4 results on '"White MR"'
Search Results
2. Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells
- Author
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Da, Moulding, Rv, Giles, Dg, Spiller, White MR, Dm, Tidd, and Steven Edwards
- Subjects
Microscopy, Confocal ,Base Sequence ,Tumor Necrosis Factor-alpha ,Blotting, Western ,Apoptosis ,Cell Differentiation ,U937 Cells ,DNA, Antisense ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,Organophosphorus Compounds ,Proto-Oncogene Proteins c-bcl-2 ,Humans ,Myeloid Cell Leukemia Sequence 1 Protein ,Tetradecanoylphorbol Acetate ,RNA, Messenger - Abstract
Mcl-1 is a member of the Bcl-2 protein family, which has been shown to delay apoptosis in transfection and/or overexpression experiments. As yet no gene knockout mice have been engineered, and so there is little evidence to show that loss of Mcl-1 expression is sufficient to trigger apoptosis. U937 cells constitutively express the antiapoptotic protein Bcl-2; but during differentiation, in response to the phorbol ester PMA (phorbol 12 beta-myristate 13 alpha-acetate), Mcl-1 is transiently induced. The purpose of this investigation was to determine the functional role played by Mcl-1 in this differentiation program. Mcl-1 expression was specifically disrupted by chimeric methylphosphonate/phosphodiester antisense oligodeoxynucleotides to just 5% of control levels. The depletion of Mcl-1 messenger RNA (mRNA) and protein was both rapid and specific, as indicated by the use of control oligodeoxynucleotides and analysis of the expression of other BCL2 family members and PMA-induced tumor necrosis factor-alpha (TNF-alpha). Specific depletion of Mcl-1 mRNA and protein, in the absence of changes in cellular levels of Bcl-2, results in a rapid entry into apoptosis. Levels of the proapoptotic protein Bax remained unchanged during differentiation, while Bak expression doubled within 24 hours. Apoptosis was detected within 4 hours of Mcl-1 antisense treatment by a variety of parameters including a novel live cell imaging technique allowing correlation of antisense treatment and apoptosis in individual cells. The induction of Mcl-1 is required to prevent apoptosis during differentiation of U937 cells, and the constitutive expression of Bcl-2 is unable to compensate for the loss of Mcl-1. (Blood. 2000;96:1756-1763)
- Published
- 2000
3. Polycythemia vera occurring in two brothers
- Author
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Riggs Sa, White Mr, Brown Ja, and Waddell Cc
- Subjects
Adult ,Male ,medicine.medical_specialty ,Polycythemia vera ,business.industry ,Karyotyping ,medicine ,Humans ,General Medicine ,medicine.disease ,business ,Dermatology ,Polycythemia Vera - Published
- 1982
4. Cnoc, Clanna Caoilte
- Author
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An Cnoc, Clanna Caoilte, Liatháin, Máire Ní, Crowley, Diarmuid, Canty, Lena, White, Teresa, Hurley, Jim, Carey, Con, White, Terry, Aherne, Nellie, White, James, Ahern, Nellie, Hurley, Jina, Collins, Madgie, Carey, John, White, Mr James, White, M., Lyons, Mrs, and Donovan, Mrs O'
- Subjects
Limekilns ,Irish Travellers (Nomadic people) ,Thunder ,Schools ,local legends ,Legal status, laws, etc ,Toys ,Traditional medicine ,Agriculture ,Manners and customs ,Winds ,Rites and ceremonies ,Fires ,Birds ,Death ,Dissenters, Religious ,Butter ,Recreation ,Occupations ,Marriage ,Weather ,Folklore ,Treasure troves - Abstract
A collection of folklore and local history stories from An Cnoc, Clanna Caoilte (school) (Knocks, Co. Cork), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Máire Ní Liatháin., Hidden Treasure -- Hidden Treasure -- Hidden Treasure -- Hidden Treasure -- Weather-Lore -- Weather-Lore / Crowley, Diarmuid -- Weather-Lore / Canty, Lena -- Strong Man / Crowley, Diarmuid -- Burning -- Great Thunder-Storm -- Great Wind -- Thunder-Storm -- Old Schools -- Old Crafts / White, Teresa -- Lime-Kilns -- Old Crafts / Canty, Lena -- Lime-Kiln / Hurley, Jim -- Penal Days - Mass Rock / Carey, Con -- Penal Days - Mass Rock / Hurley, Jim -- Names of Fields / White, Terry -- Names of Fields / Canty, Lena -- Names of Fields / Aherne, Nellie -- Names of Fields / White, James -- Bird-Lore / Crowley, Diarmuid -- Bird-Lore / Hurley, Jim -- Old Cures / White, Terry -- Old Cures / Crowley, Diarmuid -- Old Cures / Hurley, Jim -- Homemade Toys / Crowley, Diarmuid -- Homemade Toys / White, Terry -- Lore of Certain Days / White, Terry -- Field - Carraig an Aifrinn / Ahern, Nellie -- Old Forts - Carhoovauler / Crowley, Diarmuid -- Old Forts - Currycrowley and Ballinard / Hurley, Jina -- Another Fort in Carhoovauler / Collins, Madgie -- Old Forts / Canty, Lena -- Old Forts / Canty, Lena -- Fort - Coxestown / Carey, Con -- Fort - Coxestown / Ahern, Nellie -- Games I Play -- Game I Play -- Game I Play / Carey, John -- Game I Play / Carey, John -- Game I Play / Collins, Madgie -- Game I Play / White, Mr James -- Game I Play / White, Terry -- Herbs / Collins, Madgie -- Local Thunder-Storm -- Mode of Travelling -- Crafts -- Butter-Making / White, M. -- Old Crafts / Lyons, Mrs -- Old Cures / Donovan, Mrs O' -- Cromlech / Lyons, Mrs -- Forts or Cromlechs in the same Townland / Lyons, Mrs -- Cillíneach - Field Name / Lyons, Mrs -- Cros na Leanbh / Lyons, Mrs -- Forts / Lyons, Mrs -- Forts in Carhoovauler -- Knocks Cross Forts -- Setting of Seed -- Lucky Days for Seed Planting -- Síol Dearmad -- Some Supersititions -- Marriages -- Superstitions, Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.
- Published
- 1937
- Full Text
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