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Protein kinase C δ (PKCδ), a subtype of PKC family, has been recognized as a tumor promoter or suppressor depending on different tissue specificities in various tumor types. However, the effects of PKCδ on somatotropinomas are poorly understood. This study aims to explore the precise role of PKCδ in promoting tumor progression in somatotropinomas. In the present study, we examined the expression levels of PKCδ in clinical specimens of human somatotropinomas to show that PKCδ overexpression correlated with invasive properties of somatotropinomas. Furthermore, we employed rat anterior pituitary GH3 cells as the experiment model to demonstrate that PKCδ activation by PKC agonist (Phorbol-12-myristate-13-acetate, PMA) significantly promoted the proliferation and migration potential of GH3 cells, and these effects could be abolished following PKCδ inhibition by specific inhibitor Rottlerin. Mechanistically, PKCδ activated ERK1/2 signaling, which was responsible for PKCδ-induced promotion of GH3 cell proliferation and migration. Taken together, our results indicated that PKCδ functions as a tumor promoter by promoting cell proliferation and migration in somatotropinomas.

Social network analysis has adopted sociology, computer science, graph theory, topology, complex network and other subjects as its research methods and applied in macro analysis of practical social problems. This paper adopts social network analysis method through establishing unified model of Tibetan Web data, applied Tibetan entity identification, searching algorithm and extracting the semantic relations of the entity of Tibetan Web networks to analyze the overall information of Tibetan Web, in order to provide a platform for data analysis and public opinion situation forecast for national security.

Conception Relevance means the concept newly emerged in the study of relational Web. It refers to the texts of a Web page are relevant to another page's content and the relevance is based on the concepts of some words in the texts. This paper aims to establish a comprehensive and accurate knowledge database and construct a Tibetan conception relevance search engine system by acquiring Tibetan Web data, clustering and searching conception relevance data of Tibetan Web as well as gathering comprehensive information of conception relevance data set of Tibetan Web.