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Additional file 1: Scheme S1. Synthetic routes to PCL-MV and Nap-PEG. Scheme S2. Synthetic routes to Nap-DFO. Fig. S1. 1H NMR spectrum (400 MHz, CDCl3, room temperature) of PCL-Br. Fig. S2. GPC curve of PCL-Br. Fig. S3. 1H NMR spectrum (400 MHz, CDCl3, room temperature) of PCL-MV. Fig. S4. GPC curve of PCL-MV. Fig. S5. 1H NMR spectrum (400 MHz, CDCl3, room temperature) of Nap-PEG. Fig. S6. GPC curve of Nap-PEG. Fig. S7. 1H NMR spectrum (400 MHz, CDCl3, room temperature) of Nap-Boc. Fig. S8. 13C NMR spectrum (100 MHz, CDCl3, room temperature) of Nap-Boc. Fig. S9. ESI IT-TOF results of Nap-Boc. [M + Na]+ = 340.1494. Fig. S10. 1H NMR spectrum (400 MHz, DMSO-d6, room temperature) of Nap-NH2. Fig. S11. 13C NMR spectrum (100 MHz, DMSO-d6, room temperature) of Nap-NH2. Fig. S12. ESI IT-TOF results of Nap-NH2. [M + H]+ = 218.1142. Fig. S13. 1H NMR spectrum (400 MHz, DMSO-d6, room temperature) of Nap-DFO. Fig. S14. 13C NMR spectrum (100 MHz, DMSO-d6, room temperature) of Nap-DFO. Fig. S15. ESI IT-TOF result of Nap-DFO. [M – H]– = 775.3225. Fig. S16. 1H NMR spectra of a Nap-PEG, b Nap-PEG + CB[8] and c CB[8] in D2O. Fig. S17. CLSM images of HepG2 cells cultured with DOX∙HCl for 4 h and 9 h, respectively. The right images are the enlarged ones at the same time point. Fig. S18. Cytotoxicity evaluation of CB[8] against HepG2 cells using an MTT assay. Fig. S19. Cytotoxicity evaluation of PCL-MV against HepG2 cells using an MTT assay. Fig. S20. Cytotoxicity evaluation of Nap-PEG against HepG2 cells using an MTT assay. Fig. S21. Cytotoxicity evaluation of DOX·HCl and SNM@DOX against HepG2 cells after 24 h incubation using a CCK-8 assay. Fig. S22. Release profiles of Nap-DFO from the nanoformulation in water or PBS. Fig. S23. Time-dependent biodistribution of 89Zr SNM@DOX in liver and tumor. Fig. S24. Body weight changes of the mice treated with different formulations. Fig. S25. H&E staining of the heart tissues from a healthy mouse and b the mouse treated with SNM@DOX at day 18.

The domain name system is an important infrastructure of the Internet. In order to effectively prevent the management and technical risks faced by the domain name system, there is an urgent need to obtain relatively complete Internet domain name data to provide basic data support. However, due to a series of restrictive factors such as non-enumerable domain name space, scattered domain name data storage, and restricted access to registry resources, the acquisition of Internet domain name data has become a challenge. We propose a domain name acquisition method based on zone transfer: the authoritative DNS master name server and slave name server usually maintain the function of the entire domain based on the same zone file. We try to find every authoritative domain name server that provides domain name services. The zone transfer obtains the domain name data information of the corresponding domain. We explored the way to implement the method and conducted experimental evaluation. The method has shortcomings in terms of effectiveness and ability, but a considerable amount of domain name data can be obtained to support the construction of a mapping database between global domain names and IP addresses.

This research indicates that the gradient of internal relative humidity (IRH) decreases rapidly within 1-day curing age in HPC. The amount of water imported by pre-wetted light-weight aggregate can regulate IRH of concrete. By importing a proper amount of water, the process of the decline of IRH can be delayed and the autogenous shrinkage can be reduced. The relationship among the amount of water imported by pre-wetted lightweight aggregate, IRH and AS was established. The result provides a new method of reducing early AS and enhancing early cracking resistance of HPC.

EPON is considered as the strategy in solving the "last mile" of Access Wideband Network. This paper introduces the basic framework of EPON Network Management System and concentrates on the process explanation of the key function. Tornado is also used to simulate and test the program effectively and successfully.