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Additional file 5: Table S5. Top 10 significantly enriched KEGG pathways of Candida albicans (according to P value).

Additional file 1: Table S1. Significant enrichment of GO terms for Candida albicans (top 5 according to P value).

Additional file 9: Figure S1. Construction of the PPI network from four groups of Candida. Candida albicans (A), Candida glabrata (B), Candida parapsilosis (C) and Candida tropicalis (D).

Additional file 9: Figure S1. Construction of the PPI network from four groups of Candida. Candida albicans (A), Candida glabrata (B), Candida parapsilosis (C) and Candida tropicalis (D).

Additional file 2: Table S2. Significant enrichment of GO terms for Candida glabrata (top 5 according to P value).

Additional file 6: Table S6. Top 10 significantly enriched KEGG pathways of Candida glabrata (according to P value).

Additional file 3: Table S3. Significant enrichment of GO terms for Candida parapsilosis (top 5 according to P value).

Additional file 8: Table S8. Top 10 significantly enriched KEGG pathways of Candida tropicalis (according to P value).

Additional file 10: Figure S2. Top 10 hub genes of four groups of Candida. Candida albicans (A), Candida glabrata (B), Candida parapsilosis (C) and Candida tropicalis (D).

Additional file 7: Table S7. Top 10 significantly enriched KEGG pathways of Candida parapsilosis (according to P value).

Additional file 7: Table S7. Top 10 significantly enriched KEGG pathways of Candida parapsilosis (according to P value).

Additional file 4: Table S4. Significant enrichment of GO terms for Candida tropicalis (top 5 according to P value).

Additional file 6: Table S6. Top 10 significantly enriched KEGG pathways of Candida glabrata (according to P value).

Additional file 8: Table S8. Top 10 significantly enriched KEGG pathways of Candida tropicalis (according to P value).

Background Both massage and topically administered NSAIDs are safe and effective treatments for knee osteoarthritis (KOA); however, different massage technique sects in China caused assessment difficulties for the treatment of KOA. In order to standardize the massage techniques and procedures, we organized multi-disciplinary experts in China to acquire an evidence-based traditional Chinese medicine massage treatment of knee osteoarthritis. The purposes of this study will be to provide clinicians a complementary and alternative therapy for patients and to evaluate the efficacy and safety of evidence-based traditional Chinese medicine massage treatment of KOA compared to External Diclofenac Diethylamine Emulgel. Methods and design A randomized controlled trial in which 300 participants diagnosed with KOA will be recruited and randomly allocated to either the experimental group or the control group in a ratio of 2:1. Two hundred participants will receive evidence-based traditional Chinese medicine massage 2 sessions per week for 10 weeks as the experimental group, and 100 participants will receive External Diclofenac Diethylamine Emulgel 3–4 times per day for 10 weeks as the control group. The patients in the two groups will receive follow-up at two time points at 5 weeks and 10 weeks from the beginning of treatment, respectively. The MRI scans and X-ray will be performed at baseline and at the end of the intervention. The primary outcome will be the changes in the Western Ontario and McMaster Osteoarthritis Index (WOMAC). Secondary outcomes will be measured by the PRO scale for knee osteoarthritis based on the concept of traditional Chinese medicine (Chinese scale for knee osteoarthritis (CSKO)), X-ray evaluation, and MRI scan evaluation. The data of WOMAC and CSKO will be analyzed at the baseline, 5 weeks, and 10 weeks from the beginning of treatment. The data from MRI scans and X-rays will be analyzed at baseline and at the end of the intervention. The significance level sets as 5%. The safety of interventions will be evaluated after each treatment session. Discussion This study will provide clinicians with much-needed knowledge for the treatment of KOA through a controlled trial. Trial registration Chinese Clinical Trial Registry ChiCTR1800014400. Registered on 10 January 2018

Additional file 1. Flow diagram of study selection process

Additional file 2: Figure S2. The intersection results of GSE26692 and GSE41075

Additional file 1: Figure S1. The intersection results of GSE20430 and GSE20436

Purpose: To explore the therapeutic method for lameness caused by lumbar spinal stenosis. Methods: 28 cases of the patients with lameness were treated by puncturing Dachangshu (BL 25), Weizhong (BL 40), Chengshan (BL 57) and Kunlun (BL 60) and simultaneously another 26 cases were treated with routine method for control study. Results:After the treatments for four weeks, the scores of the symptoms in the two groups were remarkably elevated. In the acupuncture treatment, the results showed remarkable effect in 4 cases, effect in 21 cases. In the routine treatment, the results showed remarkable effect in 4 cases and effect in 8 cases. Conclusion: acupuncture treatment is better than the routine conventional treatment for lameness caused by lumbar spinal stenosis.