Christopher C. Rowe, Peter M. Clifton, Cassandra Szoeke, Vanessa Ward, Samantha L. Gardener, David Ames, Richard Head, Yian Gu, Nikolaos Scarmeas, Stephanie R. Rainey-Smith, Kathryn A. Ellis, Jennifer B Keogh, Ralph N. Martins, Colin L. Masters, Alinda Mondal, Margaret Barnes, S L Macaulay, Kevin Taddei, S. L. Mathieson, Gardener, S, Gu, Y, Rainey-Smith, SR, Keogh, JB, Clifton, PM, Mathieson, SL, Taddei, K, Mondal, A, Ward, VK, Scarmeas, N, Barnes, M, Ellis, KA, Head, R, Masters, CL, Ames, D, Macaulay, SL, Rowe, CC, Szoeke, C, Martins, RN, and AIBL Research Group
The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P