Search

Additional file 1. Supplementary Figure 1. Profile of baseline circulating sICs levels in definite ATB, LTBI and HC individuals. Supplementary Figure 2. Dynamic changes of ten circulating sICs during anti-TB treatment.

First-order magnetic transitions are of both fundamental and technological interest given that a number of emergent phases and functionalities are thereby created. Of particular interest are giant magnetocaloric effects, which are attributed to first-order magnetic transitions and have attracted broad attention for solid-state refrigeration applications. While the conventional wisdom is that atomic lattices play an important role in first-order magnetic transitions, a coherent microscopic description of the lattice and spin degrees of freedom is still lacking. Here, we study the magnetic phase transition dynamics on the intermetallic LaFe13-xSix, which is one of the most classical giant magnetocaloric systems, in both frequency and time domains utilizing neutron scattering and ultrafast X-ray diffraction. We have observed a strong magnetic diffuse scattering in the paramagnetic state preceding the first-order magnetic transition, corresponding to picosecond ferromagnetic fluctuations. Upon photon-excitation, the ferromagnetic state is completely suppressed in 0.9 ps and recovered in 20 ps. The ultrafast dynamics suggest that the magnetic degree of freedom dominates this magnetoelastic transition and ferromagnetic fluctuations might be universally relevant for this kind of compounds., Comment: 5 figures in the main text, plus supplementary information

The spin-orbit torque device is promising as a candidate for next generation magnetic memory, while the static in-plane field needed to induce deterministic switching is a main obstacle for its application in highly integrated circuits. Instead of introducing effective field into the device, in this work we present an alternative way to achieve the field-free current-driven magnetization switching. By adding Tb/Co multilayers at two ends of the current channel, assisting domain wall is created by interlayer exchange coupling. The field-free deterministic switching is achieved by the movement of the domain wall driven by current. By loop shift measurement we find the driven force exerted on the domain wall is determined by the direction of the in-plane moment in the domain wall. Finally, we modify the device into a synthetic antiferromagnetic structure to solve the problem of reading out signal. The present work broadens the choice of field-free spin-orbit torque device design and clearly depicts the difference between two different switching mechanism.

Objective To investigate the effect of T lymphocytes PD-1/B7-H1 path expression in patients with severe hepatitis depression from promoting liver cell growth hormone combinations from Gongying Yinchen soup. Methods With reference to the American psychiatric association’s diagnostic statistical manual of mental disorders, fourth edition (dsm-iv) criteria, 88 cases of fulminant hepatitis in patients with depression were collected as treatment group, which consist of acute severe hepatitis (n = 31), chronic severe hepatitis (n = 28) and subacute severe hepatitis (n = 29),120 mg promoting liver cell growth hormone to join within 250 ml of 10 % glucose injection, intravenous drip, 1 times a day, 15 d for a period of treatment, At the same time to add with the Gongying Yinchen soup (dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter arguments). Three period of treatment. Thirty healthy persons of control group come from blood donor of central blood stations. The expressions of PD-1/B7-H1 of T lymphocytes and T lymphocyte subsets of two groups were determined by flow cytometry. Results The positive expression of PD1 and B7—H1of T lymphocytes in patients of the treatment group was significant higher than that in healthy control group (P < 0.05); The positive expression of PD1and B7—H1of T lymphocytes significantly decreased after treatment in the treatment group (P < 0.05). The amount of CD4+, CD8+ cells of the treatment group was significantly lower than that of control group (P < 0.05). The amount of CD4+/CD8+ cells of the treatment group was higher than that of control group (P < 0.05), significantly decreased after treatment (P < 0.05). Conclusion Promoting liver cell growth hormone combination from the Gongying Yinchen soup can influence expression of T lymphocytes PD-1/B7-H1 path in patients with severe hepatitis depression, enhance the body’s immune response.

Objective Discuss the effect of using Hepatocyte growth-promoting factors combined with Gongying Yinchen soup to cure depression in patients with fulminant hepatitis. Methods Choose 61 cases of fulminant hepatitis patients with depression, With reference to the American psychiatric association Mental disorders diagnostic and statistical manual (DSM-IV) Classification standard, 31 cases patients were randomly divided into treatment group, which was given Gongying Yinchen soup and intravenous drip of 10 % glucose injection 250 ml containing Hepatocyte growth-promoting factors 120 rag, once daily, 15 days for a course of treatment and 30 in the control group, application of this method at the same time added nutgrass galingale rhizome, radix curcumae, radix angelicae sinensis, radix paeoniae alba, radix aucklandiae and other drugs. After three courses of treatment, HAMD rating scale, scores of TCM symptoms. Determine the efficacy. Results Use Gongying Yinchen soup combined with promoting liver cell growth hormone treatment of severe hepatitis patients with depression after treatment, pretherapy and post-treatment in the two groups of HAMD scale total score, treatment group before treatment 45.23 ± 17.29, after the treatment 44.25 ± 18.14; the control group before treatment 43.25 ± 18.30, after the treatment 28.46 ± 14.08, the therapeutic effect of control group patients was much better than that of treatment group cases (P < 0.05); Chinese medicine symptom curative effect as a whole,Treatment group total effectiveness 80.6 %, control group 93.3 %, had significant statistical differences were compared (P < 0.05). Conclusions Promoting liver cell growth to combination the Gongying Yinchen soup curative effect in patients with severe hepatitis depression significantly.

Objective Discuss the effect of Hepatocyte growth-promoting factors combined with Gongying Yinchen soup on peripheral blood SIL-2R of depression in fulminant hepatitis patients. Methods Choose 88 cases of fulminant hepatitis patients with depression,With reference to the American psychiatric association Mental disorders diagnostic and statistical manual (DSM-IV) Classification standard, The treatment group 88 cases, which was given GongYing Yinchen soup and intravenous drip of 10 % glucose injection 250 ml containing Hepatocyte growth-promoting factors 120 rag, once daily, 15 days for a course of treatment, Application of above methods at the same time to add with the Gongying Yinchen soup, etc. (Dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter ginseng). After the treatment for three courses, Peripheral blood levels of SIL-2R in all patients with severe hepatitis depression were detected,and 30 healthy blood donors were used as controls. Methods Adopt the method of ELISA for levels of SIL-2R in all patients of two groups were detected pre and post-treatment. Results Compare the blood level of SIL-2R of Each group patients with severe hepatitis and health adults, there is significant statistical significance (P < 0.05, P < 0.05). Treatment group after treatment level of serum SIL-2R significantly decreased, There was a significant difference in comparison with the pretreatment (P < 0.01). Conclusions Hepatocyte growth-promoting factors combined with Gongying Yinchen soup can influence peripheral blood SIL-2R of depression in fulminant hepatitis patients, efficacy significantly on severe hepatitis, Can enhance the body’s immune response.