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Buprenorphine and naloxone (Suboxone) is a combination medication-assisted treatment (MAT) for opioid use disorder. MAT withdrawal-induced psychosis is a rare clinical presentation. To our best knowledge, only three reports have summarized the characteristic manifestations of buprenorphine withdrawal psychosis, yet all of them were male. In this case report, we present a 41-year-old female patient with bipolar disorder and comorbid substance use disorder who developed new-onset psychosis and relapse of manic symptoms following abrupt discontinuation of Suboxone. Manic and psychotic symptoms remitted after a short-term hospitalization with the treatment of an antipsychotic and a mood stabilizer. In addition to discussing this case presentation and treatment approach, we review existing literature and discuss possible underlying mechanisms to enhance understanding of this clinical phenomenon. Psychopharmacology Bulletin. Accepted version

Simple Summary Through the analysis of tissue microarray (TMA) samples from colorectal cancer (CRC) patients and bioinformatical analyses of public databases and our clinical dataset, this study identifies the different expressions of CD163 in various tissues, the presence of the receptor in TME, the interaction with other biological processes and a positive correlation between CD163 dysfunction and worse prognosis. Therefore, CD163 can be used as a new biomarker to predict patient prognosis. (1) Background: CD163, a specific macrophage receptor, affects the progression of malignant tumors. Unfortunately, the regulation and expression of CD163 are poorly understood. In this study, we determined the expressions of CD163 in TMA samples from CRC patients and combined them with patient data from several Swedish hospitals. (2) Methods: The expressions of CD163 in tissue samples from CRC patients were examined. After combining 472 CRC patients gene expression and 438 CRC patients clinical data with the TCGA database, 964 cases from the GEO database, and experimental expression data from 1247 Swedish CRC patients, we selected four genes (PCNA, LOX, BCL2, and CD163) and analyzed the tumor-infiltrating immune cells (TICs) and CRC prognosis. (3) Results: Based on histopathological TMA analysis, CD163 was strongly expressed in the stroma of both normal and cancer tissues, and the expressions in normal and cancer cells varied from negative to strong. The results from public databases show decreased expression of CD163 in cancer tissue compared to normal mucosa (|log FC| > 1 and FDR < 0.01), and it is a negative prognostic factor for CRC patients (p-value < 0.05). Through tumor microenvironment (TME) analysis, we found a potential influence of CD163 on immune cell infiltration. Furthermore, the enrichment analysis indicated the possible interaction with other proteins and biological pathways. (4) Conclusions: CD163 is expressed differently in CRC tissue and is a negative prognostic factor. Its expression is associated with the TME and tumor purity of CRC. Considering all results, CD163 has the potential to be a predictive biomarker in the investigation of CRC.

We study the $\{1234, 3412\}$ pattern-replacement equivalence relation on the set $S_n$ of permutations of length $n$, which is conceptually similar to the Knuth relation. In particular, we enumerate and characterize the nontrivial equivalence classes, or equivalence classes with size greater than 1, in $S_n$ for $n \geq 7$ under the $\{1234, 3412\}$-equivalence. This proves a conjecture by Ma, who found three equivalence relations of interest in studying the number of nontrivial equivalence classes of $S_n$ under pattern-replacement equivalence relations with patterns of length $4$, enumerated the nontrivial classes under two of these relations, and left the aforementioned conjecture regarding enumeration under the third as an open problem., 13 pages, 0 figures

We extend past results on a family of formal power series $K_{n, \Lambda}$, parameterized by $n$ and $\Lambda \subseteq [n]$, that largely resemble quasisymmetric functions. This family of functions was conjectured to have the property that the product $K_{n, \Lambda}K_{m, \Omega}$ of any two functions $K_{n, \Lambda}$ and $K_{m, \Omega}$ from the family can be expressed as a linear combination of other functions from the family. In this paper, we show that this is indeed the case and that the span of the $K_{n, \Lambda}$'s forms an algebra. We also provide techniques for examining similar families of functions and a formula for the product $K_{n, \Lambda}K_{m, \Omega}$ when $n=1$., Comment: 16 pages, 0 figures

Differential expressions and functions of various micoRNAs (miRNAs) have been intensively studied in both colon and rectal cancers. However, the importance of miRNAs on radiotherapy (RT) response and clinical outcome in rectal cancer patients remains unclear. In this study, we used real-time polymerase chain reaction to examine the expressions of miR-302a, miR-105, and miR-888 in normal mucosa and cancer tissue from rectal cancer patients with and without preoperative RT. The biological function of miR-302a, miR-105, and miR-888 expression was further analyzed and identified through the public databases: TCGA (The Cancer Genome Atlas) and GEPIA (Gene Expression Profiling Interactive Analysis). The results showed that the expression of miR-105 in rectal cancer was higher than that in normal mucosa in RT (P= 0.042) and non-RT patients (P= 0.003) and was associated with mucinous histological type (P= 0.004), COX-2 (P= 0.042), and p73 expression (P= 0.030). The expression of miR-302a was shown more frequently in cancers with necrosis (P= 0.033) and with WRAP53 expression (P= 0.015), whereas miR-888 expression occurred more frequently in tumors with protein the expression of survivin (P= 0.015), AEG-1 (astrocyte elevated gene-1) (P= 0.003), and SATB1 (special AT-rich sequence binding protein 1) (P= 0.036). Moreover, TargetScan also predicted AEG-1 and SATB1 as putative targets for miR-888. The miRNA-gene network analysis showed that ABI2 was associated with all the three miRNAs, with lower expression and good diagnostic value in rectal cancers. The TCGA database demonstrated the association of miR-105 expression with high carcinoembryonic antigen level (P= 0.048). RT reduced the expressions of miR-302a, miR-105, and miR-888. Prognostic analysis showed that miR-888 expression was independently associated with worse survival of patients without RT [overall survival,P= 0.001; disease-free survival,P= 0.009]. Analysis of biological function revealed that the protein serine/threonine kinase activity and PI3K-AKT signaling pathway were the most significantly enriched functions and pathways, respectively. Our findings suggest that miR-105 is involved in rectal cancer pathogenesis and miR-888 is associated with prognosis. MiR-302a, miR-105, and miR-888 have potential influence on the pathogenesis, RT, and prognosis of rectal cancer. Funding Agencies|Swedish Cancer Foundation; Swedish Research CouncilSwedish Research Council; Health Research Council in the South-East of Sweden [1921-B91-08XBC]

Neutron scattering techniques are used to investigate the crystalline and magnetic structure of LuFe$_{0.75}$Mn$_{0.25}$O$_{3}$ in bulk polycrystalline form. We find that the crystalline structure is described by the hexagonal P6$_{3}$cm space group similar to that of thin-film LuFeO$_{3}$, and that the system orders antiferromagnetically below T$_{N}$ = 134 K. Inelastic neutron scattering reveals nearest-neighbor superexchange parameters that are enhanced relative to LuMnO$_{3}$. The observation of significant diffuse scattering above T$_{N}$ demonstrates the frustrated nature of the system; comparisons with similar materials suggest the ground state magnetic configuration is sensitive to local crystallographic distortions., 15 pages, 5 figures