1. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat
- Author
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Cheng Jing, Chen Meng, Ding Chengcheng, Xu Rui, Li Wenfang, Rong Shuang, and Xu Jiqu
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Aging ,Morris water navigation task ,High cholesterol ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Blood serum ,Cognition ,Internal medicine ,medicine ,Animals ,Humans ,Cognitive deficit ,Cholesterol ,Brain ,Phytosterols ,Esters ,General Medicine ,medicine.disease ,Acetylcholinesterase ,Choline acetyltransferase ,Rats ,030104 developmental biology ,Endocrinology ,Neuroprotective Agents ,chemistry ,Cholinergic ,Female ,medicine.symptom ,Cognition Disorders ,030217 neurology & neurosurgery ,Food Science - Abstract
Accumulating epidemiological and experimental studies have confirmed that a high-cholesterol diet is detrimental to cognitive performance in animal models. Phytosterols, a class of naturally occurring structural components in plant foods, have been demonstrated to possess cholesterol-lowering and antioxidant effects. Phytosterol esters (PSE) are esters of phytosterol. The aim of this study was to evaluate the neuroprotective effects of PSE on cognitive deficit induced by a cholesterol-enriched diet in aged rats, and to explore their underlying mechanisms for these effects. Based on their Morris water maze performance, the latencies differed by
- Published
- 2017