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Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.

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Currently a number of managers exist to manage heterogeneous networks, in this situation, the NETCONF protocol for efficient network management has been proposed as a new protocol. However, the standard NETCONF protocol stack continuous improvement since the establishment but in four layers still have some problems. Especially in situations where there are multiple administrators, problems are more highlighted in operation layer. In this paper, we focus on these issues and the Operation layer has improved the efficiency and flexibility of operations among NETCONF four layers. Additionally, for the inefficiency of updates improved the device settings based on improved operation techniques. In addition, standard protocol NETCONF did not proposed content layer data structure and we propose standard technique of content layer that can generate configuration structure of devices. Improved the three techniques are applied appropriately to the NETCONF, the proposed method and the existing NETCONF was performed experiment to compare with experimental four factors. Compare key factor are four kind as maintaining the probability of network function, the reaction performance about command, the number of control packets, performance of data creation in content layer. Such factors after performing the experiment, the proposed method in this paper is superior to the existing NETCONF and there was confirmed by analysis Experimental results.

As the growth of ubiquitous services, various types of ad hoc networks have emerged. In particular, wireless sensor networks (WSN) and mobile ad hoc networks (MANET) are widely known ad hoc networks, but there are also other kinds of wireless ad hoc networks in which the characteristics of the aforementioned two network types are mixed together. This paper proposes a variant of the Low Energy Adaptive Cluster Hierarchy (LEACH) routing protocol modified to be suitable in such a combined network environment. That is, the proposed routing protocol provides node detection and route discovery/maintenance in a network with a large number of mobile sensor nodes, while preserving node mobility, network connectivity, and energy efficiency. The proposed routing protocol is implemented with a multi-hop multi-path algorithm, a topology reconfiguration technique using node movement estimation and vibration sensors, and an efficient path selection and data transmission technique for a great many moving nodes. In the experiments, the performance of the proposed protocol is demonstrated by comparing it to the conventional LEACH protocol.

There has been some research in the equipment defect detection based on vibration information. Most research of them is based on vibration monitoring to determine the equipment defect or not. In this paper, we introduce more accurate system for engine defect detection based on vibration information and we focus on detection of engine defect for boat and system control. First, it uses the duplicated-checking method for vibration information to determine the engine defect or not. If there is a defect happened, we use the method using error part of vibration information basis with error range to determine which kind of error is happened. On the other hand, we use the engine trend analysis and standard of safety engine to implement the vibration information database. Our simulation results show that the probability of engine defect determination is 100% and the probability of engine defect classification and detection is 96%.

The purpose of this study was to analyze behavioral patterns of elderly residents and to identify the characteristics of using furniture and home appliances by elderly-headed households. For this purpose, field studies that included observation and open-ended interview were conducted with 52 elderly-headed households. The major findings of this study were as follows: elderly-headed households need home appliances with lighter body, lower capacity and simple functions. Furniture for elderly people should be designed to minimize the inconvenience of using western style furniture, also the behavior patterns which are important to the elderly like taking medicine have to be considered. And it is necessary to design furniture and equipments properly to prevent accidents happened in housing. Lastly, because the elderly relies heavily on watching TV, it will be desirable to apply TV-friendly devices such as home networking and home automation. Research results will be useful information on product design to reflect characteristics of elderly and follow-up studies associated with each furniture and appliances and specific living behavior are needed.

Recently, there have been some researches in the equipment fault detection based on shock and vibration information. Most research of them is based on shock and vibration monitoring to determine the equipment fault or not. Different with engine fault detection based on shock and vibration information we focus on detection of engine for boat and system control. First, it use the duplicated-checking method for shock and vibration information to determine the engine fault or not. If there is a fault happened, we use the integral to determine the error engine shock wave width and detect the fault area. On the other hand, we use the engine trend analysis and standard of safety engine to implement the shock and vibration information database. Our simulation results show that the probability of engine fault determination is 98% and the probability of engine fault detection is 72%

In general, routing algorithms that were applied to ad-hoc networks are not suitable for the environment with many nodes over several thousands. To solve this problem, hierarchical management to these nodes and clustering-based protocols for the stable maintenance of topology are used. In this paper, we propose the clustering-based modified LEACH protocol that can applied to an environment which moves around metal containers within communication nodes. In proposed protocol, we implemented a module for detecting the movement of nodes on the clustering-based LEACH protocol and improved the defect of LEACH in an environment with movable nodes. And we showed the possibility of the effective communication by adjusting the configuration method of multi-hop. We also compared the proposed protocol with LEACH in four points of view, which are a gradual network composition time, a reconfiguration time of a topology, a success ratio of communication on an containers environment, and routing overheads. And to conclude, we verified that the proposed protocol is better than original LEACH protocol in the metal containers environment within communication of nodes.

Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs1275988, near KCNK3), DBP at 2q11.2 (rs7599598, in FER1L5), and PP at 6p21 (rs10948071, near CRIP3) and 7p13 (rs2949837, near IGFBP3). Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association studies. Using LTA analysis, we identified genetic loci influencing BP. LTA might be one way of increasing the power of genetic associations for continuous traits in extant samples for other phenotypes that are measured serially over time.

Mobile ad hoc is a network that is applied in fields that cannot utilize the basic infrastructures in emergency situations such as natural disasters. Node of mobile ad hoc network has high mobility and it has energy limitations. Techniques to increase the network survival time by flexibly responding to the topological changes with node mobility are definitely required, In this paper, we are proposing PAOMDV-La(possibility based AOMDV with load awareness) and OLSR-ME (OLSR with modified energy efficiency) which are mixed-type protocols. We verified the performance of the proposed protocols through a comparative experiment with AODV, AOMDV, ZRP, the existing protocol.

MANET refers to a network designed for special applications for which it is difficult to use a backbone network. In MANET, a lot of network troubles occur due to the mobility of nodes and the limitation of energy. Therefore, when performing ubiquitous services with the application of MANET, a technique is required to improve the packet transmission rate so as to enable continuous packet transmission while flexibly adapting to topology changes caused by the mobility of nodes. To solve this problem, this paper proposes a mixed protocol that applies both PAOMDV (possibility based AOMDV) and OLSR-ME (OLSR with modify energy efficiency). In this protocol, PAOMDV takes charge of the outside of cluster and OLSR-ME the inside of cluster so that the two protocols can complement each other. By experiment, this study compares the proposed protocol with the conventional protocols ofAODV, AOMDV, and ZRP, and verifies its performance.

Aims Fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection (SCAD) are related, non-atherosclerotic arterial diseases mainly affecting middle-aged women. Little is known about their physiopathological mechanisms. We aimed to identify rare genetic causes to elucidate molecular mechanisms implicated in FMD and SCAD. Methods and results We analysed 29 exomes that included familial and sporadic FMD. We identified one rare loss-of-function variant (LoF) (frequencygnomAD = 0.000075) shared by two FMD sisters in the prostaglandin I2 receptor gene (PTGIR), a key player in vascular remodelling. Follow-up was conducted by targeted or Sanger sequencing (1071 FMD and 363 SCAD patients) or lookups in exome (264 FMD) or genome sequences (480 SCAD), all independent and unrelated. It revealed four additional LoF allele carriers, in addition to several rare missense variants, among FMD patients, and two LoF allele carriers among SCAD patients, including one carrying a rare splicing mutation (c.768 + 1C>G). We used burden test to test for enrichment in patients compared to gnomAD controls, which detected a putative enrichment in FMD (PTRAPD = 8 × 10−4), but not a significant enrichment (PTRAPD = 0.12) in SCAD. The biological effects of variants on human prostaclycin receptor (hIP) signalling and protein expression were characterized using transient overexpression in human cells. We confirmed the LoFs (Q163X and P17RfsX6) and one missense (L67P), identified in one FMD and one SCAD patient, to severely impair hIP function in vitro. Conclusions Our study shows that rare genetic mutations in PTGIR are enriched among FMD patients and found in SCAD patients, suggesting a role for prostacyclin signalling in non-atherosclerotic stenosis and dissection., Graphical Abstract

Accession Numbers Summary data have been deposited in the database of Genotypes and Phenotypes (dbGaP) under CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium Summary Results from Genomic Studies. The dbGaP study accession number is phs000930. Supplemental Data Supplemental data include Supplemental Acknowledgments, individual study methods and cohort descriptions, pleiotropy analysis, 10 tables, and a figure with 123 panels. Supplemental Data Document S1. Supplemental Acknowledgments, Individual Study Methods and Cohort Descriptions, Pleiotropy Analysis, and Figure S1 Download Data S1. Tables S1–S10 Download Document S2. Article plus Supplemental Data Download Web Resources Center for Genome Dynamics, http://cgd.jax.org dbGaP, http://www.ncbi.nlm.nih.gov/gap Matrix Spectral Decomposition, http://neurogenetics.qimrberghofer.edu.au/matSpD/ METASOFT 3.0c, http://www.buhmhan.com/software MGI Genes and Markers Query, http://www.informatics.jax.org/marker R/qtl v1.07-12, http://www.rqtl.org Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular hemoglobin and mean corpuscular volume. Statistical fine-mapping at this locus pointed to RBPMS at this locus and excluded nearby GTF2E2. Using zebrafish morpholino to evaluate loss of function, we observed a strong in vivo erythropoietic effect for RBPMS but not for GTF2E2, supporting the statistical fine-mapping at this locus and demonstrating that RBPMS is a regulator of erythropoiesis. Our findings show the utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits.

Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. Erythrocyte and WBC phenotypes were analyzed with Illumina HumanExome BeadChip genotypes in 52,531 individuals (37,775 of European ancestry; 11,589 African Americans; 3,167 Hispanic Americans) from 16 population-based cohorts. We then performed replication analyses of novel discoveries in 18,018 European American women and 5,261 Han Chinese. We identified and replicated four novel erythrocyte trait-locus associations (CEP89, SHROOM3, FADS2, and APOE) and six novel WBC loci for neutrophil count (S1PR4), monocyte count (BTBD8, NLRP12, and IL17RA), eosinophil count (IRF1), and total WBC (MYB). The novel association of a rare missense variant in S1PR4 supports the role of sphingosine-1-phosphate signaling in leukocyte trafficking and circulating neutrophil counts. Loss-of-function experiments of S1pr4 in mouse and zebrafish demonstrated phenotypes consistent with the association observed in humans and altered kinetics of neutrophil recruitment and resolution in response to tissue injury.