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Supplemental Material for Association of podocyte injury with clinical features and prognosis in patients with mesangial proliferative lupus nephritis by Muyao Guo, Xiaoyun Xie, Wei Lin, Yaou Zhou and Xiaoli Zhang in Lupus

In vehicular ad hoc networks (VANETs), vehicle-to-vehicle (V2V) communications can link vehicles to each other, and vehicle-to-infrastructure (V2I) messaging and communications can link roadside infrastructure such as routers. The vehicles in these networks act as relays that transmit critical messages in the network. Due to the high-speed movement of vehicles on the road, real-time messaging and minimizing the delay in sending messages is one of the most important objectives of VANET developers. On the other hand, the high mobility of vehicles causes communication interruptions and decreases the data delivery rate in VANET. To overcome this issue, predicting the path of vehicles can play an important role in sending data from the source to the destination. When an accident occurs on the road, the messages that are sensed by the imbedded sensors in the vehicles need to be sent, and if they are sent by the vehicles that change their route, these messages will not be sent to the destination and the performance of the network will be disturbed. Previous methods in the literature for data transmission in intervehicular networks have focused more on reliability and trust, and little attention has been paid to the prediction of vehicle movement paths in these types of networks. Therefore, for fast and reliable data transmission in VANET, accurate prediction of vehicle movement and creation of movement patterns can be effective in message transmission delay and data delivery rate. In this paper, we present an approach using a combination of cluster-based routing protocols and pattern discovery methods to minimize latency in VANETs. The outline of the proposed method has four modules: primary data collection and analysis, primary data preparation and analysis, pattern extraction and vehicle route discovery, and vehicle clustering and data/information transmission routing. The simulation results show that the proposed method with a delivery rate of 88.56% has significantly improved compared to the previous methods in terms of package delivery rate. Also, the proposed method with a total delay of 24.566 ms has a shorter delay than the previous methods in terms of message sending delay in the network.

The term telemedicine was first used in the 1920s, although used many years ago and has continued to evolve today. Medical diagnoses usually require visual information, but remote display systems have recently become a special place due to the constant unavailability of the treating physician or the remoteness of medical centers and the constant need of some patients for round-the-clock care. In this article, an Arduino-based heart rate information system is designed and implemented. Due to the reasonable price and easy accessibility of the created system in the fraction, it has many applications. The results of the designed system showed the system's capabilities to track and know the person's heart rate

Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. We also evaluated the therapeutic effects of exosomes secreted from adipose-derived stem cells (ADSCs) on stress-mediated senescence of EPCs induced by high glucose. Additionally, the effects of exosomes and Nrf2 overexpression in ADSCs were investigated in vitro and in vivo in a diabetic rat model. We found that ADSCs that secreted exosomes promoted proliferation and angiopoiesis in EPCs in a high glucose environment and that overexpression of Nrf2 increased this protective effect. Wounds in the feet of diabetic rats had a significantly reduced ulcerated area when treated with exosomes from ADSCs overexpressing Nrf2. Increased granulation tissue formation, angiogenesis, and levels of growth factor expression as well as reduced levels of inflammation and oxidative stress-related proteins were detected in wound beds. Our data suggest that exosomes from ADSCs can potentially promote wound healing, particularly when overexpressing Nrf2 and therefore that the transplantation of exosomes may be suitable for clinical application in the treatment of DFUs., Diabetes: Rescue sacs for foot ulcers Tiny membrane-bound sacs released by some stem cells carry chemicals that can heal the foot ulcers that are a major complication of diabetes. The sacs, called exosomes, are released by many cells for signaling between cells and other functions. Xue Li of Tongji University in Shanghai and co-workers focused on the effects of exosomes from stem cells derived from body fat cells. They found that the exosomes could encourage the healing of diabetic foot ulcers in rats. The research also uncovered useful information about the molecular interactions involved in the accelerated healing. It revealed the significance of one particular protein in the formation of new blood vessels, which is central to the healing. The authors suggest that collecting and transplanting suitable exosomes could offer a new approach for treating diabetic foot ulcers.

Stem cells therapy is an effective treatment for critical limb ischemia diseases (CLI), but is limited to low cells retention and poor target release in severe ischemia tissues. Due to the notable feature of CLI, namely, the temperature of ischemia tissues decreases with the severity of the lesions, a thermoresponsive and reversible hydrogel based on methylcellulose-salt system encapsulating stem cells is facilely prepared and successfully achieved the goal of releasing stem cells in lower temperature areas. The investigations show that the thermogel presents notable biocompatibility, thermoresponsiveness, and cytoprotection. Furthermore, the combined transplantation of hydrogel and stem cells system effectively inhibits the fibrosis and muscular atrophy of lower limb ischemia, accelerates the recovery of lower limb blood flow, and promotes angiogenesis, indicating that the reversible thermogel can promote vascular repair by controlling the release of loaded stem cells in the treatment of CLI.

In this paper, a novel feature extraction method based on Non-convex Robust Principal Component Analysis (NRPCA) and minimum noise fraction is proposed for hyperspectral image classification. The proposed method consists of following steps. First, the spectral dimension of the hyperspectral image is reduced with averaging-based image fusion. Then, each band of the hyperspectral image which dimension has been reduced are processed with NRPCA technique. Next, minimum noise fraction is performed to reduce low-rank data dimensionality and noise. Finally, SVM as a pixel-wise classifier is used to obtain final classification. Experimental results demonstrate that the proposed method is able to obtain much higher classification accuracy than other methods in hyperspectral image.

This study aimed to investigate whether ultrasound-induced microbubble destruction was able to promote targeted delivery of adipose-derived stem cells (ASCs) to improve hind-limb ischemia of diabetic mice. Ischemia was induced in the lower limb of db/db mice which were then randomly divided into 5 groups: PBS group, Sham group, ultrasound + microbubble group (US+MB), US+MB+ASCs group and ASCs group. Contrast-enhanced ultrasound perfusion imaging showed the ratio of blood flow in ischemic hind-limb to that in contralateral limb increased over time in five groups. A significant enhancement in US+MB+ASCs group was observed compared with US+MB group (P

In order to maximize the total power generation of a wind farm, several control strategies based on tilt angle, yaw angle, and cone angle were investigated numerically using computational fluid dynamics (CFD) simulation. The full rotor model (FRM) of 5 MW wind turbine was used to simulate the wake in the wind farm. According to the comparison of different cases' power generations and velocity fields, the result indicates that appropriate strategies based on tilt angle and positive yaw angle have effective improvements on the power output of whole wind farm, but changing cone angle and opposite yaw angle result in negative effects.

Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell engraftment in the infarcted region. This is mainly a result of low cell retention in the tissue and poor cell survival under ischemic, immune rejection and inflammatory conditions. Various approaches have been explored to improve cell engraftment: increase of cell retention using biomaterials as cell carriers; augmentation of cell survival under ischemic conditions by preconditioning cells, genetic modification of cells, and controlled release of growth factors and oxygen; and enhancement of cell survival by protecting cells from excessive inflammation and immune surveillance. In this paper, we review current progress, advantages, disadvantages, and potential solutions of these approaches.