106 results on '"Wenjie Dai"'
Search Results
2. High-Efficiency Aluminum–Metal Organic Framework/HEPES Electrochemiluminescence System for Ultrasensitive Detection of HBV DNA
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Gaoxu Chen, Xiaoyan Wang, Wenjie Dai, Ling Liang, Zilan Luo, Cuiru Chen, Shujun Zhen, Chengzhi Huang, and Yuanfang Li
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Analytical Chemistry - Published
- 2023
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3. The use of nomogram for detecting mild cognitive impairment in patients with type 2 diabetes mellitus
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Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Yu Xie, Atipatsa C. Kaminga, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, and Wenjie Dai
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Endocrinology, Diabetes and Metabolism - Published
- 2023
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4. Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice
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Xufeng Fu, Ling Liu, Hang Han, Yuanyuan Li, Shengbin Si, Bo Xu, Wenjie Dai, Hong Yang, Tiantian He, Xing Du, and Xiuying Pei
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Health, Toxicology and Mutagenesis ,General Medicine ,Management, Monitoring, Policy and Law ,Toxicology - Published
- 2023
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5. TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting M2 polarization of TAMs
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Jingjing Huang, Huayang Pan, Jing Sun, Jiaming Wu, Qiyue Xuan, Jinge Wang, Shanjia Ke, Shounan Lu, Zihao Li, Zhigang Feng, Yongliang Hua, Qingan Yu, Bing Yin, Baolin Qian, Menghua Zhou, Yanan Xu, Miaoyu Bai, Yingmei Zhang, Yaohua Wu, Yong Ma, Hongchi Jiang, and Wenjie Dai
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Background: The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which can be affected by transmembrane proteins localized in the ER membrane. One of them, the transmembrane protein 147 (TMEM147) has been recently implicated for its role in hepatocellular carcinoma (HCC) tumorigenesis, though the mechanisms remain unclear. Here, we investigated the role of TMEM147 in HCC and its underlying mechanisms. Methods: Expression of TMEM147 was examined in human HCC and adjacent non-tumorous tissues using quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemistry. The effects of TMEM147 on HCC progression were investigated both in vitro and in vivo. Proteins interacting with TMEM147 were identified using RNAseq analysis, immunoprecipitation, and mass spectrometry analyses. Lipidomic analysis and enzyme-linked immunosorbent assay (ELISA) were employed to identify and analyze cholesterol and 27-hydroxycholesterol (27HC) contents. Comprehensive experimental methods were used to demonstrate ferroptosis in HCC cells. The fatty acid content of macrophages affected by TMEM147 was quantified using ELISA. Macrophage phenotypes were determined using various assays, such as immunofluorescence assay and flow cytometry analysis. Results: TMEM147 mRNA and protein levels were upregulated in HCC, and increased TMEM147 expression was associated with poor survival. TMEM147 promoted tumor cell proliferation and metastasis in vitro and in vivo. It was found to interact with the key sterol reductase DHCR7, which affected cellular cholesterol homeostasis and increased extracellular 27HC levels in HCC. TMEM147 promoted the expression of DHCR7 by enhancing the activity of the transcription factor, STAT2. 27HC upregulated the expression of glutathione peroxidase 4 in HCC, leading to ferroptosis resistance and promotion of HCC proliferation. HCC cell-derived 27HC activated PPARγ signaling and enhanced lipid metabolism in macrophages, thereby activating M2 polarization, and then promoted the invasion and migration of HCC. Conclusions: Our results indicated that TMEM147 confers ferroptosis resistance and M2 macrophage polarization, which are mainly dependent on the upregulation of cellular cholesterol homeostasis and 27HC secretion, leading to cancer growth and metastasis. Our findings suggest that the TMEM147/STAT2/DHCR7/27HC axis in the tumor microenvironment may serve as a promising therapeutic target for HCC.
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- 2023
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6. A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells
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Xing Du, Jingjing Zhang, Ling Liu, Bo Xu, Hang Han, Wenjie Dai, Xiuying Pei, Xufeng Fu, and Shaozhang Hou
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General Veterinary ,General Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,General Biochemistry, Genetics and Molecular Biology - Published
- 2022
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7. Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway
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Bo Xu, Wenjie Dai, Ling Liu, Hang Han, Jingjing Zhang, Xing Du, Xiuying Pei, and Xufeng Fu
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Granulosa Cells ,TOR Serine-Threonine Kinases ,Endocrinology, Diabetes and Metabolism ,Hydrogen Peroxide ,Metformin ,Rats ,Phosphatidylinositol 3-Kinases ,Endocrinology ,Autophagy ,Animals ,Humans ,Female ,Hyperandrogenism ,Proto-Oncogene Proteins c-akt ,Polycystic Ovary Syndrome - Abstract
Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by a variety of clinical features, including anovulation, hyperandrogenism, and ovarian abnormalities, resulting in infertility. PCOS affects approximately 6%-15% of all reproductive-age women worldwide. Metformin, a popular drug used to treat PCOS in patients, has beneficial effects in reducing hyperandrogenism and inducing ovulation; however, the mechanisms by which metformin ameliorates PCOS are not clear. Hence, we aimed to explore the mechanisms of metformin in treating PCOS. In the present study, we first treated a letrozole-induced PCOS rat model with metformin, detected the pathological recovery of PCOS, and then assessed the effects of metformin on H
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- 2022
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8. Supplementary Figure S2 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Approach to assess levels of monocytic and PMN MDSC in patient PBMCs.
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- 2023
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9. Supplementary Figure S6 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Treatment impact on gene expression determined by volcano plots of RNA-seq data.
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- 2023
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10. Supplementary Figure S4 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Hematoxylin and eosin (HE) and immunohistochemistry (IHC) stains to detect CD8+ and CD33+ cells in patients who received clinical benefit.
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- 2023
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11. Data from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Activating mutations in BRAF, a key mediator of RAS signaling, are present in approximately 50% of melanoma patients. Pharmacologic inhibition of BRAF or the downstream MAP kinase MEK is highly effective in treating BRAF-mutant melanoma. In contrast, RAS pathway inhibitors have been less effective in treating epithelial malignancies, such as lung cancer. Here, we show that treatment of melanoma patients with BRAF and MEK inhibitors (MEKi) activated tumor NF-κB activity. MEKi potentiated the response to TNFα, a potent activator of NF-κB. In both melanoma and lung cancer cells, MEKi increased cell-surface expression of TNFα receptor 1 (TNFR1), which enhanced NF-κB activation and augmented expression of genes regulated by TNFα and IFNγ. Screening of 289 targeted agents for the ability to increase TNFα and IFNγ target gene expression demonstrated that this was a general activity of inhibitors of MEK and ERK kinases. Treatment with MEKi led to acquisition of a novel vulnerability to TNFα and IFNγ-induced apoptosis in lung cancer cells that were refractory to MEKi killing and augmented cell-cycle arrest. Abolishing the expression of TNFR1 on lung cancer cells impaired the antitumor efficacy of MEKi, whereas the administration of TNFα and IFNγ in MEKi-treated mice enhanced the antitumor response. Furthermore, immunotherapeutics known to induce expression of these cytokines synergized with MEKi in eradicating tumors. These findings define a novel cytokine response modulatory function of MEKi that can be therapeutically exploited.Significance:Lung cancer cells are rendered sensitive to MEK inhibitors by TNFα and IFNγ, providing a strong mechanistic rationale for combining immunotherapeutics, such as checkpoint blockers, with MEK inhibitor therapy for lung cancer.See related commentary by Havel, p. 5699
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- 2023
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12. Supplementary Table 1 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Patient characteristics per PD-L1 stratification subgroups
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- 2023
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13. Supplementary Table 3 from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Table showing frequency distribution of cell cycle phases (G1, S, G2) from 3 biological replicates in indicated cell lines (A549, LKR, PC-9, HCC44, H23).
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- 2023
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14. Supplementary Methods from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Supplementary Methods for Xie et al, MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer
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- 2023
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15. Supplementary Table 2 from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Drug screening data used in Figure 2 are shown, including drug names, cell viability and expression levels of chemokines.
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- 2023
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16. Supplementary Figure S3 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Percentage of granulocytic (PMN) and monocytic MDSC in total PBMC of NSCLC trial participants.
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- 2023
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17. Supplementary Figure S5 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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CD33 staining of patient biopsies.
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- 2023
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18. Supplementary Figure S1 from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Kaplan-Meier estimates of Progression-free survival (A) and Overall survival (B) in ICI refractory and relapsed patients.
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- 2023
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19. Supplementary Table Legend from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Supplementary Table Legend for Xie et al, MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer
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- 2023
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20. Supplementary Figures from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Supplementary Figures for Xie et al, MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer
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- 2023
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21. Data from Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer
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Amer A. Beg, Dung-Tsa Chen, Theresa A. Boyle, Ram Thapa, Kristen Goas, Nishan Tchekmedyian, Zhihua Chen, James J. Saller, Wenjie Dai, Hong Zheng, Michael Shafique, Scott J. Antonia, Ben Creelan, Eric B. Haura, Tawee Tanvetyanon, Andreas Saltos, and Jhanelle E. Gray
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Purpose:Histone deacetylase inhibitors (HDACi) enhance tumor immunogenicity through several mechanisms and may improve response to immune checkpoint inhibitors (ICIs). In a phase I/Ib trial, we tested the oral HDACi vorinostat combined with the programmed cell death protein 1 inhibitor pembrolizumab in advanced/metastatic non–small cell lung cancer.Patients and Methods:Patients received intravenous pembrolizumab (200 mg every 3 weeks) plus oral vorinostat (200 or 400 mg/day). Primary endpoint was safety/tolerability. Secondary endpoints included response rate, progression-free survival, disease control rate (DCR), and overall survival. Tumor gene expression changes, T-cell density, and myeloid cell levels were studied in serial tissue specimens.Results:Thirty-three patients were treated (13 in phase I, 20 in phase Ib). In phase I, both ICI-naïve and ICI-pretreated patients were enrolled to determine dose-limiting toxicities (DLT). No DLTs were observed, and the recommended phase I dose was pembrolizumab 200 mg and vorinostat 400 mg. Any-grade adverse events were mainly fatigue (33%) and nausea/vomiting (27%). Of six ICI-naïve and 24 ICI-pretreated patients evaluable for response, four (13%) had partial response [two confirmed, one unconfirmed with subsequent prolonged stable disease (SD), one unconfirmed with subsequent progressive disease (PD)], 16 (53%) had SD, and 10 (33%) had PD for a DCR of 67%. In the ICI-pretreated cohort, three patients (one confirmed, two unconfirmed) had partial response and 10 had SD. Pretreatment CD8+ T-cell presence in tumor stromal regions was associated with treatment benefit.Conclusions:Pembrolizumab plus vorinostat was well tolerated and demonstrated preliminary antitumor activity despite progression on prior ICI treatment.
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- 2023
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22. Supplementary Table 1 from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
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Amer A. Beg, Uwe Rix, Eric B. Haura, W. Douglas Cress, Keiran S.M. Smalley, Sarah A. Blackstone, Fumi Kinose, Zhihua Chen, Nicholas T. Gimbrone, Wenjie Dai, Ranjna Madan-Lala, Hong Zheng, and Mengyu Xie
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Microarray data expression values shown in Figure 1E
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- 2023
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23. Prevalence of comorbid depression and associated factors among hospitalized patients with type 2 diabetes mellitus in Hunan, China
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Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Atipatsa C. Kaminga, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, and Wenjie Dai
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Psychiatry and Mental health - Abstract
Background Depression and diabetes are major health challenges, with heavy economic social burden, and comorbid depression in diabetes could lead to a wide range of poor health outcomes. Although many descriptive studies have highlighted the prevalence of comorbid depression and its associated factors, the situation in Hunan, China, remains unclear. Therefore, this study aimed to identify the prevalence of comorbid depression and associated factors among hospitalized type 2 diabetes mellitus (T2DM) patients in Hunan, China. Methods This cross-sectional study involved 496 patients with T2DM who were referred to the endocrinology inpatient department of Xiangya Hospital affiliated to Central South University, Hunan. Participants’ data on socio-demographic status, lifestyle factors, T2DM-related characteristics, and social support were collected. Depression was evaluated using the Hospital Anxiety and Depression Scale-depression subscale. All statistical analyses were conducted using the R software version 4.2.1. Results The prevalence of comorbid depression among hospitalized T2DM patients in Hunan was 27.22% (95% Confidence Interval [CI]: 23.3–31.1%). Individuals with depression differed significantly from those without depression in age, educational level, per capita monthly household income, current work status, current smoking status, current drinking status, regular physical activity, duration of diabetes, hypertension, chronic kidney disease, stroke, fatty liver, diabetic nephropathy, diabetic retinopathy, insulin use, HbA1c, and social support. A multivariable logistic regression model showed that insulin users (adjusted OR = 1.86, 95% CI: 1.02–3.42) had a higher risk of depression, while those with regular physical activity (adjusted OR = 0.48, 95% CI: 0.30–0.77) or greater social support (adjusted OR = 0.20, 95% CI: 0.11–0.34) had a lower risk of depression. The area under the curve of the receiver operator characteristic based on this model was 0.741 with a sensitivity of 0.785 and specificity of 0.615. Conclusions Depression was moderately prevalent among hospitalized T2DM patients in Hunan, China. Insulin treatment strategies, regular physical activity, and social support were significantly independently associated with depression, and the multivariable model based on these three factors demonstrated good predictivity, which could be applied in clinical practice.
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- 2023
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24. Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets
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Miaoyu, Bai, Shanjia, Ke, Hongjun, Yu, Yanan, Xu, Yue, Yu, Shounan, Lu, Chaoqun, Wang, Jingjing, Huang, Yong, Ma, Wenjie, Dai, and Yaohua, Wu
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Gene Expression Regulation, Neoplastic ,Diacylglycerol Kinase ,Databases, Genetic ,Immunology ,Humans ,Membrane Transport Proteins ,Immunology and Allergy ,Gene Regulatory Networks ,Thyroid Neoplasms ,Prognosis ,Transcriptome ,RGS Proteins - Abstract
BackgroundThyroid carcinoma (THCA) has a low mortality rate, but its incidence has been rising over the years. We need to pay attention to its progression and prognosis. In this study, a transcriptome sequencing analysis and bioinformatics methods were used to screen key genes associated with THCA development and analyse their clinical significance and diagnostic value.MethodsWe collected 10 pairs of THCA tissues and noncancerous tissues, these samples were used for transcriptome sequencing to identify disordered genes. The gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database. Comprehensive analysis of thyroid clinicopathological data using The Cancer Genome Atlas (TCGA). R software was used to carry out background correction, normalization and log2 conversion. We used quantitative real-time PCR (qRT–PCR) and Western blot to determine differentially expressed genes (DEGs) expression in samples. We integrated the DEGs expression, clinical features and progression-free interval (PFI). The related functions and immune infiltration degree were established by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and single-sample Gene Set Enrichment Analysis (ssGSEA). The UALCAN database was used to analyse the methylation level.ResultsWe evaluated DEGs between normal tissue and cancer. Three genes were identified: regulator of G protein signaling 8 (RGS8), diacylglycerol kinase iota (DGKI) and oculocutaneous albinism II (OCA2). The mRNA and protein expression levels of RGS8, DGKI and OCA2 in normal tissues were higher than those in THCA tissues. Better survival outcomes were associated with higher expression of RGS8 (HR=0.38, P=0.001), DGKI (HR=0.52, P=0.022), and OCA2 (HR=0.41, P=0.003). The GO analysis, KEGG analysis and GSEA proved that the coexpressed genes of RGS8, DGKI and OCA2 were related to thyroid hormone production and peripheral downstream signal transduction effects. The expression levels of RGS8, DGKI and OCA2 were linked to the infiltration of immune cells such as DC cells. The DNA methylation level of OCA2 in cancer tissues was higher than that in the normal samples.ConclusionsRGS8, DGKI and OCA2 might be promising prognostic molecular markers in patients with THCA and reveal the clinical significance of RGS8, DGKI and OCA2 in THCA.
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- 2022
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25. Response Behavior of Typical Wire Looping under Random Vibration for Wire Bonding Packaging
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Wenjie Dai, Junfu Liu, Yunpeng Liu, Taotao Chen, and Hu He
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- 2022
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26. Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics
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Ke Feng, Wenjie Dai, Ling Liu, Shengming Li, Yi Gou, Zhongwei Chen, Guodong Chen, and Xufeng Fu
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Multiple Trauma ,Sepsis ,Succinic Acid ,Public Health, Environmental and Occupational Health ,Humans ,Uracil ,Uridine ,Biomarkers - Abstract
Sepsis after trauma increases the risk of mortality rate for patients in intensive care unit (ICUs). Currently, it is difficult to predict outcomes in individual patients with sepsis due to the complexity of causative pathogens and the lack of specific treatment. This study aimed to identify metabolomic biomarkers in patients with multiple trauma and those with multiple trauma accompanied with sepsis. Therefore, the metabolic profiles of healthy persons designated as normal controls (NC), multiple trauma patients (MT), and multiple trauma complicated with sepsis (MTS) (30 cases in each group) were analyzed with ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS)-based untargeted plasma metabolomics using collected plasma samples. The differential metabolites were enriched in amino acid metabolism, lipid metabolism, glycometabolism and nucleotide metabolism. Then, nine potential biomarkers, namely, acrylic acid, 5-amino-3-oxohexanoate, 3b-hydroxy-5-cholenoic acid, cytidine, succinic acid semialdehyde, PE [P-18:1(9Z)/16:1(9Z)], sphinganine, uracil, and uridine, were found to be correlated with clinical variables and validated using receiver operating characteristic (ROC) curves. Finally, the three potential biomarkers succinic acid semialdehyde, uracil and uridine were validated and can be applied in the clinical diagnosis of multiple traumas complicated with sepsis.
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- 2022
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27. Prevalence of Moderate to Severe Anxiety Symptoms among Patients with Myocardial Infarction: a Meta-Analysis
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Wenjie Dai, Yajun Lian, Jianzhou Yang, Wenhang Chen, Atipatsa C. Kaminga, Xiaoyan Wang, Jingsha Xiang, and Zhiwei Lai
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Moderate to severe ,medicine.medical_specialty ,business.industry ,Psychological intervention ,Publication bias ,medicine.disease ,Confidence interval ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Internal medicine ,Meta-analysis ,medicine ,Anxiety ,030212 general & internal medicine ,Myocardial infarction ,medicine.symptom ,business ,Methodological quality - Abstract
This study attempted to synthesize the evidence on the prevalence of moderate to severe anxiety symptoms among myocardial infarction (MI) patients to offer a reliable and accurate estimate on the number of MI patients suffering from moderate to severe anxiety symptoms. Comprehensive electronic searches (PubMed, Embase and Web of Science) were performed from their inception to February 2021. Between-study heterogeneity was analyzed using the Cochran’s Q test and $${I}^{2}$$ statistic, and if it was high across the eligible studies, meta-regression and subgroup analyses were conducted to examine the source of heterogeneity. Publication bias and the robustness of the pooled results were also examined. A total of 18 eligible studies covering 8,532 MI patients were included, of which 3,443 were identified with moderate to severe anxiety symptoms. Between-study heterogeneity was high ( $${I}^{2}$$ =98.8%) with the reported prevalence ranging from 9.6% to 69.17%, and the pooled prevalence was 38.08% (95% confidence interval: 28.82–47.81%) by a random-effects model. Meta-regression analyses indicated that publication year (β = −0.014) was significant moderators contributing 16.11% to the heterogeneity. Subgroup analyses indicated that studies using the anxiety subscale of Brief Symptom Inventory to assess anxiety were homogenous ( $${I}^{2}$$ =0.0). Furthermore, the pooled prevalence of moderate to severe anxiety symptoms varied significantly by geographic region, instrument used to assess anxiety, methodological quality, sex, education level, a history of previous MI and hypercholesterolemia. Additionally, the results of Egger’s linear test (t = −0.630) and Begg’s rank test (z = −0.190) indicated no evidence of publication bias, and the sensitivity of the pooled results was low. Nearly two fifth of MI patients suffered from moderate to severe anxiety symptoms, which emphasizes the importance of early identification of anxiety symptoms after MI, as well as the need of implementing psychological interventions for those with elevated anxiety symptoms.
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- 2021
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28. Lifetime prevalence of suicidal attempt among homeless individuals in North America: a meta-analysis
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Jingsha Xiang, Atipatsa C. Kaminga, Yajun Lian, Zhiwei Lai, Shi Wu Wen, Jianzhou Yang, Xiaoyan Wang, Aizhong Liu, Xinyin Wu, and Wenjie Dai
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Male ,Canada ,medicine.medical_specialty ,Suicide, Attempted ,PsycINFO ,Suicidal Ideation ,Cochran's Q test ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,medicine ,Humans ,Statistic ,Estimation ,Public health ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Meta-analysis ,Ill-Housed Persons ,North America ,Sexual orientation ,Female ,Observational study ,Psychology ,030217 neurology & neurosurgery ,Demography - Abstract
Background : Homelessness is a compelling public health problem, and homeless individuals are at increased risk for attempting suicide. However, the reported lifetime prevalence of suicidal attempt among homeless individuals in North America varied considerably. Therefore, this meta-analysis aimed to estimate the pooled lifetime prevalence of suicidal attempt among homeless individuals in North America and explore factors that may moderate this estimation. Methods : The protocol was registered in PROSPERO database (CRD42018102593). A systematic literature search was conducted in the electronic databases of PubMed, Embase, Web of Science, PsycINFO, and Google Scholar. Observational studies exploring the lifetime prevalence of suicidal attempt among homeless individuals in North America were included. Heterogeneity across studies was evaluated using the Cochran Q test and quantified using the I2 statistic. Subgroup analyses were performed to identify possible sources of heterogeneity. Results : Twenty-two eligible studies with a total of 9,727 homeless individuals were included, of which 2,986 reported having attempted suicide in their lifetime. A high degree of heterogeneity (I2=96.4%, P Limitations : All eligible studies were exclusively conducted in the US and Canada. Conclusions : Nearly three tenths of homeless individuals in North America have attempted suicide in their lifetime, and the differences in sexual orientation might have contributed to the heterogeneity.
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- 2021
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29. Victims Become Covert Aggressors: Gender Differences in the Mediating Effects of Rumination on Anger and Sadness
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Yunyun Zhang, Caina Li, Qingling Zhao, and Wenjie Dai
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Male ,Longitudinal study ,Adolescent ,media_common.quotation_subject ,education ,Psychological intervention ,050109 social psychology ,Anger ,behavioral disciplines and activities ,Peer Group ,Education ,Developmental psychology ,Sadness ,mental disorders ,0502 economics and business ,medicine ,Humans ,0501 psychology and cognitive sciences ,Longitudinal Studies ,Crime Victims ,General Psychology ,media_common ,Sex Characteristics ,Aggression ,05 social sciences ,Bullying ,Covert ,Peer victimization ,Rumination ,behavior and behavior mechanisms ,Business, Management and Accounting (miscellaneous) ,Female ,medicine.symptom ,Psychology ,psychological phenomena and processes ,050203 business & management - Abstract
This longitudinal study examined the link between peer victimization and relational aggression by testing the mediating roles of sadness and anger rumination, with attention to gender differences, among Chinese adolescents. Survey measures were administrated to 2,152 junior middle school students at two time points, one year apart. The results found that self-reported peer victimization (but not peer-nominated victimization) positively predicted relational aggression one year later, and this link was completely mediated by sadness and anger rumination. Specifically, perceived peer victimization exerted a positive influence on both sadness and anger rumination, thereby increasing adolescents' tendency to exhibit relational aggression one year later. Furthermore, victimized boys' elevated relational aggression was predominantly accounted for by their high sadness rumination, whereas victimized girls' elevated relational aggression was mainly due to their great anger rumination. Such a gender-difference suggests that interventions to reduce adolescents' externalizing problems may be most effective when tailored to each gender specifically.
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- 2021
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30. Facile synthesis of 2D Europium-metal organic frameworks nanosheets for highly efficient electrochemiluminescence in DNA detection
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Wenjie Dai, Xiaoyan Wang, Gaoxu Chen, Xue Wang, Congyi Hu, Shujun Zhen, Chengzhi Huang, and Yuanfang Li
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
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31. Association between serum chloride levels with mortality in critically ill patients with acute kidney injury: An observational multicenter study employing the eICU database
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Xu Zhu, Jing Xue, Zheng Liu, Wenjie Dai, Jingsha Xiang, Hui Xu, Qiaoling Zhou, Quan Zhou, and Wenhang Chen
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Intensive Care Units ,Multidisciplinary ,Chlorides ,Critical Illness ,Water-Electrolyte Imbalance ,Humans ,Prospective Studies ,Acid-Base Imbalance ,Acute Kidney Injury ,Retrospective Studies - Abstract
Objective The effect of the serum chloride (Cl) level on mortality in critically ill patients with acute kidney injury (AKI) remains unknown. We sought an association between mortality and serum Cl. Methods We identified AKI patients in the eICU Collaborative Research Database from 2014 to 2015 at 208 US hospitals. The outcomes included in-hospital and intensive care unit (ICU) mortality. Time-varying covariates Cox regression models and the Kaplan-Meier (K-M) curves were used to assess the association between serum Cl levels and mortality. Multivariable adjusted restricted cubic spline models were used to analyze the potential nonlinear relationship between mortality and serum Cl. Results In total, 4,234 AKI patients were included in the study. Compared with normochloremia (98≤chloride Conclusions Lower serum Cl levels after ICU admission was associated with increased in-hospital and ICU mortality in critically ill patients with AKI. The results should be verified in well-designed prospective studies.
- Published
- 2022
32. A novel anticancer property of
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Xing, DU, Jingjing, Zhang, Ling, Liu, Bo, Xu, Hang, Han, Wenjie, Dai, Xiuying, Pei, Xufeng, Fu, and Shaozhang, Hou
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Iron ,Ferroptosis ,Humans ,Breast Neoplasms ,Female ,Glutathione ,Drugs, Chinese Herbal ,Research Article - Abstract
Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women. Lycium barbarum polysaccharide (LBP) is an extract from the fruits of the traditional Chinese herb, L. barbarum. LBP is a promising anticancer drug, due to its high activity and low toxicity. Although it has anticancer properties, its mechanisms of action have not been fully established. Ferroptosis, which is a novel anticancer strategy, is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species (ROS) accumulation. In this study, human breast cancer cells (Michigan Cancer Foundation-7 (MCF-7) and MD Anderson-Metastatic Breast-231 (MDA-MB-231)) were treated with LBP. LBP inhibited their viability and proliferation in association with high levels of ferroptosis. Therefore, we aimed to ascertain whether LBP reduced cell viability through ferroptosis. We found that the structure and function of mitochondria, lipid peroxidation, and expression of solute carrier family 7 member 11 (SLC7A11, also known as xCT, the light-chain subunit of cystine/glutamate antiporter system X(c) (-)) and glutathione peroxidase 4 (GPX4) were altered by LBP. Moreover, the ferroptosis inhibitor, Ferrostatin-1 (Fer-1), rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione (GSH) production, accumulation of intracellular free divalent iron ions and malondialdehyde (MDA), and down-regulation of the expression of xCT and GPX4. Erastin (xCT inhibitor) and RSL3 (GPX4 inhibitor) inhibited the expression of xCT and GPX4, respectively, which was lower after the co-treatment of LBP with Erastin and RSL3. These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the xCT/GPX4 pathway. Therefore, LBP exhibits novel anticancer properties by triggering ferroptosis, and may be a potential therapeutic option for breast cancer.
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- 2022
33. Cell-bound IgE and plasma IgE as a combined clinical diagnostic indicator for allergic patients
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Wenjie Dai, Chunxiu Huang, Jia Long, Jingbo Wu, Wei Lv, Chongwei Xie, Junfang Zhang, Xuejun Ye, Chuanghua Qiu, and Lihong Zhong
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0301 basic medicine ,Male ,Allergy ,Epidemiology ,Cell ,lcsh:Medicine ,Immunoglobulin E ,Article ,03 medical and health sciences ,Elisa kit ,0302 clinical medicine ,Medical research ,Hypersensitivity ,Medicine ,Humans ,Patient group ,lcsh:Science ,Multidisciplinary ,biology ,business.industry ,lcsh:R ,Case-control study ,Total ige ,Therapeutic evaluation ,Allergens ,medicine.disease ,Prognosis ,030104 developmental biology ,medicine.anatomical_structure ,030228 respiratory system ,Case-Control Studies ,Immunology ,biology.protein ,Female ,lcsh:Q ,business ,Biomarkers - Abstract
Allergic responses are mainly caused by IgE, which is often located on the cell surface. The current diagnostic method detects both allergen-specific IgE and total IgE levels, but a number of allergic patients have a normal serum IgE level, which is a poor clinical correlate for allergy. Here, we developed a simple method to detect the level of cell-bound IgE by dissociating it from blood cells with lactic acid. Dissociated cell-bound IgE and plasma IgE levels were detected using the same ELISA kit at the same time. We established two clinical cohorts: an allergic patient group and a healthy participant group. In general, cell-bound IgE correlated well with plasma IgE; however, some patients exhibited high cell-bound IgE levels but low plasma IgE levels. We recommended 350 ng/mL peripheral blood total IgE (cell-bound IgE + plasma IgE) as the cut-off value for allergy diagnosis. Using this indicator, 90.32% of our allergic patients were correctly diagnosed. The peripheral blood total IgE level is a promising clinical diagnostic indicator in allergic patients and will provide more guidance for allergy diagnosis and therapeutic evaluation.
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- 2020
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34. Trial-level characteristics associate with treatment effect estimates: a systematic review of meta-epidemiological studies
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Huan Wang, Jinlu Song, Yali Lin, Wenjie Dai, Yinyan Gao, Lang Qin, Yancong Chen, Wilson Tam, Irene XY Wu, and Vincent CH Chung
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Epidemiologic Studies ,Bias ,Double-Blind Method ,Epidemiology ,Sample Size ,Outcome Assessment, Health Care ,Humans ,Health Informatics - Abstract
Background To summarize the up-to-date empirical evidence on trial-level characteristics of randomized controlled trials associated with treatment effect estimates. Methods A systematic review searched three databases up to August 2020. Meta-epidemiological (ME) studies of randomized controlled trials on intervention effect were eligible. We assessed the methodological quality of ME studies using a self-developed criterion. Associations between treatment effect estimates and trial-level characteristics were presented using forest plots. Results Eighty ME studies were included, with 25/80 (31%) being published after 2015. Less than one-third ME studies critically appraised the included studies (26/80, 33%), published a protocol (23/80, 29%), and provided a list of excluded studies with justifications (12/80, 15%). Trials with high or unclear (versus low) risk of bias on sequence generation (3/14 for binary outcome and 1/6 for continuous outcome), allocation concealment (11/18 and 1/6), double blinding (5/15 and 2/4) and smaller sample size (4/5 and 2/2) significantly associated with larger treatment effect estimates. Associations between high or unclear risk of bias on allocation concealment (5/6 for binary outcome and 1/3 for continuous outcome), double blinding (4/5 and 1/3) and larger treatment effect estimates were more frequently observed for subjective outcomes. The associations between treatment effect estimates and non-blinding of outcome assessors were removed in trials using multiple observers to reach consensus for both binary and continuous outcomes. Some trial characteristics in the Cochrane risk-of-bias (RoB2) tool have not been covered by the included ME studies, including using validated method for outcome measures and selection of the reported results from multiple outcome measures or multiple analysis based on results (e.g., significance of the results). Conclusions Consistently significant associations between larger treatment effect estimates and high or unclear risk of bias on sequence generation, allocation concealment, double blinding and smaller sample size were found. The impact of allocation concealment and double blinding were more consistent for subjective outcomes. The methodological and reporting quality of included ME studies were dissatisfactory. Future ME studies should follow the corresponding reporting guideline. Specific guidelines for conducting and critically appraising ME studies are needed.
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- 2022
35. Aln Coatings with High Thermal Conductivity and Excellent Electrical Insulation Properties for Thermal Management Devices
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Du jiaojiao, Wenjie Dai, Haijiang Kou, Weiliang Xing, Yuzhuo Zhang, Pengfei Wu, and Chao Zhang
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- 2022
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36. Improvement of Superhydrophobicity and Durability of Ep+Pdms/Sio2 Composite Coatings by Adjusting Laser Curing Powers
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Du jiaojiao, Hang Xia, Haoxiong Yuan, Haijiang Kou, Wenjie Dai, and Chao Zhang
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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37. Density estimation method of mature wheat based on point cloud segmentation and clustering
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Rong Zou, Yu Zhang, Jin Chen, Jinyan Li, Wenjie Dai, and Senlin Mu
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Forestry ,Horticulture ,Agronomy and Crop Science ,Computer Science Applications - Published
- 2023
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38. Optimal doping elements for inhibiting surface-diffusion of adatoms on Cu3Sn
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Wenjie Dai, Yang Chen, Xu Liu, Henggao Xiang, Chi Xu, Gong Zheng, and Guang Chen
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General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
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39. The Lactate/Albumin Ratio Predicts Mortality in Critically Ill Patients with Acute Kidney Injury: An Observational Multicenter Study on the eICU Database
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Xu Zhu, Jing Xue, Zheng Liu, Wenjie Dai, Hui Xu, Qiaoling Zhou, Shuangping Zhao, Quan Zhou, and Wenhang Chen
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critical care ,acute kidney injury ,International Journal of General Medicine ,General Medicine ,mortality ,Original Research ,lactate/albumin ratio - Abstract
Xu Zhu,1 Jing Xue,2 Zheng Liu,3 Wenjie Dai,4 Hui Xu,5 Qiaoling Zhou,5 Shuangping Zhao,6 Quan Zhou,7 Wenhang Chen5 1Department of Epidemiology and Health Statistics, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, Peopleâs Republic of China; 2Department of Scientific Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, Peopleâs Republic of China; 3Department of Anesthesiology, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jiânan, Shandong, 250014, Peopleâs Republic of China; 4Xiangya School of Public Health, Central South University, Changsha, Hunan, 410008, Peopleâs Republic of China; 5Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, Peopleâs Republic of China; 6Department of Intensive Care Unit, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, Peopleâs Republic of China; 7Department of Science and Education, The First Peopleâs Hospital of Changde City, Changde, Hunan, 415000, Peopleâs Republic of ChinaCorrespondence: Wenhang ChenDepartment of Nephrology, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Kaifu District, Changsha, 410008, Peopleâs Republic of ChinaFax +86 731 84327348Email wenhangchen@csu.edu.cnObjective: The serum lactate/albumin ratio (LAR) can be used to independently predict mortality due to sepsis. However, whether the LAR predicts the outcomes of critically ill patients with acute kidney injury (AKI) remains unclear. This study was performed to assess the prognostic value of the LAR in critically ill AKI patients.Methods: This retrospective observational study enrolled AKI patients, and all data were collected through the eICU Collaborative Research Database. Outcomes included in-hospital and intensive care unit (ICU) death. Multivariate Cox regression analysis was used to determine independent risk factors. Forest plots and smoothing curves were generated. A series of subgroup analyses were performed to further validate the robustness of the findings.Results: A total of 4666 eligible patients were enrolled. We divided the participants into four groups according to the LAR: quartile (Q)1 (LAR < 0.46, n = 1167), Q2 (0.46 ⤠LAR < 0.79, n = 1162), Q3 (0.79 ⤠LAR < 1.49, n = 1170), and Q4 (LAR ⥠1.49, n = 1167). The LAR, when analyzed as a continuous variable, was associated with hospital and ICU mortality (adjusted hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.18â 1.26, P < 0.0001 for both). The risk of in-hospital and ICU mortality increased with increasing LAR Q relative to Q1. The smoothing curves revealed a continuous linear association after adjusting for all covariates. By the KaplanâMeier analysis, patients in the higher LAR group showed significantly shorter survival time. By the receiver operating characteristic analysis, LAR was efficient in predicting in-hospital mortality (area under the curve [AUC]: 0.717) and ICU mortality (AUC: 0.733). A positive and consistent effect of the LAR was seen in all subgroups analyses after adjusting for all covariates.Conclusion: A high LAR is an independent risk factor for in-hospital and ICU mortality in critically ill patients with AKI. Further prospective studies are needed to validate these result.Keywords: lactate/albumin ratio, acute kidney injury, mortality, critical care
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- 2021
40. Surface protrusion induced by inter-diffusion on Cu-Sn micro-pillars
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Yang Chen, Wenjie Dai, Yingxia Liu, Chih Chen, K.N. Tu, and Guang Chen
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2022
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41. Andesite tailings and municipal solid waste incineration fly ash based glass ceramics
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Xinyi Huang, Jiali Li, Wenjie Dai, Ying Chen, and YongYa Wang
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History ,Computer Science Applications ,Education - Abstract
To realize the utilization of andesite tailings and solve the environmental problems caused by municipal solid waste incineration (MSWI) fly ash, both of them were selectively used as raw materials to prepare glass ceramics by sintering process. The effects of components on the properties of glass ceramics were analyzed. The results showed that glass-ceramic sample 21 prepared from andesite tailings and MSWI fly ash had the best performance, the bending strength was 94.8Mpa. At the same time, its acid and alkali resistance were the best, while the thermal conductivity was the lowest. The leaching of heavy metal elements in all the samples met the Chinese national standard. These results will provide some reference for the resource utilization of andesite tailings and MSWI fly ash.
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- 2022
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42. Sequence characterization and phylogenetic analysis of mitogenome of the Acanthorhodeus chankaensis Dybowsky from Cao’e River
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Pengjie Yang, Shoubao Yang, Wenjie Dai, and Haifang Xu
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0106 biological sciences ,0301 basic medicine ,Mitochondrial DNA ,Phylogenetic tree ,phylogenetic analysis ,Biology ,Acanthorhodeus chankaensis Dybowski ,010603 evolutionary biology ,01 natural sciences ,03 medical and health sciences ,030104 developmental biology ,Acanthorhodeus chankaensis ,Evolutionary biology ,mitochondrial genome ,Genetics ,characterization ,Molecular Biology ,Mitogenome Announcement ,Sequence (medicine) ,Research Article - Abstract
In the present study, the complete mitogenome sequence of a Acanthorhodeus chankaensis Dybowsky from Cao’e River was sequenced and identified. The assembled mitogenome of A. chankaensis is 16,676 bp in length, it contains 22 transfer-RNA genes, 13 protein-coding genes, 2 ribosomal-RNA genes, and 2 non-coding regions. It shows conserved gene arrangement with other Cyprinidae fishes. The overall nucleotide composition of A. chankaensis mitogenome sequence is A: 28.96%, G: 17.11%, T: 27.46%, and C: 26.47%. The phylogenetic analysis showed that the complete mitogenome could contribute to the phylogenetic analyses and population genetics study of A. chankaensis and Acanthorhodeus fish.
- Published
- 2020
43. The Prevalence of Posttraumatic Stress Disorder Among Survivors After a Typhoon or Hurricane: A Systematic Review and Meta-Analysis
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Shi Wu Wen, Xiongfeng Pan, Ziyan Liu, Zhipeng Wang, Xiaoli Wu, Xin Wu, Shixiong Hu, Aizhong Liu, Atipatsa C. Kaminga, and Wenjie Dai
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Adult ,education.field_of_study ,Cyclonic Storms ,business.industry ,Population ,Public Health, Environmental and Occupational Health ,Poison control ,Suicide prevention ,Occupational safety and health ,030227 psychiatry ,Stress Disorders, Post-Traumatic ,03 medical and health sciences ,0302 clinical medicine ,Meta-analysis ,Typhoon ,Injury prevention ,Prevalence ,Humans ,Medicine ,Population study ,Survivors ,030212 general & internal medicine ,education ,business ,Demography - Abstract
Posttraumatic stress disorder (PTSD) is a psychological disorder, which could be caused by traumatic events. The prevalence of PTSD among survivors after a typhoon or hurricane varied widely. Therefore, this study aimed to determine a combined prevalence of PTSD among survivors after a typhoon or hurricane. A systematic search of literature was performed in the 3 English databases: PubMed (National Library of Medicine, Bethesda, MD), ISI Web of Science (Thomson Reuters, New York, NY), and Embase (Elsevier, Amsterdam, Netherlands). Also, a similar search was performed in the 2 Chinese databases such as Chinese National Knowledge Infrastructure and WanFang. Loney et al.’s criteria were used to evaluate the quality of the selected articles for this study. The combined prevalence of PTSD among the study population was estimated using the Freeman–Tukey double arcsine transformation method. Subgroup analyses and a meta-regression analysis were carried out to explore the origin of heterogeneity. Thirty-nine eligible articles were included in this study. They comprised 43 123 typhoon and hurricane survivors of which 9373 were diagnosed with PTSD. The combined prevalence of PTSD among this population was 17.81%. Subgroup analyses revealed that the combined prevalence of PTSD related to typhoon and hurricane Categories 5, 4, and 2 showing a corresponding decreasing tendency. About 18% of people who experienced a severe typhoon or hurricane develop PTSD with the prevalence decreasing with reduced severity of the typhoon or hurricane.
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- 2019
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44. The influence of contact area between implant and its adjacent teeth on finite element analysis
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Xi Lu and Wenjie Dai
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Orthodontics ,Materials science ,Materials Science (miscellaneous) ,Mandible ,Mandibular first molar ,Industrial and Manufacturing Engineering ,medicine.anatomical_structure ,stomatognathic system ,medicine ,Periodontal fiber ,Implant ,Business and International Management ,Contact area ,Cancellous bone ,Dental alveolus ,Stress concentration - Abstract
The aim of this work is to investigate the influence of contact area between the first molar implant and its adjacent teeth on finite element analysis. Five types of finite element contact models containing implant and its adjacent teeth were established: non-contact model (C0), contact models with different contact area (C1, C2, C3, C4). An occlusal force was applied to finite element models to calculate the stress of implant and bone interface on mandible. Compared with the group C0, the stress of alveolar bone surrounding the implant in other groups decreased 88.08 % at most, but the stress of cancellous bone surrounding the natural teeth increased 59.42 %. In summary, a proper small contact area can not only reduce the stress concentration on the implant region, but also can avoid an excessive stress in the periodontal ligament and alveolar bone around the natural teeth. The finite element results revealed that it is effectively to distribute the load implant suffered, especially to reduce the stress generated by the lateral load when the first molar implant has a small contact with its adjacent teeth.
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- 2019
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45. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
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Yu Cao, Shikhar Mehrotra, Eslam Mohamed, David H. Munn, Anthony M. Magliocco, Ling Cen, Rosa A. Sierra, Jose R. Conejo-Garcia, Richard Klar, Carmen M. Anadon, Sven Michel, Juan R. Cubillos-Ruiz, Wenjie Dai, Jimena Trillo-Tinoco, Paulo C. Rodriguez, Douglas C. Marchion, Frank Jaschinski, Richard R. Reich, and Tara Lee Costich
- Subjects
0301 basic medicine ,Adoptive cell transfer ,medicine.medical_treatment ,General Physics and Astronomy ,02 engineering and technology ,CD8-Positive T-Lymphocytes ,Carcinoma, Ovarian Epithelial ,CHOP ,Mice ,eIF-2 Kinase ,hemic and lymphatic diseases ,Tumor Microenvironment ,RNA, Small Interfering ,lcsh:Science ,Mice, Knockout ,Ovarian Neoplasms ,Immunity, Cellular ,Multidisciplinary ,Effector ,Chemistry ,Endoplasmic Reticulum Stress ,021001 nanoscience & nanotechnology ,Adoptive Transfer ,Publisher Correction ,3. Good health ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,Tumour immunology ,Female ,0210 nano-technology ,Science ,T cell ,chemical and pharmacologic phenomena ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Lymphocytes, Tumor-Infiltrating ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Tumor microenvironment ,Immunosurveillance ,General Chemistry ,Immunotherapy ,Activating Transcription Factor 4 ,Survival Analysis ,Xenograft Model Antitumor Assays ,030104 developmental biology ,Unfolded protein response ,Cancer research ,lcsh:Q ,T-Box Domain Proteins ,Transcription Factor CHOP ,CD8 - Abstract
Understanding the intrinsic mediators that render CD8+ T cells dysfunctional in the tumor microenvironment is a requirement to develop more effective cancer immunotherapies. Here, we report that C/EBP homologous protein (Chop), a downstream sensor of severe endoplasmic reticulum (ER) stress, is a major negative regulator of the effector function of tumor-reactive CD8+ T cells. Chop expression is increased in tumor-infiltrating CD8+ T cells, which correlates with poor clinical outcome in ovarian cancer patients. Deletion of Chop in T cells improves spontaneous antitumor CD8+ T cell immunity and boosts the efficacy of T cell-based immunotherapy. Mechanistically, Chop in CD8+ T cells is elevated primarily through the ER stress-associated kinase Perk and a subsequent induction of Atf4; and directly represses the expression of T-bet, a master regulator of effector T cell function. These findings demonstrate the primary role of Chop in tumor-induced CD8+ T cell dysfunction and the therapeutic potential of blocking Chop or ER stress to unleash T cell-mediated antitumor immunity., T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting in repression of T-bet and consequent inhibition of CD8+ T cell function.”
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- 2019
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46. Prevalence of Moderate to Severe Anxiety Symptoms among Patients with Myocardial Infarction: a Meta-Analysis
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Yajun, Lian, Jingsha, Xiang, Xiaoyan, Wang, Atipatsa C, Kaminga, Wenhang, Chen, Zhiwei, Lai, Wenjie, Dai, and Jianzhou, Yang
- Subjects
Myocardial Infarction ,Prevalence ,Humans ,Anxiety ,Anxiety Disorders ,Risk Assessment - Abstract
This study attempted to synthesize the evidence on the prevalence of moderate to severe anxiety symptoms among myocardial infarction (MI) patients to offer a reliable and accurate estimate on the number of MI patients suffering from moderate to severe anxiety symptoms. Comprehensive electronic searches (PubMed, Embase and Web of Science) were performed from their inception to February 2021. Between-study heterogeneity was analyzed using the Cochran's Q test and [Formula: see text] statistic, and if it was high across the eligible studies, meta-regression and subgroup analyses were conducted to examine the source of heterogeneity. Publication bias and the robustness of the pooled results were also examined. A total of 18 eligible studies covering 8,532 MI patients were included, of which 3,443 were identified with moderate to severe anxiety symptoms. Between-study heterogeneity was high ([Formula: see text]=98.8%) with the reported prevalence ranging from 9.6% to 69.17%, and the pooled prevalence was 38.08% (95% confidence interval: 28.82-47.81%) by a random-effects model. Meta-regression analyses indicated that publication year (β = -0.014) was significant moderators contributing 16.11% to the heterogeneity. Subgroup analyses indicated that studies using the anxiety subscale of Brief Symptom Inventory to assess anxiety were homogenous ([Formula: see text]=0.0). Furthermore, the pooled prevalence of moderate to severe anxiety symptoms varied significantly by geographic region, instrument used to assess anxiety, methodological quality, sex, education level, a history of previous MI and hypercholesterolemia. Additionally, the results of Egger's linear test (t = -0.630) and Begg's rank test (z = -0.190) indicated no evidence of publication bias, and the sensitivity of the pooled results was low. Nearly two fifth of MI patients suffered from moderate to severe anxiety symptoms, which emphasizes the importance of early identification of anxiety symptoms after MI, as well as the need of implementing psychological interventions for those with elevated anxiety symptoms.
- Published
- 2021
47. Effects of olanzapine treatment on lipid profiles in patients with schizophrenia: a systematic review and meta-analysis
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Wenqiang Zhu, Rong Li, Jingmei Xiao, Xin Su, Yiqi Zhang, Chen Ding, Wen Dai, Zhenhua Xing, Wenjie Dai, and Xiansheng Huang
- Subjects
Olanzapine ,medicine.medical_specialty ,Metabolic disorders ,lcsh:Medicine ,Disease ,Cochrane Library ,Article ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,Medicine ,Humans ,In patient ,lcsh:Science ,Multidisciplinary ,business.industry ,lcsh:R ,medicine.disease ,Lipid Metabolism ,Lipids ,030227 psychiatry ,Cardiovascular diseases ,Schizophrenia ,Meta-analysis ,lcsh:Q ,lipids (amino acids, peptides, and proteins) ,business ,Psychiatric disorders ,030217 neurology & neurosurgery ,Dyslipidemia ,medicine.drug ,Antipsychotic Agents - Abstract
Olanzapine-induced dyslipidemia significantly increases the risk of cardiovascular disease in patients with schizophrenia. However, the clinical features of olanzapine-induced dyslipidemia remain hitherto unclear because of inconsistencies in the literature. This meta-analysis thus investigated the effects of olanzapine treatment on lipid profiles among patients with schizophrenia. Studies of the effects of olanzapine on lipids were obtained through the PubMed, Web of science, The Cochrane Library and Embase databases (up to January 1, 2020). Twenty-one studies and 1790 schizophrenia patients who received olanzapine therapy were included in our analysis. An olanzapine-induced increase was observed in plasma triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels in patients with schizophrenia (all P P P > 0.05). In conclusion, olanzapine-induced dyslipidemia, characterized by increased TG, TC, and LDL-C levels, was observed in patients with schizophrenia already by 4 weeks of olanzapine treatment.
- Published
- 2020
48. Delays in hospital admissions in patients with fractures across 18 low-income and middle-income countries (INORMUS): a prospective observational study
- Author
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Panthea Pouramin, Chuan Silvia Li, Jason W Busse, Sheila Sprague, P J Devereaux, Jagnoor Jagnoor, Rebecca Ivers, Mohit Bhandari, PJ Devereaux, Gordon Guyatt, Brad Petrisor, Lehana Thabane, Respicious L. Boniface, Bruce Browner, Fernando de la Huerta, Rebecca Q Ivers, Theodore Miclau, Paul Moroz, Andrew Pollak, Gerard Slobogean, Parag Sancheti, Emil Schemitsch, Junlin Zhou, Paula McKay, Raman Mundi, Nathan O'Hara, Diane Heels-Ansdell, Lisa Buckingham, Nicole Simunovic, Robyn Norton, Jing Zhang, Maoyi Tian, Soumyadeep Bhaumik, Samina Parveen, Saam Morshed, Madeline C. MacKechnie, Yang Liu, Yanrui Zhao, Junfei Li, Haoran Zhang, Zhentao Zhang, Wei Zhang, Tao Guo, Guang Chen, Zichao Jia, Jianzhong Yang, Lixing Kang, Peng Zhang, Haoqing Ma, Donghai Liu, Yinghua Ma, Yanguo Qin, Jincheng Wang, He Liu, Xinlong Ma, Jianxiong Ma, Haobo Jia, Shuangshuang Cui, Zhihu Zhao, Lin Fu, Hongqiang Jiang, Jianwei Lv, Sanbao Hu, Yongwei Wang, Mingyao Sun, Shuqing Tao, Baochang Qi, Ming Gao, Bo Wu, Chunsheng Zhi, Ben Xing, Jun Yang, Wenjie Dai, Duo Lu, Shisheng He, Xinyu Cai, Gejun Liu, Gang Rui, Baoshan Hu, Pingfang Shi, Hua Chen, Te Wang, Qingqing Wang, Linzhen Xie, Huanguang Xie, Tony Mutanda, Juliet Ntuulo, Flavia Lubega, Gayita Teddy Tracy, Kayondo Zaitun, Sylvester Ndayisaba, Titus Amone, Samuel Remmy Odong, Mark Lutomia, Caesar Okatch, Thomas Bitok, Alexander Kiambuthi, Fred Mathew Toboso Otsyeno, Pankaj G Jani, Vincent Muoki Mutiso, John EO Ating'a, Peter Kavoo Kilonzo, James Muoki, Makena Mbogori, Joan Wambui Wambugu, Dorothy Torutt, Christopher Odok, Elisha Ngetich, Dean Otsyeno, Juma Wakhayanga, Desmond Nzioka, Deogracia Owende, Ruth Lucinde, Brian Ngure Kariuki, Dennis Kinyua, Maureen Kamau, Maureen Mwancha, Mellany Murgor, Marilyn Nyabuti, Rita Njoki, Patricia Wanza, Abraham Odongo, Paul Marealle, Athman Wanini, Marwa Elisha, Damas Zumbulu, Pariyo Bonane Godfrey, Benjamin Mukulu Ndeleva, Murila Johnson, Moses Kimani, Kinuthia Gichui, Rogers Joachin Temu, Angela Neofitus Mselle, Ancelimu Rafael Kimario, Mmampapatla Thomas Ramokgopa, Gregory Firth, Anna Grisillo Biscardi, Machuene Ananias Poopedi, Johan Moolman, Brenda Milner, Matimba Maluleke, Maxwell Jingo, Susan van Deventer, Timothy Pikor, Ravi Bhaga, Michael Mara, Geoffrey Chege Mwangi, Anthony Muchiri Maina, David Wamae Gicheru, Carol Mwangi, Isaac Kingori Wangai, Peter Watson Maina, Ezra Mitei Kiptoo, Olufemi Olukemi Temiloluwa, Adeyeye Adeolu Ikechukwu, Ige Oluwole Olugbenga, Ojodu Ishaq Bamidele, Oladimeji Oladipupo Akanbi, Panchu Subramanian, Olivia L Mosweu, Samuel Hailu, Geletaw Tessema, Bahiru Bezabih, Birhanu Ayana, Hiwot Hailu, Betelhem Zewdneh, Hana Tesfaye, Sosena Tadesse, Dominic Konadu-Yeboah, Vincent Ativor, Peter Konadu, Dominic Awariyah, Raphael Quartey, Raphael Kumah-Ametepey, Osman Saani, Robert Ekow Quansah, Paa Kwesi Baidoo, Peter Trafton, David Anyitey-Korkor, Michael Leat, Johnny Sobotie, Godwin Opuni, Kwasi Kusi, Twimasi Baah, Paul Okyere, Bernice Mensah, Doris Akuoko Sarpong, Felicia Agbenorwu, Phyllis Osei-Donkor, Priscilla Opoku, Michael Segbefia, Gerald Chukwuemeka Oguzie, Emmanuel Chino Iyidobi, Cajetan Uwatoronye Nwadinigwe, Sharon Amarachi Uloma Oguzie, Emina Bami Kesiena, Henry Tanyi Ndasi, Nietiayurk Aminake Ghislain, Mala Irine Shey, Ikose John Nanje, Ashok Shyam, Madhav Borate, Sampat Dumbre Patil, Sachin Karkamakar, Shailesh Patil, Abhijeet Ranaware, Shadab Tamboli, Manish Gandhalikar, Rohini Tupe, Vishal Chaudhari, Avanti Joshi, Sanjay Patil, Mohit Madhukar Dalwekar, Tejas Gandhi, Chintamani Latkar, Gopal Pundkare, Sandeep Shrivastava, Pradeep K Singh, Sanjay Deshpande, Sumit Baheti, Ravi Mittal, Vijay Sharma, Vinoo Mathew Cherian, Thilak Samuel Jepegnanam, Vijay T K Titus, Manasseh Nithyananth, Palapattu R J V C Boopalan, Viju Daniel Varghese, Justin Arockiaraj, Anupam Mahajan, Bobby John, Ritesh Pandey, Jeewan S Prakash, Valsamma Abraham, Arti Rajkumar, Harvinder Singh Chhabra, Rajesh Sharawat, Ritabh Kumar, Pushkar Chawla, Rashmi Yadav, Rajagopalan N Iyer, Naveen Nair, Rajkumar S Amaravathi, Srinivasalu Santhanagopa, Anoop Pilar, Keith Behram Tamboowala, Mandeep S Dhillon, Sarvdeep S Dhatt, Asolie Chase, Neel M Bhavsar, Rameez Musa, Darshan Shah, Sunil Chodavadiyah, Pankaj G Patel, Raja Irfan Qadir, Syed Imran Bukhari, Khushnood Ali Baz, Subin Byanjankar, Ruban Raj Joshi, Rajeev Dwivedi, Jay Raj Sharma, La Ngoc Quang, Nguyen Duc Chinh, Vu Bao Hong, Paphon Sa-ngasoongsong, Noratep Kulachote, Norachart Sirisreetreerux, Wanjak Pongsamakthai, Irewin Alagar Tabu, Paula Veronica Reyes, Iardinne Caiquep, Joni Mitchell Robles Bituin, Jenna González, Mohammadreza Golbakhsh, Mashyaneh Haddadi, Soheil Saadat, Mohammadreza Zafarghandi, Clotilde Fuentes Orozco, José de Jesús Martínez Ruíz, Gustavo Armando Tafoya Arreguin, César Eduardo Pinedo Flores, Irydia Guadalupe Pellegrini Verduzco, Miguel Oscar Hernandez Camacho, Diego Abraham Estrada Téllez, Rodrigo Salcedo López, Ileana Guadalupe Canales Navarro, Mizael Dennis Pérez, Daniel de Jesús Enciso Carrillo, Paola Alejandra Álvarez López, Adán Cervantes Gómez, Fátima Nohemí Franco Bravo, Eugenia de los Ángeles Reyes Arias, Igor A. Escalante Elguezabal, Ennio Antonio Rizzo, Jean Michel Hovsepian, Victor Rodriguez, Manuel Malaret Baldo, Andres Serrano, Carlos G. Sanchez Valenciano, Edgar Efren Mercado Salcedo, Fryda Medina, Fernando Bidolegui, Sebastian Pereira, Gerardo Aguilar, Jorge Rubio-Avila, William Dias Belangero, José Ricardo Lenzi Mariolani, Bruno Livani, André Lugnani, Felipe Rossi, Angela Katayama, Fernando Baldy, Vinícius Ynoe de Moraes, Fabricio Fogagnolo, Kodi Edson Kojima, Jorge dos Santos Silva, Marco Kawamura Demange, Fernando Brandão de Andrade-Silva, Adriana Carvalho Gomes da Silva, Nelson Elias, Dino Aguilar Martinez, Fernando Contreras, Mario Garuz, Jose Eduardo Quintero, Gavino Merchan, Christian M. Lozano Lurita, Aturo D. Torres Manrique, Jorge Hurtado Fernandez, Sergio Iriarte Vincenti, Alfredo Pozzo Bobarin, Dalton Salinas Sanchez, Julio Segovia Altieri, Diego Almada, Derlis Bogado, Carlos Coronel, Cristian Boveda, Victor del Valle, Carlos Montiel, Nelson Marin, Antonio Barquet, Daniel Rienzi, Carlos Amanquez, Georges Beauvoir, Iván J Salce Cutipa, José Eduardo Grandi Ribeiro, José María Jiménez Avila, Luis Padilla, Hernando Cuevas Ochoa, Hernando Cuevas Cano, Adriana Vaca González, Nubia Itzel Gonzalez Gutierrez, and Victor Espinola
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Adult ,Male ,medicine.medical_specialty ,Referral ,INORMUS investigators ,030231 tropical medicine ,MEDLINE ,Logistic regression ,Time-to-Treatment ,1117 Public Health and Health Services ,03 medical and health sciences ,Fractures, Bone ,0302 clinical medicine ,Patient Admission ,Medicine and Health Sciences ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Developing Countries ,business.industry ,lcsh:Public aspects of medicine ,lcsh:RA1-1270 ,General Medicine ,Emergency department ,Odds ratio ,Middle Aged ,3. Good health ,Socioeconomic Factors ,Relative risk ,Emergency medicine ,Observational study ,Female ,business ,0605 Microbiology - Abstract
© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: The Lancet Commission on Global Surgery established the Three Delays framework, categorising delays in accessing timely surgical care into delays in seeking care (First Delay), reaching care (Second Delay), and receiving care (Third Delay). Globally, knowledge gaps regarding delays for fracture care, and the lack of large prospective studies informed the rationale for our international observational study. We investigated delays in hospital admission as a surrogate for accessing timely fracture care and explored factors associated with delayed hospital admission. Methods: In this prospective observational substudy of the ongoing International Orthopaedic Multicenter Study in Fracture Care (INORMUS), we enrolled patients with fracture across 49 hospitals in 18 low-income and middle-income countries, categorised into the regions of China, Africa, India, south and east Asia, and Latin America. Eligible patients were aged 18 years or older and had been admitted to a hospital within 3 months of sustaining an orthopaedic trauma. We collected demographic injury data and time to hospital admission. Our primary outcome was the number of patients with open and closed fractures who were delayed in their admission to a treating hospital. Delays for patients with open fractures were defined as being more than 2 h from the time of injury (in accordance with the Lancet Commission on Global Surgery) and for those with closed fractures as being a delay of more than 24 h. Secondary outcomes were reasons for delay for all patients with either open or closed fractures who were delayed for more than 24 h. We did logistic regression analyses to identify risk factors of delays of more than 2 h in patients with open fractures and delays of more than 24 h in patients with closed fractures. Logistic regressions were adjusted for region, age, employment, urban living, health insurance, interfacility referral, method of transportation, number of fractures, mechanism of injury, and fracture location. We further calculated adjusted relative risk (RR) from adjusted odds ratios, adjusted for the same variables. This study was registered with ClinicalTrials.gov, NCT02150980, and is ongoing. Findings: Between April 3, 2014, and May 10, 2019, we enrolled 31 255 patients with fractures, with a median age of 45 years (IQR 31–62), of whom 19 937 (63·8%) were men, and 14 524 (46·5%) had lower limb fractures, making them the most common fractures. Of 5256 patients with open fractures, 3778 (71·9%) were not admitted to hospital within 2 h. Of 25 999 patients with closed fractures, 7141 (27·5%) were delayed by more than 24 h. Of all regions, Latin America had the greatest proportions of patients with delays (173 [88·7%] of 195 patients with open fractures; 426 [44·7%] of 952 with closed fractures). Among patients delayed by more than 24 h, the most common reason for delays were interfacility referrals (3755 [47·7%] of 7875) and Third Delays (cumulatively interfacility referral and delay in emergency department: 3974 [50·5%]), while Second Delays (delays in reaching care) were the least common (423 [5·4%]). Compared with other methods of transportation (eg, walking, rickshaw), ambulances led to delay in transporting patients with open fractures to a treating hospital (adjusted RR 0·66, 99% CI 0·46–0·93). Compared with patients with closed lower limb fractures, patients with closed spine (adjusted RR 2·47, 99% CI 2·17–2·81) and pelvic (1·35, 1·10–1·66) fractures were most likely to have delays of more than 24 h before admission to hospital. Interpretation: In low-income and middle-income countries, timely hospital admission remains largely inaccessible, especially among patients with open fractures. Reducing hospital-based delays in receiving care, and, in particular, improving interfacility referral systems are the most substantial tools for reducing delays in admissions to hospital. Funding: National Health and Medical Research Council of Australia, Canadian Institutes of Health Research, McMaster Surgical Associates, and Hamilton Health Sciences.
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- 2020
49. Blood Pressure Variability and Outcomes in End-Stage Renal Disease Patients on Dialysis: A Systematic Review and Meta-Analysis
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Jing Xue, Peng Zhu, Wenjie Dai, Xiaohua Liao, Huihui Li, Wenhang Chen, and Qiaoling Zhou
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,medicine.medical_treatment ,Diastole ,MEDLINE ,Blood Pressure ,lcsh:RC870-923 ,End stage renal disease ,systematic review ,Renal Dialysis ,Internal medicine ,lcsh:Dermatology ,medicine ,Humans ,Dialysis ,Cardiovascular mortality ,end-stage renal disease ,hemodialysis ,business.industry ,General Medicine ,lcsh:RL1-803 ,lcsh:Diseases of the genitourinary system. Urology ,meta-analysis ,Blood pressure ,Treatment Outcome ,lcsh:RC666-701 ,Nephrology ,Cardiovascular Diseases ,Meta-analysis ,Kidney Failure, Chronic ,blood pressure variability ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: Previous studies have suggested that blood pressure variability (BPV) is associated with an increased risk of mortality and cardiovascular events in patients on dialysis. However, the results are inconsistent. A comprehensive literature review was conducted to analyze the association between BPV and outcomes in patients on dialysis. Methods: Articles in Embase, Medline, and Web of Science from the date of inception through January 1, 2020, were identified. The outcomes were all-cause and cardiovascular mortality and cardiovascular events. The risk of bias was assessed using the Newcastle-Ottawa scale tool. Random effects models were used to pool the overall effect sizes. Two reviewers extracted the data independently. Meta-regression and subgroup analyses were performed to explore potential heterogeneity. Results: Fifteen eligible studies were included, and all enrolled hemodialysis recipients only. The overall risk of bias for the included studies was low. A 1-SD increase in systolic BPV was associated with higher risks of all-cause mortality (HR = 1.18; 95% CI 1.11–1.26, I2 = 53.8%), cardiovascular mortality (HR = 1.23; 95% CI 1.10–1.37, I2 = 57.2%), and cardiovascular events (HR = 1.27; 95% CI 1.07–1.51, I2 = 69.3%). Likewise, a 1-SD increase in diastolic BPV was associated with higher HR for all-cause and cardiovascular mortality (HR = 1.14; 95% CI 1.05–1.23, I2 = 0.0%, and HR = 1.14; 95% CI 0.94–1.38, I2 = 0.0%, respectively). Conclusions: A greater BPV is associated with higher risks of cardiovascular and mortality outcomes in patients on hemodialysis. Further research is required to determine whether BPV may be useful either as a marker enabling individualized treatment of cardiovascular risk or as a treatment target in its own right.
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- 2020
50. Visit-to-visit blood pressure variability and risk of chronic kidney disease: A systematic review and meta-analyses
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Qiaoling Zhou, Wenjie Dai, Yusa Chen, Jing Xue, Wenhang Chen, and Huihui Li
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Epidemiology ,Blood Pressure ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Vascular Medicine ,0302 clinical medicine ,Mathematical and Statistical Techniques ,Endocrinology ,Risk Factors ,Chronic Kidney Disease ,Medicine and Health Sciences ,030212 general & internal medicine ,Prospective cohort study ,Multidisciplinary ,Statistics ,Metaanalysis ,Research Assessment ,Type 2 Diabetes ,Nephrology ,Meta-analysis ,Physical Sciences ,Hypertension ,Medicine ,Anatomy ,Research Article ,medicine.medical_specialty ,Systematic Reviews ,Endocrine Disorders ,Science ,Research and Analysis Methods ,Nephropathy ,03 medical and health sciences ,Internal medicine ,medicine ,Diabetes Mellitus ,Humans ,Risk factor ,Statistical Methods ,Renal Insufficiency, Chronic ,business.industry ,Biology and Life Sciences ,Renal System ,medicine.disease ,Blood pressure ,Relative risk ,Metabolic Disorders ,Medical Risk Factors ,business ,Mathematics ,Kidney disease - Abstract
Objective Previous studies have shown that visit-to-visit blood pressure variability (BPV) is associated with chronic kidney disease (CKD). However, the results have not been consistent among studies. This systematic review and meta-analysis was conducted to comprehensively assess the association between visit-to-visit BPV and the risk of CKD. Methods Medline, Embase, and the Cochrane Library were searched from the date of inception through 1 August 2019 using the terms “blood pressure variability,” “chronic kidney disease,” “nephropathy,” and other comparable terms. The primary outcome was the development of CKD. Two reviewers extracted the data independently. Meta-analysis was performed using a random effects model. Results Fourteen studies were included in the systematic review and meta-analysis. The risk of CKD was significantly greater in patients with high baseline systolic blood pressure variability (SBPV) than in patients with low baseline SBPV: the standard deviation (SD) showed relative risk (RR) of 1.69 and 95% CI of 1.38–2.08, the coefficient of variation (CV) showed RR of 1.23 and 95% CI of 1.12–1.36, and variance independent of mean (VIM) showed RR of 1.40 and 95% CI of 1.15–1.71. RRs for each unit increase in visit-to-visit SBPV and risk of CKD were 1.05 (95% CI: 1.03–1.07) for SD, 1.06 (95% CI: 1.03–1.09) for CV, and 1.1 (95% CI: 0.96–1.25) for VIM. Diastolic BPV was similarly predictive of CKD based on SD and CV. Conclusions Increased visit-to-visit BPV might be an independent risk factor for CKD. However, significant heterogeneity was present; thus, future prospective studies are needed to confirm our findings. Our results indicate that treatment of hypertension should control blood pressure levels and prevent abnormal fluctuations in blood pressure to reduce the risk of CKD.
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- 2020
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