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NANOGrav, EPTA, PPTA, and CPTA have announced the evidence for a stochastic signal from their latest data sets. Supermassive black hole binaries (SMBHBs) are supposed to be the most promising gravitational-wave (GW) sources of pulsar timing arrays. Assuming an astro-informed formation model, we use the NANOGrav 15-year data set to constrain the gravitational wave background (GWB) from SMBHBs. Our results prefer a large turn-over eccentricity of the SMBHB orbit when GWs begin to dominate the SMBHBs evolution. Furthermore, the GWB spectrum is extrapolated to the space-borne GW detector frequency band by including inspiral-merge-cutoff phases of SMBHBs and should be detected by LISA, Taiji and TianQin in the near future., Comment: 8 pages, 3 figures, 3 tables

The pulsar timing array (PTA) collaborations have recently reported compelling evidence for the presence of a stochastic signal consistent with a gravitational-wave background. In this letter, we combine the latest data sets from NANOGrav, PPTA and EPTA collaborations to explore the cosmological interpretations for the detected signal from first-order phase transitions, domain walls and cosmic strings, separately. We find that the first-order phase transitions and cosmic strings can give comparable interpretations compared to supermassive black hole binaries (SMBHBs) characterized by a power-law spectrum, but the domain wall model is strongly disfavored with the Bayes factor compared to the SMBHB model being 0.009. Furthermore, the constraints on the parameter spaces indicate that: 1) a strong phase transition at temperatures below the electroweak scale is favored and the bubble collisions make the dominant contribution to the energy density spectrum; 2) the cosmic string tension is $G \mu \in [1.46, 15.3]\times 10^{-12}$ at $90\%$ confidence interval and a small reconnection probability $p, Comment: 10 pages, 5 figures, 2 tables; References updated

Ultralight boson fields, with a mass around $10^{-23}\text{eV}$, are promising candidates for the elusive cosmological dark matter. These fields induce a periodic oscillation of the spacetime metric in the nanohertz frequency band, which is detectable by pulsar timing arrays. In this paper, we investigate the gravitational effect of ultralight tensor dark matter on the arrival time of radio pulses from pulsars. We find that the pulsar timing signal caused by tensor dark matter exhibits a different angular dependence than that by scalar and vector dark matter, making it possible to distinguish the ultralight dark matter signal with different spins. Combining the gravitational effect and the coupling effect of ultralight tensor dark matter with standard model matter provides a complementary way to constrain the coupling parameter $\alpha$. We estimate $\alpha \lesssim 10^{-6}\sim 10^{-5}$ in the mass range $m, Comment: 12 pages, 3 figures

The vulnerability of the current network has become an urgent problem to be solved. The focus of network protection should be shifted from traditional network protection to the direction of effective recovery even after being attacked and damaged, and then, the concept of resilience came into being. This paper selects physical explosion attacks to establish damaged network. An improved system resilience recovery strategy is established which considers task importance and time efficiency. Aiming at the initial population is too random, easy to mature and with poor solution, this paper improves genetic algorithm by new greedy model in population initialization and head-to-head mutation operator. Simulation shows that the improved genetic algorithm is better and more stable, the improved quotient model is more effective in system resilience recovery measured by index-E proposed in this paper.

Composed of ultralight bosons, fuzzy dark matter provides an intriguing solution to challenges that the standard cold dark matter model encounters on sub-galactic scales. The ultralight dark matter with mass $m\sim10^{-23} \rm{eV}$ will induce a periodic oscillation in gravitational potentials with a frequency in the nanohertz band, leading to observable effects in the arrival times of radio pulses from pulsars. Unlike scalar dark matter, pulsar timing signals induced by the vector dark matter are dependent on the oscillation direction of the vector fields. In this work, we search for ultralight vector dark matter in the mass range of $[2\times 10^{-24}, 2\times 10^{-22}]{\rm{eV}}$ through its gravitational effect in the Parkes Pulsar Timing Array (PPTA) second data release. Since no statistically significant detection is made, we place $95\%$ upper limits on the local dark matter density as $\rho_{\rm{\tiny{VF}}} \lesssim 5{\rm{GeV/cm^{3}}}$ for $m\lesssim 10^{-23}{\rm{eV}}$. As no preferred direction is found for the vector dark matter, these constraints are comparable to those given by the scalar dark matter search with an earlier 12-year data set of PPTA., Comment: 9 pages, 3 figures, 2 tables; accepted for publication as a Letter in Phys. Rev. D

Additional file 4: Fig. 3 GATA3 variant is associated with MRKH syndrome. (A) Sanger sequencing validating the GATA3 variant in patient Fc-M-10. The red arrow indicates the variant site c.1178C>T. (B) The full-length GATA3 wild-type (WT) protein and P393L mutant protein structures were predicted by RoseTTAFold. (C) The predicted protein structures for GATA3 WT protein (green) and the P393L mutant protein (red) were aligned. The predicted WT protein structure is more stretched, while the predicted P393L mutant protein structure is more compact. It is difficult for them to structurally overlap.

Additional file 2: Fig. 1 Urinary ultrasound images of patient Fc-M-3. The left renal region (A) and right renal region (B) are normal.

Additional file 1: Table 1. PCR Primers used in Sanger sequencing validation.

Additional file 1. Supplemental Table 1. RNAscope and PCR results in patient cervical scraped cells. Both negative. Supplemental Table 2. RNAscope result summary of patients with high HPV signal dots and/or TERC positive signals, and the disease follow-up records.

Hui Zhao, Yue He, Shu-Li Yang, Qun Zhao, Yu-Mei Wu Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China Aim: This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer.Methods: A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant chemotherapy plus radical surgery vs radical surgery alone. We measured overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), local and distant recurrence, lymph node metastasis, and parametrial infiltration per patient.Results: In all, 13 studies involving 2,158 subjects were included. In regard to OS, DFS, PFS, local and distant recurrence, and parametrial infiltration, neoadjuvant chemotherapy plus radical surgery was similar to radical surgery alone. Among them, subgroup analysis of eight studies involving 1,544 patients with locally advanced cervical cancer (FIGO stage IB2–IIB) showed that neoadjuvant chemotherapy (NACT) plus radical surgery significantly improved OS, and decreased local and distant recurrence rates, lymph node metastasis rate, and the level of parametrial infiltration compared to radical surgery alone.Conclusion: The present study demonstrates that preoperative NACT is now an accepted effective procedure in selected patients with locally advanced cervical cancer (FIGO stage IB2–IIB). However, the relationship between NACT and longer DFS and PFS cannot be demonstrated by this meta-analysis. Thus, the decision to use or not to use NACT before radical surgery depends on the surgeon’s experience and clinical judgment. Nevertheless, further research in this field is urgently needed to confirm it. Keywords: neoadjuvant chemotherapy, surgery, cervical cancer, meta-analysis &nbsp

Additional file 7: Table S2. Related to Supplementary Material and Methods: List of ChIP primers used in this study.

Additional file 6: Table S1. List of human qRT-PCR primers used in this study.

Additional file 3 Suppl Table 3. Maternal outcomes in patients received intrauterine balloon pressure or not when postpartum hemorrhage exceeding 500 ml(n = 28)

Additional file 2:Suppl Table 2. Predictors of Negative mother Outcomes in mothers with AFLP(n = 55)

Additional file 1: Suppl Table 1. The rates of Swansea criteria for the diagnosis of AFLP (n = 55).

This study compared the efficacy of neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) vs primary surgical treatment (PST) in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB2/IIA2 cervical cancer. Data of 303 cervical cancer patients who received primary therapy for stage IB2/IIA2 cervical cancer at 7 medical centers in Beijing, China between January 1, 2009 and December 31, 2016 and followed through December 31, 2017 were collected retrospectively. The response rates, surgical characteristics, and overall survival (OS) durations of patients who received NACT followed by RS were compared to those of patients who received PST. An improved short-term complete response rate was observed among patients who received intra-arterial chemotherapy compared with patients who had intravenous chemotherapy (18.3% vs 4.1%, Pdifference = .020). Patients who received NACT were more likely to undergo laparoscopic surgery and to have a lower blood loss volume (555.4 ± 520.2 ml vs PST, 682.5 ± 509.8 ml; P = .036) and increased estimated operative time (249.9 ± 101.9 vs PST, 225.1 ± 76.5 min; P = .022). No differences in high-risk factors (HRFs), the effects of supplemental treatment, or 5-year OS were observed between patients who received NACT and PST. Our findings indicate that patients who received NACT for FIGO stage IB2/IIA2 cervical cancer were more likely to undergo laparoscopic surgery. These findings have important implications regarding treatment with curative intent for stage IB2/IIA2 cervical cancer and warrant a further analysis of treatment strategies to ensure adequate treatment and patient-centered care.

Table S1. PCR primers and data analysis used in this study. (DOCX 50 kb)

Following the interpretation of matter source that the energy-momentum tensor of anisotropic fluid can be dealt with effectively as the energy-momentum tensor of perfect fluid plus linear (Maxwell) electromagnetic field, we obtain the regular higher-dimensional Reissner-Nordstr\"{o}m (Tangherlini-RN) solution by starting with the noncommutative geometry inspired Schwarzschild solution. Using the boundary conditions that connect the noncommutative Schwarzschild solution in the interior of the charged perfect fluid sphere to the Tangherlini-RN solution in the exterior of the sphere, we find that the interior structure can be reflected by the exterior parameter, the charge-to-mass ratio. Moreover, we investigate the stability of the boundary under mass perturbation and indicate that the new interpretation imposes a rigid restriction upon the charge-to-mass ratio. This restriction, in turn, permits a stable noncommutative black hole only in the 4-dimensional spacetime., Comment: v1: 24 pages, 4 figures, 2 tables; v2: 25 pages, clarifications and references added; v3: clarifications added, final version to appear in Universe

Supplemental Digital Content is available in the text, The purpose of this study is to investigate short-term efficacy as defined by the Response Evaluation Criteria in Solid Tumors (RECIST) and pathological response of neoadjuvant chemotherapy (NACT) comprised of paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced cervical cancer (LACC). This is a prospective study involving 61 women with histologically confirmed LACC referred for NACT following radical surgery at Beijing Obstetrics and Gynecology Hospital between April 2013 and January 2015. The efficacy of NACT was evaluated by the RECIST. The total short-term efficacy of NACT was 91.8% (complete remission and partial remission). The cervical invasion ≤1/2 was 82.4% in the complete remission (CR) group, 46.2% in the partial remission (PR) group, and 20% in the stable disease (SD) group. The difference between groups was statistically significant (P = .012). The slides of all surgical specimens were reviewed and classified according to the Tumor Regression Grade (TRG). The good response was defined by good short-term efficacy (RECIST) and the difference between groups was statistically significant (P = .042). The route of administration of NACT is a factor predicting response to NACT. A significant higher response rate (P = .011) and lower chemotherapy-related adverse events (P

Following the interpretation of matter source that the energy-momentum tensor of anisotropic fluid can be dealt with effectively as the energy-momentum tensor of perfect fluid plus linear (Maxwell) electromagnetic field, we obtain the regular higher-dimensional Reissner-Nordstr��m (Tangherlini-RN) solution by starting with the noncommutative geometry inspired Schwarzschild solution. Using the boundary conditions that connect the noncommutative Schwarzschild solution in the interior of the charged perfect fluid sphere to the Tangherlini-RN solution in the exterior of the sphere, we find that the interior structure can be reflected by the exterior parameter, the charge-to-mass ratio. Moreover, we investigate the stability of the boundary under mass perturbation and indicate that the new interpretation imposes a rigid restriction upon the charge-to-mass ratio. This restriction, in turn, permits a stable noncommutative black hole only in the 4-dimensional spacetime., v1: 24 pages, 4 figures, 2 tables; v2: 25 pages, clarifications and references added; v3: clarifications added, final version to appear in Universe

The relationship of marine environment and squid fishing fluctuation in North Pacific Ocean was analyzed with the method of production gravity center and generalized additive model(GAM), through the surface temperature, sea chlorophyll and ocean current data got by satellite remote sensing inversion technology, and the statistic of boat fishing in the North Pacific from 2002 to 2012. The results showed that gravity center of fisheries was located in the eastern and central fishing grounds in May and June. The range was 168°~171°E, 38°~39°N. Gravity center of fisheries was located in western traditional fishing grounds from July to November with range of 150°~160°E, 40°~44°N. Gravity center of fisheries had obvious seasonal changes. GAM module analysis indicated that appropriate sea surface temperature scope of high squid fisheries was 14~19 ℃. The appropriate chlorophyll concentration scope of high squid fisheries was 0.22~0.55 mg·m-3. The distribution range was 154°~157°E in longitude, and 41°~44°N in latitude. There was a feeding migration to north and spawning migration to south every year, its relationship with environmental factors showed different characteristics, especially the best correlation of sea surface temperature. The gravity center of fisheries and sea surface temperature were positively correlated during the northward migration from May to September, while negatively correlated during the south migration from September to November. It showed obvious seasonal changes. Current also had an important impact on fisheries. Under the interaction of Kuroshio and Oyashio, high catch fishing grounds usually located in the forward of Kuroshio and nearby the northern side of Oyashio, with the shift of warm and cold current changing.

The solid–liquid reaction method was used for the preparation of a new High Performance Liquid Chromatography (HPLC) baicalin-bonded stationary phase (BBSP) via amido linkage, by using γ-aminopropyl trimethoxy silane (TM-550) as a coupling reagent and baicalin as a ligand. The structure of the ligand was characterized by Fourier transform infrared spectrum, elemental analysis, thermal analysis and so on. The chromatographic performances of BBSP were preliminarily evaluated, and a related retention mechanism was discussed by using different solutes as probes. Meanwhile, a comparative study between BBSP and conventional octadecyl-bonded stationary phase (ODS) was also carried out under the same conditions. The results showed that the new stationary phase had a relatively weak reversed-phase chromatographic property. Besides hydrophobicity, BBSP could also provide various sites, such as, hydrogen-bonding, π-π, and n-π charge transfer interactions. Synergistic interactions improved the separation selectivity of BBSP for aromatic compounds and their positional isomers when compared with ODS. It could also be observed that the polar amido linkage and hydrophilic glucose residue could minimize the residual silanols effect and improve the separation of basic nitrogen-containing compounds. Additionally, the new packing had strong affinity to flavonoids because of their similar structures. BBSP could be used as an enriching column packing for natural organic flavonoids from medicine herbs.

Large-conductance Ca2+-activated potassium channels (BKCa) are highly expressed in the lateral amygdala (LA), which is closely involved in assigning stress disorders, but data on their role in the neuronal circuits of stress disorders are limited. In the present study, a significant reduction in BKCa channel expression in the amygdala of mice accompanied anxiety-like behaviour induced by acute stress. Whole-cell patch-clamp recordings from LA neurons of the anxious animals revealed a pronounced reduction in the fast after-hyperpolarization (fAHP) of action potentials mediated by BKCa channels that led to hyperexcitability of the LA neurons. Activation of BKCa channels in the LA reversed stress-induced anxiety-like behaviour after stress. Furthermore, down-regulated BKCa channels notably increased the evoked NMDA receptor-mediated excitatory postsynaptic potentials at the thalamo-LA synapses. These data demonstrate, for the first time, that restraint stress-induced anxiety-like behaviour could at least partly be explained by alterations in the functional BKCa channels in the LA.

The objective of this study was to explore the action and mechanism of immediate early response gene 5 (IER5) on the apoptosis induced by irradiation combined with cisplatin in HeLa cells. The IER5 gene was knocked down using IER5-specific small interfering (si)RNA to generate HeLa cells stably expressing low levels of IER5 (HeLa-siIER5). Apoptosis was induced by (60)Co γ-radiation, cisplatin, and radiation combined with cisplatin. Apoptosis and cell viability were evaluated by flow cytometry and Cell Counting Kit-8, respectively. Protein expression was determined by western blotting. Apoptosis was significantly inhibited in HeLa-siIER5 cells after γ-radiation combined with cisplatin exposure compared with siRNA control cells (P < 0.01). We also found that the expression of Bcl-2 was increased, and the levels of cleaved caspase-9 and cleaved PARP were reduced after γ-radiation combined with cisplatin treatment of HeLa-siIER5 cells. These results indicated that decreased expression of IER5 can reduce apoptosis induced by exposure to γ-radiation combined with cisplatin. Enhancing the expression of IER5 in tumor cells, and reducing its expression in normal cells, may be utilized as targeting strategies to improve the outcomes of chemo/radiotherapy for the treatment of patients with cervical cancer.