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A Pt-based CO oxidation catalyst that works even at low temperatures is desirable for industrial applications; however, its development is highly challenging because of Pt's high affinity toward CO. Here, we develop a Pt^IV single-atom/β-MnO2 composite metal-oxide surface (Pt1^IV/β-MnO2). Single Pt^IV sites were stably formed on the high surface β-MnO2 by strong interaction with Mn^IV defect sites. The resulting Pt^IV–O–Mn^IV local structures served the lattice oxygens as an oxidant to catalyze low-temperature oxidation of CO. Pt1^IV/β-MnO2 was highly resistant to CO poisoning because of the high-valence state of the Pt^IV single-atom sites. Aided by these geometric and electronic features, the CO oxidation was catalyzed with reaction rates of 0.676 and 0.206 molCO/h/gPt at 25 °C and 0 °C, respectively, under the O2-rich conditions (O2 : CO ratio of 66.7). These are record rates in the literature for Pt-based catalyst application for low-temperature CO oxidation under near atmospheric conditions.

2022, 【要旨】

Supplemental material, sj-docx-1-tct-10.1177_15330338221146024 for RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer by Satoshi Nakamura, MD, Masato Kitazawa, MD, PhD, Yusuke Miyagawa, MD, PhD, Makoto Koyama, MD, PhD, Satoru Miyazaki, MD, Nao Hondo, MD, Futoshi Muranaka, MD, PhD, Shigeo Tokumaru, MD, Yuta Yamamoto, MD, PhD, Takehito Ehara, MD, PhD, Tomio Matsumura, PhD, Michiko Takeoka, PhD, and Yuji Soejima, MD, PhD in Technology in Cancer Research & Treatment

Supplemental material, sj-docx-1-tct-10.1177_15330338221146024 for RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer by Satoshi Nakamura, MD, Masato Kitazawa, MD, PhD, Yusuke Miyagawa, MD, PhD, Makoto Koyama, MD, PhD, Satoru Miyazaki, MD, Nao Hondo, MD, Futoshi Muranaka, MD, PhD, Shigeo Tokumaru, MD, Yuta Yamamoto, MD, PhD, Takehito Ehara, MD, PhD, Tomio Matsumura, PhD, Michiko Takeoka, PhD, and Yuji Soejima, MD, PhD in Technology in Cancer Research & Treatment

The structure–catalytic property relationships of Al2O3-supported Pt–Sn nanoparticles (Pt–Sn/Al2O3) in the dehydrogenation of methylcyclohexane (MCH) were investigated by varying the Sn/Pt ratios of the catalysts. The initial activity and the deactivation rate of the Pt–Sn/Al2O3 catalysts in the MCH dehydrogenation decreased in line with an increase in the Sn/Pt ratio from 0 to 3. The Pt–Sn/Al2O3 catalyst with a Sn/Pt ratio of 2 showed good activity, durability, and toluene selectivity in the MCH dehydrogenation among the series of catalysts. The dispersion of Pt in the Pt–Sn/Al2O3 catalysts was observed to decrease with an increase in the Sn/Pt ratio. Structural changes in the catalysts from Pt–Sn clusters to intermetallic Pt3Sn and PtSn nanoparticles were also observed using scanning transmission electron microscopy and X-ray diffraction. According to structural analysis using X-ray absorption fine-structure spectroscopy and infrared spectroscopy using carbon monoxide as a probe, the electron density of Pt increased, and the fraction of Pt–Pt adjacent sites decreased with an increase in the Sn/Pt ratio. Comparing the catalytic properties and the structures of the Pt–Sn/Al2O3 catalysts, their initial activities were correlated with the dispersion of Pt. In addition, the durability and selectivity of the catalysts were enhanced due to an increase in the electron density of Pt and a decrease in the number of Pt–Pt adjacent sites. Overall, the properties of the catalysts in the MCH dehydrogenation are determined by the local structure of Pt atoms rather than the crystal structure of the Pt–Sn alloy nanoparticles on Al2O3.

To develop highly active soot combustion catalysts for gasoline direct injection exhausts under low oxygen concentration conditions, CeO2 supported-metal catalysts (M/CeO2, M = Mn, Fe, Co, Ni, Cu, Rh, Pd, and Ag) were examined. Among the catalysts tested, Cu/CeO2 and Rh/CeO2 displayed the highest soot combustion activity. By comparing the activities of Cu-based catalysts with and without a Cu–CeO2 interface, the importance of such an interface for soot combustion was inferred. The oxygen release rate of CeO2-based catalysts, enhanced by metal–CeO2 interactions, was indicated as the controlling factor of catalytic activity. The soot oxidation activity and oxygen release rate were also demonstrated to correlate with metal–oxygen bond energy. Based on the redox properties and structural characteristics of CeO2-based catalysts, loading CeO2 with Cu or Rh, which have moderate M–O bond energy, was concluded to be optimal both in terms of the dispersion of supported-metal species and reducibility of the CeO2-based catalyst.

The effects of the Pd particle size and the Al2O3 crystalline phase of Pd/Al2O3 catalysts on the CH4 combustion in the presence of H2O were investigated. According to X-ray absorption fine structure (XAFS) measurements, it was revealed that, during the CH4 combustion, the Pd nanoparticles existed on the Al2O3 support as a PdO phase, while the crystallinity of PdO depended on the Pd particle size. On the basis of X-ray diffraction (XRD), amorphous PdO particles with a size of 7 nm) were formed, which were highly active for CH4 combustion. Comparing the effects of the different Al2O3 crystalline phases, Pd/α-Al2O3 was proved to be more resistant to deactivation by H2O than Pd/γ-Al2O3 and Pd/θ-Al2O3. Moreover, according to H2O temperature-programmed desorption (TPD) and infrared (IR) measurements, since α-Al2O3 was relatively hydrophobic compared to γ-Al2O3 and θ-Al2O3, a faster and reversible adsorption/desorption of OH/H2O species was achieved, while the H2O poisoning on PdO species in the vicinity was limited., ファイル公開：2021-08-07

Mammals receive body energy information to maintain energy homeostasis. Ghrelin, insulin, leptin and vagal afferents transmit the status of fasting, blood glucose, body fat, and food intake, respectively. Estrogen also inhibits feeding behavior and lipogenesis, but increases body fat mass. However, how blood triglyceride levels are monitored and the physiological roles of estrogen from the perspective of lipid homeostasis remain unsettled. Here, we show that stomach secretes estrogen in response to the blood triglyceride levels. Estrogen-secreting gastric parietal cells predominantly use fatty acids as an energy source. Blood estrogen levels increase as blood triglyceride levels rise in a stomach-dependent manner. Estrogen levels in stomach tissues increase as blood triglyceride levels rise, and isolated gastric gland epithelium produces estrogen in a fatty acid-dependent manner. We therefore propose that stomach monitors and controls blood triglyceride levels using estrogen, which inhibits feeding behavior and lipogenesis, and promotes triglyceride uptake by adipocytes., Ito et al. demonstrate that murine gastric parietal cells produce estrogen using fatty acids as an energy source, and secrete estrogen in response to the blood triglyceride levels. The authors propose that the stomach is involved in the monitoring and the regulation of blood triglyceride levels.

The active sites of Pd/Al2O3 catalysts for CO oxidations were identified by investigating the dependence of CO oxidation activities on the surface structure and morphology of Pd nanoparticles. The maximum catalytic activity was obtained for Pd particles approximately 2 nm in particle size. We performed structural analyses on the Pd surface through infrared (IR) spectroscopy of the adsorbed CO molecules. A positive correlation was obtained between catalytic activity and the fraction of linear CO adsorbed on Pd corner sites and Pd(111) facets, indicating that these sites are highly active for CO oxidation. X-ray absorption fine structure (XAFS) and spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM) measurements demonstrated that Pd nanoparticles less than 2 nm in particle size with amorphous-like structures and Pd particles with large, well-ordered structures favor the formation of a high fraction of corner sites and Pd(111) facets, respectively., ファイル公開：2020/09/07

Background. Tension-free repair using mesh has become the standard treatment for abdominal wall incisional hernias. However, its postoperative complications reportedly include mesh infection, adhesions, and fistula formation in other organs. Here, we report an extremely rare case of mesh migration into the neobladder and ileum with entero-neobladder and neobladder-cutaneous fistulas. Case Presentation. An 80-year-old male who had undergone radical cystectomy 5 years ago and abdominal wall incisional hernia repair 3 years ago presented with fever and abdominal pain. Computed tomography (CT) scan revealed mesh migration into the neobladder and ileum. He was treated conservatively with antibiotics for a month but did not show improvement; hence, he was transferred to our hospital. He was diagnosed with mesh migration into the neobladder and ileum with complicated fistula formation. He underwent mesh removal, partial neobladder resection, and partial small bowel resection. He developed superficial incisional surgical site infection, which improved with drainage and antibiotics, and he was discharged 40 days after the surgery. Conclusions. We reported a rare case of mesh migration into the neobladder and ileum with fistula formation. Successful conservative treatment cannot be expected for this condition because mesh migration into the intestinal tract causes infection and fistula formation. Hernia repair requires careful placement of the mesh such that it does not come into contact with the intestinal tract. Early surgical intervention is important if migration into the intestinal tract is observed.

Additional file 1. Patients’ demographics and summary of data. Patients’ demographics and summary of data by study group.

The activity of Pt/Al2O3 in the hydrogenation of toluene (TOL) was found to monotonically increase in line with an increase in the Pt particle size from 1.0 to 2.5 nm, but was constant for a size above 2.5 nm. Comparing different crystalline phases of Al2O3, the activity of Pt/θ-Al2O3 was found to be around 1.5 times higher than that of Pt/γ-Al2O3 for the same Pt particle size. Scanning transmission electron microscopy showed the presence of amorphous Pt nanoparticles (NPs) with a size of < 2.0 nm and Pt nanocrystals (NCs) with a size of ≥ 2.0 nm on Al2O3. Furthermore, the fraction of amorphous Pt NPs in Pt/γ-Al2O3 was higher than that in Pt/θ-Al2O3. Pt NCs were shown to be more active than the amorphous Pt NPs in the hydrogenation of TOL owing to them having an abundance of Pt plane.

Nanophase-separated Ni3Nb alloy exhibited higher performance than traditional Pt catalysts toward the remediation of automobile exhaust., Catalytic remediation of automobile exhaust has relied on precious metals (PMs) including platinum (Pt). Herein, we report that an intermetallic phase of Ni and niobium (Nb) (i.e., Ni3Nb) exhibits a significantly higher activity than that of Pt for the remediation of the most toxic gas in exhaust (i.e., nitrogen monoxide (NO)) in the presence of carbon monoxide (CO). When subjected to the exhaust-remediation atmosphere, Ni3Nb spontaneously evolves into a catalytically active nanophase-separated structure consisting of filamentous Ni networks (thickness < 10 nm) that are incorporated in a niobium oxide matrix (i.e., NbOx (x < 5/2)). The exposure of the filamentous Ni promotes NO dissociation, CO oxidation and N2 generation, and the NbOx matrix absorbs excessive nitrogen adatoms to retain the active Ni0 sites at the metal/oxide interface. Furthermore, the NbOx matrix immobilizes the filamentous Ni at elevated temperatures to produce long-term and stable catalytic performance over hundreds of hours.

資料番号: SA1005157000

資料番号: SA1005186000

平成29年度宇宙輸送シンポジウム（2018年1月18日-19日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)(ISAS)）, 相模原市, 神奈川県, Space Transportation Symposium FY2017 (January 18-19, 2018. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000210061, レポート番号: STEP-2017-001

平成28年度宇宙輸送シンポジウム（2017年1月19日-20日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)(ISAS)）, 相模原市, 神奈川県, Space Transportation Symposium FY2016 (January 19-20, 2017. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000086092, レポート番号: STEP-2016-055

Pseudo-Meigs’ syndrome is used to describe cases of ascites and/or pleural effusion associated with ovarian neoplasms other than benign tumors, which improve after removal of the ovarian lesion. We present three cases of pseudo-Meigs’ syndrome secondary to ovarian metastasis from colorectal cancer. In case 1, the patient has severe dyspnea and hypoxia due to massive right pleural effusion; therefore preoperative thoracic drainage was needed. In case 2, the patient needed paracentesis every two or three days to improve abdominal distension. After two courses of 5-fluorouracil, levofolinate, and oxaliplatin (mFOLFOX6), her ascites could be controlled by diuretics without aspiration and her general condition improved. Then she underwent operation. In case 3, the patient developed a massive pleural effusion and ascites coincident with a rapid enlargement of ovarian tumor after resection and adjuvant chemotherapy for rectal cancer. In all cases, pleural effusions and/or ascites resolved and general conditions and daily activities of the patients improved after oophorectomy. They are all currently in good health without recurrence of pleural effusion or ascites. In patients with suspected pseudo-Meigs’ syndrome secondary to ovarian metastasis of colorectal cancer, operation including oophorectomy may reduce pleural effusions and/or ascites and improve the general condition.

【目的】スポーツに必要な視覚能力をスポーツビジョンという.その要素の静止視力,動体視力,それらに関連性のある調節近点距離,全身と眼の疲労感を指標とし,運動負荷直前での鍼刺激が各指標に及ぼす影響について検討した.【方法】健康成人男性8名を対象に,クロスオーバーデザインにて,鍼刺激と無刺激の2つの介入を一週間以上の間隔を空けて行った.被験者は測定室入室15分後,15分間の介入後,自転車エルゴメーターによる負荷後,負荷後15分,30分に静止視力,動体視力,調節近点,全身,眼の疲労感の測定を行った.鍼刺激は太陽,合谷,光明に座位にて10分間の置鍼術を行い,無刺激は安静座位とした.【結果】群内比較では,無刺激群で運動負荷後,静止視力・動体視力は低下,調節近点は延長したが,鍼刺激群ではいずれの変化も抑制された.群間比較では,静止視力,動体視力,調節近点で時間経過に伴う変動に交互作用を認めた.全身と眼の疲労感は運動負荷で両群ともに増加し,差は認めなかった.【考察】運動負荷により生じた静止視力・動体視力・調節近点の機能低下は鍼刺激により抑制され,鍼刺激が運動負荷による視覚機能低下を予防する可能性が示された.(著者抄録)

平成27年度宇宙輸送シンポジウム（2016年1月14日-15日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)(ISAS)）, 相模原市, 神奈川県, Space Transportation Symposium FY2015 (January 14-15, 2016. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS)), Sagamihara, Kanagawa Japan, 資料番号: SA6000050113, レポート番号: STEP-2015-049

This study was designed to examine the trial-to-trial reliability of stepping parameters and to compare the center of foot pressure (COP) when adapting to different tempos. Twenty healthy men (M age = 20.8, SD = 1.9 years) performed stepping tests to fixed tempos. The intra-class correlation coefficients of stepping and COP parameters were high (0.75 - 0.97). The time difference between foot contact time and fixed tempo and COP sway velocities of the X- and Y-axis were the largest at 40 beats per minute (bpm). At 60 and 120 bpm tempos, single support and swing times reflecting the stepping strategy correlated significantly with the root mean square and the velocity of the X-axis (r = I0.45 - 0.53I) . Because these step tempos are controlled largely by the automation of stepping, the single support and swing phases appeared to have a constant frequency. On the other hand, a stepping tempo of 40 bpm showed the largest sway velocity of X and Y and the smallest surrounding area mean path length. The above suggests that stepping at 40 bpm induced a larger sway area in relation to total path length and faster COP sway. Hence, it is inferred that the stepping task becomes more difficult at 40 bpm than at 60 and 120 bpm.

宇宙構造・材料シンポジウム(第25回)(2009年12月4日、宇宙航空研究開発機構宇宙科学研究本部), 25th Symposium on Aerospace Structure and Materials (December 4, 2009. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)), Sagamihara, kanagawa Japan, 資料番号: AA0064732007

資料番号: AA0063716006

GIS (Geographical Information System) is one of useful tools for disaster prevention. Especially Web GIS based on Internet is a reliable system to collect information of many maps and the attribute data. And Web GIS will be very effective to exchange information. Therefore, the disaster prevention system with Web GIS is required. The target of this study is to establish a system for collecting GIS data by using GPS digital camera. The image of GPS digital camera contains the coordinate of latitude and longitude in EXIF data. GIS data can be established by using the coordinate. However, the coordinate is just position of camera. The coordinate should be converted to point of the object in the taken image. Moreover, disaster area should be mapped on GIS. In this study, converting method for coordinate of the object in GPS camera image will be developed using Digital Surface Model (15 meters grid). The skyline image on the camera point can be simulated using DSM. Direction of the camera can be calculated by image matching with the skyline. After that, disaster area will be mapped. Field surveying with GPS digital camera was carried out for verification of this system. The correct ratio of skyline matching showed about 45%. A incorrect reason might be come from simple shape of skyline. Correct ratio may be raised by using high resolution DSM. In future, correct ratio must be raised, and shape of slope disaster in taken picture is generated as GIS data.

during last 2 years, very severe natural disasters have occurred such like tsunami by Indian Ocean Earthquake, Niigata Earthquake and Katrina which is category 5 Hurricane. The disaster taught us that the fast data acquisition is important to reduce the damages. Satellite images and aerial photographs are often used to extract damages in a rough scale. Field survey is required to monitor damage in a detail scale. This study focused on the proposal of a practical data acquisition method for field survey using a handheld GPS camera and WebGIS. The evaluation of the proposed method was carried out by comparing data acquisition using a paper map. The result of evaluation shows the proposed method is 1.5 times faster than data acquisition using a paper map. The proposed method reduced data acquisition time and processing time. The third generation cellular phone which equipped a digital camera and GPS become the standard in 2007. Therefore the proposed method will take important role in the near future.