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Additional file 1: Figure S1. Microglia-specific HDAC3 knockout does not alter baseline inflammation level in the homeostatic brain. Figure S2. Microglial expression of activation markers under baseline conditions (related to Fig. 2). Figure S3. HDAC3 miKO promotes the resolution of inflammation in the brain after TBI (related to Fig. 3). Table S1. Key resources. Table S2. The numbers of mice used in this study. Table S3. Tissue samples processed in this study. Table S4. Statistics reporting.

In the present study Inconel 625 alloy fabricated using Cold Metal Transfer (CMT) Wire Arc Additive Manufacturing (WAAM) has been investigated. The microstructure and mechanical properties of the fabricated Inconel625 alloy, and the influence of torch travel speed on the properties of the manufactured specimens were researched. Microstructural studies revealed variation in microstructure in different layers of the specimen, with the bottom layer consisting of fine primary cellular grains. Mechanical properties that include hardness and tensile properties showed that with the increase in the travel speed, average micro-hardness of the manufactured specimens slightly improved from 248 HV to 253 HV. The ultimate tensile strength (UTS) increased from 647 MPa to 687 MPa, while yield strength (YS) increased from 376 MPa to 400 MPa. Results showed that the mechanical performance of the manufactured components by CMT-WAAM method was better than the mechanical properties of Inconel 625 alloy casting parts except UTS, which demonstrated that the Inconel 625 alloys can be fabricated by cold metal transfer process.

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211028680 for Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury by Hongjian Pu, Cheng Ma, Yongfang Zhao, Yangfan Wang, Wenting Zhang, Wanying Miao, Fang Yu, Xiaoming Hu, Yejie Shi, Rehana K Leak, T Kevin Hitchens, C Edward Dixon, Michael VL Bennett and Jun Chen in Journal of Cerebral Blood Flow & Metabolism

Higher performance suspensions are necessary to obtain ultra-high magnetic areal density in hard disk drives (HDDs). Currently suspension-based dual stage actuated (DSA) designs utilize two piezoelectric actuators placed at the base of the suspension, allowing for a secondary input that can respond to undesirable off-track motion. Collocated designs are a probable DSA alternative. The design of a collocated head-based dual stage actuator is investigated using finite element analysis. The effect of gimbal design dimensions on the lateral deflection of the read-write element is evaluated. The resonant frequency response and stress distribution are studied. A comparison of the proposed dual stage head-based actuator is made with other suspension-based designs and the collocated design proposed by Lengert et al.[1]. Guidelines for optimization of the designs are presented and discussed