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Takotsubo syndrome (TTS) is featured by activation of sympatho-β-adrenoceptor (βAR) system leading to acute loss of ventricular contractile performance. However, the molecular mechanism remains undefined. We demonstrated, in an isoproterenol-induced murine TTS-like model, extensive mitochondrial damage, metabolic dysfunction, and downregulated mitochondrial marker proteins, changes temporarily associated with cardiac dysfunction. Mechanistically, stimulation of βAR activated Hippo signaling pathway and genetic inactivation of Mst1 kinase ameliorated mitochondrial damage and metabolic dysfunction at the acute phase of TTS.

The Lam\'e function can be used to construct plane wave factors and solutions to the Korteweg-de Vries (KdV) and Kadomtsev-Petviashvili (KP) hierarchy. The solutions are usually called elliptic solitons. In this chapter, first, we review recent development in the Hirota bilinear method on elliptic solitons of the KdV equation and KP equation, including bilinear calculations involved with the Lam\'e type plane wave factors, expressions of $\tau$ functions and the generating vertex operators. Then, for the discrete potential KdV and KP equations, we give their bilinear forms, derive $\tau$ functions of elliptic solitons, and show that they share the same vertex operators with the KdV hierarchy and the KP hierarchy, respectively., Comment: 24 pages

A significant portion of the memory in servers today is often unused. Our large-scale study of HPC systems finds that more than half of the total memory in active nodes running user jobs are unused for 88% of the time. Google and Azure Cloud studies also report unused memory accounts for 40% of the total memory in their servers, on average. Leaving so much memory unused is wasteful. To address this problem, we note that in the context of CPUs, Turbo Boost can turn off the unused cores to boost the performance of in-use cores. However, there is no equivalent technology in the context of memory; no matter how much memory is unused, the performance of in-use memory remains the same. This dissertation explores architectural techniques to utilize the unused memory to boost the performance of in-use memory and refer to them collectively as Memory Turbo Boost. This dissertation explores how to turbo boost memory performance through memory replication; specifically, it explores how to efficiently store the replicas in the unused memory and explores multiple architectural techniques to utilize the replicas to enhance memory system performance. Performance simulations show that Memory Turbo Boost can improve node-level performance by 18%, on average across a wide spectrum of workloads. Our system-wide simulations show applying Memory Turbo Boost to an HPC system provides 1.4x average speedup on job turnaround time. Doctor of Philosophy Today's servers often have a significant portion of their memory unused. Our large-scale study of HPC systems finds that more than half of the total memory of an HPC server is unused for most of the time; Google and Azure Cloud studies find that 40% of the total memory in their servers is often unused. Today's servers usually have 100s of GBs to TB memory; 40% unused memory means 10s-100s of GBs unused memory on the servers. Leaving so much memory unused is wasteful. To address this problem, I note that there are techniques to leverage unused hardware resources to improve the performance of in-use resources in other types of hardware. For example, CPU Turbo Boost can turn off the unused cores to boost the performance of in-use cores; modern SSDs can use the unused space to switch the Multi-Level Cell blocks to Single-Level Cell blocks to boost performance. However, there is no equivalent technology in the context of memory; no matter how much memory is unused, the performance of in-use memory remains the same. This dissertation explores techniques to utilize the unused memory to boost the performance of in-use memory and refer to them collectively as Memory Turbo Boost. Performance evaluations show that Memory Turbo Boost can provide up to 18% average performance improvement.

Expanding multi-country emissions trading system is considered as crucial to fill the existing mitigation gap for the 2\degree C climate target. Trustworthy emissions accounting is the cornerstone of such a system encompassing different jurisdictions. However, traditional emissions measuring, reporting, and verification practices that support data authenticity might not be applicable as detailed data from large utilities and production facilities to be covered in the multi-country emissions trading system are usually highly sensitive and of severe national security concern. In this study, we propose a cryptographic framework for an authenticated and secure emissions accounting system that can resolve this data dilemma. We demonstrate that integrating a sequence of cryptographic protocols can preserve data authenticity and security for a stylized multi-country emissions trading system. We call for more research to promote applications of modern cryptography in future international climate governance to build trust and strengthen collaboration.

As human stem cells with the special pluripotency play important roles in the innovative drug discovery and regenerative medicine, development of extracellular matrix (ECM) mimetics or functional materials that can support stem cell growth and propagation is of high significance. Despite numerous efforts spent, one major limitation restricting the wide applications of stem cells to the clinical translation is the lack of efficient strategies for low cost and large-scale stem cell production under xeno-free culture conditions. Herein, we reported a new strategy with peptides-modified polystyrene-based polymers coated onto the surface of coverslips for the growth and reproduction of human embryonic stem cells (hESCs). The modified peptides are the active parts of proteins which has been shown to contribute to the pluripotent stem cell attachment or proliferation. The peptides were linked to the glass coverslips coated by the polymer materials via chemical crosslinking, and the composite substrates successfully maintain the long-term growth of HUES-7, H7 and DF699. Our study shows that the coating of polystyrene-derived polymer modified by our developed peptides is a good matrix for long-term growth and reproduction of stem cells. This polystyrene-derived polymer substrate can be produced in large scale and stored for a long time. The most important thing is that it can support the growth of undifferentiated human pluripotent stem cells (hPSCs) for more than ten passages, which could provide a new and relatively easy way to amplify hESCs in vitro.

In the recent paper [Stud. App. Math. 147 (2021) 752], squared eigenfunction symmetry constraint of the differential-difference modified Kadomtsev-Petviashvili (D$\Delta$mKP) hierarchy converts the D$\Delta$mKP system to the relativistic Toda spectral problem and its hierarchy. In this paper we introduce a new formulation of independent variables in the squared eigenfunction symmetry constraint, under which the D$\Delta$mKP system gives rise to the discrete spectral problem and a hierarchy of the differential-difference derivative nonlinear Schr\"odinger equation of the Chen-Lee-Liu type. In addition, by introducing nonisospectral flows, two sets of symmetries of the D$\Delta$mKP hierarchy and their algebraic structure are obtained. We then present a unified continuum limit scheme, by which we achieve the correspondence of the mKP and the D$\Delta$mKP hierarchies and their integrable structures., Comment: 23 pages

GRB 221009A is the brightest gamma-ray burst ever detected since the discovery of this kind of energetic explosions. However, an accurate measurement of the prompt emission properties of this burst is very challenging due to its exceptional brightness. With joint observations of \textit{Insight}-HXMT and GECAM-C, we made an unprecedentedly accurate measurement of the emission during the first $\sim$1800 s of GRB 221009A, including its precursor, main emission (ME, which dominates the burst in flux), flaring emission and early afterglow, in the hard X-ray to soft gamma-ray band from $\sim$ 10 keV to $\sim$ 6 MeV. Based on the GECAM-C unsaturated data of the ME, we measure a record-breaking isotropic equivalent energy ($E_{\rm iso}$) of $\bf \sim 1.5 \times 10^{55}$ erg, which is about eight times the total rest-mass energy of the Sun. The early afterglow data require a significant jet break between 650 s and 1100 s, most likely at $\sim950$ s from the afterglow starting time $T_{AG}$, which corresponds to a jet opening angle of $\sim {0.7^\circ} \ (\eta_\gamma n)^{1/8}$, where $n$ is the ambient medium density in units of $\rm cm^{-3}$ and $\eta_\gamma$ is the ratio between $\gamma$-ray energy and afterglow kinetic energy. The beaming-corrected total $\gamma$-ray energy $E_{\gamma}$ is $\sim 1.15 \times10^{51} \ (\eta_\gamma n)^{1/4}$ erg, which is typical for long GRBs. These results suggest that this GRB may have a special central engine, which could launch and collimate a very narrowly beamed jet with an ordinary energy budget, leading to exceptionally luminous gamma-ray radiation per unit solid angle. Alternatively, more GRBs might have such a narrow and bright beam, which are missed by an unfavorable viewing angle or have been detected without distance measurement., Comment: Submitted to National Science Review. This paper is under press embargo, contact the corresponding author for details

The gamma-ray detectors (GRDs) of GECAM-C onborad SATech-01 satellite is designed to monitor gamma-ray transients all over the sky from 6 keV to 6 MeV. The energy response matrix is the key to do spectral measurements of bursts, which is usually generated from GEANT4 simulation and partially verified by the ground calibration. In this work, energy response matrix of GECAM-C GRD is cross-calibrated with Fermi/GBM and Swift/BAT using a sample of Gamma-Ray Bursts (GRBs) and Soft Gamma-Ray Repeaters (SGRs). The calibration results show there is a good agreement between GECAM-C and other reasonably well calibrated instrument (i.e. Fermi/GBM and Swift/BAT). We also find that different GRD detectors of GECAM-C also show consistency with each other. All these results indicate that GECAM-C GRD can provide reliable spectral measurements., preliminary version, will be updated soon

As a new member of GECAM mission, GECAM-C (also named High Energy Burst Searcher, HEBS) was launched onboard the SATech-01 satellite on July 27th, 2022, which is capable to monitor gamma-ray transients from $\sim$ 6 keV to 6 MeV. As the main detector, there are 12 gamma-ray detectors (GRDs) equipped for GECAM-C. In order to verify the GECAM-C GRD detector performance and to validate the Monte Carlo simulations of detector response, comprehensive on-ground calibration experiments have been performed using X-ray beam and radioactive sources, including Energy-Channel relation, energy resolution, detection efficiency, SiPM voltage-gain relation and the non-uniformity of positional response. In this paper, the detailed calibration campaigns and data analysis results for GECAM-C GRDs are presented, demonstrating the excellent performance of GECAM-C GRD detectors., third version

Learning physical properties of high-dimensional states is crucial for developing quantum technologies but usually consumes an exceedingly large number of samples which are difficult to afford in practice. In this Letter, we use the methodology of quantum metrology to tackle this difficulty, proposing a strategy built upon entangling measurements for dramatically reducing sample complexity. The strategy, whose characteristic feature is symmetrization of observables, is powered by the exploration of symmetric structures of states which are ubiquitous in physics. It is provably optimal under some natural assumption, efficiently implementable in a variety of contexts, and capable of being incorporated into existing methods as a basic building block. We apply the strategy to different scenarios motivated by experiments, demonstrating exponential reductions in sample complexity., throughly revised, 4+8 pages, 1 figure

Supplemental material, sj-docx-1-npx-10.1177_1934578X221110661 for Antimycic Acid and its Acetyl Derivative from Deep-sea-derived Alcanivorax sp. SHA4 with Neuroprotective Properties by Shuang Chen, Da-shan Zhang and Jin-hui Wang in Natural Product Communications

Synthesis method, experimental data, calculation process, etc.

Supplemental Material for Three-stage channel sprays carbon nanotubes onto carbon fibers surface, preparing high performance carbon fibers composites by Chuanqi Zhang, Song Shi, Chenyu Gao, Da Zhang, Lansen Bi, Lintao Wang and Yan He in Journal of Composite Materials

TEM images, XRD patterns, Emission spectra, lifetimes, etc.

Non-Hermitian Floquet topological phases appear in systems described by time-periodic non-Hermitian Hamiltonians. This review presents a sum-up of our studies on non-Hermitian Floquet topological matter in one and two spatial dimensions. After a brief overview of the literature, we introduce our theoretical framework for the study of non-Hermitian Floquet systems and the topological characterization of non-Hermitian Floquet bands. Based on our theories, we describe typical examples of non-Hermitian Floquet topological insulators, superconductors and quasicrystals with a focus on their topological invariants, bulk-edge correspondences, non-Hermitian skin effects, dynamical properties and localization transitions. We conclude this review by summarizing our main discoveries and discussing potential future directions., Comment: 86 pages, 10 figures, comments are welcome

Additional file 1 (Table S1-S4).

In the recent paper [Stud. App. Math. 147 (2021) 752], squared eigenfunction symmetry constraint of the differential-difference modified Kadomtsev-Petviashvili (D$Δ$mKP) hierarchy converts the D$Δ$mKP system to the relativistic Toda spectral problem and its hierarchy. In this paper we introduce a new formulation of independent variables in the squared eigenfunction symmetry constraint, under which the D$Δ$mKP system gives rise to the discrete spectral problem and a hierarchy of the differential-difference derivative nonlinear Schrödinger equation of the Chen-Lee-Liu type. In addition, by introducing nonisospectral flows, two sets of symmetries of the D$Δ$mKP hierarchy and their algebraic structure are obtained. We then present a unified continuum limit scheme, by which we achieve the correspondence of the mKP and the D$Δ$mKP hierarchies and their integrable structures., 23 pages

Additional file 1: Figure S1 Construction of recombinant FHV WX19 with deletion of the gI, gE, and TK genes. A: presence of gI/E, fragment in the parenteral FHV by PCR, deletion and replacement of the counterpart by eGFP in the FHV-ΔgI/E- eGFP and FHV ΔgIgE/TK eGFP–mCherry. B: presence of TK, fragment in the parenteral FHV by PCR, deletion and replacement of the counterpart by eGFP in the FHV-ΔTK-mCherry and FHV ΔgIgE/TK eGFP–mCherry.

The Lamé function can be used to construct plane wave factors and solutions to the Korteweg-de Vries (KdV) and Kadomtsev-Petviashvili (KP) hierarchy. The solutions are usually called elliptic solitons. In this chapter, first, we review recent development in the Hirota bilinear method on elliptic solitons of the KdV equation and KP equation, including bilinear calculations involved with the Lamé type plane wave factors, expressions of $τ$ functions and the generating vertex operators. Then, for the discrete potential KdV and KP equations, we give their bilinear forms, derive $τ$ functions of elliptic solitons, and show that they share the same vertex operators with the KdV hierarchy and the KP hierarchy, respectively., 24 pages

Additional file 2 (Figure S1-S2).

Background: Schisandronic acid (SA), a triterpenoid from fruits of Schisandra sphenanthera, inhibited pan-genotypic HCV entry into human hepatocytes by interfering with virion-cell membrane fusion. It was a promising lead compound for the development of novel HCV entry inhibition agents. Objective: The aim of the present study is to search for compounds with more potent anti-HCV and antitumor activities and explore SARs. A series of novel derivatives of SA were designed and synthesized and evaluated for in vitro, their anti-HCV and antitumor activities. Methods: SA derivatives were synthesized by reduction, condensation, esterification or amidation. The anti-HCV activity of title compounds was tested by inhibition on HCVcc infection of Huh7 cells, and a preliminary MOA study was conducted by determining inhibition on HCVpp entry into Huh7 cells. The antitumor activity in vitro was determined by MTT methods. Results: In total, 24 novel derivatives were synthesized. Most of the compounds inhibited HCVcc infection. Compounds 5h and 6 showed the most potent anti-HCVcc activities and inhibition of HCVpp entry into Huh7 cells without obvious cytotoxicity. Most of the title compounds showed potent in vitro antitumor activities against Bel7404 and SMMC7721 tumor cell lines. Compounds 5j and 6 exhibited more potent antitumor activity than positive control SA and DOX. Conclusion: Structural modification of SA could lead to the discovery of potent anti-HCV or antitumor agents. Compounds 5h, 5j and 6 were promising lead compounds for development of novel HCV entry inhibition or antitumor agents.

Red sage, the dry root and rhizome of the herbaceous plant Salvia miltiorrhiza Bunge, is widely used for treating various diseases. The low content of tanshinones (terpenoids) has always restricted development of the S. miltiorrhiza industry. Here, we found that SmDXS5, a rate-limiting enzyme-coding gene located at the intersection of primary and secondary metabolism, can effectively change the transcription level and secondary metabolome profile of hairy roots of S. miltiorrhiza, and significantly increase the content of tanshinones. Agrobacterium rhizogenes was used to infuse S. miltiorrhiza explants, and hairy roots of S. miltiorrhiza expressing the SmDXS5 gene were obtained successfully. We identified 39 differentially accumulated metabolites (DAMs) by metabolomics based on ultra-high performance liquid chromatography quadrupole exactive mass spectrometry and multivariate statistics. These DAMs might be key metabolites of SmDXS5 gene regulation. RNA sequencing was used to compare gene expression between the hairy roots of the SmDXS5 overexpressing group and the blank control (BC) group. Compared with the BC group, 18,646 differentially expressed genes were obtained: 8994 were upregulated and 9,652 downregulated. The combined transcriptome and metabolome analyses revealed that the mevalonate and methylerythritol phosphate pathways and synthase gene expression levels in the SmDXS5 overexpressing group were upregulated significantly, and the accumulation of tanshinone components was increased significantly, which promoted the process of glycolysis and promoted the transformation of carbohydrates to secondary metabolism. Moreover, the expression of SmPAL, the first rate-limiting enzyme gene of the phenylpropane pathway, decreased, reducing the accumulation of phenolic acid, another secondary metabolite. Therefore, SmDXS5 can be defined as a ‘valve’ gene, mainly responsible for regulating the distribution of primary and secondary metabolic flow of tanshinones in S. miltiorrhiza, and for other secondary metabolic pathways. The discovery of SmDXS5 and its molecular valve function in regulating primary and secondary metabolism will provide a basis for the industrial production of tanshinone components, and cultivation of high quality S. miltiorrhiza.

Azo-linked porous organic polymers (APOPs) were synthesized by a simple azo reaction, with 2,2'-bis(trifluoromethyl)benzidine and 1,3,5-trihydroxybenzene as the monomers. The preparation process was mild, green and environmental-friendly, avoiding the use of high temperature, metal catalysis and harmful organic reagent. The obtained APOPs were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, powder X-ray diffraction and Brunauer-Emmett-Teller. With the prepared APOPs as adsorbent, a method of pipette tip solid-phase extraction-liquid chromatography tandem mass spectrometry detection (PTSPE-LC-MS/MS) was proposed for the analysis of target sedatives in animal tissues. Furthermore, the parameters for the extraction of five sedatives, including the amount of adsorbent, pH value, ion strength, elution solvent and volume, were investigated. Under the conditions optimized, the linear dynamic range was found from 0.1 µg kg− 1 to 10.0 µg kg− 1, and the limits of detection were ranged from 0.02 µg kg− 1 to 0.1 µg kg− 1. The method was assessed by the analysis of target sedatives in animal tissues, and the recoveries for the spiked pork samples and egg samples were 84–102% and 83–101%, respectively. The results show that the developed method of PTSPE-LC-MS/MS with APOPs as adsorbent is efficient for the analysis of trace sedatives in animal tissues.

It is natural to construct a multi-frame instead of a single-frame 3D detector for a continuous-time stream. Although increasing the number of frames might improve performance, previous multi-frame studies only used very limited frames to build their systems due to the dramatically increased computational and memory cost. To address these issues, we propose a novel on-stream training and prediction framework that, in theory, can employ an infinite number of frames while keeping the same amount of computation as a single-frame detector. This infinite framework (INT), which can be used with most existing detectors, is utilized, for example, on the popular CenterPoint, with significant latency reductions and performance improvements. We've also conducted extensive experiments on two large-scale datasets, nuScenes and Waymo Open Dataset, to demonstrate the scheme's effectiveness and efficiency. By employing INT on CenterPoint, we can get around 7% (Waymo) and 15% (nuScenes) performance boost with only 2~4ms latency overhead, and currently SOTA on the Waymo 3D Detection leaderboard., accepted by ECCV2022

Purpose/significanceStudying the correlation between short video users’ personality traits and their sharing motivation can enrich the theoretical research on social sharing motivation and provide a reference for short-video content management and platform construction.Methods/processBased on uses and gratifications theory and personality traits theory, a structural model affecting short-video users’ sharing motivations was proposed. A total of 579 valid questionnaires were collected from a social network, and the proposed hypotheses were tested using SPSS and Amos software.Results/conclusionThe results show that the personality traits of short-video users affect their sharing motivation and that their specific sharing motivation also differ due to their personality traits. At the same time, the research results also confirm the Matthew effect of “the rich getting richer” and the social compensation effect of “the poor getting richer” in the context of social platforms that host short videos.

In this work, CO2 effervescence–assisted emulsification microextraction method using an efficient switchable solvent was proposed for the enrichment of azaperone and azaperol in swine adipose samples. The azaperone and azaperol in swine adipose were extracted by 1% (v/v) ammoniated acetonitrile at 55 °C. A medium-chain fatty acid as switchable-hydrophilicity solvent is used for further enrichment and purification, and it is able to be easily switched into hydrophobic/hydrophilic forms in pH changeable media. The main parameters were optimized as follows: 100 mg octanoic acid, 0.3 mL acetic acid–water solution (1:1, v/v), and 0.5 mL 3.0 mol L−1 Na2CO3 solution. Under the optimal conditions, azaperone and azaperol showed good linearity within the studied range, and the values of the correlation coefficient were higher than 0.999. The limits of detection for the method ranged from 5 to 10.0 ng kg−1. The recoveries of azaperone and azaperol in swine adipose were 95–104%, with relative standard deviations ranging from 3 to 5%. The proposed method was successfully applied for the analysis of azaperone and azaperol in swine adipose samples.

Introduction Recurrent aphthous stomatitis (RAS) is a distressing symptom experienced by patients. Many methods are used to treat, including pudilan anti-inflammatory oral liquid and doxycycline and laser therapy, but these take a long time to produce positive effects and compliance is low. Previous reviews into acupuncture for RAS has been growing, but a systematic review is not available. Therefore, this protocol was conducted to evaluate the efficacy and safety of acupuncture on RAS, by conducting a systematic review and meta-analysis. Methods and analysis The following databases will be searched from their inception to 1 February 2020: PubMed, Embase, CINAHL, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang. The randomized controlled trials (RCTs) in English or Chinese associated with acupuncture for patients with RAS will be included. Eligible study conference abstracts and reference lists of manuscripts will also be searched. The data collection and analysis will be conducted independently by two reviewers. The risk of bias of each study will be conducted by the Cochrane risk of bias tool. The heterogeneity will be measured by the I2 statistic. According to heterogeneity testing, data will be synthesized using a fixed-effects model or a random-effects model. A meta-analysis will be performed using Rev Man V.5.3.5 statistical software for each outcome. Subgroup analysis and sensitivity analysis are planned according to clinical evidence. Mean difference or standardized mean difference for continuous data and risk ratio for dichotomous data will be calculated. Ethics and dissemination This protocol will not involve individual patient information and endangering participant rights. The results will be reported in a peer- reviewed journal or disseminated in relevant conferences.

Cancer-related fatigue (CRF) is one of the most commonly found problems among the cancer survivors which affect all aspects of quality of life (QOL), but it is a treatable problem. CRF is the highly prevalent and debilitating symptom experienced by most of the cancer patients at diagnosis, which increase during therapy and often seen for considerable period of time (months and years) after well-structured cancer diagnosis. Globally, around 50%–90% of the cancer patients experiences the difficulties of cancer-related fatigue, the latter number resemble to the patients subjected to active anticancer chemotherapy and radiotherapy. CRF has been well-defined as per the guiding principle of the National Comprehensive Cancer Network (NCCN) as “a distressing, persistent, subjective sense of tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning.” Although a lot of evidence and research findings on CRF have been provided within the last two decades, CRF is still underreported, underdiagnosed, and undertreated. Effective management of CRF is important for patients and challenging for clinicians. Moxibustion appeared an efficacious auxiliary therapeutic method for CRF.

Primary insomnia is an independent disease, while it is also a symptom caused by or closely related to other physical or mental illnesses and sleep disorders. Insomnia often occurs temporarily and then improves; it may become chronic due to poor sleep habits, conditional hyperactivity, and cognitive distortions about sleep. Sleep disorders are common in the general population and yet are relatively poorly undiagnosed and untreated despite poor sleep strongly affects the quality of life of many people around the world.

Chronic fatigue syndrome (CFS) is characterized by chronic debilitating fatigue of unknown cause. The symptoms of fatigue last for at least six months and, as a result of the appearance of fatigue, there is a significant decline in the patient's daily activities and this fatigue cannot be relieved by rest or increased nutrition. This study will provide a systematic evaluation to investigate the time management of non-drug therapy of TCM for chronic fatigue syndrome with insomnia.

Introduction Constipation is a distressing symptom experienced by cancer patients during chemotherapy. Many methods are used to treat chemotherapy-induced constipation, including fiber and fluids and physical activity, but these take a long time to produce positive effects and compliance is low. Previous reviews into acupuncture and acupressure for cancer patients with constipation has been growing, but a systematic review is not available. Therefore, this protocol was conducted to evaluate the efficacy and safety of acupuncture and acupressure on constipation, by conducting a systematic review and meta-analysis. Methods and analysis The following databases will be searched from their inception to 1 February 2020: PubMed, Embase, CINAHL, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang. The randomized controlled trials (RCTs) in English or Chinese associated with acupuncture and acupressure for cancer patients with constipation will be included. Eligible study conference abstracts and reference lists of manuscripts will also be searched. The data collection and analysis will be conducted independently by two reviewers. The risk of bias of each study will be conducted by the Cochrane risk of bias tool. The heterogeneity will be measured by the I2 statistic. According to heterogeneity testing, data will be synthesized using a fixed-effects model or a random-effects model. A Meta-analysis will be performed using Rev Man V.5.3.5 statistical software for each outcome. Subgroup analysis and sensitivity analysis are planned according to clinical evidence. The Grading of Recommendations Assessment, Development and Evaluation approach will be evaluated the quality of the results. Mean difference or standardized mean difference for continuous data and risk ratio for dichotomous data will be calculated. Ethics and dissemination This protocol will not involve individual patient information and endangering participant rights. Ethical approval is not available. The results will be reported in a peer- reviewed journal or disseminated in relevant conferences.

云南镇沅地区位于哀牢山构造带中段，是古特提斯哀牢山洋关闭及碰撞造山的关键部位。本文对该地区出露的花岗斑岩进行了年代学、岩石地球化学与同位素地球化学研究。锆石U-Pb年代学给出加权平均年龄为253.3±2.0Ma，表明花岗斑岩形成于晚二叠世。3个花岗斑岩脉共5个样品分析结果表明，其SiO2含量65.30%~70.79%，全碱含量（K2O+Na2O）3.53%~4.39%，Al2O3含量13.42%~16.40%，为高钾钙碱性亚碱性系列岩石，成分上与花岗闪长岩类似，为S型花岗岩。稀土元素含量较低，轻重稀土分异程度较高，稀土配分曲线为右倾，无明显Ce异常，具弱负Eu异常，微量元素配分曲线为右倾，大离子亲石元素相对富集，高场强元素相对亏损，与典型地壳相一致。锆石Hf同位素eHf（t）为-1.0~4.1，显示岩浆源区为亏损地幔和古老地壳物质部分熔融。岩石大地构造环境分析表明，该花岗斑岩形成于晚二叠世同碰撞构造环境。

AIM: To investigate whether non-canonical autophagy transport receptor cell cycle progression 1 (CCPG1) is involved in the corneal antifungal immune response. METHODS: Human corneal epithelial cells (HCECs) and human myeloid leukemia mononuclear cells (THP-1) macrophages stimulated by Aspergillus fumigatus (A. fumigatus) were used as cell models. The expression of CCPG1 mRNA was detected by qRT-PCR. Western blot was used to determine the protein expression of CCPG1 and interleukin-1β (IL-1β). The dectin-1 neutralizing antibody was used to detect the association between dectin-1 and CCPG1. Immunofluorescence was used to observe the colocalization of CCPG1 and C-type lectin-like receptor-1 (CLEC-1) in THP-1 macrophages. RESULTS: The expression of CCPG1 started to increase at 4h after infection and increased in a time-dependent manner in HCECs and THP-1 macrophages. With dectin-1 neutralizing antibody pretreatment, the expression of IL-1β was down-regulated. CCPG1 up-regulation in response to A. fumigatus infection was independent of dectin-1. Immunofluorescence showed the colocalization of CCPG1 and CLEC-1 in THP-1 macrophages. CONCLUSION: As a specific autophagy protein of non-canonical autophagy pathway, CCPG1 is involved in corneal infection with A. fumigatus.

在国家“973”项目“雷电重大灾害天气系统的动力-微物理-电过程和成灾机理”(简称: 雷暴973)资助下, 2014~2018年连续五年在北京组织开展了雷电(也称闪电)灾害天气系统的暖季综合协同观测实验, 旨在获得对北京及周边城市群区域的雷电天气系统特征和规律的实际认识, 探索雷电资料在数值预报模式中的同化方法, 以期改进雷电重大灾害天气系统的预报效果. 主要观测设备包括: 由16个子站构成的雷电(全闪)三维定位系统、2台X波段双线偏振多普勒雷达和4台激光雨滴谱仪等, 协同观测还充分利用了中国气象局在京津冀地区的中尺度气象观测网. 观测结果表明, 受地形和环境条件影响, 飑线和多单体雷暴是影响北京地区的两类主要的雷电灾害天气系统, 它们除产生频繁的雷电活动外, 还常伴随突发性局地短时强降水和冰雹, 造成城区突发洪涝灾害. 雷电密度的高值区位于北京昌平区东部、顺义区的中部和东部以及中心城区. 超强雷暴(占总雷暴数的5%)、强雷暴(占比35%)和弱雷暴(占比60%)对总雷电分布的贡献分别为37%、56%和7%. 北京城区的热岛效应对过境雷暴增强产生了重要作用, 超强雷暴在中心城区的雷电频数可以高达每分钟数百次. 雷电活动与雷暴云的热动力、微物理特征之间存在紧密联系, 因此雷电频数可以作为冰雹、短时强降水等灾害性天气的指示因子. 在对流可分辨数值预报模式中, 建立并引入雷电资料同化方案, 通过调整或修正模式的热动力和微物理参量, 可明显提高模式对强对流和降水的预报效果.

The benefit of transurethral laser prostatectomy over open simple prostatectomy (OSP) is controversial in aged symptomatic benign prostatic hyperplasia (BPH) patients with large volume prostates, and the aim of this study is to compare the safety and efficiency of these two methods. Meta-analysis was applied using the Review Manager V5.3 software and the retrieved randomized controlled clinical trials (RCTs) comparing transurethral laser prostatectomy with OSP were analyzed for the treatment of large volume prostates from 2000 to 2019 in PubMed, Web of Science, Cochrane, and EMBASE datasets. Five RCTs assessing transurethral laser prostatectomy versus OSP were considered suitable for this meta-analysis, which included a total of 448 patients, with 232 patients undergoing laser and 216 patients undergoing OSP. Compared with OSP, although transurethral laser prostatectomy required a longer operative time (weighted mean difference (WMD) 27.49 mins; 95% confidence interval (CI) 16.54–38.44; P

In this paper we consider two examples of certain recurrence relations, or nonlinear discrete dynamical systems, that appear in the theory of orthogonal polynomials, from the point of view of Sakai's geometric theory of Painlev\'e equations. On one hand, this gives us new examples of the appearance of discrete Painlev\'e equations in the theory of orthogonal polynomials. On the other hand, it serves as a good illustration of the effectiveness of a recently proposed procedure on how to reduce such recurrences to some canonical discrete Painlev\'e equations. Of particular interest is the fact that both recurrences are regularized on the same family of rational algebraic surfaces, but at the same time their dynamics are non-equivalent., Comment: 28 pages

The fourth-order lattice Gel'fand-Dikii equations in quadrilateral form are investigated. Utilizing the direct linearization approach, we present some equations of the extended lattice Gel'fand-Dikii type. These equations are related to a quartic discrete dispersion relation and can be viewed as higher-order members of the extended lattice Boussinesq type equations. The resulting lattice equations given here are in five-component form, and some of them are multi-dimensionally consistent by introducing extra equations. Lax integrability is discussed both by direct linearization scheme and also through multi-dimensional consistent property. Some reductions of the five-component lattice equations to the four-component forms are considered.

Current efficient LiDAR-based detection frameworks are lacking in exploiting object relations, which naturally present in both spatial and temporal manners. To this end, we introduce a simple, efficient, and effective two-stage detector, termed as Ret3D. At the core of Ret3D is the utilization of novel intra-frame and inter-frame relation modules to capture the spatial and temporal relations accordingly. More Specifically, intra-frame relation module (IntraRM) encapsulates the intra-frame objects into a sparse graph and thus allows us to refine the object features through efficient message passing. On the other hand, inter-frame relation module (InterRM) densely connects each object in its corresponding tracked sequences dynamically, and leverages such temporal information to further enhance its representations efficiently through a lightweight transformer network. We instantiate our novel designs of IntraRM and InterRM with general center-based or anchor-based detectors and evaluate them on Waymo Open Dataset (WOD). With negligible extra overhead, Ret3D achieves the state-of-the-art performance, being 5.5% and 3.2% higher than the recent competitor in terms of the LEVEL 1 and LEVEL 2 mAPH metrics on vehicle detection, respectively.

simulation data

Additional file 3: Table S2. The species of C11orf96 gene in this study.

Additional file 1: Fig S1. and Fig S5. Uncropped images.

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We establish a bilinear framework for elliptic soliton solutions which are composed by the Lamé-type plane wave factors. $τ$ functions in Hirota's form are derived and vertex operators that generate such $τ$ functions are presented. Bilinear identities are constructed and an algorithm to calculate residues and bilinear equations is formulated. These are investigated in detail for the KdV equation and sketched for the KP hierarchy. Degenerations by the periods of elliptic functions are investigated, giving rise to the bilinear framework associated with trigonometric/hyperbolic and rational functions. Reductions by dispersion relation are considered by employing the so-called elliptic $N$-th roots of the unity. $τ$ functions, vertex operators and bilinear equations of the KdV hierarchy and Boussinesq equation are obtained from those of the KP. We also formulate two ways to calculate bilinear derivatives involved with the Lamé-type plane wave factors, which shows that such type of plane wave factors result in quasi-gauge property of bilinear equations., 41 pages

Additional file 2: Table S1. The detailed physical and chemical properties of C11orf96.

The synthesis process of AF-Ali-PC MA and P(MMA-co-GMA) and the extra optical power loss caused by the Al electrode.