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We present a comment on "Spin-Momentum-Locked Edge Mode for Topological Vortex Lasing, Phys. Rev. Lett. vol. 125, 013903 (2020)"(hereafter the Letter).In the Letter, Yang et al. reported on an elegant topological vortex laser and proposed that the near-field spin and OAM of the topological edge mode lasing have a one-to-one far-field radiation correspondence. The near-field information is based on frequency dispersions of the topological edge modes, without supporting measurements and/or computer simulations. Unfortunately, their frequency dispersions shown in Fig. 1(c) (see also Fig. S6 and Eqs. (5.3) and (5.4) in Supplemental Material) are wrong. As the result, the mode assignment of the main mode |-2,+> investigated in the Letter is mistaken, which should be |2,+>. This spoils the one-to-one correspondence claimed in the Letter.

Our previous studies have shown that Ginkgo biloba extract increased endothelial progenitor-cell (EPC) numbers and functional activity. However, the mechanisms remain to be determined. Recent studies have demonstrated that increased EPC numbers and activity were associated with the inhibition of EPC senescence, which involved activation of telomerase. Therefore, we investigated whether Ginkgo biloba extract inhibited the onset of EPC senescence through telomerase activation, leading to potentiation of cellular activity. After ex vivo cultivation, EPCs became senescent as determined by acidic ss-galactosidase staining. Ginkgo biloba extract dose-dependently prevented the onset of EPC senescence in culture. Moreover, Ginkgo biloba extract increased proliferation of EPCs as assessed by MTT assay and colony-forming capacity. To get further insights into the underlying mechanisms of these effects, we measured telomerase activity and determined the phosphorylation of Akt by Western blotting. Ginkgo biloba extract significantly increased telomerase activity and phosphorylation of the serine/threonine protein kinase Akt, a downstream effector of phosphoinositide 3-kinase (PI3K). Moreover, pretreatment with PI3K inhibitor, LY294002, significantly attenuated the Ginkgo biloba extract-induced telomerase activity. Taken together, the results indicated that Ginkgo biloba extract delayed the onset of EPC senescence, which may be related to activation of telomerase through the PI3k/Akt signaling pathway. The inhibition of EPC senescence by Ginkgo biloba extract in vitro may improve the functional activity of EPCs in a way that is important for potential cell therapy.

The Bianchi type-III cosmological model for a cloud string with bulk viscosity are studied. To obtain a determinate solution, it is assumed that the coefficient of bulk viscosity is a power function of the scalar of expansion ζ = kθm and the shear scalar is proportional to scalar of expansion σ∝θ, which leads to the relation between metric potentials B = Cn. The physical features of the model are also discussed. It is found that the power index m has significant influence on the string model. There is a ``big bang'' start in the model when m≤1 but there is no the big-bang start when m>1. In the special case m = 0, the model reduces to the string model of constant coefficient of bulk viscosity that was the result previously given in the literature.

The Bianchi type III cosmological model for a cloud string with bulk viscosity are presented. To obtain a determinate model, an equation of state and a relation between metric potentials are assumed. The physical and geometric aspects of the model are also discussed. The model describes a shearing non-rotating continuously expanding universe with a big-bang start, and the relation between the coefficient of bulk viscosity and the energy density is .

Some locally rotationally symmetric Bianchi type-I cosmological solutions for a cloud string with bulk viscosity are presented. In the first case, an equation of state ρ = kλ and the relation between metric potentials R = ASn are considered, and the solution represents shearing non-rotating model with the bulk viscosity ζ∝ρ1/2, where ρ is the rest energy density of the cloud of strings with particles attached to them, λ is the tension density of the cloud of strings, ζ is the coefficient of the bulk viscosity, R and S are only the functions of time t, while A and k are constant. In the second case, the constant coefficient of bulk viscosity is considered.

The Bianchi type-III cosmological model for a cloud string in the presence of bulk viscosity and magnetic field are presented. To obtain the determinate model it is assumed that there is an equation of state ρ = kλ and the scalar of expansion is proportional to the shear scalar θσ, which leads to a relation between metric potentials B = mCn. The physical and geometric aspects of the model are also discussed. The model describes a shearing non-rotating continuously expanding universe with a big-bang start. In the absence of magnetic field, it reduces to the string model with bulk viscosity that was previously given in the literature.

A locally rotationally symmetric (LRS) Bianchi type-I string cosmological model with bulk viscosity is investigated. To obtain a determinate solution, it is assumed that the coefficient of bulk viscosity is a power function of the energy density ζ = ζ0ρm and the scalar of expansion is proportional to the shear scalar θ∝σ, which leads to a relation between metric potentials R = ASn, where R and S are only the functions of time. The physical and geometrical aspects of the model are also discussed. The solution includes some results previously given in the literature as special cases.

The locally rotationally symmetric Bianchi-type II string cosmological models with bulk viscosity are obtained, where an equation of state, , and a relation between metric potentials, , are adopted. The physical features of the models are also discussed. In special cases the model reduces to the string models without viscosity that was previously given in the literatures.

Some more general cosmological solutions of Bianchi types II, VIII, and IX for a cloud string are presented. The physical implications of the solutions are briefly discussed. Our solutions include some of the results previously given in the literature as special cases.

Plasmodium sporozoites suppress the respiratory burst and antigen presentation of Kupffer cells, which are regarded as the portal of invasion into hepatocytes. It is not known whether immune modulation of Kupffer cells can affect the liver stage. In the present study, we found that sporozoites inoculated into Wistar rats could be detected in the liver, spleen, and lung; however, most sporozoites were arrested in the liver. Sporozoites were captured by Kupffer cells lined with endothelial cells in the liver sinusoid before hepatocyte invasion. Pretreatment with TLR3 agonist poly(I:C) and TLR2 agonist BCG primarily activated Kupffer cells, inhibiting the sporozoite development into the exoerythrocytic form, whereas Kupffer cell antagonists dexamethasone and cyclophosphamide promoted development of the liver stage. Our data suggests that sporozoite development into its exoerythrocytic form may be associated with Kupffer cell functional status. Immune modulation of Kupffer cells could be a promising strategy to prevent malaria parasite infection.

This paper gives a general solution of the 5-dimensional Bianchi-V type cosmological model for a perfect fluid with equation of state P = (γ−1) ρ and discusses two particular solutions for γ = 3 2 and γ = 1 2 . Both solutions tend in time to the 5-dimensional model of isotropic expansion. The character of the singularity is also examined.

A new spherically symmetric interior solution in higher dimensions is presented by specifying mass density, i.e. k2 ρ = A + Br2. The solution includes the Schwarzschild-like solution as a special case and can reduce to the interior Mehra solution when the number of dimension is four.

Aims: The aim of this study is to investigate whether angiotensin-converting enzyme inhibitor (ACEI) therapy with ramipril could augment circulating endothelial progenitor cells (EPCs) with enhanced functional activity in patients with stable coronary artery diseases. Methods and results: 20 patients with angiographically documented stable coronary artery disease (CAD) were prospectively treated with 5 mg of ramipril per day for 4 weeks. Before and weekly after the initiation of ramipril therapy, EPCs were isolated from peripheral blood and counted. Ramipril treatment of patients with stable CAD was associated with an approximately 1.5-fold increase in the number of circulating EPCs by 1 week after initiation of treatment; this was followed by sustained increased levels to approximately 2.5-fold throughout the 4-week study period. In addition, ramipril treatmen was associated with increases in the functional activity of EPCs, as assessed by their proliferation, migration, adhesion and in vitro vasculogenesis capacity. Conclusion: The results of the present study define a novel mechanism of action of ACEI treatment in patients with stable CAD: the augmentation of circulating EPCs with enhanced functional activity. Given the well-established role of EPCs of participating in repair after ischemic injury, stimulation of EPCs by ACEI may contribute to the clinical benefit of ACEI therapy in patients with CAD.

In this paper, the static and dynamic analyses of tall buildings are studied as the space system by the application of “JIGFEX-II” programme. Suggestions have been made for the calculation of earthquake forces and torques. Besides that, a practical approach is proposed for realizing the analysis of complicated structures on minicomputers or on medium sized computers. Reference data and charts from practical engineering applications are also presented.

A new interior Reissner-Nordstrom solution is presented. The solution includes the Florides' solution as a special case and can reduce to the Wyman's interior solution in the limit of vanishing charge.

An exact solution of the field equations of general relativity is obtained for a static, spherically symmetric distribution of charge and mass. Their physical properties are studied in some detail. Our solution includes as special cases the results given previously by Cooperstock and De La Cruz, Mehra and Bohra, Santos, and Shi-Chang.

ObjectivesThe goal of this study was to investigate the feasibility, safety, and initial clinical outcome of intravenous infusion of autologous endothelial progenitor cells (EPCs) in patients with idiopathic pulmonary arterial hypertension (IPAH).BackgroundExperimental data suggest that transplantation of EPCs attenuates monocrotaline-induced pulmonary hypertension in rats and dogs. In addition, clinical studies suggest that autologous progenitor cell transplantation is feasible and safe in patients with ischemic diseases.MethodsWe conducted a prospective, randomized trial comparing the effects of EPC transplantation plus conventional therapy with those of conventional therapy alone in patients with IPAH. The primary end point was change in the 6-min walk distance using a standardized protocol. The secondary end points were changes in hemodynamic variables as assessed by right heart catheterization.ResultsAfter 12 weeks of follow-up, the mean distance walked in 6 min increased by 48.2 m in the cell infusion group (from 263 ± 42 m to 312 ± 34 m), and an increase of 5.7 m occurred in the conventional therapy group (from 264 ± 42 m to 270 ± 44 m). The mean difference between the 2 groups was 42.5 m (95% confidence interval 28.7 to 56.3 m, p < 0.001). The patients in the cell infusion group also had significant improvement in mean pulmonary artery pressure, pulmonary vascular resistance, and cardiac output. There were no severe adverse events with cell infusion.ConclusionsThis preliminary study showed that intravenous infusion of autologous EPCs seemed to be feasible and safe, and might have beneficial effects on exercise capacity and pulmonary hemodynamics in patients with IPAH. (Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension; http://www.clinicaltrials.gov/ct/show/NCT00257413?order=1; NCT00257413).

Previously the calculation of plate on semi-unlimited elastic ground carried out by method of finite elements is first to take flexibility matrix of ground for finding its inversion values and therefrom to get stiffness matrix of ground; and then to be added to stiffness matrix of plate to obtain the total stiffness matrix; and finally, the deformation and internal force of plate is solved. This paper presents a suggestion of a kind of new method of finite element. On base of equilibrium equation of plate and conditions of co-ordination of plate and ground deformation, let the reaction of ground and angle rotation of plate be as unknown values, it can be directly to establish equtions without necessity of previous processing for finding out matrix inversion values for flexibility matrix of ground, and hence, a great save of work load of computation. This method can also be extended to the uses of calculations of shallow spherical shell on semi-unlimited elastic ground, and thus, can be deemed as a presentation of theoretic base for designing shell foundations in sectors of building engineering.