81 results on '"Xin-chun Yang"'
Search Results
2. Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study
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Xin-chun Yang, Yong Liu, Wei-wei Sun, Guang Shi, Ying Wu, Cai Xu, Qing-wei Meng, Zeng-ping Hao, Qian Han, and Rui-hua Zhao
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Complementary and alternative medicine ,Pharmacology (medical) ,General Medicine - Published
- 2023
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3. MiRNA-122-5p inhibitor abolishes angiotensin II–mediated loss of autophagy and promotion of apoptosis in rat cardiofibroblasts by modulation of the apelin-AMPK-mTOR signaling
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Mei Yang, Juan-Juan Song, Xin-Chun Yang, Guang-Zhen Zhong, and Jiu-Chang Zhong
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Angiotensin II ,TOR Serine-Threonine Kinases ,Apoptosis ,Cell Biology ,General Medicine ,AMP-Activated Protein Kinases ,Rats ,Rats, Sprague-Dawley ,MicroRNAs ,Autophagy ,Animals ,Apelin ,Signal Transduction ,Developmental Biology - Abstract
MicroRNAs (miRNAs) have emerged as essential regulators that could have pivotal roles in cardiac homeostasis and pathological remodeling of various cardiovascular diseases. We previously demonstrated that miRNA-122-5p overexpression exacerbated the process of vascular hypertrophy, fibrosis, and dysfunction in hypertensive rats and rat aortic adventitial fibroblasts. However, the exact roles and underlying mechanisms of miRNA-122-5p in myocardial fibroblasts remain largely unknown. In this work, neonatal rat cardiofibroblasts (CFs) were isolated and primarily cultured from the hearts of 2- to 3-d-old Sprague-Dawley rats. Stimulation of angiotensin II (Ang II) resulted in marked increases in cellular proliferation and migration and levels of collagen I, collagen III, CTGF, and TGF-β1 in cultured CFs. Furthermore, Ang II led to promoted expression of P62, Bax, and phosphorylated mTOR as well as downregulation of LC3II, beclin-1, and AMPK-phosphorylated levels, thereby contributing to imbalance of autophagy and apoptosis, and cellular injury in CFs, which were significantly ameliorated by treatment with miRNA-122-5p inhibitor. These changes were associated with decreased levels of collagen I, collagen III, CTGF, and TGF-β1. Furthermore, Ang II-induced loss of autophagy and promotion of apoptosis in CFs were prevented by the treatment with Pyr
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- 2022
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4. Synthesis of ZIF-8-coated Pt/SiO2 by vapor deposition for alkyne semi-hydrogenation
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Fan-chun Meng, Gen Luo, Xin-chun Yang, Hui-bin Wu, Yong Qin, Liming Zhai, and Bin Zhang
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Atomic layer deposition ,Olefin fiber ,Chemical engineering ,X-ray photoelectron spectroscopy ,law ,Chemistry ,Nanowire ,Chemical vapor deposition ,Crystallization ,Selectivity ,Catalysis ,law.invention - Abstract
In this work, ZIF-8/Pt/SiO2 catalysts were prepared by combining atomic layer deposition (ALD) and vapor phase conversion methods. First, Pt metal nanoparticles were deposited on SiO2 nanowires by ALD. Then, ZnO was further deposited, also by ALD. Subsequently, the ZnO film was converted into ZIF-8 film by vapor phase crystallization to form a sandwich structure (ZIF-8/Pt/SiO2). The microstructures of the catalysts were characterized by XRD, TEM, BET, IC-MS, XPS, and CO-DRIFT. It was shown that the Pt particles were highly dispersed on the SiO2 nanowires before and after coating with ZIF-8, and the ZIF-8 film was coated continuously on the entire catalyst with high conformity. The performance of the catalyst was studied by using the semi-hydrogenation of 1-heptyne as a probe reaction. The ZIF-8 film induces an electron density increase in the Pt component, leading to an increase of the olefin selectivity from 14% to 70% in the 1-heptyne hydrogenation reaction. A reduced thickness of the ZIF-8 film increases the catalytic activity but does not affect the selectivity of 1-heptylene.
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- 2021
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5. The selective deposition of Fe species inside ZSM-5 for the oxidation of cyclohexane to cyclohexanone
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Xin-chun Yang, Yong Qin, Wu Huibin, Haojie Liang, Liming Zhai, Gen Luo, Bin Zhang, and Shichao Zhao
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Cyclohexane ,010405 organic chemistry ,Inorganic chemistry ,Iron oxide ,Cyclohexanone ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Atomic layer deposition ,chemistry ,Lewis acids and bases ,Selectivity ,Brønsted–Lowry acid–base theory - Abstract
The design of efficient iron-based catalysts remains a great challenge for selective cyclohexane oxidation to cyclohexanone under mild conditions. Because of the complex distribution of iron location on the support, the selectivity is always low. Here, we report a general strategy to selectively deposit highly-dispersed FeOx into the micropore of ZSM-5 by atomic layer deposition (ALD). The framework of ZSM-5 and the Bronsted acid sites are intact during ALD, and the Fe species are selectively deposited onto the defect and Lewis acid sites of ZSM-5. Besides, more Fe-O-Si bonds are formed over FeOx/ZSM-5 with a low loading of Fe, while FeOx nanoparticles are generated at high Fe loading. They cannot be realized by the traditional solution method. The obtained FeOx/ZSM-5 catalysts perform high selectivity of cyclohexanone (92%–97%), and ALD cycle numbers of FeOx control the activity. Compared with the Fe nanoparticles, the Fe-O-Si species performs higher turnover frequency and stability in the oxidation reaction.
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- 2021
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6. Plasma Exosomal Proteins Predict the Prognosis of Acute ST-segment Elevation Myocardial Infarction
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Hai-Yang Li, Hong-Jiang Wang, Xiang-Peng Du, Jia-Peng Liu, Xin-Chun Yang, and Mei-Li Zheng
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Acute ST-segment elevation myocardial infarction (ASTEMI) leads to great morbidity and mortality, even after immediate reperfusion therapy by primary percutaneous coronary intervention (PCI). Plasma exosomal proteins detected in the acute stage are supposed to affect the outcomes of ASTEMI. The present study collected ASTEMI patients with ischemic time around 6 hours and underwent successful emergency PCI, used exosomal proteomics to identify the plasma exosomal proteins, and performed a 1-year follow-up on ASTEMI outcomes. We observed that plasma exosomes concentration significantly decreased in ASTEMI after PCI than before it. Receiver operating characteristic (ROC) curve analysis revealed that several plasma exosomal proteins detected were strong predictors for coronary reintervention, which were revalidated in Cox regressions; while several plasma exosomal proteins were strong predictors for heart failure, which were revalidated in logistic regressions. The protein–protein network interactions and literature review suggest that plasma exosomal proteins might correlate with ASTEMI prognosis though involving in lipid and carbohydrate metabolism, regulation of cardiac muscle contraction, inflammation, platelet activation, or ferroptosis. Our results provide potential preventive and therapeutic targets for ASTEMI outcomes after PCI.
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- 2022
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7. Study of the Characteristics of the Pulmonary Vein and Superior Vena Cava of Rabbits
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Xiu-Lan Liu, Rong-Feng Bao, Xin-Chun Yang, Tai-Feng Liu, Huai-Yu Ding, Pan Wang, and Ou Li
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medicine.medical_specialty ,business.industry ,Superior vena cava ,Internal medicine ,Biomedical Engineering ,Cardiology ,medicine ,Medicine (miscellaneous) ,Bioengineering ,business ,Biotechnology ,Pulmonary vein - Abstract
Background: This study aims to (1) investigate the characteristics of the action potential and triggering activity of cardiomyocytes in the pulmonary vein (PV) and superior vena cava (SVC) of rabbits and (2) study the features of cation currents in cardiomyocytes in rabbit PV and SVC-inward rectifier potassium current (IK1), transient outward potassium current (Ito), and non-selective cation currents (INSCC). Methods: The standard glass microelectrode and whole-cell patch-clamp techniques were used to record the action potential and various currents in the above cells. Results: (1) Cardiomyocytes in either PV or SVC had longer action potential durations than in the adjacent atrium, and spontaneous early after depolarization (EAD) could occur in both PV and SVC under normal physiological conditions. (2) The action potential in PV cardiomyocytes had a relative refractory period but did not have an absolute refractory period, and this characteristic enabled a premature beat that triggered a second plateau response, which led to EAD. (3) INSCC was found for the first time in the PV, SVC, and atria. (4) The current intensity of IK1, Ito, and INSCC was significantly lower in the PV and SVC than in the left and right atria, and the difference in the current intensity in INSCC could influence the action potential. Conclusions: PV and SVC can both initiate and maintain AF, but PV is the primary ectopic foci in initiating AF. The present study found that the second plateau response was easily induced in cardiomyocytes in PA shortly after depolarization. This was a specific characteristic of the action potential of PV. In addition, we preliminarily analyzed the differences in the main outward currents and noted a voltage-dependent INSCC in both PV and SVC rabbits’ cardiomyocytes. Furthermore, the current intensities of IK1, Ito, and INSCC were significantly lower in the PV and SVC than in the left and right atria, and the difference in the current intensity of INSCC influenced the action potential. The different permeability of INSCC for cations at different phases may play a role in inducing EAD.
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- 2021
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8. Expression profile of circular RNAs in epicardial adipose tissue in heart failure
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Mei-Li Zheng, Xiang-Peng Du, Lei Zhao, Xin-Chun Yang, Xiu-Yuan Hao, and Xin Chen
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lcsh:Medicine ,Biology ,law.invention ,CFLAR ,Andrology ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,law ,Circular RNA ,Epicardial adipose tissue ,medicine ,Humans ,KEGG ,Gene ,Polymerase chain reaction ,Heart Failure ,Sequence Analysis, RNA ,lcsh:R ,Original Articles ,RNA, Circular ,General Medicine ,medicine.disease ,Fold change ,CircRNA ,Gene Ontology ,Adipose Tissue ,030220 oncology & carcinogenesis ,030217 neurology & neurosurgery - Abstract
Background. Recent studies have reported circular RNA (circRNA) expression profiles in various tissue types; however, circRNA expression profile in human epicardial adipose tissue (EAT) remains undefined. This work aimed to compare circRNA expression patterns in EAT between the heart failure (HF) and non-HF groups. Methods. RNA-sequencing was carried out to compare circRNA expression patterns in EAT specimens from coronary artery disease cases between the HF and non-HF groups. Quantitative real-time polymerase chain reaction was performed for validation. Comparisons of patient characteristics between the two groups were using t test, Mann-Whitney U test, and Chi-squared test. Results. A total of 141 circRNAs substantially different between the HF and non-HF groups (P 2) were detected, including 56 up-regulated and 85 down-regulated. Among them, hsa_circ_0005565 stood out, for it had the highest fold change and was significantly increased in HF patients in quantitative real-time polymerase chain reaction validation. The top highly expressed EAT circRNAs corresponded to genes involved in cell proliferation and inflammatory response, including GSE1, RHOBTB3, HIPK3, UBXN7, PCMTD1, N4BP2L2, CFLAR, EPB41L2, FCHO2, FNDC3B, and SPECC1. The top enriched Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway were positive regulation of metabolic processes and insulin resistance, respectively. Conclusion. These data indicate EAT circRNAs may contribute to the pathogenesis of metabolic disorders causing HF.
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- 2020
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9. Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol: a sub-group analysis of the BISO-CAD study
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Yun-Dai Chen, Xin-Chun Yang, Vinh Nguyen Pham, Shi-An Huang, Guo-Sheng Fu, Xiao-Ping Chen, Binh Quang Truong, Yu Yang, Shao-Wen Liu, Tian-Rong Ma, Dong-Soo Kim, Tae-hoon Kim, and Ning-Ning Wang
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Bisoprolol Fumarate ,China ,medicine.medical_specialty ,Acute coronary syndrome ,lcsh:Medicine ,Cardiac outcome ,Coronary Artery Disease ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Risk Factors ,Internal medicine ,Republic of Korea ,medicine ,Bisoprolol ,Humans ,Aged ,Retrospective Studies ,business.industry ,lcsh:R ,Original Articles ,General Medicine ,Odds ratio ,Middle Aged ,Prognosis ,Resting heart rate ,medicine.disease ,Confidence interval ,Blood pressure ,030220 oncology & carcinogenesis ,Heart failure ,Hypertension ,Cardiology ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background. Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension. Methods. We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study (n = 866), which was a phase IV, multination, multi-center, single-arm, observational study carried out from October 2011 to July 2015 across China, South Korea, and Vietnam. Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome (CCCO), the results were presented as adjusted odds ratio (OR) along with 95% confidence interval (CI) and adjusted P value. Results. A total of 681 patients (mean age: 64.77 ± 10.33 years) with hypertension from BISO-CAD study were included in the analysis. Bisoprolol improved CCCOs in CAD patients with comorbid hypertension, with RHR
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- 2020
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10. Ablation index-guided ablation with milder targets for atrial fibrillation: Comparison between high power and low power ablation
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Zheng Liu, Li-feng Liu, Xiao-qin Liu, Jiapeng Liu, Yu-xin Wang, Ye Liu, Xing-peng Liu, Xin-chun Yang, and Mu-lei Chen
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Cardiology and Cardiovascular Medicine - Abstract
BackgroundHigh power-ablation index (HP-AI)-guided ablation for atrial fibrillation (AF) targeting high AIs has been implemented in European countries. However, milder AI targets are widely used in Asia. The safety and efficacy of HP-AI-guided ablation compared with those of low-power AI-guided ablation in a milder AI-targeting setting are unknown. The goal of this study was to explore the efficacy and safety of HP-AI-guided ablation in a milder AI-targeting setting.MethodsPatients who underwent pulmonary vein isolation (PVI) for AI-guided atrial fibrillation ablation in our center were enrolled and divided into 2 groups according to the ablation power used. In the HP-AI group, the ablation power was over 45 W, while the low power-AI group was ablated with ResultsA total of 134 patients were enrolled, of whom 74 underwent PVI using HP-AI, while 60 received low power-AI ablation. After a mean follow-up time of 7.4 months, 22 (16.4%) patients showed arrhythmia recurrence: 5 (6.8%) patients in the HP-AI group and 17 (28.3%) patients in the low power-AI group. The HP-AI group showed a significantly higher arrhythmia-free survival than the low power-AI group (p = 0.011). Two patients in the low power-AI group and 1 patient in the HP-AI group developed an SAE (p = NS). Compared with the low power-AI group, the HP-AI group demonstrated a higher PV first-pass isolation rate, shorter ablation time, and fewer patients with anatomical leakages and sites of unreached AI.ConclusionIn a milder AI setting, HP-AI ablation might result in significantly higher arrhythmia-free survival than low power-AI ablation and a similar safety profile.
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- 2022
11. A Novel Reperfusion Strategy for Primary Percutaneous Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Prospective Case Series
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Ji-Fang He, Yi-Xing Yang, Jiang-Yuan Li, Lu Liang, Li Xu, Yu Liu, Zong-Sheng Guo, Qi Yang, Tao Jiang, Xiang-Min Lin, Xin-Chun Yang, Mu-Lei Chen, Pi-Xiong Su, Jiu-Chang Zhong, and Le-Feng Wang
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percutaneous coronary intervention ,ST-segment elevation myocardial infarction ,ischemia–reperfusion injury ,microvascular obstruction ,General Medicine - Abstract
Background: Ischemia reperfusion injury (IRI) remains a major problem in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). We have developed a novel reperfusion strategy for PCI and named it “volume-controlled reperfusion (VCR)”. The aim of the current study was to assess the safety and feasibility of VCR in patients with STEMI. Methods: Consecutive patients admitted to Beijing Chaoyang Hospital with STEMI were prospectively enrolled. The feasibility endpoint was procedural success. The safety endpoints included death from all causes, major vascular complications, and major adverse cardiac event (MACE), i.e., a composite of cardiac death, myocardial reinfarction, target vessel revascularization (TVR), and heart failure. Results: A total of 30 patients were finally included. Procedural success was achieved in 28 (93.3%) patients. No patients died during the study and no major vascular complications or MACE occurred during hospitalization. With the exception of one patient (3.3%) who underwent TVR three months after discharge, no patient encountered death (0.0%), major vascular complications (0.0%), or and other MACEs (0.0%) during the median follow-up of 16 months. Conclusion: The findings of the pilot study suggest that VCR has favorable feasibility and safety in patients with STEMI. Further larger randomized trials are required to evaluate the effectiveness of VCR in STEMI patients.
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- 2023
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12. Relationship between circulating miRNA-21, atrial fibrosis, and atrial fibrillation in patients with atrial enlargement
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Hao Chen, Fang Zhang, Yuan-Li Zhang, and Xin-Chun Yang
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Advanced and Specialized Nursing ,MicroRNAs ,Anesthesiology and Pain Medicine ,Atrial Fibrillation ,Humans ,Circulating MicroRNA ,Heart Atria ,Fibrosis - Abstract
Atrial fibrosis is a landmark of cardiac remodeling to perpetuate atrial fibrillation (AF), and recent studies have indicated that microRNAs (miRNAs) are essential regulators of multiple cardiovascular disease processes. Herein, we aimed to investigate the relationship between circulating microRNA-21 (miR-21), atrial fibrosis, and AF in patients with atrial enlargement.A total of 60 persistent AF patients and 60 matched sinus rhythm (SR) controls were enrolled in the study. We measured their plasma miR-21 levels by using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Then, each patient underwent transthoracic echocardiography (TTE), while persistent AF patients underwent delayed enhancement magnetic resonance imaging (MRI).The plasma miR-21 concentrations in the AF group were significantly higher than in the controls, and highly correlated [R=0.689, 95% confidence interval (CI): 0.527 to 0.802; P0.001] with left atrial (LA) fibrosis measured by delayed enhancement MRI. Receiver operating characteristics (ROC) curve analysis showed that the area under the curve (AUC) of plasma miR-21 to identify AF was 0.813 (95% CI: 0.731 to 0.878). The increasing levels of circulating miR-21 were significantly associated with the higher risk of AF by using logistic regression analysis, even after adjustment for known confounding variables.Circulating miR-21 highly correlates with the quantification of LA fibrosis by using delayed enhancement MRI and is associated with the risk of persistent AF in patients with LA enlargement.
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- 2021
13. Assessing the association of appropriateness of coronary revascularization and 1-year clinical outcomes for patients with stable coronary artery disease in China
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Shen Lin, Heng Zhang, Chen-Fei Rao, Si-Peng Chen, Shu-Bin Qiao, Hong-Bing Yan, Ke-Fei Dou, Yong-Jian Wu, Yi-Da Tang, Xin-Chun Yang, Zhu-Jun Shen, Jian Liu, Zhe Zheng, Ning-Ning Wang, and Beijing Coronary Angiography Registry Collaborative Group
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medicine.medical_specialty ,China ,medicine.medical_treatment ,lcsh:Medicine ,Coronary Artery Disease ,Revascularization ,Coronary revascularization ,Appropriate Use Criteria ,Coronary artery disease ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Internal medicine ,Medicine ,Humans ,Myocardial infarction ,Prospective Studies ,Prospective cohort study ,Stroke ,Aged ,business.industry ,Hazard ratio ,lcsh:R ,General Medicine ,Original Articles ,Middle Aged ,medicine.disease ,Appropriate use criteria ,Clinical trial ,030220 oncology & carcinogenesis ,Cardiology ,Stable coronary artery disease ,business ,030217 neurology & neurosurgery - Abstract
Background: The Chinese appropriate use criteria (AUC) for coronary revascularization was released in 2016 to improve the use of coronary revascularization. This study aimed to evaluate the association between the appropriateness of coronary revascularization based on the Chinese AUC and 1-year outcomes in stable coronary artery disease (CAD) patients. Methods: We conducted a prospective, multi-center cohort study of stable CAD patients with coronary lesion stenosis ≥50%. After the classification of appropriateness based on Chinese AUC, patients were categorized into the coronary revascularization group or the medical therapy group based on treatment received. The primary outcome was a composite of death, myocardial infarction, stroke, repeated revascularization, and ischemic symptoms with hospital admission. Results: From August 2016 to August 2017, 6085 patients were consecutively enrolled. Coronary revascularization was associated with a lower adjusted hazard of 1-year major adverse cardiovascular and cerebrovascular events (MACCEs; hazard ratio [HR]: 0.62; 95% confidence interval [CI]: 0.45–0.86; P = 0.004) than medical therapy in patients with appropriate indications (n = 1617). No significant benefit in 1-year MACCEs was found after revascularization compared to after medical therapy in patients with uncertain indications (n = 2658, HR: 0.81; 95% CI: 0.52–1.25; P = 0.338) and inappropriate indications (n = 1810, HR: 0.80; 95% CI: 0.51–1.23; P = 0.308). Conclusions: In patients with appropriate indications according to Chinese AUC, coronary revascularization was associated with significantly lower risk of MACCEs at 1 year. No benefit was found in coronary revascularization in patients with inappropriate indications. Our findings provide evidence for using Chinese AUC to guide clinical decision-making. Clinical trial registration: NCT02880605. https://www.clinicaltrials.gov. Key words: Stable coronary artery disease; Appropriate use criteria; Coronary revascularization
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- 2020
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14. A risk score model for predicting cardiac rupture after acute myocardial infarction
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Yuan Fu, Kui-Bao Li, Xin-Chun Yang, and Xin Chen
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Male ,medicine.medical_specialty ,health care facilities, manpower, and services ,medicine.medical_treatment ,Heart Rupture ,Myocardial Infarction ,lcsh:Medicine ,Acute myocardial infarction ,Ventricular Function, Left ,03 medical and health sciences ,Risk score model ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Humans ,Medicine ,cardiovascular diseases ,Myocardial infarction ,health care economics and organizations ,Aged ,Retrospective Studies ,Ventricular Septal Rupture ,Aged, 80 and over ,Framingham Risk Score ,business.industry ,lcsh:R ,Primary percutaneous coronary intervention ,Cardiac Rupture ,Case-control study ,Percutaneous coronary intervention ,Retrospective cohort study ,Original Articles ,General Medicine ,medicine.disease ,Logistic Models ,Case-Control Studies ,030220 oncology & carcinogenesis ,Cardiology ,Myocardial infarction complications ,Female ,Mechanical complications ,Cardiac rupture ,business ,Complication ,030217 neurology & neurosurgery - Abstract
Background:. Cardiac rupture (CR) is a major lethal complication of acute myocardial infarction (AMI). However, no valid risk score model was found to predict CR after AMI in previous researches. This study aimed to establish a simple model to assess risk of CR after AMI, which could be easily used in a clinical environment. Methods:. This was a retrospective case-control study that included 53 consecutive patients with CR after AMI during a period from January 1, 2010 to December 31, 2017. The controls included 524 patients who were selected randomly from 7932 AMI patients without CR at a 1:10 ratio. Risk factors for CR were identified using univariate analysis and multivariate logistic regression. Risk score model was developed based on multiple regression coefficients. Performance of risk model was evaluated using receiver-operating characteristic (ROC) curves and internal validity was explored using bootstrap analysis. Results:. Among all 7985 AMI patients, 53 (0.67%) had CR (free wall rupture, n = 39; ventricular septal rupture, n = 14). Hospital mortalities were 92.5% and 4.01% in patients with and without CR (P
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- 2019
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15. Comparing the effects of depression, anxiety, and comorbidity on quality-of-life, adverse outcomes, and medical expenditure in Chinese patients with acute coronary syndrome
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Kun Xia, Le-Feng Wang, Xin-Chun Yang, Hong-Yan Jiang, Li-Jing Zhang, Dao-Kuo Yao, Da-Yi Hu, Rong-Jing Ding, and Li-Shao Guo
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Male ,Acute coronary syndrome ,medicine.medical_specialty ,Myocardial Infarction ,lcsh:Medicine ,Comorbidity ,Anxiety ,Adverse outcome ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,medicine ,Major depression ,Humans ,Longitudinal Studies ,Prospective Studies ,Myocardial infarction ,Depression (differential diagnoses) ,Aged ,Depression ,business.industry ,lcsh:R ,Original Articles ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Logistic Models ,Mood ,030220 oncology & carcinogenesis ,Quality of Life ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background: Depression and anxiety have been correlated with elevated risks for quality-of-life (QOL), adverse outcomes, and medical expenditure in patients with acute coronary syndrome (ACS). However, the relevant data are lacking for Chinese ACS populations, especially regarding different effects of major depression, anxiety, and comorbidity. The objective of this study was to evaluate the dynamic changes of depression and/or anxiety over 12 months and examine the effects of depression, anxiety, and comorbidity on QOL, adverse outcomes, and medical expenditure in Chinese patients with ACS. Methods: For this prospective longitudinal study, a total of 647 patients with ACS were recruited from North China between January 2013 and June 2015. Among them, 531 patients (82.1%) completed 12-month follow-ups. Logistic regression model was utilized for analyzing the association of baseline major depression, anxiety, and comorbidity with 12-month all-cause mortality, cardiovascular events, QOL, and health expenditure. Results: During a follow-up period of 12 months, 7.3% experienced non-fatal myocardial infarction (MI) and 35.8% cardiac rehospitalization. Baseline comorbidity, rather than major depression/anxiety, strongly predicted poor 12-month QOL as measured by short-form health survey-12 (odds ratio [OR]: 1.77, 95% confidence interval [CI]: 1.22–2.52, P = 0.003). Regarding 12-month non-fatal MI and cardiac re-hospitalization, baseline anxiety (OR: 2.83, 95% CI: 1.33–5.89, P < 0.01; OR: 4.47, 95% CI: 1.50–13.00, P < 0.01), major depression (OR: 2.58, 95% CI: 1.02–6.15, P < 0.05; OR: 5.22, 95% CI: 1.42–17.57, P < 0.03), and comorbidity (OR: 6.33, 95% CI: 2.96–13.79, P < 0.0001, OR: 14.08, 95% CI: 4.99–41.66, P < 0.0001) were all independent predictors, and comorbidity had the highest predictive value. Number of re-hospitalization stay, admission frequency within 12 months and medical expenditure within 2 months were the highest in patients with ACS with comorbidity. Conclusions: Major depression and anxiety may predict 12-month non-fatal MI and cardiac re-hospitalization. However, comorbidity has the highest predictive value with greater medical expenditure and worse QOL in Chinese patients with ACS. And depression with comorbid anxiety may be a new target of mood status in patients with ACS. Key words: Acute coronary syndrome; Major depression; Anxiety; Comorbidity; Adverse outcome
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- 2019
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16. Toward the Controlled Synthesis of Highly Dispersed Metal Clusters Enabled by Downsizing Crystalline Porous Organic Cage Supports
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Liying Zhu, Suyun Zhang, Xin‐Chun Yang, Qiang Zhuang, and Jian‐Ke Sun
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General Materials Science ,General Chemistry - Abstract
The controlled synthesis of subnanometer-sized metal clusters (MCs) presents a fascinating prospect for the research of size-dependent properties. In this study, a facile approach by employing porous racemic organic cage crystals as supports for immobilizing a broad range of noble MCs (e.g., Ru, Ir, Rh) is reported. Downsizing the support to the nanoscale leads to resultant MCs with precisely controlled sizes 0.7 nm. Such enhanced stabilization ability is a result of enhanced metal-support interactions as well as the nanoconfinement of organic cages in controlling the growth of MCs. Moreover, the obtained MCs display excellent catalytic performance in a series of liquid-phase reactions owing to a decrease in the diffusion resistance from the substrate to MCs immobilized by the nano-sized cage support.
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- 2022
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17. Incidence and Outcome of Acute Myocardial Infarction in Patients with Aortic Dissection and Risk Factor Control
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Fang Liu, Si-Chong Qian, Mu-Lei Chen, Zhe Wang, and Xin-Chun Yang
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Background The contradiction of management modality between acute myocardial infarction(AMI) and aortic dissection(AD) may result in clinical catastrophe. Data on risk factors, incidence and outcome of AD and AMI are limited, and there have been no studies on the long-term outcomes of AMI in patients with AD. So we aimed to investigate long-term outcomes after AMI in patients with AD, and propose a useful diagnostic paradigm. Methods Consecutively enrolled patients with AD and AMI who were referred to our center from 2010 to 2017. Baseline patient characteristics, risk factors, all medical treatments, echocardiographic parameters, laboratory data and treatment were recorded. All patients were followed up from the first hospitalization until a first heart event, death or 17 March, 2018. Results 0.13% in AMI and 7.49% in AD patients had a concomitant diagnosis of AD and AMI. The average patient age was 53.3 ± 12.1 years and 84.6% were male. The most prevalent vascular risk factors were hypertension (69.2%) and current smoker (64.1%). Of all the 39 patients, 66.7% were managed surgically. Overall in-hospital mortality was 10.3%. The 30-day and 5-year fatality rates were 23.1% and 35.9%, but were higher for female than for male(66.7% vs 30.3%, log-rank P = 0.045) on 5-year mortality. The overall survival of females was inferior to the males (log-rank P = 0.045). Conclusions Patients with AMI and AD exhibit high 5-year fatality rates. For these patients, surgical management tend to have lower mortality. Improved management of hypertension and smoking, may reduce future incidence rates.
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- 2020
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18. Increased, Decreased, or Stable Left Ventricle Ejection Fraction over Time in a Series of 626 Heart Failure Patients Receiving Medical Treatment
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Meng-Meng, Han, Wen-Shu, Zhao, Xiao-Rong, Xu, Xin, Wang, Kui-Bao, Li, Cai-Jing, Dang, Juan, Zhang, Jia-Mei, Liu, Mu-Lei, Chen, Xin-Chun, Yang, Lin, Xu, and Hua, Wang
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Heart Failure ,Heart Failure/mortality ,Heart Ventricles ,Prognóstico ,Artigo Original ,Stroke Volume ,Disfunção Ventricular Esquerda ,Prognosis ,Ventricular Function, Left ,Drug Utilization ,Ventricular Dysfunction, Left ,Insuficiência Cardíaca/mortalidade ,Uso de Medicamentos ,Humans ,Original Article ,Volume Sistólico - Abstract
Ejection fraction (EF) has been used in phenotype analyses and to make treatment decisions regarding heart failure (HF). Thus, EF has become a fundamental part of daily clinical practice.This study aims to investigate the characteristics, predictors, and outcomes associated with EF changes in patients with different types of severe HF.A total of 626 severe HF patients with New York Heart Association (NYHA) class III-IV were enrolled in this study. The patients were classified into three groups according to EF changes, namely, increased EF (EF-I), defined as an EF increase ≥10%, decreased EF (EF-D), defined as an EF decrease ≥10%, and stable EF (EF-S), defined as an EF change10%. A p-value lower than 0.05 was considered significant.Out of 377 severe HF patients, 23.3% presented EF-I, 59.5% presented EF-S, and 17.2% presented EF-D. The results further showed 68.2% of heart failure with reduced ejection fraction (HFrEF) in the EF-I group and 64.6% of heart failure with preserved ejection fraction (HFpEF) in the EF-D group. The predictors of EF-I included younger age, absence of diabetes, and lower left ventricular ejection fraction (LVEF). The predictors of EF-D were absence of atrial fibrillation, lower uric acid level, and higher LVEF. Within a median follow-up of 40 months, 44.8% of patients suffered from all-cause death.In severe HF, HFrEF presented the highest percentage in the EF-I group, and HFpEF was most common in the EF-D group.A fração de ejeção (FE) tem sido utilizada em análises fenotípicas e na tomada de decisões sobre o tratamento de insuficiência cardíaca (IC). Assim, a FE tornou-se parte fundamental da prática clínica diária.Este estudo tem como objetivo investigar características, preditores e desfechos associados a alterações da FE em pacientes com diferentes tipos de IC grave.Foram incluídos neste estudo 626 pacientes com IC grave e classe III–IV da New York Heart Association (NYHA). Os pacientes foram classificados em três grupos de acordo com as alterações da FE, ou seja, FE aumentada (FE-A), definida como aumento da FE ≥10%, FE diminuída (FE-D), definida como diminuição da FE ≥10%, e FE estável (FE-E), definida como alteração da FE10%. Valores p inferiores a 0,05 foram considerados significativos.Dos 377 pacientes com IC grave, 23,3% apresentaram FE-A, 59,5% apresentaram FE-E e 17,2% apresentaram FE-D. Os resultados mostraram ainda 68,2% de insuficiência cardíaca com fração de ejeção reduzida (ICFEr) no grupo FE-A e 64,6% de insuficiência cardíaca com fração de ejeção preservada (ICFEp) no grupo FE-D. Os preditores de FE-A identificados foram faixa etária mais jovem, ausência de diabetes e fração de ejeção do ventrículo esquerdo (FEVE) menor. Já os preditores de FE-D encontrados foram ausência de fibrilação atrial, baixos níveis de ácido úrico e maior FEVE. Em um seguimento mediano de 40 meses, 44,8% dos pacientes foram vítimas de morte por todas as causas.Na IC grave, a ICFEr apresentou maior percentual no grupo FE-A e a ICFEp foi mais comum no grupo FE-D.
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- 2020
19. Roles of Growth Differentiation Factor 15 in Atherosclerosis and Coronary Artery Disease
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Jiuchang Zhong, Liqun Wei, Juan Wang, and Xin-Chun Yang
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Growth Differentiation Factor 15 ,Angiogenesis ,medicine.medical_treatment ,Inflammation ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Proinflammatory cytokine ,03 medical and health sciences ,0302 clinical medicine ,Contemporary Review ,medicine ,Macrophage ,Animals ,Humans ,030212 general & internal medicine ,arteriosclerosis ,business.industry ,Arteries ,Atherosclerosis ,Vulnerable plaque ,Plaque, Atherosclerotic ,myocardial ischemia ,Cytokine ,myocardial infarction ,inflammation ,Cancer research ,GDF15 ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Acute Coronary Syndromes ,Biomarkers ,Transforming growth factor ,Signal Transduction - Abstract
The majority of acute cardiovascular events (CVE) in patients are caused by occlusive thrombosis because of rupture or erosion of atherosclerotic plaques.1 Growth differentiation factor 15 (GDF‐15), a stress‐responsive member of the transforming growth factor‐β (TGF‐β) cytokine superfamily, has been shown to be a strong and independent predictor of mortality and disease progression in patients with atherosclerosis and coronary artery disease (CAD), such as acute coronary syndromes (ACS) and stable angina pectoris.2 The development of atherosclerosis is dependent upon a high‐inflammatory content, which has been shown to modulate lesion initiation, progression, and potentially devastating thrombotic complications.3 Angiogenesis plays an important role in the progression of atherosclerotic plaque and complications.4, 5, 6 Atherosclerosis and cancer arise from multiple factors and are consolidated from the very early stages of development up to the advanced forms in inflammatory processes. Uncontrolled cell proliferation and oxidative stress and angiogenesis appear to be unifying causal factors in both diseases.7 A local inflammatory state occurring in atherosclerotic lesions has been implicated in angiogenesis through activation of endothelial cells, release of chemokines, cytokines, growth factors, lipid mediators, proteases, and increase of endothelial metabolic rate. The angiogenesis allows extravasation of the plasma component, leading to future thromboembolic events.8, 9, 10, 11 GDF‐15 might be an acute phase modifier of TGF‐βRII‐dependent proinflammatory responses to atherosclerotic plaque rupture and thrombus formation12 (Figure). Although the exact biological functions of GDF‐15 are still poorly understood, it has been shown to regulate inflammatory and angiogenesis pathways (Figure). GDF‐15 exhibits differing and even opposing functions under various circumstances. For instance, GDF‐15 has proapoptosis, antiapoptosis, proangiogenesis, antiangiogenesis, proinflammatory, and anti‐inflammatory properties.12, 13 Therefore, GDF‐15 exhibits a complex pattern with beneficial and harmful functions. GDF‐15 promoter contains p53‐transcription factor binding sites that are required and sufficient for the induction of GDF‐15 expression.14 Activation of p53 is a fundamental cellular response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene activation. The circulating levels of GDF‐15 reflect these acute and chronic inflammatory conditions linked with atherosclerosis and CAD. Open in a separate window Figure 1 Schematic overview of a vulnerable plaque in advanced atherosclerosis. Plaque formation is initiated by endothelial cell dysfunction and subsequent angiogenesis and release of proinflammatory factors mediated by GDF‐15, contributing to the progression of atherosclerotic lesions and the development of plaque rupture and thrombus formation in atherosclerotic status. CRP indicates C‐reactive protein; GDF‐15, growth differentiation factor 15; MAPK, mitogen‐activated protein kinase; M‐CSF, macrophage colony‐stimulating factor; TGF‐βRII, transforming growth factor‐βRII; TNF‐α, tumor necrosis factor‐α.
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- 2019
20. [Adjusting Platelet Counts for Platelet Aggregation Tests]
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Li-Qin, Ling, Xin-Chun, Yang, Hao, Chen, Chao-Nan, Liu, Si, Chen, Hong, Jiang, Ya-Xiong, Jin, and Jing, Zhou
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Adenosine Diphosphate ,Adult ,Young Adult ,Arachidonic Acid ,Adolescent ,Epinephrine ,Platelet Aggregation ,Platelet Function Tests ,Ristocetin ,Platelet Count ,Humans ,Collagen ,Middle Aged - Abstract
To explore a better method to adjust platelet counts for light transmission aggregometry (LTA).Blood samples from 36 healthy participants aged from 18 to 50 yr. were collected.Platelet-rich plasma (PRP) was diluted using platelet-poor plasma (PPP) and physiological saline (PS),respectively,in a ratio of 1.5,2,2.5 and 3 times. Platelet aggregation was induced by adenosine diphosphate (ADP),arachidonic acid (ARA),collagen (COL), epinephrine (EPI),or ristocetin (RIS). The maximal aggregation rates (MAs) of different approaches were compared. We also compared the MAs induced by RIS between PRP-obtained-PPP and whole blood-obtained-PPP (2 100×Compared with the original PRP,the MAs induced by ADP,ARA,and EPI decreased in PPP-adjusted PRP (significant at 2-3 times dilution ratio,PS is recommended for adjusting platelets counts for platelet aggregation induced by ADP,ARA,COL and EPI. Whole blood-obtained-PPP (2 100 ×
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- 2018
21. A8128 The Difference of Hypertension Prevalence between Blood Pressure Measured in First Day or 3 Different Days in Community Population
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Liu-Yan Yu, Fang-Xia Guan, Wei Yu, Jing Yan, Qing-Min Liu, Xin-Chun Yang, Li Yang, Xiaoling Xu, Min-Hua Fan, Cheng Xuan, Fang Ding, Wu Xing-Li, and Shiyun Hu
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medicine.medical_specialty ,Blood pressure ,Physiology ,business.industry ,Internal medicine ,Hypertension prevalence ,Community population ,Internal Medicine ,medicine ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
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22. Investigation of Precipitated Hardening Layer Performance on Machined NAK80 Steel Surface
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Hong Jun Wang and Xin Chun Yang
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Materials science ,Mechanical Engineering ,Metallurgy ,Condensed Matter Physics ,Grinding ,Precipitation hardening ,Electrical discharge machining ,Machining ,Mechanics of Materials ,Residual stress ,Surface roughness ,Hardening (metallurgy) ,General Materials Science ,Composite material ,Surface integrity - Abstract
The surface integrity of NAK80 steel by grinding and electrical discharge machining (EDM) was studied in this paper. Microhardness, 3D topography and surface roughness of machined surface precipitation hardening layer were measured respectively. And the residual stress of the machined steel surface was measured with X-ray diffraction. Further experiments indicated that, compared with EDM, grinding method can obtain better surface integrity, and lower stress concentration sensitivity of NAK80 steel. But when machining the parts with complex shapes, EDM has the unparalleled advantages to grinding method.
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- 2011
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23. NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
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Shu-juan Li, Qi Zhang, Xin-hong Wan, Xiaofeng Wang, Guang-zhen Zhong, Ping Cheng, Xin-chun Yang, Wenli Hu, and Li Jin
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Linkage disequilibrium ,Cell Adhesion Molecules, Neuronal ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Brain Ischemia ,Asian People ,Risk Factors ,Polymorphism (computer science) ,Internal medicine ,Diabetes mellitus ,Genetic model ,Genotype ,medicine ,Humans ,Allele ,Genetic Association Studies ,Aged ,Genetic association ,Aged, 80 and over ,Genetics ,business.industry ,Genetic Variation ,Middle Aged ,medicine.disease ,Introns ,Stroke ,Neurology ,Case-Control Studies ,Female ,Neurology (clinical) ,business - Abstract
Recently, a genome-wide association study reported an association between two single nucleotide polymorphisms (SNPs) rs11833579 and rs12425791 near NINJ2 gene and ischemic stroke in Caucasians. Therefore, NINJ2 gene is an important candidate locus in the prevalence of ischemic stroke. We performed a hospital based genetic association study in Chinese Han subjects to investigate the relationship between NINJ2 gene and ischemic stroke. We genotyped 14 tagging single nucleotide polymorphisms (tSNP) in 749 ischemic stroke subjects and 924 control subjects and conducted the association between these tSNPs and ischemic stroke. We detected a tSNP rs10849373 in the first intron of the NINJ2 gene significantly associated with ischemic stroke (both genotype and allelic p = 0.0001). The minor A allele increased the risk of ischemic stroke with a per-allele OR of 1.37 for the additive genetic model in univariate analysis (p = 0.0001). The significance remained after adjustment for the covariates of age, gender, BMI, cigarette smoking, alcohol drinking, hypertension, and diabetes. Therefore, we report a new genetic variant, rs10849373, located in the first intron of the NINJ2 gene, conferring risk of ischemic stroke in Chinese Han subjects. Further genetic association and functional studies are required to search the causal functional variant in linkage disequilibrium with this polymorphism.
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- 2011
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24. Independent no-reflow predictors in female patients with ST-elevation acute myocardial infarction treated with primary percutaneous coronary intervention
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Zhi-jun Sun, Hong-bin Liu, Lian Chen, Le-Feng Wang, Yun-dai Chen, Xin-Chun Yang, and Chang-Hua Wang
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China ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Collateral Circulation ,Blood Pressure ,Coronary Angiography ,Risk Assessment ,Sex Factors ,Predictive Value of Tests ,Risk Factors ,Coronary Circulation ,Internal medicine ,Angioplasty ,Odds Ratio ,Humans ,Medicine ,Prospective Studies ,cardiovascular diseases ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Aged ,Chi-Square Distribution ,business.industry ,Coronary Thrombosis ,ST elevation ,Percutaneous coronary intervention ,Odds ratio ,Middle Aged ,Collateral circulation ,medicine.disease ,Logistic Models ,Treatment Outcome ,Multivariate Analysis ,No reflow phenomenon ,Conventional PCI ,Cardiology ,No-Reflow Phenomenon ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Independent no-reflow predictors should be evaluated in female patients with ST-segment elevation acute myocardial infarction (STEMI) and successfully treated with primary percutaneous coronary intervention (PPCI) in the current interventional equipment and techniques, thus to be constructed a no-reflow predicting model. In this study, 320 female patients with STEMI were successfully treated with PPCI within 12 h after the onset of AMI from 2007 to 2010. All clinical, angiographic, and procedural data were collected. Multiple logistic regression analysis was used to identify independent no-reflow predictors. The no-reflow was found in 81 (25.3%) of 320 female patients. Univariate and multivariate stepwise logistic regression analysis identified that low SBP on admission100 mmHg (OR 1.991, 95% CI 1.018-3.896; p = 0.004), target lesion length20 mm (OR 1.948, 95% CI 1.908-1.990; p = 0.016), collateral circulation 0-1 (OR 1.952, 95% CI 1.914-1.992; p = 0.019), pre-PCI thrombus score ≥ 4 (OR 4.184, 95% CI 1.482-11.813; p = 0.007), and IABP use before PCI (OR 1.949, 95% CI 1.168-3.253; p = 0.011) were independent no-reflow predictors. The no-reflow incidence significantly increased as the numbers of independent predictors increased [0% (0/2), 10.8% (9/84), 14.5% (17/117), 37.7% (29/77), 56.7% (17/30), and 81.8% (9/11) in female patients with 0, 1, 2, 3, 4, and 5 independent predictors, respectively; p0.0001]. The five no-reflow predicting variables were admission SBP100 mmHg, target lesion length20 mm, collateral circulation 0-1, pre-PCI thrombus score ≥ 4, and IABP use before PCI in female patients with STEMI treated with PPCI.
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- 2011
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25. Design of Straw Reuse & Soil Levelling Compound Machine in Paddy Field
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Xin Chun Yang and H.J. Wang
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Engineering ,Mechanics of Materials ,Levelling ,business.industry ,Mechanical Engineering ,Slurry ,Paddy field ,General Materials Science ,Agricultural engineering ,Rice straw ,Reuse ,Straw ,business - Abstract
The parameters of paddy field straw reuse and leveling machine, such as the rotating angle of leveling board, the force and placement angle of the ascend cylinder, were optimized in design. The machine integrated the function of rotary tilling, breaking soil, cutting straw, burying straw and leveling soil. It is applied to leveling soil and returning straw to field in paddy field mechanized harvest, and it has many merits such as small working resistance, good burying straw, and leveling soil effect etc. Experiment shows that it can directly return straw such as rice straw, wheat straw, and high stubble to field in one time. It has strong ability to carry soil and slurry with no interference. It ascends freely, and acts to respond quickly. It integrates three processes such as cutting straw, breaking soil and leveling soil, which is an efficient technology to return straw in paddy field.
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- 2010
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26. The characteristics of action potential and nonselective cation current of cardiomyocytes in rabbit superior vena cava
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Pan Wang, Xiu-Lan Liu, Xin-Chun Yang, TaiFeng Liu, and Rong-Feng Bao
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Agonist ,Patch-Clamp Techniques ,Vena Cava, Superior ,medicine.drug_class ,Action Potentials ,Cesium ,4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid ,Pharmacology ,Ion Channels ,General Biochemistry, Genetics and Molecular Biology ,Afterdepolarization ,TRPC3 ,Superior vena cava ,Cations ,Atrial Fibrillation ,Potassium Channel Blockers ,medicine ,Extracellular ,Animals ,Humans ,Myocyte ,Myocytes, Cardiac ,4-Aminopyridine ,General Environmental Science ,Chemistry ,Antagonist ,Arrhythmias, Cardiac ,Anatomy ,Electrophysiology ,Rabbits ,General Agricultural and Biological Sciences - Abstract
As a special focus in initiating and maintaining atrial fibrillation (AF), cardiomyocytes in superior vena cava (SVC) have distinctive electrophysiological characters. In this study, we found that comparing with the right atrial (RA) cardiomyocytes, the SVC cardiomyocytes had longer APD90 at the different basic cycle lengths; the conduction block could be observed on both RA and SVC cardiomyocytes. A few of SVC cardiomyocytes showed slow response action potentials with automatic activity and some others showed early after depolarization (EAD) spontaneously. Further more, we found that there are nonselective cation current (INs) in both SVC and RA cardiomyocytes. The peak density of I Ns in SVC cardiomyocytes was smaller than that in RA cardiomyocytes. Removal of extracellular divalent cation and glucose could increase INs in SVC cardiomyocytes. The agonist or the antagonist of INs may increase or decrease APD. To sum up, some SVC cardiomyocytes possess the ability of spontaneous activity; the difference of transmembrane action potentials between SVC and RA cardiomyocytes is partly because of the different density of INs between them; the agonist or the antagonist of INs can increase or decrease APD leading to the enhancement or reduction of EAD genesis in SVC cardiomyocytes. INs in rabbit myocytes is fairly similar to TRPC3 current in electrophysiological property, which might play an important role in the mechanisms of AF.
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- 2008
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27. Cyclosporin A Suppresses Proliferation of Endothelial Progenitor Cells: Involvement of Nitric Oxide Synthase Inhibition
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Ying-Hua Guo, Jun-Ke Yang, Long Yang, Qian Fan, Xin-Chun Yang, Fang-Fang Yi, and Xiu-Lan Liu
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Nitric Oxide Synthase Type III ,Apoptosis ,Nitric Oxide ,Peripheral blood mononuclear cell ,Nitric oxide ,chemistry.chemical_compound ,Enos ,Cyclosporin a ,Internal Medicine ,Humans ,Medicine ,RNA, Messenger ,Progenitor cell ,Cells, Cultured ,Cell Proliferation ,Dose-Response Relationship, Drug ,biology ,business.industry ,Endothelial Cells ,Mesenchymal Stem Cells ,General Medicine ,biology.organism_classification ,Molecular biology ,Vascular endothelial growth factor ,Nitric oxide synthase ,Biochemistry ,chemistry ,Cyclosporine ,Leukocytes, Mononuclear ,cardiovascular system ,biology.protein ,business ,Immunosuppressive Agents - Abstract
Objective To investigate the effects of the potent immunosuppressive agent cyclosporin A (CsA) on the proliferation of human endothelial progenitor cells (EPCs) and endothelial nitric oxide synthase (eNOS) expression in EPCs. Methods and Results The EPCs were obtained from cultured mononuclear cells, which were isolated from the peripheral blood of healthy adults, and stimulated with CsA (10 μg/mL) in the presence or absence of either vascular endothelial growth factor (VEGF; 50 ng/mL) or L-arginine (1 mM). To explore the effect of different concentrations of CsA alone on EPC proliferation, some cells were treated with CsA in a series of final concentrations ranging from 0 to 10 μg/mL. Cell proliferation and apoptosis were determined, respectively, by the Cell Counting Kit-8 assay and terminal deoxynucleotidyl transferase-mediated nick end labeling staining. The expression of eNOS was assayed by reverse transcription-polymerase chain reaction analysis while nitric oxide (NO) generation was detected using the Griess method. The effects of CsA on EPC proliferation, apoptosis, and eNOS/NO production were dose dependent in the concentration ranging from 0.1 μg/mL to 10 μg/mL. Treatment with VEGF (50 ng/mL) significantly promoted EPC proliferation and eNOS/NO production, which were completely abrogated by pre-incubation with CsA (10 μg/mL). The supplement of L-arginine (1 mM) promoted NO production that enhanced EPC proliferation and attenuated the effect of CsA on EPC proliferation and apoptosis. Conclusion CsA significantly inhibited proliferation, eNOS mRNA expression and NO production of human EPCs, in a dose-dependent manner.
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- 2008
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28. Adenoviral gene transfer of HCN4 creates a genetic pacemaker in pigs with complete atrioventricular block
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Yan-Hui Li, Wei Wang, Jian Song, Fang-Fang Yi, Xin-Chun Yang, Hong Jiang, Xuejun Jiang, Guosheng Lin, and Jun Cai
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Potassium Channels ,Genetic enhancement ,medicine.medical_treatment ,Genetic Vectors ,Green Fluorescent Proteins ,Sus scrofa ,Cyclic Nucleotide-Gated Cation Channels ,Muscle Proteins ,Biology ,Transfection ,Ion Channels ,General Biochemistry, Genetics and Molecular Biology ,Cardiac pacemaker ,Adenoviridae ,Green fluorescent protein ,Heart Rate ,Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ,HCN channel ,medicine ,Animals ,RNA, Messenger ,Patch clamp ,General Pharmacology, Toxicology and Pharmaceutics ,Microscopy, Confocal ,Cell Membrane ,Isoproterenol ,Genetic Therapy ,General Medicine ,Adrenergic beta-Agonists ,medicine.disease ,Molecular biology ,Reverse transcription polymerase chain reaction ,Heart Block ,biology.protein ,Atrioventricular block - Abstract
The hyperpolarization-activated, cyclic nucleotide-gated cation channels (HCN) have been identified as a key factor of cardiac pacemaker activity. The present study investigated the feasibility of using transfection of HCN4, an important subunit in the HCN family, to cure an experimental cardiac bradyarrhythmia. Two adenoviral vectors containing HCN4 and GFP (Ad–HCN4) or GFP alone (Ad–GFP) were constructed. Three or four days after gene injection, the pigs underwent catheter ablation of the atrioventricular (AV) node. After a complete AV block was created, the idioventricular heart rate in the Ad–HCN4 group was significantly greater than in controls. The heart rhythm in the Ad–HCN4 group could be modulated by the β-adrenergic agonist isoproterenol. An I f current could be observed in the ventricular myocytes of the Ad–HCN4 group under patch clamp technique investigations. The expected cell membrane localization of GFP-tagged HCN4 expression was confirmed with confocal fluorescent microscopy. The successful in vivo transfection with Ad–HCN4 was also identified by real-time reverse transcription polymerase chain reaction (RT-PCR). Our study suggested that site-specific gene therapy for cardiac bradyarrhythmias using adenoviral vectors to overexpress HCN4 channels might be feasible.
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- 2007
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29. Glutathione Reverses Peroxynitrite-mediated Deleterious Effects of Nitroglycerin on Ischemic Rat Hearts
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Xiu Lan Liu, Qian Fan, Shu Yan Wang, Shu Ling Yang, Feng Gao, Xue Bin Cao, and Xin Chun Yang
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Male ,Cardiac function curve ,Necrosis ,Myocardial Ischemia ,Ischemia ,Apoptosis ,Myocardial Reperfusion Injury ,Pharmacology ,Rats, Sprague-Dawley ,Nitroglycerin ,chemistry.chemical_compound ,Peroxynitrous Acid ,Lactate dehydrogenase ,medicine ,Animals ,Myocytes, Cardiac ,business.industry ,Nitrotyrosine ,Glutathione ,medicine.disease ,Myocardial Contraction ,Rats ,chemistry ,Anesthesia ,Tyrosine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Reperfusion injury ,Peroxynitrite - Abstract
This study examined the potential deleterious effect of high-dose nitroglycerin (NTG) on cardiac function and cellular injury after ischemia (30 min) and reperfusion (120 min) in isolated perfused rat hearts. Low-dose (0.75 microg/h), medium-dose (3.75 microg/h), high-dose (15 microg/h) NTG or high-dose NTG plus glutathione (GSH, 1 mmol/L) was administrated at the time of reperfusion. Administration of high-dose NTG significantly exacerbated cardiac reperfusion injury as evidenced by increased creatine kinase and lactate dehydrogenase activity in coronary effluent, increased cardiomyocyte apoptosis and necrosis, and decreased cardiac function recovery after reperfusion. Compared with the vehicle group, formation of nitrotyrosine, a footprint for peroxynitrite (ONOO) production, was markedly increased in the hearts treated with medium-dose or high-dose NTG. Most interestingly, cotreatment with GSH blocked high-dose NTG-induced ONOO formation and attenuated myocardial ischemia/reperfusion injury. Taken together, our present results demonstrated that administration of high-dose NTG aggravated, rather than attenuated myocardial ischemia/reperfusion injury likely via increasing ONOO formation. Coadministration of GSH may reverse the advert action of high-dose NTG.
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- 2006
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30. Association study between three polymorphisms and myocardial infarction and ischemic stroke in Chinese Han population
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Xin-hong Wan, Xiaofeng Wang, Li Jin, Guang-zhen Zhong, Shu-juan Li, Xin-chun Yang, Shun-Zhang Yu, Qi Zhang, Lei Li, and Wenli Hu
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Adult ,Male ,China ,medicine.medical_specialty ,Myocardial Infarction ,Chinese han population ,Asian People ,Beijing ,Epidemiology ,medicine ,Humans ,Aged ,Aged, 80 and over ,Polymorphism, Genetic ,business.industry ,Public health ,Hematology ,Middle Aged ,Coronary heart disease ,Surgery ,Stroke ,Receptors, LDL ,Family medicine ,Ischemic stroke ,Female ,business ,Genome-Wide Association Study ,Biomedical sciences - Abstract
a Heart Center, Beijing Chaoyang Hospital, Institute of Cardiovascular Disease, Capital University of Medical Sciences, Beijing 100020, China b Department of Cardiology, Tangshan Gongren Hospital, Hebei Medical University, Tangshan, 063000, Hebei province, China c Department of Neurology, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China d State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China e Institute of epidemiology, School of public health, Fudan University, Shanghai, China f CMC Institute of Health Sciences, Taizhou 225300, Jiangsu Province, China
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- 2010
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31. [Control rate of increased low-density lipoprotein cholesterol levels in cardiology outpatients with coronary heart disease in Beijing]
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Rong-jing, Ding, Chang-sheng, Ma, Hong, Chen, Yan, Wu, Xin-chun, Yang, Qi, Hua, Rui-jie, Li, Wen-lin, Ren, Ming-sheng, Wang, Xiao-ping, Xiang, Xin, Du, Lin, Pi, and Da-yi, Hu
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Adult ,Aged, 80 and over ,Male ,Humans ,Coronary Disease ,Female ,Cholesterol, LDL ,Middle Aged ,Aged - Abstract
To investigate the low-density lipoprotein cholesterol (LDL-C) levels in outpatients with coronary heart disease (CHD) visiting cardiology outpatient clinics of 8 hospitals in Beijing.A total of 903 outpatients with CHD were enrolled from 4 three-tier hospitals and 4 two-tier hospitals in Beijing. All patients were asked to finish the questionnaire including demographic data, CHD history, the knowledge on cholesterol, and the use of statins. Blood lipid was examined and the LDL-C control rate and related factors were then analyzed.Questionnaire was obtained from 876 patients [619 male: 70.7%, mean age: (64.9 ± 10.7) years old] and blood lipid data were available in 709 patients. The general LDL-C control rate was 36.9% (262/709) and was 13.5% (27/173) in very high risk CHD patients, and lower in patients treated in two-tier hospitals than patients treated in three-tier hospitals[31.3% (121/386) vs. 43.7% (141/323), P0.01], in female patients than in male patients [27.1% (60/261) vs. 41.3% (201/496), P0.01] and in diabetic patients than in non-diabetic patients [13.5% (27/200) vs. 44.7% (197/441), P0.01]. The LDL-C control rate was lower in patients less than 60 years old and patients over 80 years old than that in 60-70 years old patients and 70 - 80 years old patients (P0.05). LDL-C control rate was not affected by the history of hypertension, percutaneous coronary intervention or coronary artery bypass grafting, smoking, lipid examination frequency, knowledge on goal level of LDL-C, diet control and regularly physical exercising (all P0.05). There were 18.2% (129/709) patients not taking statins or not aware if they were taking statin or not. The main reason for not taking statin [47.9% (23/48)] was statin was no prescribed by doctors, followed by withdrawal by patients due to various reasons [27.1% (13/48)].LDL-C control rate was low in patients with CHD visiting cardiology outpatient clinics in Beijing. The CHD patients and cardiologists should be encouraged to achieve better LDL-C control by following lipid lowering guidelines and it is also important to improve the drug compliance among CHD patients.
- Published
- 2013
32. Brain natriuretic peptide and copeptin levels are associated with cardiovascular disease in patients with chronic kidney disease
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Xin, Li, Xin-chun, Yang, Qian-mei, Sun, Xiang-dong, Chen, and Yan-chun, Li
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Adult ,Male ,Glycopeptides ,Enzyme-Linked Immunosorbent Assay ,Middle Aged ,Young Adult ,Cardiovascular Diseases ,Echocardiography ,Natriuretic Peptide, Brain ,Humans ,Female ,Renal Insufficiency, Chronic ,Aged ,Glomerular Filtration Rate - Abstract
Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage renal disease (ESRD). We explored the relationship between CVD, plasma brain natriuretic peptide (BNP) and copeptin in non-dialysis patients with chronic kidney disease (CKD).BNP and copeptin were measured using ELISA in 86 non-dialysis patients with different degrees of CKD and in 20 control patients. The effects of BNP, copeptin levels and other biochemical indices on carotid ultrasound echocardiography and CVD history were determined using correlation analysis.BNP and copeptin levels were significantly higher in the CKD group than in the control group. Both indices increased progressively, in parallel with the decline in glomerular filtration rate (GFR). BNP levels were (184.25 ± 65.18) ng/L in early phase CKD, (975.245 ± 354.09) ng/L in middle phase CKD, and (1463.51 ± 614.92) ng/ml in end phase CKD compared with levels of (101.56 ± 42.76) ng/L in the control group (all P0.01). Copeptin levels in the middle phase ((20.36 ± 9.47) pmol/L) and end phase groups ((54.26 ± 18.23) pmol/L were significantly higher than in the control group ((9.21 ± 2.64) pmol/L; both P0.01). There was no difference in copeptin levels between early phase CKD ((10.09 ± 5.23) pmol/L) and control patients. Stepwise multiple regression analysis identified GFR, intima-media thickness (IMT), left ventricular hypertrophy (LVH), and previous history of CVD as independent risk factors for elevated BNP and copeptin levels.BNP and copeptin appear to provide sensitive biological markers for the evaluation of atherosclerosis in non-dialysis patients with CKD.
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- 2013
33. [Cause of in-hospital death among acute myocardial infarction patients undergoing primary percutaneous coronary intervention in Beijing]
- Author
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Lei, Song, Yue-jin, Yang, Shu-zheng, Lü, Xin-chun, Yang, Hong-wei, Li, Jin-cheng, Guo, Wei, Gao, Chao-lian, Huang, Quan, Fang, Ming-ying, Wu, and Heng-jian, Hao
- Subjects
Adult ,Aged, 80 and over ,Male ,China ,Percutaneous Coronary Intervention ,Myocardial Infarction ,Humans ,Female ,Hospital Mortality ,Middle Aged ,Aged - Abstract
To analyze the cause of in-hospital death among acute myocardial infarction patients undergoing primary percutaneous coronary intervention (PPCI) in Beijing area to evoke better individualized preventive approach.In-hospital mortality and causes were analyzed based on database from Beijing percutaneous coronary intervention registry study (BJPCI Registry) in 2010.A total of 4660 PPCI patients from 48 hospitals were included. In-hospital mortality was 2.4% (n = 110). Cardiogenic shock (39.1%, 43/110), mechanical complications (28.2%, 31/110) and intervention-related complications [28.2%, 31/110: procedure related (n = 28), drug related (n = 3)] were the leading causes of in-hospital death. Five deaths was attributed to comorbidity related reason (4.5%, 5/110). The in-hospital mortality had no significant difference among hospitals of different grade or total annual PCI (all P0.05). In-hospital mortality was slightly higher in hospital with annual PPCI300 than in hospitals with annual PPCI ≥ 300 (2.9% vs. 1.8%, P0.05).Cardiogenic shock, mechanical complications and intervention-related complications are the main causes of in-hospital death among acute myocardial infarction patients receiving PPCI.
- Published
- 2012
34. [New progress on epigenetic mechanisms of cardiology diseases]
- Author
-
Jing-Yu, Liu, Xin-Chun, Yang, and Jun, Cai
- Subjects
Heart Failure ,Histones ,Gene Expression Regulation ,Hypertension ,Animals ,Humans ,DNA Methylation ,Atherosclerosis ,Epigenesis, Genetic - Published
- 2012
35. [The in-hospital mortality and its determinants for very elderly patients with acute myocardial infarction]
- Author
-
Wen-shu, Zhao, Kui-bao, Li, Yuan, Zhang, Hong-shi, Wang, Le-feng, Wang, and Xin-chun, Yang
- Subjects
Aged, 80 and over ,Causality ,Cohort Studies ,Hospitalization ,Male ,Age Factors ,Myocardial Infarction ,Humans ,Female ,Hospital Mortality ,Prognosis ,Retrospective Studies - Abstract
To explore the in-hospital mortality and its determinants for very eldly (80+ years of age) patients with acute myocardial infarction (AMI).A retrospective cohort method was used. The 499 study subjects were very eldly patients with newly diagnosed AMI consecutively admitted into our department between January 1, 2002 and February 22, 2010.Ninety-seven out of 499 patients died during hospitalization period, with total in-hospital mortality of 19.4%. Multivariable logistic regression analysis showed the independent determinants for mortality of very elderly AMI patients were cardiac Killip grades, complete A-V block, renal dysfunction, stent implant, and the type of AMI.The independent determinants for mortality of elderly AMI patients are as following, cardiac Killip grade, complete A-V block, renal dysfunction, stent implant, and the type of MAI. Urgent PCI is safe and effective for some very elderly with AMI, which could improve their survival rate within hospitalization period.
- Published
- 2012
36. Identification of two novel mitochondrial DNA deletions induced by ionizing radiation
- Author
-
Xiao Tao, Zhao, Jiang Bin, Feng, Yu Wen, Li, Qun, Luo, Xin Chun, Yang, Xue, Lu, De Qing, Chen, and Qing Jie, Liu
- Subjects
Genetic Markers ,Radiation, Ionizing ,Humans ,Lymphocytes ,Cloning, Molecular ,Cobalt Radioisotopes ,Real-Time Polymerase Chain Reaction ,DNA, Mitochondrial ,Gene Deletion ,Cell Line ,DNA Damage - Abstract
We identify ionizing radiation-induced mitochondrial DNA (mtDNA) deletions in human lymphocytes and their distribution in normal populations.Long-range polymerase chain reactions (PCR) using two pairs of primers specific for the human mitochondrial genome were used to analyze the lymphoblastoid cell line following exposure to 10 Gy (60)Co γ-rays. Limited-condition PCR, cloning and sequencing techniques were applied to verify the mtDNA deletions detected with long-range PCR. Human peripheral blood samples were irradiated with 0, 2 and 6 Gy (60)Co γ-rays, and real-time PCR analysis was performed to validate the mtDNA deletions. In order to know the distribution of mtDNA deletions in normal population, 222 healthy Chinese adults were also investigated.Two mtDNA deletions, a 7455-bp deletion (nt475-nt7929 in heavy strand) and a 9225-bp deletion (nt7714 -nt369 in heavy strand), occurring between two 8-bp direct repeats, were identified in lymphoblastoid cells using long-range PCR, limited-condition PCR and sequencing. These results were also observed for (60)Co γ-rays irradiated human peripheral blood cells.Two novel mtDNA deletions, a 7455-bp deletion and a 9225-bp deletion, were induced by ionizing radiation. The rate of the mtDNA deletions within a normal population was related to the donors' age, but was independent of gender.
- Published
- 2012
37. Comparison of tirofiban combined with dalteparin or unfractionated heparin in primary percutaneous coronary intervention of acute ST-segment elevation myocardial infarction patients
- Author
-
Wei-Ming, Li, Xin-Chun, Yang, Le-Feng, Wang, Yong-Gui, Ge, Hong-Shi, Wang, Li, Xu, Zhu-Hua, Ni, and Da-Peng, Zhang
- Subjects
Dalteparin ,Male ,Treatment Outcome ,Tirofiban ,Heparin ,Myocardial Infarction ,Anticoagulants ,Humans ,Tyrosine ,Female ,Angioplasty, Balloon, Coronary ,Middle Aged ,Aged - Abstract
Primary percutaneous coronary intervention (PCI) is the best treatment of choice for acute ST segment elevation myocardial infarction (STEMI). This study aimed to determine the clinical outcomes of tirofiban combined with the low molecular weight heparin (LMWH), dalteparin, in primary PCI patients with acute STEMI.From February 2006 to July 2006, a total of 120 patients with STEMI treated with primary PCI were randomised to 2 groups: unfractionated heparin (UFH) with tirofiban (group I: 60 patients, (61.2 ± 9.5) years), and dalteparin with tirofiban (group II: 60 patients, (60.5 ± 10.1) years). Major adverse cardiac events (MACE) during hospitalization and at 4 years after PCI were examined. Bleeding complications during hospitalization were also examined.There were no significant differences in sex, mean age, risk factors, past history, inflammatory marker, or echocardiography between the 2 groups. In terms of the target vessel and vascular complexity, there were no significant differences between the 2 groups. During the first 7 days, emergent revascularization occurred only in 1 patient (1.7%) in group I. Acute myocardial infarction (AMI) occurred in 1 (1.7%) patient in group I and in 1 (1.7%) in group II. Three (5.0%) patients in group I and 1 (1.7%) in group II died. Total in-hospital MACE during the first 7 days was 4 (6.7%) in group I and 2 (3.3%) in group II. Bleeding complications were observed in 10 patients (16.7%) in group I and in 4 patients (6.7%) in group II, however, the difference was not statistically significant. No significant intracranial bleeding was observed in either group. Four years after PCI, death occurred in 5 (8.3%) patients in group I and in 4 (6.7%) in group II. MACE occurred in 12 (20.0%) patients in group I and in 10 (16.7%) patients in group II.Dalteparin was effective and safe in primary PCI of STEMI patients and combined dalteparin with tirofiban was effective and safe without significant bleeding complications compared with UFH. Although there was no statistically significant difference, LMWH decreased the bleeding complications compared with UFH.
- Published
- 2011
38. [MicroRNA expression profile and pathogenetic initial study in essential hypertension]
- Author
-
Li-Ping, Yu, Lin-Ying, Shi, Ming-Ming, Zhang, Shu-Yan, Wang, Jun, Cai, Ming-Ming, Gao, Wei, Xiong, and Xin-Chun, Yang
- Subjects
Adult ,Male ,MicroRNAs ,Case-Control Studies ,Gene Expression Profiling ,Hypertension ,Humans ,Female ,Middle Aged ,Transcriptome ,Oligonucleotide Array Sequence Analysis - Abstract
To study the differential microRNAs expression between patients with essential hypertension and healthy controls.Whole blood from 15 hypertensive patients and 5 controls healthies were separated into plasma at 3000 rpm for 10 minutes. MicroRNAs were harvested using kit, and stored at -80°C. MicroRNAs profiling were performed using Exiqon microRCURY(TM) LNA microRNAs array, and were quantitative RT-PCR for the differential microRNAs expression. In addition, we used a set of plasma samples from 24 hypertensive patients and 22 healthy donors to independently validate the expression of these signature microRNAs.MicroRNAs expression profile was found to be differentially in the essential hypertensive patients compared with the healthy donors. Of 1700 microRNAs detected on the microarray, 46 microRNAs were found to be differentially expressed in the essential hypertensive patient, 27 microRNAs were collected in Sanger microRNAs data-bank, the function of remaining 19 microRNAs were unknown. In the 27 microRNAs, 9 microRNAs were up-regulated in the hypertension patient samples, while 18 known microRNAs were down-regulated. MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples. The microRNAs expression was independently validated using another sample. We showed that MHC class I polypeptide-related chain B (MHC class I polypeptide-related chain B, MICB) and Interferon regulatory factor 1 (Interferon regulatory factor 1, IRF1) were functional targets of hcmv-miR-UL112 by fluorescent reporter assays.The hypertensive patients have distinct microRNAs expression Profile. Hcmv-miR-UL112 may have important implications toward pathogenesis of essential hypertension.
- Published
- 2011
39. [Evaluation of shensongyangxin capsules in the treatment of paroxysmal atrial fibrillation: a randomized, double-blind and controlled multicenter trial]
- Author
-
Ai-hu, Wang, Jie-lin, Pu, Xiao-yong, Qi, Wen-lin, Miao, Zi-shan, Hou, Hong-liang, Cong, Jian-zhong, Zhou, Xiao-fang, Liu, Shu-mei, Li, Qing-hua, Han, Yong-Jia, Liu, and Xin-chun, Yang
- Subjects
Male ,Double-Blind Method ,Propafenone ,Atrial Fibrillation ,Humans ,Multicenter Studies as Topic ,Female ,Middle Aged ,Anti-Arrhythmia Agents ,Aged ,Drugs, Chinese Herbal ,Follow-Up Studies ,Phytotherapy - Abstract
To evaluate the efficacy and safety of Chinese medicinal shensongyangxin capsules in the treatment of paroxysmal atrial fibrillation.From August 2007 to July 2008, Beijing Chaoyang Hospital conducted a multicenter study, select the eleven hospital's outpatient subjects, aged 18 to 75 years old, male or female, paroxysmal atrial fibrillation (at least one electrocardiogram diagnosis) seizure frequency ≥ 2 times/month, according to the ratio 1:1:1, subjects were randomly divided into three groups: a. shensongyangxin group, taking shensongyangxin capsule 4 + propafenone analogues 150 mg, 3 times a day; b. propafenone group, taking propafenone tablets 150 mg + 4 shensongyangxin analogues, 3 times a day; shensongyangxin capsule + propafenone group, taking shensongyangxin capsule 4 + propafenone 150 mg, 3 times a day. The treatment course is 8 weeks, with 3 times of follow-up.Total of 349 cases of paroxysmal atrial fibrillation, which 117 cases in shensongyangxin group, 115 cases in propafenone group; 117 cases in shensongyangxin + propafenone group. The baseline data analysis showed that there were no significantly difference (P0.05) among the three groups of atrial fibrillation seizure frequency, vital signs, general condition, medical history, 24-hour ambulatory ECG, 12-lead normal electrocardiogram, cardiac ultrasound and symptoms. The comparison before and after (8 weeks) treatment showed that the frequency (from 6 times/m to 2 times/m in each group, P0.01), number of cases [from 46 (43.3%) to 22 (20.8%), 43 (43.4%) to 25 (25.3%), and 40 (40.6%) to 31 (29.2%), respectively P0.01] and duration time of attack of atrial fibrillation (from 4 h to 0.5 h, 4 h to 0.5 h, and 4.25 h to 0.5 h, respectively P0.01) all decreased in three groups. No significant difference among the three groups comparing the overall effect (62.3%, 58.6%, and 58.5%, respectively, P0.05), while the efficacy of TCM symptoms in shensongyangxin group (80.2%) was better than that of propafenone group (67.7%) (P0.05). Safety evaluation showed that adverse reaction rate was 1.8% in shensongyangxin group, and 8.2% and 5.4% in propafenone group and shensongyangxin + propafenone group.Shensongyangxin capsules and propafenone have comparable efficacies in the treatment of PAF. The efficacy of TCM symptoms is better than propafenone. Shensongyangxin capsules have an excellent profile of safety.
- Published
- 2011
40. [The efficacy and safety of transradial versus transfemoral approach for percutaneous coronary intervention in acute myocardial infarction]
- Author
-
Kun, Xia, Rong-Jing, Ding, Da-Yi, Hu, Xin-Chun, Yang, and Le-Feng, Wang
- Subjects
Femoral Artery ,Male ,Radial Artery ,Myocardial Infarction ,Humans ,Female ,Angioplasty, Balloon, Coronary ,Middle Aged ,Emergency Treatment ,Aged ,Retrospective Studies - Abstract
To compare the safety and efficacy of radial artery access versus femoral artery access for percutaneous coronary intervention in acute myocardial infarction population.From June 2004 to December 2006, 446 patients with acute myocardial infarction treated with percutaneous stenting were reviewed retrospectively. The radial artery approach was used in 242 patients, and the femoral artery approach in 204 patients. The success of the procedure, procedure duration, X-ray exposition, volume of contrast, incidence of major adverse cardiac events and complications were compared between the radial artery and femoral artery approach.Total procedure duration, X-ray exposition, the immediate success of the procedure and the proportion of patients with reperfusion time above 60min are higher in patients with radial artery acess than that with femoral artery access [(62.1 ± 23.4) min vs (56.8 ± 16.7) min, (2829.4 ± 1365.2) mGY vs (2352.3 ± 903.1) mGY, 4% vs 0.9% and 7.44% vs 2.94% respectively, all P0.05].In non-selected patients with acute myocardial infarction treated with primary stent implantation, the success rate of the radial artery approach is lower than the femoral artery approach and could prolong the reperfusion time. It is suitable to change artery access immediately if abnormality is found via radial artery access.
- Published
- 2011
41. [The effect of admission hyperglycemia on coronary reflow in primary percutaneous coronary intervention]
- Author
-
Chang-Hua, Wang, Yun-Dai, Chen, Xin-Chun, Yang, Le-Feng, Wang, Hong-Shi, Wang, Zhi-Jun, Sun, Hong-Bin, Liu, and Lian, Chen
- Subjects
Male ,Treatment Outcome ,Hyperglycemia ,Reperfusion ,Myocardial Infarction ,Humans ,Female ,Angioplasty, Balloon, Coronary ,Middle Aged ,Aged ,Retrospective Studies - Abstract
To assess the association between admission plasma glucose (APG) and no-reflow during primary percutaneous coronary intervention (PCI) in patients with ST-elevation acute myocardial infarction (STEMI).A total of 1413 patients with STEMI successfully treated with PCI were divided into no-reflow group and normal reflow group.The no-reflow was found in 297 patients (21.0%) of 1413 patients; their APG level was significantly higher than that of the normal reflow group [(13.80 ± 7.47) vs (9.67 ± 5.79) mmol/L, P0.0001]. Multivariate logistic regression analysis revealed that current smoking (OR 1.146, 95%CI 1.026 - 1.839, P = 0.031), hyperlipidemia (OR 1.082, 95%CI 1.007 - 1.162, P = 0.032), long reperfusion (6 h, OR 1.271, 95%CI 1.158 - 1.403, P = 0.001), admission creatinine clearance (90 ml/min, OR 1.046, 95%CI 1.007 - 1.086, P = 0.020), IABP use before PCI (OR 9.346, 95%CI 1.314 - 67.199, P = 0.026), and APG (13.0 mmol/L, OR 1.269, 95%CI 1.156 - 1.402, P = 0.027) were the independent no-reflow predictors. The no-reflow incidence was increased as APG increased (14.6% in patients with APG7.8 mmol/L and 36.7% in patients with APG13.0 mmol/L, P = 0.009).APG13.0 mmol/L is an independent no-reflow predictor in patients with STEMI and PPCI.
- Published
- 2011
42. A no-reflow prediction model in patients with ST-elevation acute myocardial infarction and primary drug-eluting stenting
- Author
-
Chang-Hua Wang, Zhi-jun Sun, Hong-bin Liu, Hong-shi Wang, Yun-dai Chen, Xin-Chun Yang, and Le-Feng Wang
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,Collateral Circulation ,Myocardial Reperfusion ,Logistic regression ,Preoperative care ,Internal medicine ,Angioplasty ,Preoperative Care ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Prospective Studies ,Thrombus ,Angioplasty, Balloon, Coronary ,Prospective cohort study ,Aged ,Intra-Aortic Balloon Pumping ,business.industry ,ST elevation ,Age Factors ,Models, Cardiovascular ,Drug-Eluting Stents ,Thrombosis ,Middle Aged ,medicine.disease ,Collateral circulation ,Treatment Outcome ,Cardiology ,No-Reflow Phenomenon ,Regression Analysis ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
This study was undertaken to assess independent no-reflow predictors in patients with ST-elevation acute myocardial infarction (STEMI) and primary drug-eluting stenting in the current interventional strategies.One thousand four hundred and thirteen patients with STEMI were successfully treated with primary drug-eluting stenting within 12 h after AMI. All clinical, angiographic and procedural data were collected. Univariate and multivariate logistic regression was used to identify independent no-reflow predictors.The no-reflow was found in 297 (21%) of 1413 patients. Univariate and multivariate logistic regression identified that age (65 years, OR 1.47, 95% CI 1.46-1.49; p = 0.007), long time-to-reperfusion (6 h, OR 1.27, 95% CI 1.16-1.40; p = 0.001), admission plasma glucose (13.0 mmol/L, OR 1.27, 95% CI 1.16-1.40; p = 0.027), collateral circulation (0-1, OR 1.69, 95% CI 1.25-2.29; p = 0.001), pre-PCI thrombus score (≥4, OR 1.36, 95% CI 1.16-1.79; p = 0.011), and IABP use before PCI (OR 2.89, 95% CI 1.65-5.05; p0.0001) were independent no-reflow predictors. The no-reflow rate significantly increased as the number of independent predictors increased (0%, 6%, 15%, 25%, 40%, 50% and 100% in patients with 0, 1, 2, 3, 4, 5, and 6 independent predictors, respectively; p0.0001).The prediction model consisted of six no-reflow predictors in patients with STEMI and primary drug-eluting stenting and should be confirmed in large-scale prospective studies.
- Published
- 2011
43. [Using the combination of traditional risk factors and quantitative coronary angiography (QCA) in predicting the risk of individuals with subclinical artherosclerosis]
- Author
-
Guo-zhong, Wang, Shu-zheng, Lv, Jing-hua, Liu, Yun-dai, Chen, Yong, Huo, Wei, Gao, Wei-min, Wang, Fang, Chen, Yu-jie, Zhou, Zhi-zhong, Li, Yuan-nan, Ke, Xin-chun, Yang, Shu-yang, Zhang, Hong-bing, Yan, Hong-wei, Li, Da-zhuo, Shi, and Bu-xing, Chen
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Coronary Artery Disease ,Middle Aged ,Atherosclerosis ,Coronary Angiography ,Prognosis ,Risk Assessment ,Young Adult ,Logistic Models ,Risk Factors ,Humans ,Female ,Prospective Studies ,Aged ,Follow-Up Studies - Abstract
To determine whether the combination of traditional risk factors and quantitative coronary angiography (QCA) assessment could provide accurate prognostic information on a population-based study including 1137 adults with subclinical artherosclerosis and with coronary risk factors.Participants underwent coronary angiography examination before the minimal stenotic diameters, segment diameters, percent stenosis, plaque areas. Other parameters were analyzed by the computer-assisted Coronary Angiography Analysis System. The Framingham Risk Score for each participant was assessed. During the 1 year follow-up period, all kinds of endpoint cardiovascular events were screened. Endpoint events were defined as death from coronary heart disease, nonfatal myocardial infarction (MI) or unstable angina pectoris.During the 1 year of follow-up period, a total of 124 participants developed an endpoint event, which was significantly associated with the Framingham Risk Score, calcium of plaques and the plaque areas (all Ps0.05). The QCA score incorporated with the QCA parameters was related to the endpoint events. The Framingham Risk Score was combined with QCA score through logistic regression for prediction of end-point events. Data from the ROC analysis showed the accuracy of this prediction algorithm was superior to the accuracy when variables themselves were used. The event-free survival rate was inferior to the control group in participates under high risk, when being screened with this prediction algorithm (P0.05).The risk of cardiovascular attack in subclinical artherosclerosis individual seemed to be associated with the Framingham Risk Score, calcium of plaques and the plaque areas. When the traditional risk factors (the Framingham Risk Score) were combined with QCA, the new method could provide more prognostic information on those adults with subclinical artherosclerosis.
- Published
- 2011
44. [Efficacy comparison of primary percutaneous coronary intervention with biodegradable polymer- and durable polymer-based sirolimus-eluting stents for patients with acute myocardial infarction]
- Author
-
Qiang, Li, Le-feng, Wang, Xin-chun, Yang, Yong-gui, Ge, Hong-shi, Wang, Wei-ming, Li, Li, Xu, Zhu-hua, Ni, and Kun, Xia
- Subjects
Male ,Sirolimus ,Treatment Outcome ,Polymers ,Myocardial Infarction ,Humans ,Drug-Eluting Stents ,Female ,Prospective Studies ,Angioplasty, Balloon, Coronary ,Middle Aged ,Aged - Abstract
This prospective random control study was performed to compare the efficacy and safety of primary percutaneous coronary intervention (PCI) with biodegradable polymer (Excel) and with durable polymer (Cypher Select) sirolimus-eluting stents in patients with acute ST-elevation myocardial infarction (STEMI).Consecutive patients with STEMI underwent primary PCI were randomly divided into Cypher group (n = 113) and Excel group (n = 115). The primary endpoints were major adverse cardiac events (MACE, including death, reinfarction and target vessel revascularization) within 12 months. The second endpoints included late luminal loss and restenosis at 9 months.Angiographic follow-up data at 9 months were available in 43 (38%) patients in Cypher group and 48 (42%) in Excel group. The rates of in-stent restenosis and in-segment restenosis were 2.3% vs. 2.1% (P = 0.937) and 4.7% vs. 6.3% (P = 0.738), respectively. The late luminal loss of in-stent and in-segment were (0.17 ± 0.26) mm vs. (0.18 ± 0.33) mm (P = 0.483) and (0.19 ± 0.36) mm vs. (0.20 ± 0.42) mm (P = 0.419), respectively. There were no significant differences in death (3.5% vs. 2.6%, P = 0.692), reinfarction (1.8% vs. 2.6%, P = 0.658), target vessel revascularization (1.8% vs. 2.6%, P = 0.658), MACE (5.3% vs. 6.1%, P = 0.788) or stent thrombosis (4.4% vs. 3.5%, P = 0.692) at 12 months between Cyper group and Excel group.Excel and Cypher Select stents may have similar mid-term efficacy and safety in patients with STEMI treated with primary PCI.Further investigation is warranted to validate the long-term efficacy and safety.
- Published
- 2010
45. [Association between post primary percutaneous coronary intervention myocardium reperfusion and prognosis in patients with acute ST-elevation myocardial infarction]
- Author
-
Da-peng, Zhang, Yong-gui, Ge, Le-feng, Wang, Hong-shi, Wang, Wei-ming, Li, Li, Xu, Zhu-hua, Ni, Kun, Xia, Yong, Lian, Yong-li, Xue, and Xin-chun, Yang
- Subjects
Adult ,Aged, 80 and over ,Male ,Treatment Outcome ,Myocardial Infarction ,Humans ,Female ,Myocardial Reperfusion ,Angioplasty, Balloon, Coronary ,Middle Aged ,Prognosis ,Aged ,Retrospective Studies - Abstract
To explore the prognostic impact of post primary percutaneous coronary intervention (PCI) reperfusion status on outcome in patients with acute ST-elevation myocardial infarction (STEMI).A retrospective analysis was performed in 964 patients undergoing primary PCI for STEMI. Electrocardiogram and TIMI myocardial perfusion grade (TMPG) were analyzed by reader blinded to the clinical course. Patients were divided to four groups according to ST segment resolution (STR) and TMPG: group A were patients with good STR and TMPG(425/964), group B were patients with poor STR and good TMPG (239/964), group C were patients with good STR and poor TMPG (113/964) and group D were patients with poor STR and TMPG (113/964).Although TIMI grade III flow was achieved after mechanical reperfusion, abnormal reperfusion was still present in about 1/3 patients as shown by poor STR or TMPG. Older age, cardiac dysfunction and diabetes, prolonged time of pain to balloon/emergency room are independent risk factors for abnormal reperfusion post PCI. Major adverse cardiac events events in hospital (RR = 64. 63, P0.01) and during follow up (RR = 11.69, P0.01) were significantly higher in group D than in group A.Poor post PCI reperfusion status is associated with higher in hospital and during follow up major adverse cardiac events event in STEMI patients.
- Published
- 2010
46. Attenuation of tumor necrosis factor-alpha elevation and improved heart function by postconditioning for 60 seconds in patients with acute myocardial infarction
- Author
-
Xiang-Min, Lin, Zhi-Yong, Zhang, Le-Feng, Wang, Li, Zhang, Yu, Liu, Xiu-Lan, Liu, Xin-Chun, Yang, Liang, Cui, and Lin, Zhang
- Subjects
Male ,Tumor Necrosis Factor-alpha ,Ischemic Preconditioning, Myocardial ,Myocardial Infarction ,Humans ,Female ,Myocardial Reperfusion Injury ,Angioplasty, Balloon, Coronary ,Middle Aged - Abstract
Postconditioning has been shown to reduce infarct size, ischemic/reperfusion injury and myocardial injury in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). This study tested the hypothesis that postconditioning attenuates the elevation of tumor necrosis factor-alpha (TNF-alpha) and improves heart function in patients with AMI after PCI.A total of 75 patients were randomly assigned to 1 of 3 groups: the routine group (n = 26), in which no intervention was given at the onset of reperfusion; and the Postcon-30s (n = 25) or Postcon-60 s (n = 24) groups, in which 3 cycles of 30- or 60-second balloon deflation and inflation were repetitively performed. TNF-alpha serum concentration was measured by ELISA. Global and regional left ventricular systolic function was determined by echocardiography at 1 year. Thirty-four normal controls (NC) were enrolled in the study.The TNF-alpha concentration in patients with AMI was significantly elevated at baseline compared to controls (P0.01). Concentration levels increased in the routine and Postcon-30s, but not in Postcon-60s group at 7 days (P0.05). As for linear associations among the three groups, left ventricular ejection fraction (LVEF) and wall motion score index (WMSI) were ranked as follows: Postcon-60sPostcon-30sroutine (P values all0.05, 65% vs. 57% vs. 52% and 1.10 vs. 1.27 vs. 1.53) after 1 year. More importantly, there was a significant relevance between the soluble TNF-alpha serum concentration at 7 days and LVEF or WMSI after 1 year (P values all0.0001).Postconditioning, in particular Postcon-60s was associated with long-term cardioprotective effects for inhibition of the inflammatory response and reperfusion injury. The soluble TNF-alpha serum concentration provided powerful prognostic information of global and regional left ventricular systolic function in patients with AMI.
- Published
- 2010
47. Thorombolytic therapy with rescue percutaneous coronary intervention versus primary percutaneous coronary intervention in patients with acute myocardial infarction: a multicenter randomized clinical trial
- Author
-
Run-lin, Gao, Ya-ling, Han, Xin-chun, Yang, Jie-ming, Mao, Wei-yi, Fang, Lei, Wang, Wei-feng, Shen, Zhan-quan, Li, Guo-liang, Jia, Shu-zheng, Lü, Meng, Wei, Ding-yin, Zeng, Ji-lin, Chen, Xue-wen, Qin, Bo, Xu, Chang-hui, DU, and Jin-fa, Shi
- Subjects
Male ,Fibrinolytic Agents ,Myocardial Infarction ,Humans ,Female ,Thrombolytic Therapy ,Angioplasty, Balloon, Coronary ,Middle Aged ,Coronary Angiography ,Aged - Abstract
Although thrombolytic therapy with rescue percutaneous coronary intervention (PCI) is a common treatment strategy for ST-segment elevation acute myocardial infarction (STEMI), scant data are available on its efficacy relative to primary PCI, and comparison was therefore the aim of this study.This multicenter, open-label, randomized, parallel trial was conducted in 12 hospitals on patients (ageor = 70 years) with STEMI who presented within 12 hours of symptom onset (mean interval3 hours). Patients were randomized to three groups: primary PCI group (n = 101); recombinant staphylokinase (r-Sak) group (n = 104); and recombinant tissue-type plasminogen activator (rt-PA) group (n = 106). For all patients allocated to the thrombolytic therapy arm, coronary angiography was performed at 90 minutes after drug therapy to confirm infarct-related artery (IRA) patency; rescue PCI was performed in cases with TIMI flow gradeor = 2. Bare-metal stent implantation was planned for all patients.After randomization it required an average of 113.4 minutes to start thrombolytic therapy (door-to-needle time) and 141.2 minutes to perform first balloon inflation in the IRA (door to balloon time). Rates of IRA patency (TIMI flow grade 2 or 3) and TIMI flow grade 3 were significantly lower in the thrombolysis group at 90 minutes after drug therapy than in the primary PCI group at the end of the procedure (70.5% vs. 98.0%, P0.0001, and 53.0% vs. 85.9%, P0.0001, respectively). Rescue PCI with stenting was performed in 117 patients (55.7%) in the thrombolytic therapy arm. Rates of patency and TIMI flow grade 3 were still significantly lower in the rescue PCI than in the primary PCI group (88.9% vs. 97.9%, P = 0.0222, and 68.4% vs. 85.0%, P = 0.0190, respectively). At 30 days post-therapy, mortality rate was significantly higher in the thrombolysis combined with rescue PCI group than in primary PCI group (7.1% vs. 0, P = 0.0034). Rates of death/MI and bleeding complications were significantly higher in the thrombolysis with rescue PCI group than in the primary PCI group (10.0% vs. 1.0%, P = 0.0380, and 28.10% vs. 8.91%, P = 0.0001, respectively).Thrombolytic therapy with rescue PCI was associated with significantly lower rates of coronary patency and TIMI flow grade 3, but with significantly higher rates of mortality, death/MI and hemorrhagic complications at 30 days, as compared with primary PCI in this group of Chinese STEMI patients with late presentation and delayed treatments.
- Published
- 2010
48. [Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity]
- Author
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Qi, Zhang, Shuang-shuang, Cheng, Jie, Yan, Xing-dong, Chen, Xiao-feng, Wang, and Xin-chun, Yang
- Subjects
Adult ,Male ,Genotype ,Myocardial Infarction ,Middle Aged ,Polymorphism, Single Nucleotide ,Asian People ,Gene Frequency ,Purine-Nucleoside Phosphorylase ,Case-Control Studies ,Humans ,Female ,Genetic Predisposition to Disease ,Alleles ,Aged - Abstract
To investigate the association between methylthioadenosine phosphorylase (MTAP) gene single nucleotide polymorphisms (SNP) and myocardial infarction (MI) in the Chinese Han ethnicity.432 patients suffered from myocardial infarction and 430 controls were involved for case and control groups, respectively. Nine tag SNPs in MTAP gene were selected and genotyped.We found no significant association of selected tag SNPs with MI in all of the samples. However, in stratified analysis, significant association was observed at rs7027989 in male subjects. The risk of MI increased by 26% (P = 0.005) for male subjects of minor allele carriers in a dominant model. The increased risk of MI at rs7027989 remained significant after adjusting for confounding factors.MTAP gene might be involved in the etiology of MI in Chinese Han ethnicity.
- Published
- 2010
49. [Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes]
- Author
-
Liang, Shi, Xin-Chun, Yang, Xiu-Lan, Liu, Min, Zong, and Yi-Ling, Wu
- Subjects
Male ,Patch-Clamp Techniques ,Calcium Channels, L-Type ,Pulmonary Veins ,Atrial Fibrillation ,Action Potentials ,Animals ,Female ,Myocytes, Cardiac ,Rabbits ,Potassium Channels, Inwardly Rectifying ,Cells, Cultured ,Drugs, Chinese Herbal - Abstract
To investigate the effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes and to elucidate its possible mechanism of curing atrial fibrillation.Action potentials as well as L-type calcium channel current (I(Ca-L)), transient outward potassium current (I(K1)) and inward rectifier potassium current (I(To)) were recorded using whole cell patch-clamp technique.ShenSongYangXin prolonged the action potential duration (APD) significantly, APD90 was enlarged from (187 +/- 49) ms to (286 +/- 76) ms at the concentration of 5 mg/ml and to (312 +/- 82) ms at the concentration of 10 mg/dl respectively (P0.05). It also depressed the current of I(Ca-L), I(K1) and Iro in a concentration-dependent manner.ShenSongYangXin can be used to treat atrial fibrillation through its actions on multiple current channels.
- Published
- 2010
50. [Hyperglycemia at admission and outcome in elderly patients with acute ST segment elevation myocardial infarction underwent primary percutaneous coronary intervention]
- Author
-
Hong-jie, Chi, Da-peng, Zhang, Xin-chun, Yang, Zhong-su, Yang, and Yuan, Xu
- Subjects
Blood Glucose ,Male ,Treatment Outcome ,Hyperglycemia ,Myocardial Infarction ,Humans ,Female ,Angioplasty, Balloon, Coronary ,Middle Aged ,Prognosis ,Aged ,Retrospective Studies - Abstract
To investigate the association between hyperglycemia and outcome in elderly patients with acute ST segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI).This retrospective analysis was performed on 284 elderly patients (ageor = 60 years) with acute STEMI underwent primary PCI between January 2000 to April 2004 in our department. Patients were divided into 3 groups according to the level of blood glucose on admission: group A,7.8 mmol/L; group B, 7.8 - 10.9 mmol/L; group C,or = 11.0 mmol/L.(1) The proportion of female in group B and group C was greater than that of group A (33.3% vs. 26.5%, P0.01; 40.2% vs. 26.5%, P0.01). The hospital stay time of group B and group C was significantly longer than that of group A (16.0 days vs. 13.9 days, P0.05; 16.6 days vs. 13.9 days, P0.05). There were more patients with history of hypertension in group C than that in group A (72.1% vs. 54.9%, P0.01). (2) After PCI, the proportion of patients with TIMI myocardial perfusion grade (TMPG) 0-1 in group B and C was greater than that of group A (22.6% vs. 13.3%, P0.05; 34.1% vs. 13.3%, P0.05). The proportion of patients with TMPG 3 in group B and C was less than that in group A (74.3% vs. 84.4%, P0.05; 57.6% vs. 84.4%, P0.05). The complication rate of PCI was significantly higher in group C than in group A (42.5% vs. 20.6%, P0.01) and group B (42.5% vs. 26.6%, P0.01). IABP use was significantly more in group C than that in group A (19.5% vs. 4.9%, P0.01) and group B (19.5% vs. 6.4%, P0.01). (3) There were more patients with grade of Killip classor = 2 in group C than that in group A (44.8% vs. 23.5%, P0.01) and group B (44.8% vs. 27.7%, P0.01). The in-hospital mortality rate (8.0% vs. 1.1%, P0.05) and one-year mortality rate (18.7% vs. 3.4%, P0.05) of group C were significantly higher than those in group A.Hyperglycemia at admission was associated with poor tissue perfusion, cardiac function and prognosis in elderly patients with acute STEMI underwent primary PCI.
- Published
- 2009
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