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The rheological properties of cement grouts are significantly affected by the changes of the time and the water-cement ratio, which determine the diffusion state of grouts in rocks and soils and influence the outcome of projects. In this study, Portland cement grouts with water-cement ratios of 0.50, 0.55, 0.60, 0.65, 0.70, and 0.75 at six moments, including 0 minutes, 5 minutes, 10 minutes, 20 minutes, 30 minutes, and 60 minutes, were evaluated to figure out the comprehensive effect of the time and the water-cement ratio on the rheological properties of power-law cement grouts. The results showed that the water-cement ratio had a great influence on both the consistency coefficient and the rheological index of the power-law cement grouts. The former appeared to have a downward trend with the increase of the water-cement ratio, and the latter appeared to have an upward trend. There was a rising tendency between the time and the consistency coefficient, while the rheological index was less affected by time. The difference between its maximum and minimum values was within 5%. Combined with the perspectives of statistical theory, practical applicability, and accuracy, the exponential model was the optimal model for showing the relationship between the comprehensive effects of the time, water-cement ratio, and consistency coefficient of the power-law cement grouts. The linear model was the optimal model of the rheological index based on the comprehensive effect of time and the water-cement ratio. Based on this, a power-law rheological equation with consideration of the comprehensive effect of time and water-cement ratio was established. The research results could not only improve the rheological theory of power-law cement grouts but also provide technical support for engineering practice.

Zi-Zheng Song, 1 Li-Fen Zhao, 2 Jing Zuo, 3 Zhi-Song Fan, 3 Long Wang, 3 Yu-Dong Wang 3 1Department of Medical Oncology, The Affiliated Hospital of Hebei University, Baoding, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The Shanxi Dayi Hospital, Taiyuan, People’s Republic of China; 3Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of ChinaCorrespondence: Yu-Dong WangDepartment of Medical Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People’s Republic of ChinaTel +86 159 3116 6600Email wyd_999@126.comPurpose: This study investigated the clinical outcomes and safety of apatinib mesylate in the treatment of advanced non-squamous non-small cell lung cancer (NSCLC) in patients who progressed after standard therapy, and analyzed the kinase insert domain receptor (KDR) gene polymorphism.Methods: A total of 135 patients with advanced non-squamous NSCLC who received apatinib mesylate were included. Objective response rates were evaluated. Subsequently, progression-free survival (PFS) and overall survival (OS) were assessed and safety data were recorded. Additionally, peripheral blood and biopsy cancer tissue specimens were collected from the patients with NSCLC for the genotyping of the genetic polymorphism and mRNA expression of the KDR gene, respectively. Analysis on the association between genotypes and prognosis was conducted.Results: The objective response rate of the 135 patients with NSCLC was 18.52%, disease control rate was 65.19%, median PFS was 3.95 months, and median OS was 10.05 months. Regarding the KDR gene polymorphism analysis, the distribution of the 4397T>C polymorphism genotypes was in accordance with the Hardy–Weinberg Equilibrium (P=0.868). Moreover, the prognosis analysis indicated that the median PFS of patients with the CC/TC and TT genotypes was 2.80 and 4.80 months, respectively (P=0.002). Furthermore, the median OS of patients with the two genotypes was 9.10 and 10.56 months, respectively (P=0.041). The multivariate Cox regression analysis showed that the TC/CC genotypes were an independent factor for PFS (odds ratio: 1.72, P=0.009). There was no correlation between the polymorphism and adverse reactions. Additionally, the mRNA expression analysis suggested that the mRNA levels of KDR in cancer tissues were significantly different between the TT and TC/CC genotypes (P< 0.001).Conclusion: The clinical outcomes of treatment with apatinib mesylate for advanced non-squamous NSCLC in patients who progressed after standard therapy may be influenced by the KDR 4397T>C polymorphism through mediation of the mRNA expression of KDR.Keywords: non-small cell lung cancer, apatinib mesylate, kinase insert domain receptor, polymorphism, clinical outcomes, safety

The process with the center-of-mass (CM) energy in the range from 3.7 to 10.6 GeV is calculated up to the next-to-leading order (NLO) in quantum chromodynamics (QCD). At 10.6 GeV, the result is consistent with the experimental result from Belle. However, the predictions are much smaller than the background in the measurements at BESIII in the low CM energy range from 3.7 to 4.6 GeV. This indicates that the convergence of the QCD perturbative expansion becomes worse as the CM energy is closer to the inclusive production threshold. For a further study of the QCD mechanism of production in collisions with different CM energies, the initial state radiation effect of and are calculated in QCD NLO. The results are plotted and the number of events for different CM energy bins are provided for SuperKEKB. This provides a method to precisely test the validity of perturbative predictions for production in future measurements.

At the designed circular electron-positron collider (CEPC), similar to the hadron collider, the angular distribution coefficients of the decay lepton pair from the produced Z(W) boson in collisions are predicted. Their dependence on cos (cos ) are presented in four different polarization frames. Furthermore, the value of the angular distribution coefficients in different bins of cos are presented in the C-S frame. In comparison with the case at the hadron collider, better accurate measurement for Z(W) is expected because there is less background, and W could be reconstructed from its leptonic decay channel. This works provides a method to precisely test the electroweak production mechanism or some effect induced from new physics in the future measurements at the CEPC.

Up to the next-leading order (NLO) of quantum chromodynamics (QCD), the process $e^+e^-\to J/\psi +X$ with the center-of-mass (CM) energy range from 3.7 to 10.6 GeV is calculated. At 10.6 GeV, the results is consistent with the experiment results at the Belle. However, the predictions are much smaller than the measurement at BESIII at low CM energy range from 3.7 to 4.6 GeV. This indicates that the convergence of QCD perturbative expansion becomes worse as the CM energy becomes lower and closer to the inclusive $J/\psi$ production threshold. For a further study of the QCD mechanism on $J/\psi$ production at $e^+e^-$ collider with different CM energy, the initial state radiation effect of $e^+e^-\to J/\psi+gg$ and $e^+e^-\to J/\psi+c \bar{c}$ are calculated at the QCD NLO. The results are plotted and the numbers of events for different CM energy bins are provided for the designed SuperKEKB. This provides a method to precisely test the validity of perturbative prediction on $J/\psi$ production in future measurements., Comment: 7 pages, 9 figures

Up to the next-leading order (NLO) of quantum chromodynamics (QCD), the process $e^+e^-\to J/��+X$ with the center-of-mass (CM) energy range from 3.7 to 10.6 GeV is calculated. At 10.6 GeV, the results is consistent with the experiment results at the Belle. However, the predictions are much smaller than the measurement at BESIII at low CM energy range from 3.7 to 4.6 GeV. This indicates that the convergence of QCD perturbative expansion becomes worse as the CM energy becomes lower and closer to the inclusive $J/��$ production threshold. For a further study of the QCD mechanism on $J/��$ production at $e^+e^-$ collider with different CM energy, the initial state radiation effect of $e^+e^-\to J/��+gg$ and $e^+e^-\to J/��+c \bar{c}$ are calculated at the QCD NLO. The results are plotted and the numbers of events for different CM energy bins are provided for the designed SuperKEKB. This provides a method to precisely test the validity of perturbative prediction on $J/��$ production in future measurements., 7 pages, 9 figures

The WST-1 assay is an efficient test for cell viability measurement and the standard incubation time is 2h. In order to test if one-time addition of WST-1 reagent can reflect the relative cell viability trend of the testing agents at different time points, the effects of 2h standard incubation time and long term incubation time (2h+24h, 2h+48h) of WST-1 were compared in the rat airway smooth muscle cells (ASM cells) after adding of the testing protein MRP-14. Our study demonstrated that the effect of different dosages of the protein after 2h WST-1 incubation on ASM cells showed a tendency of inhibition and achieved the maximal inhibition effect at 72h. The relative cell viability trend of the 2h+24h group was the same to that of the 2h WST-1 incubation, which means that 24h prolonged incubation time of WST-1 reagent could still reflect the relative cell viability trend. In conclusion, the study suggested that the WST-1 is a proper candidate reagent for continuous monitation of cell viability.

Objective: To analyze the plasmatic ADM level in early pregnancy and to investigate the diagnostic value of ADM in early ectopic pregnancy (EP). Methods: 70 patients with EP who had menopause for 5~8 weeks were included as study group, while 155 women with normal intrauterine pregnancy were also included as control group. The correlation between ADM level and menopause weeks was statistically analyzed and ROC curve was used to identify the diagnostic value of ADM. Results: (1) In 155 cases of normal intrauterine pregnancy, the plasmatic ADM level was increased with menopause weeks in linear relationship, and the correlation coefficient (R) was 0.991 (P0.05). (2) The multiple of median of plasmatic ADM level in EP group of menopause for 8 weeks was obviously lower than the intrauterine control group (P0.05) regardless of menopause weeks, however, the area under the ROC curve was 0.702 (P

Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection (IMI) alone and combination of IMI with Chinese herbal medicine.Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chorionic gonadotropin β (β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse.Results: The treatment of all the 35 women was successful. The recovery duration of serum β-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0±7.8 days, 1.2±0.7 months and 10.7±2.9 days respectively, which were significantly different from those in the control group (24. 4 ±8.1 days, 3.6±1.7 months and 19.1±3. 2 days respectively(P 0.05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43.8% respectively, that in the treatment group was less significant (P 0.05).Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain equal efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.

The practice of stimulating follicular development by Shen-invigorating herbs is directed by traditional Chinese medical theories of "the Shen stores essence of life and governs reproduction" and also the theory of "females" periodicity of the ebb and flow of the blood sea". The follicular phase has physiologic characteristics of blood sea ebbing and yin growing, accordingly using the treating principle of invigorating Shen and nourishing the essence can stimulate follicles" normal development and maturation which can cure many diseases such as female infertility, menoxenia and amenorrhoea. This article will give an introduction of the recent 10 years" research of Shen-invigorating treatment in stimulating follicular development

Channel estimation is important for coherent detection in UWB-OFDM systems, which accuracy affects system performance directly. Based on direct DFT, a windowed DFT estimation algorithm is proposed. The Hanning window is applied to channel impulse response to reduce the spectral leakage in the time domain. The channel information gained from the estimation is used for equalizing signals to reduce the influence of the multi-path channel. Analysis and simulation results show that with low estimation complexity the proposed method performance is better than the direct DFT.

Traditional methods could not satisfy the requirements of the system, because the duration time of the UWB pulse signals is short and the emissive power is low. Using the technique of wavelet transform, the effect of denoising, is obvious in UWB systems. Base on wavelet modulus maxima method, an improved method is proposed to denoising, that is ratio threshold with similar coefficients. It can restrain the noise and reserves the singularity of UWB signals. The simulation results show the new method is simpler and more efficient in denoising than traditional wavelet modular maximum method.

A study on the single event transient (SET) induced by a pulsed laser in a silicon-germanium (SiGe) heterojunction bipolar transistor (HBT) is presented in this work. The impacts of laser energy and collector load resistance on the SET are investigated in detail. The waveform, amplitude, and width of the SET pulse as well as collected charge are used to characterize the SET response. The experimental results are discussed in detail and it is demonstrated that the laser energy and load resistance significantly affect the SET in the SiGe HBT. Furthermore, the underlying physical mechanisms are analyzed and investigated, and a near-ideal exponential model is proposed for the first time to describe the discharge of laser-induced electrons via collector resistance to collector supply when both base-collector and collector-substrate junctions are reverse biased or weakly forward biased. Besides, it is found that an additional multi-path discharge would play an important role in the SET once the base-collector and collector-substrate junctions get strongly forward biased due to a strong transient step charge by the laser pulse.

Ionizing radiation effects in silicon-germanium (SiGe) heterojunction bipolar transistors (HBTs) at different dose rates were investigated. Experimental results show that the base current increases with increasing accumulated dose for the high and low dose rates of irradiation, causing a significant drop in current gain. Besides, the lower the dose rate, the higher the radiation damage, which demonstrates a significantly enhanced low-date-rate sensitivity (ELDRS) effect in the SiGe HBTs. The different degradation behaviors for high and low dose rates of irradiation are compared with each other and discussed; furthermore, the underlying physical mechanisms are analyzed and investigated in detail.

An analytical model for the drain-source breakdown voltage of an RF LDMOS power transistor with a Faraday shield is derived on the basis of the solution of the 2D Poisson equation in a p-type epitaxial layer, as well as an n-type drift region by means of parabolic approximation of electrostatic potential. The model captures the influence of the p-type epitaxial layer doping concentration on the breakdown voltage, compared with the previously reported model, as well as the effect of the other device parameters. The analytical model is validated by comparing with a numerical device simulation and the measured characteristics of LDMOS transistors. Based on the model, optimization of LDMOS device parameters to achieve proper trade-off between the breakdown voltage and other characteristic parameters such as on-resistance and feedback capacitance is analyzed.