206 results on '"Yuxiu Li"'
Search Results
2. Nickel-Catalyzed Stereoselective Cascade C–F Functionalizations of gem-Difluoroalkenes
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Xiaowei Li, Yuxiu Li, Zemin Wang, Wenlong Shan, Ruihua Liu, Cong Shi, Hongyun Qin, Leifeng Yuan, Xiangqian Li, and Dayong Shi
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General Chemistry ,Catalysis - Published
- 2023
3. SnO2 nanostructured materials used as gas sensors for the detection of hazardous and flammable gases: A review
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Dian Ma, Yude Wang, Tingrun Lai, Xuechun Xiao, Yulin Kong, Xiuxiu Cui, Yuxiu Li, Lijia Yao, and Linfeng Su
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Flammable liquid ,Nanostructure ,Materials science ,Materials Science (miscellaneous) ,Nanostructured materials ,Nanotechnology ,Nanomaterials ,Quantum size ,Preparation method ,chemistry.chemical_compound ,Reliability (semiconductor) ,chemistry ,Mechanics of Materials ,Hazardous waste ,Chemical Engineering (miscellaneous) - Abstract
SnO2 has been extensively used in the detection of various gases. As a gas sensing material, SnO2 has excellent physical-chemical properties, high reliability, and short adsorption-desorption time. The application of the traditional SnO2 gas sensor is limited due to its higher work-temperature, low gas response, and poor selectivity. Nanomaterials can significantly impact gas-sensitive properties due to the quantum size, surface, and small size effects of nanomaterials. By applying nanotechnology to the preparation of SnO2, the SnO2 nanomaterial-based sensors could show better performance, which greatly expands the application of SnO2 gas sensors. In this review, the preparation method of the SnO2 nanostructure, the types of gas detected, and the improvements of SnO2 gas-sensing performances via elemental modification are introduced as well as the future development of SnO2 is discussed.
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- 2022
4. Hypoglycemia Caused by Exogenous Insulin Antibody Syndrome: A Large Single-Center Case Series From China
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Yiwen Liu, Fan Ping, Jie Yu, Lu Lv, Yuan Zhao, Mengya Qi, Wei Li, Lingling Xu, Miao Yu, Ming Li, Huabing Zhang, and Yuxiu Li
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,Biochemistry - Abstract
ContextExogenous insulin antibody syndrome (EIAS) can lead to unexpected and potentially life-threatening recurrent hypoglycemia.ObjectiveWe aimed to better define autoimmune hypoglycemia caused by EIAS in patients with diabetes and shed light on the improvements in the identification and intervention for this rare but possibly life-threatening condition.MethodsWe summarized the clinical characteristics of autoimmune hypoglycemia caused by EIAS in 23 patients with diabetes. Furthermore, we performed human leukocyte antigen (HLA) genotyping of 10 patients.ResultsWe identified a high frequency of autoimmune comorbidities (21.7%), food or drug allergy (48%), insulin allergy (30%), lipodystrophy at the insulin injection sites (22%), and antinuclear antibodies (25%) in the patients. Alternation between hyperglycemia and hypoglycemia was observed in more than 90% of the patients. Most patients showed a high insulin autoantibody titer (>90%) and inappropriately increased insulin concentration (insulin/C-peptide molar ratio >7, >85%). We detected similar frequencies of DRB1*0405-DQB1*0401 and DRB1*0901-DQB1*0303 compared with previously reported frequencies in type 1 diabetes, and a lower frequency of DRB1*0406 compared with insulin autoimmune syndrome. The spontaneous remission rate exceeded 70%.ConclusionPredisposing factors for autoimmune hypoglycemia caused by EIAS include a strong autoimmune background. Susceptible HLA genotypes for type 1 diabetes or insulin autoimmune syndrome might not explain susceptibility to this condition. Additionally, insulin autoantibodies and the insulin/C-peptide molar ratio are reliable screening options. The prognosis for this condition is favorable. Monitoring of insulin and insulin autoantibodies may contribute to treatment effectiveness.
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- 2022
5. Insulin induces insulin receptor degradation in the liver through EphB4
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Xingfeng Liu, Kai Wang, Shaocong Hou, Qian Jiang, Chunxiao Ma, Qijin Zhao, Lijuan Kong, Jingwen Chen, Zhenhe Wang, Huabing Zhang, Tao Yuan, Yuxiu Li, Yi Huan, Zhufang Shen, Zhuowei Hu, Zhifeng Huang, Bing Cui, and Pingping Li
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Endocrinology, Diabetes and Metabolism ,Receptor, EphB4 ,Cell Biology ,Clathrin ,Receptor, Insulin ,Mice ,Glucose ,Diabetes Mellitus, Type 2 ,Liver ,Physiology (medical) ,Internal Medicine ,Animals ,Insulin ,Insulin Resistance - Abstract
Insulin signaling is essential for glucose metabolism, and insulin decreases insulin receptor (InsR) levels in a dose-dependent and time-dependent manner. However, the regulatory mechanisms of InsR reduction upon insulin stimulation remain poorly understood. Here, we show that Eph receptor B4 (EphB4), a tyrosine kinase receptor that modulates cell adhesion and migration, can bind directly to InsR, and this interaction is markedly enhanced by insulin. Due to the adaptor protein 2 (Ap2) complex binding motif in EphB4, the interaction of EphB4 and InsR facilitates clathrin-mediated InsR endocytosis and degradation in lysosomes. Hepatic overexpression of EphB4 decreases InsR and increases hepatic and systemic insulin resistance in chow-fed mice, whereas genetic or pharmacological inhibition of EphB4 improve insulin resistance and glucose intolerance in obese mice. These observations elucidate a role for EphB4 in insulin signaling, suggesting that EphB4 might represent a therapeutic target for the treatment of insulin resistance and type 2 diabetes.
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- 2022
6. Research on support vector regression optimization method based on fruit fly algorithm
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Yan Xia, Shun Yu, Xueyan Hao, Yuxiu Li, Shasha Chen, and Qingze Shen
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- 2023
7. Chinese Empirical Dietary Inflammatory Index Is Associated with High Risk of Systematic Inflammation and Aging in Rural China
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Lu Lyu, Jie Yu, Yiwen Liu, Shuli He, Mengya Qi, Na Yang, Liyun He, Jialu Wang, Fan Ping, Lingling Xu, Huabing Zhang, Wei Li, and Yuxiu Li
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Background:China is rapidly transforming into an aging society and houses the largest elderly population in the world. Diet patterns increase inflammation and oxidative stress, which may provide effective intervention strategies for mitigating the health burden in aging societies. This study sought to develop a Chinese empirical dietary inflammatory index(CEDII) that assesses Chinese diet quality based on its inflammatory potential and examine whether the index was associated with an accelerated aging process. Methods:A cross-sectional study conducted in the community of Beijing recruited 388 participants. Dietary intake was collected based on 24-h dietary recalls. The Chinese Diet Balance Index(DBI) and its derivatives, as well as the empirical dietary inflammatory pattern(EDIP) based on the western diet, were calculated to assess dietary quality in different aspects. Chinese empirical dietary inflammatory index(CEDII) was derived using reduced-rank regression(RRR) according to Chinese diet patterns. The population was categorized into tertiles of the CEDII. Leukocyte telomere length(LTL) and mitochondrial DNA copy number(mtDNAcn) were determined by polymerase chain reaction assay. Tumor necrosis factor α(TNFα) and interleukin-6(IL-6), 8-oxo-2'-deoxyguanosine (8-oxo-dG), superoxide dismutase (SOD) activities, and glutathione reductase (GR) were measured. ResultsA total of 388 subjects were enrolled. High CEDII group was characterized by high intake of carbohydrates. This pattern predicted higher levels of TNFα, IL-6, shorter LTL and lower mtDNAcn. Neither DBI nor EDIP was correlated with biomarkers of inflammation or aging. High CEDII scores were associated with short LTL and decreased mtDNAcn using multivariate linear regression with adjustment for confounding variables. The stratified analysis demonstrated that the high CEDII group had an increased risk of short LTL in subjects with abnormal metabolic status. Conclusions: This study developed a Chinese empirical dietary inflammatory index(CEDII). High CEDII scores were associated with an increased risk of aging. Compared with indexes related to DBI and EDIP, CEDII was much more effective in assessing inflammation and aging potential of diet patterns for Chinese residents.
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- 2023
8. Creating of watermelon haploid inducer line via ClDMP3 mediated single fertilization of the central cell
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Xiner Chen, Yuxiu Li, Gongli Ai, Jinfan Chen, Dalong Guo, Zhonghou Zhu, Xuejie Zhu, Shujuan Tian, Jiafa Wang, Man Liu, and Li Yuan
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Genetics ,Plant Science ,Horticulture ,Biochemistry ,Biotechnology - Abstract
Creating doubled haploids is one of the most efficient breeding methods in modern agriculture. Radiated pollen grains could induce haploids in cucurbit crops, which leads to a hypothesis that radiated pollen results in the preferential fertilization of the central cell over the egg cell was the reason of haploid formation. Disruption of DMP gene caused single fertilization of the central cell, which further induced haploids formation in plants. In the present study, a detailed method of creating watermelon haploid inducer line via ClDMP3 mutation was described. cldmp3 mutant induced haploids in different watermelon genotypes at the rates up to 1.12%. The generated haploids have been confirmed by different methods, including fluorescent marker, flow cytometry, molecular marker and immuno-staining assisted verifications. The haploid inducer created by this method will greatly advance the traditional watermelon breeding in future.
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- 2023
9. Hypoglycemia as a potential risk for patients taking clopidogrel: A systematic review and meta-analysis
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Shi Chen, Jiaqi Qiang, Yuelun Zhang, Bin Zhao, Ran Tian, Tao Yuan, Ming Li, Mei Li, Yuxiu Li, Huijuan Zhu, and Hui Pan
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Endocrinology, Diabetes and Metabolism - Abstract
BackgroundClopidogrel is a cornerstone antiplatelet drug used in cardiovascular, cerebrovascular, and peripheral artery diseases. The sulfhydryl group of clopidogrel metabolite could induce insulin autoimmune syndrome (IAS) with hypoglycemia as the major symptom. Discontinuing clopidogrel and substituting it with ticagrelor has been revealed as an effective treatment in previous studies. Since hypoglycemia serves as a risk factor for cardiovascular and cerebrovascular events, we aimed to determine the association between hypoglycemia/IAS and clopidogrel and to investigate whether clopidogrel is a modifiable and causal risk factor of hypoglycemia/IAS.MethodsMEDLINE, Embase, Cochrane databases, and clinical trial registries were searched for randomized controlled trials (RCTs) of clopidogrel from inception to 28 February 2022. RCTs comparing clopidogrel with placebo or other antiplatelet drugs were eligible if meeting the inclusion criteria: 1) clopidogrel was administrated 75 mg qd orally as a long-term antiplatelet prescription at least for months, and 2) hypoglycemia-inducible drugs were not used in the control arm. One investigator abstracted articles and performed a quality assessment. Uncertainties were resolved by discussions with two investigators independently. Odds ratio (OR) and risk difference (RD) were calculated and performed with subgroup analyses. The pre-specified protocol was registered in PROSPERO (CRD42022299622).ResultsSix trials with 61,399 participants in total fulfilled the criteria and were included in the meta-analysis. Clopidogrel might not be associated with higher hypoglycemia odds (OR 0.95, 95% CI 0.65 to 1.40). However, Asian participants (p = 0.0437) seemed more likely to develop clopidogrel-associated hypoglycemia. Clopidogrel-associated hypoglycemia occurred at the highest rate of 0.03% (RD −0.00023, 95% CI −0.00077 to 0.00031), and this increased to 0.91% (RD 0.00210, 95% CI −0.00494 to 0.00914) in an aging population and to 0.18% (RD 0.00040, 95% CI −0.00096 to 0.00177) when Asian ratio of the population was elevated.ConclusionsWe raise the concern that clopidogrel might be a modifiable and causal risk factor of hypoglycemia. The Asian population might be more vulnerable and need additional care.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022299622.
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- 2023
10. Efficacy of unblinded and blinded intermittently scanned continuous glucose monitoring for glycemic control in adults with type 1 diabetes
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Lixin Guo, Yuxiu Li, Mei Zhang, Xinhua Xiao, Hongyu Kuang, Tao Yang, Xiaofan Jia, and Xianbo Zhang
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Endocrinology, Diabetes and Metabolism - Abstract
ObjectiveIntermittently scanned continuous glucose monitoring (isCGM) is used for unblinded or blinded monitoring of interstitial glucose. We aimed to compare the efficacy of blinded and unblinded isCGM with the FreeStyle Libre system for glycemic control in adults with type 1 diabetes (T1D).Research design and methodsThis randomized clinical trial conducted between October 2018 and September 2019 across four endocrinology practices in China included 273 adults aged ≥18 years with T1D, who were randomly divided in a 2:1 ratio into the unblinded (n = 199) or blinded isCGM group (n = 78). In the blinded group, the clinician used FreeStyle Libre Pro system for monitoring, but self-monitoring was also performed by the patients.ResultsTwo hundred sixteen (78%) participants completed the study (152 [75%] in the unblinded and 64 [82%] in the blinded group). At 12 weeks, a significant increase in TIR (3.9-10.0 mmol/L) was only observed in the unblinded group, along with a significant decrease in hyperglycemia (>13.9 mmol/L), hypoglycemia (ConclusionsThe unblinded isCGM system was associated with benefits for glucose management, but nearly 100% of the attempted profiles were obtained successfully with the blinded isCGM system. Thus, combining real-time and retrospective data with isCGM might be the most impactful way to utilize flash glycemic monitoring devices.
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- 2023
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11. Estimates and trends of the global burden of NASH-related liver cancer attributable to high fasting plasma glucose in 1990–2019: analysis of data from the 2019 Global Burden of Disease Study
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Ziyi Li, Na Yang, Liyun He, Jialu Wang, Fan Ping, Wei Li, Lingling Xu, Huabing Zhang, and Yuxiu Li
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Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Background Experimental and epidemiological studies have indicated an association between diabetes exposure and an increased risk of liver cancer due to nonalcoholic steatohepatitis (NASH). However, to date, no systematic study has specifically investigated the burden of NASH-related liver cancer due to exposure to high fasting plasma glucose (HFPG) levels worldwide. Methods The number and rate of deaths and disability-adjusted life years (DALYs) from HFPG-induced NASH-related liver cancer were estimated based on the results of the 2019 Global Burden of Disease Study. The estimated annual percentage changes (EAPCs) for age-standardized death or DALYs rates were calculated using a generalized linear model with a Gaussian distribution to quantify the temporal trends in the global burden of NASH-related liver cancer attributable to HFPG. The strength and direction of the association between the sociodemographic index (SDI) and death or DALY rate were measured using Spearman’s rank-order correlation. Results Globally, approximately 7.59% of all DALY and 8.76% of all mortalities of NASH-related liver cancer in 2019 were due to HFPG. The age-standardized death and DALY rates of NASH-related liver cancer attributable to HFPG increased from 1990 to 2019. The corresponding EAPCs were 0.69 (95% UI 0.48–0.89), and 0.30 (95% UI 0.05–0.56), respectively. This increasing pattern was most obvious in the high- and low-SDI regions. The age-standardized mortality and DALYs rate of NASH-related liver cancer attributable to HFPG varies considerably worldwide, with the middle SDI region having the highest death and DALY rates in 2019 (DALY 0.96 [95% UI 0.23–2.18]; death 0.05 [95% UI 0.01–0.11]). Conclusion The burden of NASH-related liver cancer attributable to HFPG has increased over the past three decades, particularly in regions with high and low SDI.
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- 2023
12. Hierarchical Analysis of Intelligent Fusion Data of College Training Theory based on Virtual Cloud Classroom
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Yuxiu Li
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- 2023
13. Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway
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Jie Yu, Yuan Zhao, Lingling Xu, Wei Li, Huabing Zhang, Fan Ping, and Yuxiu Li
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Article Subject ,Immunology ,Cell Biology - Abstract
Liraglutide has been extensively applied in the treatment of type 2 diabetes mellitus and also has hepatoprotective effects. However, the role of liraglutide treatment on liver injury in a mouse model of type 1 diabetes mellitus (T1DM) induced by streptozotocin (STZ) and its underlying mechanisms remain to be elucidated. In the present study, diabetes was initiated in experimental animals by single-dose intraperitoneal inoculation of STZ. Forty female C57BL/6J mice were equally assigned into five groups: diabetic group, insulin+diabetic group, liraglutide+diabetic group, insulin+liraglutide+diabetic group, and control group for eight weeks. Diabetic mice exhibited a significantly elevated blood glucose level and decreased body weight, and morphological changes of increased steatosis and apoptosis were observed in the liver compared with the control. Furthermore, a significant increase in the levels of malondialdehyde and inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin 1β (IL-1β) and the proapoptotic proteins caspase-3 and Bax were observed in the livers of diabetic mice, together with marked increases in antioxidants superoxide dismutase (SOD) and glutathione peroxidase (GPX) as well as antiapoptotic protein Bcl-2, all of which were significantly mitigated by treatment with liraglutide, insulin, and their combinations. Interestingly, liraglutide monotherapy showed better efficacy in ameliorating liver injury in T1DM mice than insulin monotherapy, similar to the combined drug therapy. Furthermore, the expression of Wnt/β-catenin signaling pathway-associated molecules was upregulated in the liver of mice treated with liraglutide or insulin. The results of the present study suggested that liraglutide improves T1DM-induced liver injury and may have important implications for the treatment of nonalcoholic fatty liver disease (NAFLD) in patients with T1DM.
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- 2023
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14. Saa1 Exacerbates Pancreatic Β-Cell Dysfunction Through Activation of Nf-Κb Signaling in High-Fat Diet-Induced T2dm
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Qi Wang, Hong Li, Henghao Lu, Shumin Wang, Yuxiu Li, Zhenfen Zhang, Jing Han, Zhe Yang, Yanping Yang, and Yan Hong
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- 2023
15. Nickel-catalyzed stereoselective reductive cross-coupling of gem-difluoroalkenes with alkenyl electrophiles
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Xiaowei Li, Yuxiu Li, Wenlong Shan, Zemin Wang, Ruihua Liu, Zhong Zhang, Xiangqian Li, and Dayong Shi
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Materials Chemistry ,Metals and Alloys ,Ceramics and Composites ,General Chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
A Ni-catalyzed stereoselective defluorinative cross-electrophile coupling of gem-difluoroalkenes with alkenyl electrophiles is developed.
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- 2023
16. Simultaneous Determination of Fifteen Polyphenols in Fruit Juice Using Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry Combining Dispersive Liquid-Liquid Microextraction
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Yuxiu Li, Zengyang He, Youmei Bao, Qingsheng Zhu, Yong Ning, Zhenfeng Tian, and Xiaolan Zhu
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Article Subject ,Analytical Chemistry - Abstract
Polyphenols are secondary metabolites of plants and used as effective antioxidants in dietary supplements, whose main sources are fruits, vegetables, and grains. To clarify the content and distribution of polyphenols in different fruit species samples accurately, a rapid and sensitive ultrahigh-pressure liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) method combining dispersive liquid-liquid microextraction (DLLME) was developed for quantitative determination of fifteen polyphenol compounds in fruit juice. In this method, the targets were first extracted from 1 g of fruit juice sample using 10 mL of 80% ethanol solution by ultrasonic-assisted extraction (UAE). Then, 1.0 mL of UAE extracted solution, 60 μL of n-octanol and 2.0 mL of H2O were performed in the following DLLME procedure. A C18 reversed-phase column, ZORBAX SB (100 × 4.6 mm, 3.5 μm), was proposed under gradient elution with 0.1% formic acid aqueous solution and methanol mobile phases for the determination of 15 polyphenols, allowing us to obtain polyphenolic profiles in less than 23.0 min. Under the optimum conditions, the enrichment factors ranged from 162 to 194. The results showed that the 15 polyphenols had linear correlation coefficients (R2) more than 0.99. The limits of detection (LODs) were between 18.3 and 103.5 ng/g, and the average recoveries were between 96.9 and 116.3% with interday relative standard deviations (RSDs) ranging from 4.4 to 8.2% in all cases. The method was successfully applied to the analysis of real fruit juice samples and presented itself as a simple, rapid, practical, and environment-friendly technique.
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- 2022
17. Diabetes duration and weight loss are associated with onset age and remote metastasis of pancreatic cancer in patients with diabetes mellitus
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Minglei Ma, Wei Li, Lingling Xu, Fan Ping, Huabing Zhang, and Yuxiu Li
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Pancreatic Neoplasms ,Diabetes Mellitus, Type 2 ,Risk Factors ,Endocrinology, Diabetes and Metabolism ,Weight Loss ,Diabetes Mellitus ,Humans ,Hypoglycemic Agents ,Age of Onset ,Retrospective Studies - Abstract
To analyze the clinical characteristics of patients with pancreatic cancer (PC) and diabetes and to explore the impact of diabetes duration, weight loss, and hypoglycemic drugs on the tumor biological behavior of PC.This is a retrospective study on patients with PC and diabetes. Subjects were grouped according to the onset age of PC, distant metastasis, duration of diabetes, degree of weight loss (∆Wt), and type of hypoglycemic drugs. Logistic regression analysis was used to evaluate the association between diabetes duration, weight loss, hypoglycemic drugs, and early-onset PC, distant metastasis.Compared with late-onset PC, patients with early-onset PC had a higher proportion of new-onset DM (35 [79.5%] vs. 217 [46.9%], p 0.001), smoker, drinker, and more obvious weight loss (8.5 [3.8, 15] kg vs. 5 [0, 10] kg, p 0.001). Patients with remote metastasis had an earlier diagnosis age, heavier weight loss, lower body mass index, and were more likely to be smokers but had cancer less likely to be localized in the head of pancreas. Regression analysis showed that new-onset diabetes and weight loss were independently correlated to early-onset PC: odds ratio (OR) = 3.38 (95% CI 1.36-8.4, p = 0.09; OR = 1.56 (95% CI 1.16-2.1), p = 0.003, respectively. In contrast, long-term diabetes, and heavy weight loss were independently associated with remote metastasis: OR = 3.38 (95% CI 1.36-8.4, p = 0.09; OR = 1.56 (95% CI 1.16-2.1), p = 0.003, respectively.New-onset diabetes and weight loss were common presentation and risk factors of early-onset PC, which required more attention. Long-term diabetes and heavy weight loss were risk factors contributing to distant metastases, indicating potential risk factors contributing to the adverse prognosis of patients with PC.目的: 分析胰腺癌(PC)合并糖尿病患者的临床特点, 探讨糖尿病病程、体重减轻及降糖药物对PC肿瘤生物学行为的影响。 方法: 对PC合并糖尿病患者进行回顾性研究。受试者根据PC的发病年龄、远处转移、糖尿病病程、体重减轻程度(∆Wt)和降糖药物的类型进行分组。采用Logistic回归分析评估糖尿病病程、体重减轻、降糖药物与早发性PC、远处转移之间的关系。 结果: 与晚发PC相比, 早发PC患者新发DM比例更高(35[79.5%]vs 217[46.9%], p0.001), 吸烟、饮酒和体重减轻更明显(8.5[3.8, 15]kg vs 5[0, 10]kg, p0.001)。远处转移的患者诊断年龄较早, 体重减轻较大, 体重指数较低, 且更有可能是吸烟者, 但癌症不太可能发生在胰头。回归分析显示, 新发糖尿病和体重减轻与早发PC独立相关:分别为优势比(OR)=3.38(95%置信区间(CI) 1.36~8.4, P=0.09), OR=1.56(95%CI 1.16~2.1), P=0.003。相反, 长期糖尿病和严重的体重减轻与远处转移独立相关:分别为OR=3.38(95%CI 1.36-8.4, p=0.09, OR=1.56(95%CI 1.16-2.1), p=0.003)。 结论: 新发糖尿病和体重减轻是早发性PC的常见表现和危险因素, 应引起更多重视。长期糖尿病和体重减轻是导致远处转移的危险因素, 这表明潜在的危险因素导致了PC患者的不良预后。.
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- 2022
18. Fluorescent probes based on an oxonium-coumarin scaffold for the detection of SO2 derivatives
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Jing Feng, Weiliang Shen, Yi Mou, Zhiping Zhou, Yuxiu Li, Wei Han, and Bingdong Li
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Materials Chemistry ,General Chemistry ,Catalysis - Abstract
In this work, a pair of fluorescent probes CPO were designed for the detection of SO2 derivatives based on the FRET principle.
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- 2022
19. Occupational and domestic physical activity and diabetes risk in adults: Results from a long-term follow-up cohort
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Jialu, Wang, Liyun, He, Na, Yang, Ziyi, Li, Lingling, Xu, Wei, Li, Fan, Ping, Huabing, Zhang, and Yuxiu, Li
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Adult ,Endocrinology, Diabetes and Metabolism ,Diabetes Mellitus ,Humans ,Prospective Studies ,Motor Activity ,Exercise ,Follow-Up Studies - Abstract
BackgroundPhysical activity (PA) has been associated with decreased incidence of diabetes. However, few studies have evaluated the influence of occupational and domestic PA on the risk of diabetes with a long-term follow-up. We aimed to examine the association between occupational and domestic PA and the risk of diabetes in a long-term prospective cohort of Chinese adults.MethodsA total of 10,343 adults who were followed up in the China Health and Nutrition Survey from 1997 to 2015 were included in our analysis. Occupational and domestical PA were collected with detailed seven-day data and were converted into metabolic equivalents values. Total PA included occupational, domestic, transportation, and leisure time PA. Diabetes cases were identified by self-reported doctor/health professional diagnosis of diabetes, fasting blood glucose ≥7.0 mmol/L, and glycosylated hemoglobin (HbA1c) ≥6.5%. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI).ResultsDuring up to 18 years of follow-up (median 10 years), there were 575 diabetes cases documented. Occupational PA accounted for the majority of total PA (68%) in Chinese population, followed by domestic PA (25%). With adjustments for possible covariates, the highest quartiles of total PA (HR, 0.728 [95% CI, 0.570–0.929]) and occupational PA (HR, 0.765 [95% CI, 0.596–0.982]) were significantly associated with a lower risk of diabetes compared with lowest quartiles. The association between domestic PA and the risk of diabetes was insignificant (P >0.05).ConclusionHigher levels of occupational PA were associated with a decreased risk of diabetes risk in the Chinese population. Domestic PA was not associated with the incidence of diabetes.
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- 2022
20. [A case of type A insulin resistance syndrome]
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L Y, Zhu, T S, Ma, X J, Li, X Y, Chang, K, Sun, H B, Zhang, and Yuxiu, Li
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Metabolic Syndrome ,Diabetes Mellitus, Type 2 ,Diabetes Mellitus ,Humans ,Insulin ,Insulin Resistance - Abstract
A型胰岛素抵抗综合征是罕见的胰岛素受体基因突变引起的常染色体显性遗传病,表现为黑棘皮、严重胰岛素抵抗,但血甘油三酯正常,女性可表现为多囊卵巢综合征和高雄激素血症。本文报道1例青少年女性,以月经不规律、黑棘皮、严重胰岛素抵抗及血甘油三酯正常为特点,通过基因检测诊断为胰岛素受体杂合突变导致的A型胰岛素抵抗综合征,随访2年余,控制满意。提示严重胰岛素抵抗患者采用适宜的诊疗流程可帮助这些疑难患者得到确诊。.
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- 2022
21. High Hemoglobin Glycation Index Is Associated With Telomere Attrition Independent of HbA1c, Mediated by TNFα
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Shuli He, Jie Yu, Fan Ping, Yiwen Liu, Huabing Zhang, Wei Li, Lingling Xu, Yuan Zhao, Yuxiu Li, Lu Lyu, and Mengya Qi
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Adult ,Male ,medicine.medical_specialty ,Glycosylation ,DNA Copy Number Variations ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Population ,Glutathione reductase ,Context (language use) ,medicine.disease_cause ,DNA, Mitochondrial ,Biochemistry ,Endocrinology ,Intolerances ,Glycation ,Internal medicine ,Humans ,Medicine ,education ,Telomere Shortening ,Glycated Hemoglobin ,education.field_of_study ,Tumor Necrosis Factor-alpha ,business.industry ,Biochemistry (medical) ,Middle Aged ,Telomere ,Oxidative Stress ,Cross-Sectional Studies ,Ageing ,Female ,Hemoglobin ,business ,Oxidative stress - Abstract
Context The hemoglobin glycation index (HGI) is correlated with metabolic diseases and inflammation. Whether the HGI is associated with the aging process and how inflammation and oxidative stress affect the relationship remain unclear. Objective We aimed to analyze links between the HGI and aging biomarkers, and to explore a potential role of inflammation and oxidative stress in the correlations. Methods A cross-sectional study of 434 subjects with different glucose intolerances in a rural community was enrolled. The HGI was calculated as the difference between the measured and predicted hemoglobin A1c (HbA1c). The population was categorized into tertiles of the HGI. Telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) determined by polymerase chain reaction assay. Tumor necrosis factor (TNF) α and interleukin (IL) 6, 8-oxo-2′-deoxyguanosine (8-oxo-dG), superoxide dismutase (SOD) activities, and glutathione reductase (GR) were measured. Results Participants in the high HGI group were older and reported a shorter LTL, higher levels of TNFα, SOD activities, and HbA1c. Correlation analyses demonstrated that HGI was correlated with LTL (r = –0.25, P < .001) and TNFα (r = 0.19, P < .001) regardless of HbA1c levels. No relationship was found between HGI and mtDNAcn. HGI (β = –0.238, 95% CI –0.430, –0.046, P = .015) and TNFα (β = –0.02, 95% CI –0.030, –0.014, P < .001) were proved to be correlated with LTL independently, using multiple linear regression analysis. Ordinal logistic regression models showed that compared with subjects the high HGI group, the possibilities of a higher-level LTL was 5.29-fold in the low HGI group (OR 5.29, 95% CI (2.45, 11.41), P < .001), 2.41-fold in the moderate HGI group (OR 2.41, 95% CI 1.35, 4.30, P = .003) after controlling for confounding variables. Mediation analyses indicated that TNFα accounted for 30.39% of the effects of the HGI on LTL. Conclusion HGI was negatively related to telomere attrition, independent of HbA1c. TNFα acted as a mediator of the relationship between HGI and LTL.
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- 2021
22. Nickel-Catalyzed Arylation of C(sp3)–O Bonds in Allylic Alkyl Ethers with Organoboron Compounds
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Zhong Zhang, Xiaolin Shi, Dayong Shi, Yuxiu Li, Xiangqian Li, Ruihua Liu, Zemin Wang, and Xiaowei Li
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chemistry.chemical_classification ,Allylic rearrangement ,Organic Chemistry ,food and beverages ,Regioselectivity ,chemistry.chemical_element ,Cleavage (embryo) ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,Organoboron compounds ,Nickel ,chemistry ,Functional group ,Organic chemistry ,Physical and Theoretical Chemistry ,Alkyl - Abstract
A nickel-catalyzed cross-coupling of allylic alkyl ethers with organoboron compounds through the cleavage of the inert C(sp3)-O(alkyl) bonds is described. Several types of allylic alkyl ethers can be coupled with various boronic acids or their derivatives to give the corresponding products in good to excellent yields with wide functional group tolerance and excellent regioselectivity. The gram-scale reaction and late-stage modification of biologically active compounds further prove the practicality of this synthetic method.
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- 2021
23. Large mid-upper arm circumference is associated with reduced insulin resistance independent of BMI and waist circumference: A cross-sectional study in the Chinese population
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Jialu Wang, Liyun He, Na Yang, Ziyi Li, Lingling Xu, Wei Li, Fan Ping, Huabing Zhang, and Yuxiu Li
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Endocrinology, Diabetes and Metabolism - Abstract
BackgroundBody mass index (BMI) is a common indicator in clinical practice, but it is not sufficient to predict insulin resistance (IR). Other anthropometric methods supplement BMI in the assessment of body composition, which can be predicted more accurately. This cross-sectional study aimed to evaluate the association between mid-upper arm circumference (MUAC), triceps skinfold (TSF) thickness, mid-arm muscle circumference (MAMC) and IR in Chinese adults.MethodsThis cross-sectional study analyzed data from the 2009 China Health and Nutrition Survey database. The study population was divided into four groups according to the MUAC quartiles, and the homeostasis mode assessment was used to evaluate the degree of IR. Logistic regression analysis was performed to calculate odds ratios (ORs) with 95% confidence intervals (CIs), with adjustments for multiple covariates. Subgroup analyses stratified by age, sex, BMI, waist circumference (WC), smoking status, and alcohol consumption were performed.ResultsIn total, 8,070 participants were included in the analysis. As MUAC increased, BMI, TSF thickness, MAMC, and the proportion of IR tended to increase. However, we found that there was a significant negative association between MUAC and MAMC and IR in the logistic regression analysis, independent of BMI and WC, the ORs for the highest quartiles compared with the lowest quartiles were 0.662 (95%CI: 0.540-0.811) and 0.723 (95%CI: 0.609-0.860), respectively. There was no significant association was observed between the TSF thickness and IR (OR=1.035 [95%CI: 0.870-1.231]). The inverse associations were more pronounced among participants with lower BMI and WC. No significant age-specific differences were observed (P-heterogeneity > 0.05).ConclusionsAfter adjusting for BMI and WC, MUAC was negatively associated with IR in Chinese adults, and the association between MUAC and IR was derived from arm muscle instead of subcutaneous fat. MUAC could be an additional predictor of IR besides BMI and WC in clinical practice.
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- 2022
24. Mutational Profile and Potential Molecular Therapeutic Targets of Pheochromocytoma
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Xiaosen Ma, Chao Ling, Meng Zhao, Fen Wang, Yunying Cui, Jin Wen, Zhigang Ji, Caili Zhang, Shi Chen, Anli Tong, and Yuxiu Li
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Paraganglioma ,Endocrinology, Diabetes and Metabolism ,Mutation ,Adrenal Gland Neoplasms ,Humans ,Pheochromocytoma ,Protein-Tyrosine Kinases - Abstract
PurposePheochromocytoma/paraganglioma (PCC/PGL; collectively known as PPGL) can be driven by germline and somatic mutations in susceptibility genes. We aimed to investigate the mutation profile and clinical features of pathogenic genes in highly genetically heterogeneous PPGL and to preliminary explore molecular therapeutic targets in PPGL.MethodsWe established a panel of 260 genes, including susceptibility genes of PPGL and other important tumorigenic genes to sequence 107 PPGL tissues.ResultsOverall, 608 genomic mutations were identified in 107 PPGL tissues. Almost 57% of PPGL tissue samples exhibited pathogenic mutations, and the most frequently mutated gene was SDHB (15/107, 14%). SDHB and HRAS were the most commonly mutated genes in germline-mutated PPGL (25/107, 23%) and nongermline-mutated PPGL (36/107, 34%), respectively. In addition, novel pathogenic mutations were detected in sporadic PPGL. PPGL with mutations in the hypoxia pathway had an earlier onset and higher norepinephrine level than those in the kinase pathway. Receptor tyrosine kinase (RTK; 22%, 24/107), mitogen-activated protein kinase (MAPK; 14%, 15/107), and tyrosine kinase (TK; 2%, 2/107) pathways were the most frequently mutated pathways in PPGL.ConclusionOur results provided the genetic mutation profile in PPGL tissues. Genetic mutations in PPGL were mainly concentrated in the RTK, TK, and MAPK pathways, suggesting potential molecular therapeutic targets for PPGL.
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- 2022
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25. Clopidogrel-associated hypoglycaemia and alternative antiplatelet therapy: a real-world, pharmacovigilance study
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Shi Chen, Jiaqi Qiang, Ran Tian, Tao Yuan, Mei Li, Yuxiu Li, Huijuan Zhu, Yan Tang, Bin Zhao, and Hui Pan
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Pharmacovigilance ,Humans ,Pharmacology (medical) ,Cardiology and Cardiovascular Medicine ,Prasugrel Hydrochloride ,Platelet Aggregation Inhibitors ,Hypoglycemia ,Clopidogrel - Published
- 2022
26. The optimal diagnostic criteria of endogenous hyperinsulinemic hypoglycemia based on a large cohort of Chinese patients
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Jie Yu, Yiwen Liu, Lu Lyu, Yuan Zhao, Mengya Qi, Fan Ping, Lingling Xu, Wei Li, Qiang Xu, Huabing Zhang, Wenming Wu, and Yuxiu Li
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Pancreatic Neoplasms ,China ,Glucose ,C-Peptide ,Endocrinology, Diabetes and Metabolism ,Humans ,Insulin ,Congenital Hyperinsulinism ,Fasting ,Proinsulin ,Retrospective Studies - Abstract
PurposeAn end-of-fast insulin level ≥ 3 µIU/ml, C-peptide level ≥ 0.6 ng/ml, and proinsulin level ≥ 5 pmol/l with end-of-fast glucose level ≤ 3.0 mmol/l have been established as the criteria for endogenous hyperinsulinemic hypoglycemia. However, all these criteria have been proposed based on patients in Western populations. This study aimed to determine the optimal criteria using a large series of Chinese patients.MethodsThis retrospective study comprised 144 patients with surgically proven insulinoma and 40 controls who underwent a 72-h fasting test at the Peking Union Medical College Hospital(PUMCH) from 2000 to 2020. Receiver operating characteristic curves were used for analysis.ResultsIn this series of patients, the optimal diagnostic criteria for endogenous hyperinsulinemic hypoglycemia were insulin ≥ 5.5 μIU/ml, C-peptide ≥ 0.7 ng/ml, and proinsulin ≥ 12 pmol/l with end-of-fast glucose ≤ 2.8 mmol/l; the sensitivity and specificity were 99% and 100% for insulin, 100% and 100% for C-peptide, and 93% and 100% for proinsulin, respectively. The diagnostic efficacy of the criteria based on Western populations was then tested. The sensitivity and specificity of end-of-fast insulin ≥ 3 μIU/ml, C-peptide ≥ 0.6 ng/ml, and proinsulin ≥ 5 pmol/l with end-of-fast glucose ≤ 3.0 mmol/l were 100% and 83%, 100% and 80%, and 97% and 78%, respectively.ConclusionsNew and optimized diagnostic criteria for endogenous hyperinsulinemic hypoglycemia in Chinese populations have been proposed, and these criteria yield satisfactory accuracy.
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- 2022
27. Equilibrium solubility and modeling of Glibenclamide in cosolvent mixtures of Methanol, n-Propanol, Isopropanol, and Acetonitrile + Water
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Yuxiu Li, Yu Zhu, Wanwan Wang, Juan Song, and Hua Lv
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General Materials Science ,Physical and Theoretical Chemistry ,Atomic and Molecular Physics, and Optics - Published
- 2023
28. Mid‐Arm Muscle and Subcutaneous Fat Associated with All‐Cause Mortality Independent of BMI: A Prospective Cohort Study
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Fan Ping, Huabing Zhang, Na Yang, Wei Li, Yuxiu Li, Liyun He, Lingling Xu, Jingyue Huang, and Jialu Wang
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Adult ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Subcutaneous Fat ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Subcutaneous fat ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Aged ,Proportional Hazards Models ,Nutrition and Dietetics ,Anthropometry ,business.industry ,Proportional hazards model ,Muscles ,Hazard ratio ,Middle Aged ,Circumference ,Confidence interval ,Quartile ,business ,All cause mortality - Abstract
Objective This study aimed to systematically evaluate the association between triceps skinfold (TSF) thickness (which indicates subcutaneous fat) mid-arm muscle circumference (MAMC; which reflects muscle mass), mid-upper arm circumference (MUAC), and all-cause mortality. Methods A total of 17,717 adults from the China Health and Nutrition Survey (1993-2015) were included. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. The joint effect of TSF thickness and MAMC was examined, and planned subgroup analyses were performed. Results The highest quartiles of TSF thickness, MAMC, and MUAC were significantly associated with low all-cause mortality, independent of BMI (TSF thickness: HR = 0.704 [95% CI: 0.575-0.862]; MAMC: HR = 0.729 [95% CI: 0.607-0.876]; MUAC: HR = 0.713 [95% CI: 0.583-0.872]). A 1-SD increase showed comparable risk reductions for TSF thickness and MAMC (14.6% and 14.0%), with 16.1% risk reductions in MUAC. There were positive additive interactions between TSF thickness and MAMC. The inverse association existed in young, middle-aged, and elderly participants (P-heterogeneity > 0.05). Conclusions Mid-arm muscle and subcutaneous fat were inversely associated with all-cause mortality, independent of BMI, beyond the elderly population. Mid-arm muscle and subcutaneous fat made comparable contributions to and had positive joint effects on all-cause mortality.
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- 2021
29. Palladium‐Catalyzed Remote C−H Phosphonylation of Indoles at the C4 and C6 Positions by a Radical Approach
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Xiaolin Shi, Dayong Shi, Xiaowei Li, Xiangqian Li, Yuxiu Li, and Zemin Wang
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Indole test ,010405 organic chemistry ,chemistry.chemical_element ,Regioselectivity ,General Medicine ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,chemistry ,Moiety ,Palladium - Abstract
Palladium-catalyzed direct C-H activation of indole benzenoid moiety has been achieved in the past decade. However, palladium-catalyzed remote C-H activation of indoles is rare. Herein, we report a challenging palladium-catalyzed remote C4-H phosphonylation of indoles by a radical approach. The method provides access to a series of C4-phosphonylated indoles, including tryptophan and tryptophan-containing dipeptides, which are typically inaccessible by direct C4-H activation due to its heavy reliance on C3 directing groups. Notably, unexpected C6-phosphonylated indoles were obtained through blocking of the C4 position. The preliminary mechanistic studies indicated that the reactions may proceed via a C7-palladacycle/remote-activation process. Based on the strategy, examples of remote C4-H difluoromethylation with BrCF2 COOEt are also presented, suggesting that the strategy may offer a general blueprint for other cross-couplings.
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- 2021
30. Highly E-Selective Synthesis of α-Fluoro-β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates
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Xiangqian Li, Xiaowei Li, Yuxiu Li, and Dayong Shi
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chemistry.chemical_compound ,chemistry ,010405 organic chemistry ,Sodium ,Organic Chemistry ,Functional group ,chemistry.chemical_element ,Stereoselectivity ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences - Abstract
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
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- 2021
31. Differences in Clinical Manifestations and Tumor Features Between Metastatic Pheochromocytoma/Paraganglioma Patients With and Without Germline SDHB Mutation
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Ting Zhou, Shi Chen, Fen Wang, Huiping Wang, Yunying Cui, Yuxiu Li, Anli Tong, and Xiaosen Ma
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Adult ,medicine.medical_specialty ,Adolescent ,SDHB ,Endocrinology, Diabetes and Metabolism ,Adrenal Gland Neoplasms ,030209 endocrinology & metabolism ,Pheochromocytoma ,Gastroenterology ,Germline ,Metastasis ,Paraganglioma ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Progression-free survival ,Child ,Germ-Line Mutation ,Retrospective Studies ,business.industry ,Incidence (epidemiology) ,Bone metastasis ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Succinate Dehydrogenase ,Mutation ,business - Abstract
To compare metastatic pheochromocytoma/paraganglioma (MPP) patients with germline SDHB mutations (SDHB MPP) and without SDHB mutations (non-SDHB MPP) in terms of baseline clinical manifestations, tumor characteristics, and outcomes.Clinical data were retrospectively reviewed in 101 MPP patients, including 34 SDHB MPP patients and 61 non-SDHB MPP patients.SDHB MPP patients presented at a younger age at onset, diagnosis, or metastasis (25 ± 16 vs 36 ± 14, 28 ± 17 vs 38 ± 15, and 31 ± 17 vs 44 ± 14 years old, respectively, P.01 for all) than non-SDHB patients. Compared with their non-SDHB counterparts, SDHB patients were more likely to have paragangliomas (83% vs 47%, P.05), synchronous metastases (44% vs 23%, P.05), bone metastases (80% vs 48%, P.01), and a shorter progression-free survival (3 years vs 5 years, P.01). The Ki-67 index was higher in SDHB tumors (P.05). The 5- and 10-year survival rates were 79% and 74%, respectively, in all patients. Seventeen patients died from MPP, and the time from metastasis to death in patients who had received systemic therapy was significantly longer than in those who had not (3.1 ± 1.5 vs 1.4 ± 0.7 years, P.01).Compared with MPP patients without SDHB mutations, MPP patients with SDHB mutations were younger at onset, diagnosis, or metastasis; had a higher incidence of synchronous metastases, higher ratio of paraganglioma, and higher Ki-67 index; had a shorter postoperative progression-free survival; and were more likely to develop bone metastasis or sole liver metastasis. Our results suggest that patients with SDHB mutations should be identified early and monitored regularly to achieve optimal clinical outcomes.
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- 2021
32. Dipeptidyl Peptidase 4 Inhibitors and Gallbladder or Biliary Diseases: Data From the U.S. Food and Drug Administration Adverse Event Reporting System
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Liyun He, Jialu Wang, Ziyi Li, Yuxiu Li, and Huabing Zhang
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Advanced and Specialized Nursing ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Published
- 2022
33. Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway
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Yuan, Zhao, Jie, Yu, Fan, Ping, Lingling, Xu, Wei, Li, Huabing, Zhang, and Yuxiu, Li
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Cancer Research ,Immunology and Microbiology (miscellaneous) ,General Medicine - Abstract
Insulin and liraglutide have been demonstrated to control blood glucose and exert neuroprotective effects. However, the impact of liraglutide or insulin alone or in combination on brain pathology in type 1 diabetes mellitus (T1DM) and their underlying mechanisms are unclear. In the present study, diabetes mellitus (DM) was induced via intraperitoneal injection of streptozotocin in mice and subsequently mice were treated with insulin, liraglutide, a combination of the two drugs or saline. Changes in body weight and blood glucose were assessed weekly. The pathological changes in the brain tissue and the apoptosis of neurons were assessed using HE staining and TUNEL staining. The mRNA and protein expression levels of apoptosis-related proteins were detected using reverse transcription-quantitative PCR (RT-qPCR) and western blotting, respectively. Moreover, Ki67 protein expression was analyzed using immunohistochemistry and the mRNA and protein expression levels of Wnt/β-catenin signaling pathway-related proteins were examined using RT-qPCR and western blotting, respectively. The results of the present study suggested that DM mice developed hyperglycemia and weight loss and also exhibited significantly increased neural cell apoptosis and significantly reduced numbers of Ki67-positive cells. Liraglutide significantly decreased blood glucose levels in DM mice, whereas both insulin and the combination of the two drugs failed to control blood glucose well. Insulin, liraglutide and their combination also failed to control body weight well, but significantly attenuated brain pathological changes and activation of the pro-apoptotic proteins Caspase-3 and Bax, which may have resulted in the significant increase in the expression levels of Wnt/β-catenin signaling pathway-associated molecules such as Wnt3a and S9-pGSK-3β. Liraglutide also promoted the protein expression of the neurogenesis marker of Ki67 and the antiapoptotic factor Bcl-2. These results suggested that insulin and liraglutide may improve brain damage via upregulation of the Wnt/β-catenin signaling pathway and could be of therapeutic relevance for improvement of cognitive impairment in patients with DM.
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- 2022
34. New insights on hyperglycemia in 17-hydroxylase/17,20-lyase deficiency
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Lingling Xu, Lin Lu, Anli Tong, Shi Chen, Wei Li, Huabing Zhang, Fan Ping, and Yuxiu Li
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Glucose ,Adolescent ,Metabolic Diseases ,Endocrinology, Diabetes and Metabolism ,Hyperglycemia ,Glucose Intolerance ,Diabetes Mellitus ,Humans ,Insulin ,Steroid 17-alpha-Hydroxylase ,Hypokalemia ,Glucose Tolerance Test ,Progesterone - Abstract
ObjectiveThe adrenal glands of patients with 17-hydroxylase/17,20-lyase deficiency (17OHD) synthesize excessive 11-deoxycorticosterone(DOC) and progesterone, and produce less amount of sex steroid production. Mineralocorticoids and sex hormones play an important role in regulating glucose homeostasis. This study aimed to describe the glucose metabolism in 17OHD patients diagnosed at Peking Union Medical College Hospital (PUMCH).Design/methodsA total of 69 patients diagnosed with 17OHD after adolescence in PUMCH from 1995 to June in 2021. Among them 23 patients underwent a 3-hours oral glucose tolerance test (3hOGTT) after being diagnosed with 17OHD. Insulin response in patients with normal glucose tolerance (NGT) were further compared between the study two groups with different kalemia status. Another 19 patients were followed up to 30 years and older. All clinical data were obtained from the hospital information system of PUMCH.ResultsBaseline: (1) The average body mass index(BMI) of all patients at baseline was 20.3 ± 3.7kg/m2. Twenty-three patients underwent 3hOGTT, of whom three were diagnosed with diabetes mellitus, and one with impaired glucose tolerance (IGT). Positive correlation between the ratio of progesterone to upper limit of normal range (P times) and hyperglycaemia was exist(r=0.707, P=0.005). (2) In 19 NGT patients, the insulin concentrations at 0 minute, results of the homeostasis model assessment for β-cell function and insulin resistance were lower in the hypokalaemia group than in the normal kalemia group(7.0(5.8-13.2) vs 12.4(8.9-14.9) μIU/ml, P=0.017; 115.5(88.2-240.9) vs 253.1(177.2-305.8), P=0.048; 1.54(1.17-2.61) vs 2.47(1.91-2.98), P=0.022, respectively). Follow-up: Four patients had IGT, while seven patients had diabetes mellitus. Of the 19 patients,11 had hyperglycaemia. P times was significantly higher(7.6(5.0-11.0) vs 3.75(2.2-5.3), P=0.008) in hyperglycemia group than in the normal glucose group.ConclusionsAbnormal glucose metabolism was common in 17OHD patients, which was possibly associated with hypokalaemia and high progesterone levels. Routine monitoring on glucose metabolism in 17OHD patient should be conducted.
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- 2022
35. Sm-doped SnO2 nanoparticles synthesized via solvothermal method as a high-performance formaldehyde sensing material for gas sensors
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Tingrun Lai, Yuxiu Li, Xiuxiu Cui, Yude Wang, Yan Ran, Rongjun Zhao, Lijia Yao, and Lihong Wang
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010302 applied physics ,chemistry.chemical_classification ,Materials science ,Tin dioxide ,Doping ,Formaldehyde ,Oxide ,Nanoparticle ,Environmental pollution ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,X-ray photoelectron spectroscopy ,0103 physical sciences ,Volatile organic compound ,Electrical and Electronic Engineering - Abstract
Formaldehyde (HCHO) is a colorless and irritating volatile organic compound, which has been proven to be one of the raw materials that cause pathological building syndrome, as well as a major source of indoor environmental pollution. Long-term exposure of human body to formaldehyde will cause certain health risks, so it is of great practical significance to develop a fast and effective formaldehyde detection sensor. Tin dioxide (SnO2), an n-type semiconductor metal oxide with a specific bandgap (3.62 eV, at 300 K), has been widely used as efficient sensors material for hazardous gases detecting. Different ratios of Sm-doped SnO2 nanoparticles had been successfully prepared by a simple solvothermal route and used as sensing materials in this work. The sample structure, micromorphology, and ingredient were characterized by XRD, SEM, TEM, XPS, and other methods of formaldehyde gas-sensing characteristics were studied. The results shown the optimum compound ratio of Sm-doped SnO2 nanoparticles was 5.0 mol%, the optimal operating temperature was 160 °C, and the sensor shown high gas response, reliable stability and selectivity to formaldehyde. The sensor shown the outstanding gas-sensing performances to formaldehyde ascribed the average grain size of the Sm-doped SnO2 nanoparticles and the positive role of Sm. Besides, the possible gas-sensing mechanism of the prepared sensor to formaldehyde was analyzed in detail.
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- 2021
36. Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report
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Huabing Zhang, Yong Yao, Yuxiu Li, Liyun He, Hui You, Huijuan Zhu, and Na Yang
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medicine.medical_specialty ,endocrine system diseases ,Intracranial tumor ,genetic structures ,Perioptic meningeal seeding ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,Visual acuity decrease ,Case report ,medicine ,Central diabetes insipidus ,Germinoma ,business.industry ,food and beverages ,General Medicine ,medicine.disease ,VISUAL ACUITY DECREASE ,female genital diseases and pregnancy complications ,Impaired Vision ,eye diseases ,030220 oncology & carcinogenesis ,Diabetes insipidus ,030211 gastroenterology & hepatology ,business - Abstract
BACKGROUND Germinoma is a type of germ cell tumor that most frequently arises in the midline axis of the brain. Impaired vision is a clinical manifestation of germinnoma. Although rare, intracranial germinoma seeding to the perioptic arachnoid space is one cause of visual acuity decrease. CASE SUMMARY An 11yearold girl who presented with polyuria and polydipsia and subsequently developed diminution of vision. Imaging showed bilateral heterogeneous enhancement of the optic nerve sheaths and atrophy of the optic nerve, and transsphenoidal biopsy revealed a germinoma. The patient experienced poor visual recovery following chemotherapy and radiotherapy. Germinomas are rare and they are mostly identified in children and adolescents. The manifestations include diabetes insipidus, pituitary dysfunction, visual complaints, etc. The mechanisms that lead to visual loss include intracranial hypertension, compression of optic chiasma, and tumor invasion. A literature review was performed to summarize the cases with a tumor infiltrating the optic nerve. Most of the reported patients were adolescents and presented with anterior pituitary hormone deficiency. Enhancement of optic nerve sheaths and optic disc pallor could be identified in most of the cases. The purpose of this report is to provide awareness that in cases where a germinoma is associated with visual loss, though rare, perioptic meningeal seeding should be taken into consideration. CONCLUSION The case report suggests that children with diabetes insipidus need a complete differential diagnosis.
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- 2021
37. Instabilities of a freely moving spherical particle in a Newtonian fluid: Direct Numerical Simulation
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Shashank S. Tiwari, Yuxiu Li, Geoffrey Evans, Jyeshtharaj B. Joshi, and Krishnaswamy Nandakumar
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Physics ,General Chemical Engineering ,0103 physical sciences ,Newtonian fluid ,Direct numerical simulation ,Particle ,02 engineering and technology ,Mechanics ,021001 nanoscience & nanotechnology ,0210 nano-technology ,01 natural sciences ,010305 fluids & plasmas - Abstract
Direct Numerical Simulations (DNS) were carried out for a freely falling/rising rigid particle in an otherwise quiescent fluid, using a non-Lagrangian multiplier based fictitious domain (FD) method. Validation studies showed that the proposed FD based DNS are in good agreement with the existing experimental results in the transition regime of falling/rising spheres. Simulations done in the transitional regime (50 Γ = ρ p / ρ f ${\Gamma}={\rho }_{p}/{\rho }_{f}$ from 0.08 to 4), confirmed that (i) a falling spherical particle (Γ = 4) exhibits a helical trajectory in the range 270 1). Fast Fourier Transform (FFT) analysis characterized the presence of a bimodal frequency similar to that exhibited by flow past an isolated stationary bluff body.
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- 2021
38. Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus
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Jian Zhu, Junfeng Han, Liehua Liu, Yu Liu, Wen Xu, Xiaomu Li, Lin Yang, Yong Gu, Wei Tang, Yongquan Shi, Shandong Ye, Fei Hua, Guangda Xiang, Ming Liu, Zilin Sun, Qing Su, Xiaoying Li, Yuxiu Li, Yanbing Li, Hong Li, Yiming Li, Tao Yang, Jing Yang, Lixin Shi, Xuefeng Yu, Li Chen, Jiaqing Shao, Jun Liang, Xiao Han, Yaomin Xue, Jianhua Ma, Dalong Zhu, and Yiming Mu
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Published
- 2023
39. RANKL inhibition: a new target of treating diabetes mellitus?
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Baodi Xing, Jie Yu, Huabing Zhang, and Yuxiu Li
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Endocrinology, Diabetes and Metabolism - Abstract
Accumulating evidence demonstrates the link between glucose and bone metabolism. The receptor activator of nuclear factor-kB ligand (RANKL)/the receptor activator of NF-κB (RANK)/osteoprotegerin (OPG) axis is an essential signaling axis maintaining the balance between bone resorption and bone formation. In recent years, it has been found that RANKL and RANK are distributed not only in bone but also in the liver, muscle, adipose tissue, pancreas, and other tissues that may influence glucose metabolism. Some scholars have suggested that the blockage of the RANKL signaling may protect islet β-cell function and prevent diabetes; simultaneously, there also exist different views that RANKL can improve insulin resistance through inducing the beige adipocyte differentiation and increase energy expenditure. Currently, the results of the regulatory effect on glucose metabolism of RANKL remain conflicting. Denosumab (Dmab), a fully human monoclonal antibody that can bind to RANKL and prevent osteoclast formation, is a commonly used antiosteoporosis drug. Recent basic studies have found that Dmab seems to regulate glucose homeostasis and β-cell function in humanized mice or in vitro human β-cell models. Besides, some clinical data have also reported the glucometabolic effects of Dmab, however, with limited and inconsistent results. This review mainly describes the impact of the RANKL signaling pathway on glucose metabolism and summarizes clinical evidence that links Dmab and DM to seek a new therapeutic strategy for diabetes.
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- 2023
40. A Novel Type of Extreme Insulin Resistance: Nonhypoglycemic Insulin Autoimmune Syndrome
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Ou Wang, Yu Li, He Liu, Jiangfeng Mao, Hui Pan, Siyu Liang, Yuxiu Li, Junling Fu, Ming Li, Yan Qin, Shi Chen, Tao Yuan, and Huijuan Zhu
- Subjects
Male ,China ,medicine.medical_specialty ,Insulin Antibodies ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Clinical Biochemistry ,Context (language use) ,Severity of Illness Index ,Biochemistry ,Autoimmune Diseases ,Endocrinology ,Internal medicine ,Insulin autoimmune syndrome ,Diabetes Mellitus ,medicine ,Humans ,Insulin ,Extreme insulin resistance ,biology ,business.industry ,Biochemistry (medical) ,Therapeutic effect ,Autoantibody ,Syndrome ,Middle Aged ,Insulin receptor ,Hyperglycemia ,biology.protein ,Insulin Resistance ,Antibody ,business - Abstract
Context Extreme insulin resistance is caused by genetic defects intersecting with the insulin action pathway or by the insulin receptor antibodies. Insulin autoimmune syndrome (IAS) is not considered one of the causes of extreme insulin resistance. Objective This work aimed to expand the current knowledge of extreme insulin resistance and to propose the diagnostic criteria and management strategy of a novel type of extreme insulin resistance. Methods A patient with IAS never experienced hypoglycemia but had persistent hyperglycemia and extreme insulin resistance with treatment with 200 U of intravenous insulin per day. Immunoreactive insulin (IRI), free insulin, and total insulin were measured. The ratio of free insulin to total insulin (insulin-free ratio, IFR) was calculated. Results Extreme insulin resistance has not been reported to be caused by IAS. At admission, IRI and free insulin were undetectable in our patient; total insulin was more than 20 160 pmol/L; and the IFR was lower than 0.03% (control, 90.9%). After adding 500 U porcine insulin to the precipitate containing insulin antibodies, the IRI was still undetectable. Since the patient started glucocorticoid therapy, the free insulin has gradually increased to 11.16 pmol/L, his total insulin has decreased to 5040 pmol/L, and the IFR has increased to 18.26%. Intravenous insulin was stopped, with good glycemic control. Conclusion High-affinity insulin autoantibodies with a large capacity can induce a novel type of extreme insulin resistance characterized by extremely high total insulin and very low free insulin levels. The IFR can be used to evaluate therapeutic effects.
- Published
- 2020
41. Long Sleep Duration is Associated with Increased High-Sensitivity C-Reactive Protein: A Nationwide Study on Chinese Population
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Liyun He, Lingling Xu, Wei Li, Fan Ping, Yuxiu Li, Huabing Zhang, and Na Yang
- Subjects
Pharmacology ,Chinese population ,Short sleep ,biology ,business.industry ,C-reactive protein ,Chinese adults ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Health outcomes ,03 medical and health sciences ,0302 clinical medicine ,Duration (music) ,Long sleep ,Internal Medicine ,biology.protein ,Medicine ,business ,Demography ,Sleep duration - Abstract
Purpose High-sensitivity C-reactive protein (hs-CRP) has been shown as an important predictor of cardiovascular risk, and sleep duration is an important factor influencing health outcomes. However, the association between hs-CRP and sleep duration among Chinese adults remained unknown and controversial. We aimed to explore the associations between sleep duration and hs-CRP levels among Chinese adults, and the differences in sex and geographical regions. Methods This cross-sectional study was based on nationally representative Chinese samples from the 2009 China Health and Nutrition Survey, which employed multistage, random cluster designs. Habitual sleep duration was self-reported with short and long sleep duration defined as ≤6h and ≥9h per day, respectively. Participants were divided into 4 groups based on the categories of self-reported sleep duration (≤6h, 7h, 8h, ≥9h per day), excluding hs-CRP levels ≥10 mg/L. Subset samples were stratified by sex and geographical regions. Results A total of 8170 Chinese adults with a mean age of 50.0±14.9 years and 4369 (53.5%) men were included. Participants sleeping eight hours had the lowest hs-CRP levels. Long sleep duration (≥9h) was significantly associated with elevated hs-CRP levels after adjusting for multiple covariates in full samples (β=0.0356; 95% CI: 0.0050-0.0663; P=0.0228), but the associations of short sleep duration (≤ 6h) were limited to the unadjusted model. Long sleep duration was associated with elevated hs-CRP levels in women (β= 0.0512; 95% CI: 0.0097-0.0927; P=0.0155) and in the northern region of China (β=0.0699; 95% CI: 0.0210-0.1187; P=0.0051), but not in men or the southern region. Conclusion Long but not short sleep duration was positively associated with elevated hs-CRP levels, independent from traditional risk factors among Chinese adults, and sex and geographical differences were observed. Our findings imply that modifications of long sleep duration might be added to behavioral therapy to reduce cardiovascular risk in Chinese adults.
- Published
- 2020
42. Equilibrium Solubility and Modeling of Glibenclamide in Cosolvent Mixtures of Methanol, n-Propanol, Isopropanol, and Acetonitrile + WaterYuxiu Li, Yu Zhu, Wanwan Wang, Juan Song, Hua LvCollege of Pharmacy and Chemistry & Chemical Engineering, TaiZhou University, Taizhou, Jiangsu 225300, People’s Republic of ChinaCorresponding author . Tel: + 86 15161061813* E-mail address: yuxiulitzu@163.com ABSTRACTEquilibrium solubility of glibenclamide (GCM) in aqueous solutions of methanol, n-propanol, isopropanol, and acetonitrile were studied by static technique at temperatures ranging from 288.15 K to 323.15 K under p = 101.3 kPa. When the composition of cosolvents was constant in the four mixed solvents, GCM solubility increased with the rising temperature. When the temperature was fixed, the GCM mole fraction solubility showed positive dependence on the increasing mass fraction
- Author
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yuxiu li, Yu Zhu, Wanwan Wang, Juan Song, and Hua Lv
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
43. Development and Validation of Questionnaire-Based Machine Learning Models for Predicting All-Cause Mortality in a Representative Population of China
- Author
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Ziyi Li, Na Yang, Liyun He, Jialu Wang, Fan Ping, Wei Li, Lingling Xu, Huabing Zhang, and Yuxiu Li
- Subjects
Public Health, Environmental and Occupational Health - Abstract
BackgroundConsidering that the previously developed mortality prediction models have limited applications to the Chinese population, a questionnaire-based prediction model is of great importance for its accuracy and convenience in clinical practice.MethodsTwo national cohort, namely, the China Health and Nutrition Survey (8,355 individual older than 18) and the China Health and Retirement Longitudinal Study (12,711 individuals older than 45) were used for model development and validation. One hundred and fifty-nine variables were compiled to generate predictions. The Cox regression model and six machine learning (ML) models were used to predict all-cause mortality. Finally, a simple questionnaire-based ML prediction model was developed using the best algorithm and validated.ResultsIn the internal validation set, all the ML models performed better than the traditional Cox model in predicting 6-year mortality and the random survival forest (RSF) model performed best. The questionnaire-based ML model, which only included 20 variables, achieved a C-index of 0.86 (95%CI: 0.80–0.92). On external validation, the simple questionnaire-based model achieved a C-index of 0.82 (95%CI: 0.77–0.87), 0.77 (95%CI: 0.75–0.79), and 0.79 (95%CI: 0.77–0.81), respectively, in predicting 2-, 9-, and 11-year mortality.ConclusionsIn this prospective population-based study, a model based on the RSF analysis performed best among all models. Furthermore, there was no significant difference between the prediction performance of the questionnaire-based ML model, which only included 20 variables, and that of the model with all variables (including laboratory variables). The simple questionnaire-based ML prediction model, which needs to be further explored, is of great importance for its accuracy and suitability to the Chinese general population.
- Published
- 2022
44. Comparison of differences in bone microarchitecture in adult- versus juvenile-onset type 1 diabetes Asian males versus non-diabetes males: an observational cross-sectional pilot study
- Author
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Jie Yu, Qun Xu, Lingling Xu, Yanfang Hou, Yuxiu Li, Huabing Zhang, Wei Li, Ou Wang, Weibo Xia, and Fan Ping
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Fracture risk ,Endocrinology, Diabetes and Metabolism ,Urology ,Pilot Projects ,030209 endocrinology & metabolism ,Bone and Bones ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Endocrinology ,Bone Density ,Diabetes mellitus ,Bone mineral density ,medicine ,Humans ,Tibia ,Quantitative computed tomography ,Bone mineral ,Type 1 diabetes ,medicine.diagnostic_test ,business.industry ,Bone microarchitecture ,medicine.disease ,Radius ,Cross-Sectional Studies ,Diabetes Mellitus, Type 1 ,030104 developmental biology ,Juvenile onset ,Original Article ,Observational study ,business ,Body mass index - Abstract
Purpose Evidence about bone microarchitecture in Asian type 1 diabetes (T1D) patients is lacking. We assessed the bone microarchitecture in T1D patients versus controls and compare the differences between juvenile-onset and adult-onset T1D patients. Methods This cross-sectional study recruited 32 Asian males with T1D and 32 age-, sex-, and body mass index (BMI)-matched controls. Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) for ultradistal nondominant radius and tibia were performed. The data were analyzed using Student’s t test and analysis of covariance. Results Among the patients, 15 had juvenile-onset T1D, with a median disease duration of 11 years, and 17 had adult-onset T1D, with a median disease duration of 7 years. At the radius, adult-onset and juvenile-onset T1D patients had lower total volumetric bone mineral density (vBMD), trabecular vBMD, trabecular bone volume fraction (BV/TV), and trabecular thickness (Tb.Th) (p p p Conclusions T1D patients were associated with compromised bone microarchitecture, adult-onset and juvenile-onset T1D patients demonstrated some differences in cortical and trabecular microarchitecture.
- Published
- 2020
45. Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction
- Author
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Huabing Zhang, Fan Ping, Yiwen Liu, Yuxiu Li, Lu Lv, Chunxiao Ma, Jingbo Zeng, Chifa Ma, Shuli He, Lingling Xu, Wei Li, and Pingping Li
- Subjects
0301 basic medicine ,Aging ,medicine.medical_specialty ,Article Subject ,medicine.medical_treatment ,Glutathione reductase ,030209 endocrinology & metabolism ,medicine.disease_cause ,Biochemistry ,Superoxide dismutase ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,medicine ,National Cholesterol Education Program ,QH573-671 ,Triglyceride ,biology ,business.industry ,Insulin ,Cell Biology ,General Medicine ,medicine.disease ,030104 developmental biology ,Endocrinology ,chemistry ,biology.protein ,Metabolic syndrome ,Cytology ,business ,Oxidative stress - Abstract
The interplays of cellular aging and oxidative stress (OS) markers form a complex network, which has been reported to be interrelated with numerous age-related and metabolic diseases, including metabolic syndrome (MS). However, given the multifactorial mechanisms of MS, several important confounders such as dietary factors and the reciprocal effect among these markers have not been considered and adjusted in previous investigations regarding the associations of cellular aging and OS markers with MS and its related metabolic abnormalities. To explicate this, we conducted a cross-sectional study among 533 Chinese adults. All the participants underwent a 75 g oral glucose tolerance test. Dietary data were collected via a 24-hour dietary recall and subsequently analyzed by a registered dietitian using nutrition calculation software. Clinical diagnosis of MS was made according to the revised National Cholesterol Education Program Adult Treatment Panel III criteria (2004) with waist circumference cutoff modified for an Asian population. The leukocyte telomere length, mitochondrial DNA copy number, 8-hydroxy-2-deoxyguanosine, superoxide dismutase (SOD) activity, and glutathione reductase were examined. SOD activity was significantly decreased in MS subjects (62.06±16.89 U/mL vs. 56.25±22.61 U/mL, P=0.001) and exhibited a descending trend across sequential increase of MS component number (P for trend=0.031). SOD activity is modestly correlated with glucose indicators and insulin sensitivity and β-cell function indices and was independently and negatively correlated with the level of triglyceride. An independent association between SOD activity and MS was observed after adjusting for metabolic indicators, dietary factors, cellular aging, and OS markers, as well as insulin sensitivity and β-cell function indices. However, the statistical significance of the association between SOD activity and MS was attenuated after adjusting for the Matsuda insulin sensitivity index (ISIM) and insulin secretion-sensitivity index-2 (ISSI-2), suggesting a possible mediating effect. Therefore, we conducted a mediation model analysis, which showed that decreased ISIM and ISSI-2 partially and synergistically mediated the contribution of decreased SOD activity to MS. In conclusion, decreased SOD activity is an independent predictor for increased risk of MS, and insulin resistance and β-cell dysfunction partially mediate the relationship between decreased SOD activity and MS.
- Published
- 2020
46. Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states
- Author
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Haibin Liu, Huabing Zhang, Qi Sun, Shuli He, Minglei Ma, Fan Ping, Lingling Xu, Pingping Li, Jie Yu, Chunxiao Ma, Yuxiu Li, and Wei Li
- Subjects
Blood Glucose ,Male ,China ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Population ,Superoxide dismutase ,Carbohydrate metabolism ,Triglyceride ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,medicine ,Humans ,education ,lcsh:RC620-627 ,Triglycerides ,Aged ,Dyslipidemias ,education.field_of_study ,business.industry ,Research ,Biochemistry (medical) ,Hypertriglyceridemia ,Diabetes ,nutritional and metabolic diseases ,Beta cell function ,Middle Aged ,Lipid ,Lipid Metabolism ,medicine.disease ,Oxidative Stress ,lcsh:Nutritional diseases. Deficiency diseases ,Glucose ,Lipotoxicity ,chemistry ,Female ,business ,Dyslipidemia - Abstract
Background Previous studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), oxidative stress indicators, insulin resistance, and beta cell function in populations with different glucose and lipid metabolism states. Methods A total of 517 individuals were recruited from a rural community in Beijing, China. Glucose metabolism status was defined according to the results of a 75-g oral glucose tolerance test (OGTT). Dyslipidemia was defined as abnormal TG, HDL-c, or LDL-c levels. The population was divided into four groups: individuals with normal glucose and lipid levels (group A, n = 62); those with dyslipidemia alone (group B, n = 82); those with dysglycemia alone (group C, n = 121); and those with dysglycemia and dyslipidemia (group D, n = 247). Oxidative stress indicators, including superoxide dismutase (SOD), glutathione reductase (GR) and 8-hydroxydeoxyguanosine (8-OHdG), were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) and glucose disposition index (DI30, DI120) were calculated to assess insulin resistance and islet beta cell function, respectively. Stratified multiple linear regression analysis was used to explore relationships between TG, HDL-c, LDL-c, oxidative stress indicators, and insulin resistance (natural log transformation of HOMA-IR, LnHOMA-IR) and beta cell function (natural log transformation of DI30, Ln DI30). Results Compared with the control group, populations with dyslipidemia and/or dysglycemia showed significantly increased insulin resistance. Dyslipidemia aggravated insulin resistance and beta cell dysfunction in individuals with dysglycemia. Stratified regression analysis showed that TG positively correlated with LnHOMA-IR in individuals with normal glucose levels (beta = 0.321, 0.327, P = 0.011, 0.003 in groups A and B, respectively) and negatively correlated with LnDI30 in participants with dyslipidemia (beta = − 0.225, − 0.122, P = 0.035, 0.048 in groups B and D, respectively). Reduced serum SOD levels in individuals with dysglycemia plus dyslipidemia were observed, and a negative association between TG and SOD levels was found (r = − 0.461, P Conclusion TG correlated with both insulin resistance and beta cell function in individuals with dyslipidemia alone. SOD negatively correlated with TG, indicating a close relationship between oxidative stress and glucose-lipid metabolism. Due to the adverse effect of hypertriglyceridemia on insulin sensitivity and islet beta cell function, more attention should be paid to the detection and management of hypertriglyceridemia.
- Published
- 2020
47. The Effect of LM25 and LM50 on Hypoglycemia in Chinese T2DM Patients: Post Hoc Analysis of a Randomized Crossover Trial
- Author
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Huabing Zhang, Wei Li, Kang Yu, Yaxiu Dong, Fan Ping, Lingling Xu, and Yuxiu Li
- Subjects
medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Hypoglycemia ,Bedtime ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,Post-hoc analysis ,Type 2 diabetes mellitus ,Internal Medicine ,Medicine ,Insulin lispro ,Acarbose ,Original Research ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,Crossover study ,Premixed insulin ,Regimen ,business ,medicine.drug - Abstract
Introduction To investigate the safety of insulin lispro Mix 25 and 50 (LM25 and LM50) in hypoglycemia in patients with type 2 diabetes mellitus (T2DM). Methods This was a post hoc analysis of a phase IV, randomized, crossover clinical trial in Chinese patients with T2DM switching from premixed human insulin 70/30 (PHI70/30) to LM25 or LM50. Eighty-one subjects received a two-stage crossover protocol of either LM25 or LM50 twice daily for 16 weeks. Habitual diet was taken, and self-monitoring of blood glucose (SMBG) was performed throughout the study period. High-carbohydrate diet (HCD), high-fat diet (HFD) and habitual diet patterns were taken, and 72 h continuous glucose monitoring (CGM) was performed at the last 3 days of each treatment stage. Results The frequencies of nocturnal hypoglycemia in LM50 were lower than those in LM25 under a Chinese habitual diet pattern. The related factors of hypoglycemia in patients with T2DM treated with a LM25 or LM50 regimen were the weight-based daily mean insulin dose and the type of combined oral hypoglycemic agents. Under both HCD and habitual diet patterns, the optimal cut point values of bedtime glucose predicting nocturnal hypoglycemia in LM50 were lower than those in LM25. Conclusions The risk of nocturnal hypoglycemia in the LM50 regimen was lower than that in the LM25 regimen under the HCD pattern, and the safety range of bedtime glucose for the LM50 regimen was wider than that of the LM25 regimen in Chinese T2DM patients. Premixed insulin analogs combined with acarbose were more helpful to reduce the incidence of hypoglycemia. Trial Registration http://www.chictr.org.cn #ChiCTR-TTRCC-12002516.
- Published
- 2020
48. Bromine anion-induced synthesis of copper nanoplates and their recyclable catalytic activity towards 4-nitrophenol reduction
- Author
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Chuan Wang, Zhengyang Fan, Ximin Yuan, Yunxiu Chao, Hongwei Yang, Yao Li, and Yuxiu Li
- Subjects
Bromine ,Inorganic chemistry ,chemistry.chemical_element ,4-Nitrophenol ,General Chemistry ,Condensed Matter Physics ,Copper ,Ion ,Catalysis ,Reduction (complexity) ,chemistry.chemical_compound ,chemistry ,Selective adsorption ,General Materials Science ,Copper nanowires - Abstract
Copper nanoplates have been obtained with bromine ions as shape modifiers. Selective adsorption of bromine ions on the {111} crystal plane of copper promoted the formation of copper nanoplates instead of copper nanowires. Moreover, the copper nanoplates exhibited considerable catalytic activity and reusability in the reduction of 4-nitrophenol.
- Published
- 2020
49. The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population
- Author
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Xinqi Cheng, Fan Ping, Na Yang, Huabing Zhang, Yuxiu Li, Ling Qiu, Wei Li, Qi Sun, and Lingling Xu
- Subjects
Adult ,Blood Glucose ,Male ,0301 basic medicine ,China ,β cell function ,medicine.medical_specialty ,Group based ,Glucose response curve ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Fasting insulin ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Insulin-Secreting Cells ,Diabetes mellitus ,Internal medicine ,medicine ,OGTT ,Humans ,Insulin ,Oral glucose tolerance ,Chinese population ,Chinese ,lcsh:RC648-665 ,business.industry ,General Medicine ,Glucose Tolerance Test ,Prognosis ,medicine.disease ,030104 developmental biology ,Endocrinology ,Diabetes Mellitus, Type 2 ,Female ,Insulin Resistance ,business ,Biomarkers ,Homeostasis ,Follow-Up Studies ,Research Article - Abstract
Background The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict β-cell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, we aimed to verify the usefulness of the glucose response curve in a large Chinese population. Methods A total of 9059 OGTT (3-h tests) were categorized into either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, the Matsuda Index, the insulinogenic index, and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT. Results The shape of the OGTT glucose response curve was monophasic in 87.3% and multiphasic in 12.7% of participants. Individuals in the multiphasic group were younger compared to those in the monophasic group (38.6 ± 13.6 vs. 35.4 ± 13.5, P P P P P Conclusion The monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.
- Published
- 2019
50. Analysis of 55 patients with multiple endocrine neoplasia type 1-associated insulinoma from a single center in China
- Author
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Yuan Zhao, Jie Yu, Yiwen Liu, Lu Lyu, Fan Ping, Lingling Xu, Wei Li, Ou Wang, Qiang Xu, Wenming Wu, Huabing Zhang, and Yuxiu Li
- Subjects
Adult ,Male ,Insulins ,General Medicine ,Hypoglycemia ,Pancreatic Neoplasms ,Young Adult ,Multiple Endocrine Neoplasia Type 1 ,Humans ,Neuroectodermal Tumors, Primitive ,Pharmacology (medical) ,Female ,Insulinoma ,Genetics (clinical) - Abstract
Objective To investigate the clinical characteristics of patients with multiple endocrine neoplasia type 1 (MEN1)-related insulinoma and their relationship with specific biochemical changes and to summarize the features of treatment options for the Chinese population with this disease and the impact on long-term prognosis. Methods “MEN1” and “insulinoma” were used when searching the Peking Union Medical College Hospital (PUMCH) medical record retrieval system to obtain clinical information about patients. We identified patients diagnosed with MEN1-associated insulinoma based on endocrinological, radiological, and pathological examinations, and subsequently analyzed their clinical data. Results A total of 55 patients with MEN1-associated insulinoma were included, including 29 (52.7%) men and 26 (47.3%) women. The parathyroid gland was the most commonly affected (78.2%), followed by the pituitary gland (69.1%) and adrenal gland (16.4%). Insulinoma was the first manifestation of MEN1 in at least 23.6% (13/55) of patients. Nineteen (34.5%) patients presented with initial symptoms of hypoglycemia before the age of 22 years. Among the 24 Patients with high serum calcium (Ca) had significantly lower serum insulin levels than those with normal serum Ca levels (p Conclusions In our study, the rates of postoperative recurrence and long-term complications in patients with MEN1 with multifocal pNETs were significantly different from those in other international centers and might be related to the choice of surgical method. In addition, elevated serum Ca levels in patients with primary hyperparathyroidism may affect insulin secretion.
- Published
- 2021
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