Search

Necrotizing vasculitis (NV), which could be observed in systemic necrotizing vasculitides suchas classic polyarteritis nodosa, is characterized by fibrinoid necrosis, which typically involves the media.Among the gynecologic organs, the uterine cervix is the most frequent site of vasculitis; NV of the uterinecervix is usually asymptomatic and unrelated to systemic vasculitis. Pathological differences betweenisolated or single-organ NV and systemic necrotizing vasculitides have been rarely evaluated. Thus, thisstudy aimed to determine the clinicopathological characteristics of NV of the uterine cervix and evaluatewhether affected vessels are pathologically different from those in classic polyarteritis nodosa. We selected405 cases of conization that were operated from 2003 to 2017 in our hospital, and follow-up data until 2018was obtained for patients with vasculitis. NV was evaluated with sections stained by hematoxylin and eosin,elastica van Gieson, phosphotungstic acid-hematoxylin, and immunohistochemistry. Histological specimensof systemic necrotizing vasculitides were unavailable. NV and lymphocytic vasculitis (LV) of the uterinecervix were found in, respectively, six (1.5%) and 26 (6.4%) of the 405 cases; no granulomatous vasculitis wasobserved. All cases with vasculitis were asymptomatic and uneventful during the follow-up period, whichsuggested that the vasculitis of the uterine cervix in our study was single-organ vasculitis. Lymphocyteswere the main inflammatory infiltrates in NV and LV, and neutrophilic infiltrate was inconspicuous. All NVcases showed subintimal localization of fibrinoid necrosis, which did not involve the media. The NV cases inour study differ from the typical NV in classic polyarteritis nodosa.

The anaplastic variant of diffuse large B‐cell lymphoma (A‐DLBCL) is morphologically defined but remains an enigmatic disease in its clinicopathologic distinctiveness. Here, we report two cases involving Japanese women aged 59 years, both with A‐DLBCL with the hallmark cell appearance and both indistinguishable from common and giant cell‐rich patterns, respectively, of anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma. Case 1 was immunohistochemically positive for CD20, CD79a and OCT‐2 but not for the other pan–B‐cell markers, CD30 and ALK. Case 2 showed CD20 and CD30 positivity for 50% and 20% of tumor cells in addition to strong expression of p53 and MYC. Both were positive for fascin without Epstein–Barr virus association. Our cases provide additional support for the earlier reports that A‐DLBCL exhibits clinicopathologic features distinct from ordinal diffuse large B‐cell lymphoma (DLBCL), and documented its broader morphologic diversity than previously recognized. They also shed light on the unique feature of absent expression of pan–B‐cell markers except for CD20 and CD79a, suggesting that A‐DLBCL may biologically mimic a gray zone or intermediate lymphoma between DLBCL and classic Hodgkin lymphoma., ファイル公開：2019-04-02

Additional file 2. Intratumoral expression patterns of MCT4 and GPC3 in 44 cases of MCT4+ GPC3+ HCC.

Additional file 1. Clinicopathological data of patients with HCC.