Dominik Derendarz, Federico Meloni, Hannes Mildner, Elizaveta Shabalina, Farès Djama, Walter Hopkins, Pablo Martinez-Agullo, Mark Oreglia, Konstantinos Bachas, Troels Petersen, Thomas G McCarthy, Caterina Doglioni, Nikita Smirnov, Javier Sanchez, Mario Lassnig, John Baines, Carlos Lacasta, Driss Benchekroun, Steven Schramm, Christos Leonidopoulos, Margherita Primavera, Elisabetta Barberio, Enrico Junior Schioppa, Beojan Stanislaus, Klaudia Maj, Fabien Jeanneau, Evgeny Shulga, Andy Buckley, Joseph Muse, Max Isacson, Matteo Negrini, Daniele Zanzi, Stefan Schmitt, Nihal BRAHIMI, Pierre-Antoine Delsart, Marco Sessa, Gunnar Jakel, Kamal Saoucha, Matthias Danninger, Louis-Guillaume Gagnon, Stamatios Gkaitatzis, Harald Fox, Katharine Leney, Khuram Tariq, William Leight, Francesco Giuli, Mukesh Kumar, Maximilian Swiatlowski, Matthew Heath, Djamel BOUMEDIENE, Anna Sfyrla, Yingjie Wei, Laura Barranco Navarro, Peter Loch, Ruth Pöttgen, Juan Antonio Garcia Pascual, Ana Rosario Cueto Gómez, Loïc Valéry, Marek Palka, Jyoti Prakash Biswal, Maximilian Hils, Christian Ohm, Susana Cabrera Urbán, Thomas Stevenson, Henri Bachacou, Liza Mijovic, Davide Costanzo, Monika Wielers, Madar Romain, Edoardo Maria Farina, Craig Wiglesworth, Hongtao Yang, Steven Worm, Sinem Simsek, Kazunori Hanagaki, David Britton, Rosa Simoniello, Andrea Ventura, Michael Duehrssen-Debling, Javier Jiménez Peña, Jaroslav Guenther, Evelin Bakos, Paolo Camarri, Sergio Calvente Lopez, Marcel Weirich, Werner Spolidoro Freund, Andrea Knue, Christopher Gorham Lester, Yanlin Liu, Tigran Mkrtchyan, Shahzad Ali, Benedict Tobias Winter, Marc-André Pleier, David Sankey, Frederick Luehring, Johannes Erdmann, Soufiane Zerradi, Nicolas Morange, Scott Snyder, Hartmut Sadrozinski, Nikiforos Nikiforou, Valentina Tudorache, Florian Leitgeb, Guglielmo Frattari, Johannes Mellenthin, Fabian Hügging, Zoya Karpova, Oliver Majersky, Tiago Vale, Michael Begel, Tamar Djobava, Marco Valente, Vincent R. Pascuzzi, MARILEA REALE, Andrey Ryzhov, Abhishek Sharma, Siqi Yang, Sergio Grancagnolo, Francesca Ungaro, Richard Keeler, Stefano Camarda, Kathleen Whalen, Jose Enrique Garcia Navarro, Federico Sforza, Hans-Christian Schultz-Coulon, Simone Francescato, Alvaro Lopez Solis, Justin Albert, Giuseppe Callea, Xiaotian Liu, Kehinde Tomiwa, Laura Pereira Sánchez, Yu Zhang, Philipp Mogg, Armin Nairz, Koji Sato, Takanori Kono, Jared Little, Jiangyong Jia, Mingyi Liu, Thomas Billoud, Matteo Mario Beretta, Torsten Akesson, Bartosz Dziedzic, Christopher Pollard, Patrawan Pasuwan, Yuta Okazaki, Valentina Maria Martina Cairo, Krzysztof Sliwa, Martine Bosman, Ioannis Maniatis, Artur Coimbra, Kohei Yorita, Veronica Fabiani, Fabrizio Napolitano, Panagiotis Bellos, Jean-Francois Arguin, Brian Moser, Shigeki Hirose, Masahiko Saito, Pavel Starovoitov, Jacopo Magro, Noam Tal Hod, Tomas Jakoubek, Alessandra Camplani, Andrew Blue, Nico Giangiacomi, Claire Antel, PHILLIP URQUIJO, Santu Mondal, Tobias Golling, Hector De la Torre Perez, Jacob Kempster, Louis Portales, Yuan-Tang Chou, Kayla McLean, Leszek Adamczyk, Giordon Stark, Arno Straessner, Anjishnu Bandyopadhyay, Jochen Jens Heinrich, María Moreno Llácer, Tatsuya Masubuchi, Yanjun Tu, Iwona Grabowska-Bold, Marija Vranjes Milosavljevic, Riccardo Poggi, Ahmed Bassalat, Alessia Murrone, Sophie Trincaz-Duvoid, Giuseppe Carratta, Aishik Ghosh, Joseph Carter, Nenad Vranjes, Jianhuan Xiang, Jonathan Butterworth, Francisca Munoz Sanchez, Guenter Duckeck, Masato Aoki, Sebastian Weber, Osamu Jinnouchi, Christian Weiser, Jean-François Grivaz, Flavia De Almeida Dias, Sarah Heim, Elena Freundlich, Liaoshan Shi, Claire David, Marcel Vos, Robin Newhouse, and Paul Dervan

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2022
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45. Observation of WWW Production in pp Collisions at s=13 TeV with the ATLAS Detector

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Kaili Zhang, Michel Vetterli, Zhiqing Zhang, Eleanor Jones, Renjie Wang, Christos Bakalis, Umberto De Sanctis, Fridolin Dittus, Christophe Roland, Aidan Robson, António Jacques Costa, Sergey Karpov, Alberto Valero, Christina Potter, Hassane Hamdaoui, Clara Troncon, Santosh Parajuli, Louis D'Eramo, Marta Czurylo, SERKANT ALİ ÇETİN, Ovidiu Miu, Wasikul Islam, Andrea Formica, Francois Corriveau, Joaquin Hoya, Zekeriya Uysal, Matt Zhang, Pawel Klimek, Deepak Kar, Alessandra Betti, Melissa Ridel, Andrey Kiryunin, Emily Anne Thompson, Juan Antonio Aguilar Saavedra, Aidan Grummer, Abdualazem Fadol, Yohei Yamaguchi, Philip Sommer, Stanislav Nemecek, Vladimir Cindro, Katherine Pachal, Artur Trofymov, Naryshkin Iurii, Pascal Pralavorio, Nello Bruscino, Evgenii Baldin, Jos Vermeulen, Arka Santra, Roberto Di Nardo, Sigve Haug, Yee Chinn Yap, Amanda Steinhebel, Lailin Xu, Chris Hays, Kunlin Han, Bobby Acharya, Vitaliano Chiarella, Dirk Sammel, Serena Palazzo, Gabriele D'Amen, Daniela Köck, Philipp Windischhofer, Lee Sawyer, Alessio Pizzini, Thu LH Pham, Andrew Haas, Alison Lister, Zuzana Rurikova, Fang-Ying Tsai, Xiangyang Ju, Amanda Cooper-Sarkar, Jonas Strandberg, Giuseppe Iacobucci, Riccardo Vari, Stephen Lloyd, Yann Coadou, AIMILIANOS KOULOURIS, Lorenzo Marcoccia, George Iakovidis, Sandro Palestini, Alberto Stabile, Ljiljana Morvaj, Tomas Komarek, Sylvain Tisserant, Trine Poulsen, Wendy Taylor, Ruggero Turra, Baptiste Ravina, Eirik Gramstad, Iacopo Vivarelli, Anna Lipniacka, Pienpen Seema, Tal Van Daalen, Spyridon Argyropoulos, Lawrence Lee, Guillaume Unal, Joaquin Poveda, Wolfgang Walkowiak, Francesco Guescini, Hyungsuk Son, Jan-Hendrik Arling, Sergey Burdin, Ismet Siral, Allen Mincer, Ewelina Maria Lobodzinska, Hideyuki Oide, Andrea Dell’Acqua, Giovanni Darbo, Krzysztof Korcyl, Peter Berta, Carlo Dallapiccola, Giada Mancini, Fabian Becherer, Christian Scharf, Kuan-Yu Lin, Pedro Teixeira-Dias, Patrick Czodrowski, Nicola Orlando, John Raine, Johannes Junggeburth, Nadezda Proklova, Neelam Kumari, Masahiro Kuze, Klaus Moenig, Geoffrey Mullier, Cristobal Padilla, Alexandre Lebedev, Elisabetta Pianori, Jens Weingarten, Vasiliki A. Mitsou, Roberto Iuppa, Evelyn Thomson, Krisztian Peters, Paolo Morettini, Angel Abusleme, Oleg Brandt, Tibor Zenis, Sara Alderweireldt, Gonzalo Enrique Orellana, Mattias Ellert, Bakar Chargeishvili, Heather Gray, Ioan-Mihail Dinu, Farid Ould-Saada, Efstathios Karentzos, Amir Farbin, Teng Jian Khoo, John Stupak III, Tamara Vazquez Schroeder, Vassili Kazanin, Marco Cristoforetti, Marino Romano, Oxana Smirnova, ERIC BALLABENE, Victor Solovyev, Hannah Herde, Peter Johannes Falke, Joern Lange, Hajime Nanjo, Kun Liu, Konstantinos Nikolopoulos, Julie Kirk, Jonathan David Long, Salvatore Loffredo, Valerio Dao, Philip Allport, Marjorie Shapiro, Takuya Nobe, Aaron Angerami, Deb Sankar Bhattacharya, Saskia Falke, William Murray, Thomas Charman, Tomasz Bold, Hans Peter Beck, Kaan Yüksel Oyulmaz, Borut Kersevan, Vadim Bednyakov, Andrea Di Luca, JOAO VICTOR DA FONSECA PINTO, Andrea Matic, Andrew Pilkington, María Pilar Casado Lechuga, Javier Montejo Berlingen, José Ocariz, Michael Hank, Stefano Terzo, Alessandro Cerri, Jose Guillermo Panduro Vazquez, Alexander Bitadze, Ming-chung Chu, Paul Thompson, Jean-Baptiste De Vivie, Gianluca Alimonti, Humphry Tlou, Ivan Sykora, Vincent Alexander Croft, Thorsten Wengler, Jiri Kroll, George Redlinger, Martin Barisits, Mariusz Przybycien, Torre Wenaus, Cristinel Diaconu, Alexandros Marantis, Robert McPherson, Ilija Vukotic, Tomas Davidek, Nabila Wahab Shaikh, Michel Lefebvre, Ivo Van Vulpen, Santiago Gonzalez de la Hoz, Anthony Doyle, Tomas Dado, Stephane JEZEQUEL, TROCME Benjamin, Marc Escalier, Lars Henkelmann, Polyneikis Tzanis, Emanuel Gouveia, Pablo Augusto Ulloa Poblete, Anthony Affolder, Aleandro Nisati, Aurelio Juste, Emma Kuwertz, Dengfeng Zhang, Yusheng Wu, Georges Aad, Koji Terashi, Vincent Wai Sum Wong, Athanasios Manousos, Alena Loesle, Wladyslaw Dabrowski, Rahul Balasubramanian, Michele LIVAN, Wenhao Xu, Frank Filthaut, Yassine El Ghazali, Nuno Castro, Antoine Marzin, Christian Johnson, Luis Pascual Domínguez, Tommaso Lari, Laurent Schoeffel, Marco Rimoldi, Carolyn Gee, Bruce Yabsley, Jahred Adelman, Jana Faltova, Björn Wendland, Sebastian Grinstein, Ellis Kay, Michele Weber, Fabio Cardillo, Minghui Liu, Michal Svatos, Nicolas Berger, Carlos Escobar Ibáñez, Bartosz Mindur, Petr Baroň, Claire Gwenlan, Peter Van Gemmeren, Asma HADEF, Dominik Duda, Craig Buttar, Frank Winklmeier, Frederik Ruehr, Daniel Camarero Muñoz, Yoram Rozen, Thomas Koffas, Yohei Noguchi, Claude Leroy, Kyle Cranmer, Peter Onyisi, Thi Ngoc Loan Truong, LUCAS FLORES, Clara Leitgeb, Ali EL Moussaouy, Konstantinos Ntekas, Ryan Atkin, Elodie Resseguie, William Fawcett, Luc Goossens, Lydia Roos, Alexey Zhemchugov, Tatyana Kharlamova, Francisco Alonso, Paolo Gauzzi, Rebeca Gonzalez Suarez, Mario Giordani, Mario Grandi, Maria Josefina Alconada Verzini, Gaogalalwe Mokgatitswane, Ranjit Nayak, Julia Gonski, Lucia Masetti, Calin Alexa, Davide Pietro Mungo, Ana Paula Pereira Peixoto, Mateusz Dyndal, Georges Azuelos, Robert Astalos, Werner Wiedenmann, Marcos Vinicius Silva Oliveira, Lea Halser, Arnaud Lucotte, Lesya Horyn, Jesus Guerrero Rojas, Giancarlo Panizzo, Ning Zhou, Masahiro Morii, Wade Fisher, Theodore Georgio Zorbas, Petr Balek, Nicolas Ellis, Silvia Resconi, Oleg Meshkov, Christine Kourkoumelis, James Walder, Gianluca Introzzi, Murtaza Safdari, Cristiano Sebastiani, Evelina Bouhova-Thacker, Paola Giannetti, Trevor Vickey, Christos Vergis, Barbora Eckerová, MARCELLO FANTI, Harish Potti, Anna Kaczmarska, Alison Elliot, Alexey Anisenkov, Paolo Francavilla, Trisha Farooque, Jan Kretzschmar, Patrick Rieck, Eric Edward Corrigan, Farida Fassi, James Keaveney, James Mueller, Kendall Reeves, Song-Ming Wang, Jay Chan, Francesco Maria Follega, Silvia Biondi, Roman Lysak, Daniela Marcella Rebuzzi, Minyu Feng, Hongbo Zhu, Stefio Yosse Andrean, Sau Lan Wu, Adrian Bevan, Andre Sopczak, Harold Evans, Craig Sawyer, Nikola Makovec, Costa Mezquita, Luis Roberto Flores Castillo, Christian Gutschow, Salah-eddine Dahbi, Tristan Beau, Ryu Sawada, Andre Rummler, Alexander Held, JUAN TERRON, Danijela Bogavac, Eftychia Tzovara, Sinead Farrington, Jörn Große-Knetter, Riccardo Maria Bianchi, Liron Barak, Frank Ellinghaus, Peter Kodyš, Fabrizio Trovato, Joany Manjarrés Ramos, Victor Maleev, Xin Wu, Alexandra Tudorache, Sukanya Sinha, Andrei-Alexandru Geanta, Bingxuan Liu, Alessandro Lapertosa, Yury Smirnov, Benjamin Carlson, Hok-Chuen Cheng, Giuliano Gustavino, Susumu Oda, Eleni Myrto Asimakopoulou, Andrei Snesarev, Jonathan David Bossio Sola, Frederic Deliot, Markus Elsing, Alexandre Laurier, Benoit Roland, Marina Rotaru, Marcello Bindi, Ki Lie, Tim Adye, Evangelos Kourlitis, Marcin Wolter, William McCormack, Katharina E. Schleicher, Paolo Sabatini, Shawn McKee, Knut Oddvar Høie Vadla, Arnaud Duperrin, Luigi Longo, Giuseppe Avolio, Pavel Řezníček, Stephane Willocq, Cristiano Alpigiani, Robert Les, Javier Llorente Merino, Matteo Franchini, Seth Zenz, Stefania Stucci, Matthias Saimpert, Juerg Beringer, Ester Ricci, Janusz Chwastowski, Soumya Mohapatra, Saverio D'Auria, Ferdinand Krieter, Manuella Vincter, Jianming Qian, Oana Vickey Boeriu, Laurent Chevalier, Stephen Hillier, Jordy Degens, Emily Takeva, Victor Araujo Ferraz, Dongshuo Du, Ondrej Penc, Laura Gonella, Archil Durglishvili, Salvador Marti-Garcia, Andrea Gabrielli, Bjarne Stugu, Muhammad Usman, Lorenzo Massa, Alexey Ezhilov, Iacopo Longarini, Melissa Franklin, James Heinlein, Jana Schaarschmidt, Sabrina Groh, Nikolai Russakovich, Jeffrey Shahinian, Giacomo Artoni, Sonia Kabana, Andreas Warburton, Konie Al khoury, Armin Ilg, Liang Li, Anthony Morley, Junpei Maeda, Miguel Villaplana Perez, Paul Gessinger, Jiri Chudoba, Marcella Bona, Steffen Stärz, Fernando Barreiro, Robert Kowalewski, Aliaksei Hrynevich, Jason Nielsen, Karel Smolek, Elizabeth Brost, Lorenzo Feligioni, Maximiliano Sioli, J. Katharina Behr, Yuri Kulchitsky, Murrough Landon, Krzysztof Cieśla, Nikolaos Konstantinidis, Knut Zoch, Mikhail Levchenko, Sergi Rodríguez Boscà, Peter Henrik Hansen, Elisabeth Schopf, Lidia Dell'Asta, ANNA GOUSSIOU, Kevin Varvell, Shyam Balaji, Stefania Xella, Yuji Yamazaki, Stephen Jiggins, Matei-Eugen Vasile, Jonathan Jamieson, Hucheng Chen, Vincent Goumarre, Sahal Yacoob, Matt LeBlanc, Nataliia Zakharchuk, Alexey Buzykaev, Gideon Bella, Emmanuel Sauvan, Muhammad Alhroob, Lorenzo Bellagamba, Ole Myren Røhne, Benedikt Vormwald, Ngoc Khanh Vu, Martin White, Paul Jackson, Rachik Soualah, Juan Pedro Ochoa-Ricoux, Zhiying Li, Anton Wolf, Lennart Adam, Antonio Ereditato, Vojtech Pleskot, Christian Schmitt, Domizia Orestano, Heather Russell, Leonid Kurchaninov, James Kendrick, Yifan Hu, Carl Gwilliam, Florencia Luciana Castillo, Pingchuan Zhao, Bernhard Meirose, Evgeny Khramov, Avik Roy, Supriya Sinha, Kunlin Ran, Luigi Sabetta, Damiano Vannicola, Jay Sandesara, Eric Schanet, Micael Veríssimo de Araújo, Khalil Bouaouda, Carmen Garcia, Kevin Sedlaczek, Markus Cristinziani, Marie-Helene Genest, Emma Torro Pastor, Sergei Smirnov, Andrea Coccaro, Massimo Lazzaroni, Didier Ferrere, Edward Moyse, Daniel Kelsey, Dominik Derendarz, Federico Meloni, Hannes Mildner, Elizaveta Shabalina, Farès Djama, Walter Hopkins, Pablo Martinez-Agullo, Mark Oreglia, Konstantinos Bachas, Troels Petersen, Thomas G McCarthy, Caterina Doglioni, Javier Sanchez, Mario Lassnig, John Baines, Carlos Lacasta, Driss Benchekroun, Steven Schramm, Christos Leonidopoulos, Margherita Primavera, Elisabetta Barberio, Enrico Junior Schioppa, Beojan Stanislaus, Klaudia Maj, Lukas Novotny, Fabien Jeanneau, Andy Buckley, Joseph Muse, Matteo Negrini, Daniele Zanzi, Stefan Schmitt, Nihal BRAHIMI, Pierre-Antoine Delsart, Marco Sessa, Gunnar Jakel, Kamal Saoucha, Matthias Danninger, Louis-Guillaume Gagnon, Harald Fox, Katharine Leney, Khuram Tariq, William Leight, Francesco Giuli, Mukesh Kumar, Maximilian Swiatlowski, Matthew Heath, Djamel BOUMEDIENE, Anna Sfyrla, Yingjie Wei, Laura Barranco Navarro, Peter Loch, Ruth Pöttgen, Juan Antonio Garcia Pascual, Ana Rosario Cueto Gómez, Marek Palka, Jyoti Prakash Biswal, Christian Ohm, Susana Cabrera Urbán, Thomas Stevenson, Henri Bachacou, Liza Mijovic, Davide Costanzo, Monika Wielers, Madar Romain, Edoardo Maria Farina, Craig Wiglesworth, Hongtao Yang, Steven Worm, Cristóvão Da Cruz e Silva, Marzieh Bahmani, Sinem Simsek, Kazunori Hanagaki, David Britton, Rosa Simoniello, Andrea Ventura, Michael Duehrssen-Debling, Javier Jiménez Peña, Noemi Cavalli, Evelin Bakos, Paolo Camarri, Marcel Weirich, Werner Spolidoro Freund, Andrea Knue, Christopher Gorham Lester, Yanlin Liu, Rickard Ström, Tigran Mkrtchyan, Blaž Leban, Shahzad Ali, Benedict Tobias Winter, Marc-André Pleier, David Sankey, Frederick Luehring, Johannes Erdmann, Soufiane Zerradi, Nicolas Morange, Scott Snyder, Hartmut Sadrozinski, Nikiforos Nikiforou, Valentina Tudorache, Florian Leitgeb, Guglielmo Frattari, Fabian Hügging, Zoya Karpova, Oliver Majersky, Tiago Vale, Michael Begel, Tamar Djobava, Marco Valente, Vincent R. Pascuzzi, Andrey Ryzhov, Siqi Yang, Sergio Grancagnolo, Richard Keeler, Stefano Camarda, Kathleen Whalen, Jose Enrique Garcia Navarro, Federico Sforza, Roman Müller, Hans-Christian Schultz-Coulon, Simone Francescato, Alvaro Lopez Solis, Justin Albert, Giuseppe Callea, Xiaotian Liu, Laura Pereira Sánchez, Philipp Mogg, Armin Nairz, Koji Sato, Marvin Flores, Takanori Kono, Jared Little, Jiangyong Jia, Mingyi Liu, Katherine Dunne, Thomas Billoud, Matteo Mario Beretta, Torsten Akesson, Bartosz Dziedzic, Christopher Pollard, Patrawan Pasuwan, Yuta Okazaki, Valentina Maria Martina Cairo, Martine Bosman, Ioannis Maniatis, Artur Coimbra, Kohei Yorita, Fabrizio Napolitano, Panagiotis Bellos, Jean-Francois Arguin, Brian Moser, Shigeki Hirose, Masahiko Saito, Pavel Starovoitov, Antonio Carbone, Jacopo Magro, Noam Tal Hod, Tomas Jakoubek, Alessandra Camplani, Andrew Blue, Nico Giangiacomi, Claire Antel, PHILLIP URQUIJO, Santu Mondal, Tobias Golling, Hector De la Torre Perez, Jacob Kempster, Louis Portales, Yuan-Tang Chou, Kayla McLean, Leszek Adamczyk, Giordon Stark, Arno Straessner, Anjishnu Bandyopadhyay, Francesco Ragusa, Jochen Jens Heinrich, María Moreno Llácer, Tatsuya Masubuchi, Yanjun Tu, Iwona Grabowska-Bold, Marija Vranjes Milosavljevic, Riccardo Poggi, Ahmed Bassalat, Alessia Murrone, Sophie Trincaz-Duvoid, Giuseppe Carratta, Aishik Ghosh, Joseph Carter, Nenad Vranjes, Jonathan Butterworth, Francisca Munoz Sanchez, Guenter Duckeck, Tasnuva Chowdhury, Masato Aoki, Sebastian Weber, Osamu Jinnouchi, Christian Weiser, Bruna Pascual Dias, Jean-François Grivaz, Flavia De Almeida Dias, Sarah Heim, Elena Freundlich, Liaoshan Shi, Claire David, Marcel Vos, Robin Newhouse, and Paul Dervan

Subjects
General Physics and Astronomy
Published
2022
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46. Antibacterial Peptide NP-6 Affects Staphylococcus aureus by Multiple Modes of Action

Author

Xiaoyan Hou, Jianlong Li, Huaqiao Tang, Qingye Li, Guanghui Shen, Shanshan Li, Anjun Chen, Zixin Peng, Yu Zhang, Chaowei Li, and Zhiqing Zhang

Subjects
Inorganic Chemistry, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, antibacterial peptide, Staphylococcus aureus, modes of action, Spectroscopy, Catalysis, Computer Science Applications
Abstract

Our previous study extracted and identified an antibacterial peptide that was named NP-6. Herein, we investigated the physicochemical properties of NP-6, and elucidated the mechanisms underlying its antimicrobial activity against Staphylococcus aureus. The results showed that the hemolysis activity of NP-6 was 2.39 ± 0.13%, lower than Nisin A (3.91 ± 0.43%) at the same concentration (512 µg/mL). Negligible cytotoxicity towards RAW264.7 cells was found when the concentration of NP-6 was lower than 512 µg/mL. In addition, it could keep most of its activity in fetal bovine serum. Moreover, transmission electron microscopy, confocal laser scanning microscopy, and flow cytometry results showed that NP-6 can destroy the integrity of the bacterial cell membrane and increase the membrane permeability. Meanwhile, NP-6 had binding activity with bacterial DNA and RNA in vitro and strongly inhibited the intracellular β-galactosidase activity of S. aureus. Our findings suggest that NP-6 could be a promising candidate against S. aureus.

Published
2022
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47. Inhibition of imrecoxib on mRNA and protein expression of CYP2C11 enzyme in rats

Author

Xikun Wu, Qi An, Jie Dong, Kexin Wang, Yiran Jin, Xiujv Liu, and Zhiqing Zhang

Subjects
Pharmacology, Clinical Biochemistry, General Medicine, Sulfides, Biochemistry, Rats, Analytical Chemistry, Steroid 16-alpha-Hydroxylase, Drug Discovery, Microsomes, Liver, Animals, Pyrroles, Aryl Hydrocarbon Hydroxylases, RNA, Messenger, Cytochrome P450 Family 2, Molecular Biology
Abstract

To evaluate the effect of imrecoxib on CYP2C11 enzyme activity, mRNA, and protein expression, a UPLC method was established. Tolbutamide was selected as the CYP2C11 enzyme-specific probe drug and incubated with imrecoxib in rat liver microsomes. The yield of 4-hydroxytolbutamide was measured using UPLC to investigate the effect of imrecoxib on CYP2C11 enzyme activity. Imrecoxib (10 mg/kg) was administered intragastrically twice daily. After 1, 7, and 14 days of administration, the liver tissues were analyzed. The expression of CYP2C11 enzyme mRNA was determined using reverse transcription-polymerase chain reaction, and its protein expression was determined using Western blot analysis. Imrecoxib concentration was inversely proportional to the production of 4-hydroxytolbutamide in liver microsomes. Imrecoxib demonstrated a dose-dependent inhibitory effect on CYP2C11 activity with IC

Published
2022
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48. Creep behavior and microstructural evolution of 8030 aluminum alloys compressed at intermediate temperature

Author

Xiangze Fan, Qingbo Yang, Zhiqing Zhang, Qing Liu, Zhihong Jia, and Peng Chen

Subjects
Materials science, chemistry.chemical_element, 02 engineering and technology, Activation energy, 01 natural sciences, Biomaterials, Stress (mechanics), Aluminium, 0103 physical sciences, Compression creep, Compression (geology), Composite material, Microstructure, 010302 applied physics, Mining engineering. Metallurgy, Metals and Alloys, TN1-997, 021001 nanoscience & nanotechnology, Surfaces, Coatings and Films, 8030 aluminum alloys, Intermediate temperature, chemistry, Creep, Ceramics and Composites, Deformation (engineering), Dislocation, 0210 nano-technology, Constitutive equation
Abstract

The compression creep behavior of 8030 aluminum alloys at intermediate temperature was studied under the deformation temperature of 200∼250 °C and compression stress ranging from 20 to 40 MPa. The apparent stress exponent (na), the true stress exponent (nt) and the activation energy Qc for creep were na = 3.6, nt = 3 and Qc = 145.5 kJ/mol, respectively, indicating that the dislocation viscous glide controlled by lattice self-diffusion was the dominant creep mechanism of the samples at 200 °C-20 MPa. A creep constitutive equation was introduced with the threshold stress σ0 = 5.1 MPa. The microstructure characterization of selected samples was investigated by transmission electron microscopy (TEM), indicating that the sub-grain contours became ambiguous and the dislocations with long curved morphologies were homogeneously distributed within grain inners after creep for 100h.

Published
2021

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