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Additional file 1:Figure S1. EDS measurement of the elemental composition ofthe Fe3O4@Chl/Cu CNPs. Figure S2. Raman spectra of the Fe3O4@Chl/FeCNPs synthesized with different Chl/Fe concentrations, capping-free Fe3O4nanocrystals, and Chl/Fe molecules. Figure S3. (a) DLS, (b) zeta potential, and (c–f) the sizedistribution of cluster particles of Fe3O4@Chl/Fe CNPssynthesized with different Chl/Fe concentrations. Figure S4. SQUID measurement of Fe3O4@Chl/Fep[0–200 mg] CNPs at 300 K. Figure S5. (a) Photographs and (b–e) TEM images of Fe3O4nanocrystal solutions with different citric acid concentrations. TEM images:(b) 2.1 mg (c) 10.6 mg (d) 21.2 mg (e) 42.4 mg. Figure S6. X-ray diffraction pattern of Fe3O4nanocrystals synthesized by using different citrate acid concentrations. Figure S7. RNO/imidazole assay for theproduction of singlet oxygen species at 25 ppm[Fe] from the Fe3O4@Chl/FeCNPs, Fe3O4, Chl/Fe, and physically mixed Fe3O4+Chl/Femolecules upon 660 nm light irradiation for 10 min. Figure S8. Thermal cycle curves of the Fe3O4@Chl/Fep[200 mg] CNPs ([Fe] = 100 ppm) under (a) 650 nm and (b) 808 nm laserirradiation. (c) Thermal cycle curves of Chl/Fe ([Chl/Fe] = 0.2 mM) under 650 nm and 808 nm laser irradiation. Figure S9. In vitro characterizations of the chromogenic performance of a varietyof Fe3O4@Chl/Fe[0–200 mg] CNPs ([Fe] = 0.5 ppmfrom AAS and [Chl/Cu] = 0.001 mM from UV–Visible measurements). Fe3O4–N2H4is the iron oxide from reference 45. (b) TMB assay for the reaction of iron-basedmaterials at 0.5 ppm[Fe] with 1 mM H2O2. (c) UV–Vis spectra of Fe3O4@Chl/Fe[200 mg] CNPs at 0.5 ppm[Fe]. Figure S10. TMB assay for evaluating the reaction of H2O2with (a) 0.5 ppm[Fe] Fe3O4@Chl/Fe[200 mg]CNPs and 0.5 ppm[Fe] ppm[Fe] Fe3O4@Chl/Fe[200 mg] CNPs plus 1 mM GSH and (b) 0.5 ppm[Fe] Chl/Fe molecule andChl/Fe molecule plus 1 mM GSH. Figure S11. GSH depletion assay under (a) 20 ppm[Fe]Fe-based treatments and (b) 20 ppm[Fe] Fe-based treatments combinedwith a 100 μM H2O2 solution. Figure S12. GSH depletion assay with 20 ppm Fe3O4@Chl/Fe[200 mg] CNPs and Fe3O4@Chl/Fe[200 mg]-CPBACNPs combined with irradiation by a 75 mW/cm2 660 nm laser. Figure S13. AAS measurements for theuptake analysis of (a) T24 cancer cells, (b) MB49 cancer cells, (c) SV-HUC1normal cells, and (d) Vero normal cells after treatment with Fe3O4@Chl/Fe[200 mg] and Fe3O4@Chl/Fe[200 mg]-CPBA CNPsfor 1, 16 and 24 h. Figure S14.Confocal images of T24 cells treated with Fe3O4@Chl/Fe[200 mg]-CPBA CNPs. (a) Fluorescence and confocal images from bottom to top (b–d).(scale bar: 20 μm). Figure S15. Cellviability after treated with different concentrations of modified Fe3O4@Chl/Fe[200 mg] CNPs with targeting molecules such as CPBA, FA, RGD, and transferrin(a) without and (b) with a 660 nm LED light source are displayed. Figure S16. The cell viability of HeLa,NIH 3T3 and VERO cells treated with Fe3O4@Chl/Fe[200 mg] CNPs group and CPBA-, RGD-, andtransferrin-conjugated Fe3O4­@Chl/Fe[200 mg] CNPs without (a, c, e) and with (b, d, f) a 660 nmLED light source at 75 mW/cm2. Figure S17. The cell viability of MB49 treated with Fe3O4@Chl/FeCNPs and Fe3O4@Chl/Fe-CPBA CNPs (a) without and (b) withirradiation by a 660 nm LED light source at 75 mW/cm2. Figure S18.The viability of T24 cells treated with Fe3O4@Chl/Fe[5 mg and 200 mg] CNPs synthesized with 5 and 200 mg of Chl/Fe for 24 h. (a)Without light exposure (b) exposed to 660 nm LED light (75 mW/cm2)([Fe] = 0.2, 1, 5, 10, 50, 100 ppm). Figure S19. Confocal images of MB49 cells treated with Fe3O4@Chl/Fe[200 mg]-CPBA CNPs after24 h: (a) Fluorescence and confocal images from bottom to top (b–d). Scale bar:20 μm.

In this paper, the robust output feedback cruise control for high-speed train movement with uncertain parameters is investigated. The dynamic of a high-speed train is modeled by a cascade of cars connected by flexible couplers, which is subject to rolling mechanical resistance, aerodynamic drag and wind gust. Based on Lyapunov’s stability theory, the sufficient condition for the existence of the robust output feedback cruise control law is given in terms of linear matrix inequalities (LMIs), under which the high-speed train tracks the desired speed, the relative spring displacement between the two neighboring cars is stable at the equilibrium state, and meanwhile a small prescribed H∞ disturbance attenuation level is guaranteed. One numerical example is given to illustrate the effectiveness of the proposed methods.