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The Inquiry-Based approach to Science Education (IBSE) is presented in scienti#c literature (Hake, 1998; Sharma et al., 2010) and in research projects reports (e.g. ESTABLISH, 2010; SAILS, 2014) as a credible solution to the reported lack of ef#cacy of more ‘traditional’ educative approaches, especially when focused on Research and Innovation (RRI) (Sutcliffe, 2006; IRRESISTIBLE, 2013; Ark of Inquiry, 2013). IBSE is an inductive approach to science teaching that considers direct experience at the center of learning. IBSE activities and strategies actively involve students in the identi#cation of relevant evidence, in critical and logical reasoning on the evidence collected and in re+ection on their interpretation. Students learn to conduct investigations, but are also led by the teachers to understand the typical processes scientists use to build knowledge. IBSE strategies are credited to improve student understanding in many conceptual #elds, due to their strongly contextualized nature, that focuses on the interdependence of situation and cognition, and on the ways they facilitate learning processes (Fazio, 2020) info:eu-repo/semantics/publishedVersion

It is widely acknowledged today that an Inquiry-Based approach to Research and Innovation processes can improve the interest of students in studying scientific topics. Such approaches can enable students to have the opportunity to interact with cutting edge topics, research results and work with researchers and other societal actors to better align research processes and their outcomes with the values, needs and expectations of today's society. However, there is still no clear consensus between researchers about the impact that inquiry-based approaches have on the student scientific knowledge and conceptual understanding at different ages and cultural levels. This paper discusses these aspects from a vertical and interdisciplinary curriculum perspective. Firstly, the impact of a series of inquiry-based learning activities on the acquisition of scientific knowledge and in the development of pupils' positive attitudes toward science in pupils aged 10–13 is discussed. Secondly, a discussion on important preconditions needed for an introduction of cutting-edge topics to the classroom, and the role of the inquiry that has to be offered to students to effectively construct knowledge is considered at the pre-university level. Following this, an approach adopted by three large scale European projects (ESTABLISH, SAILS and OSOS) that focus on enhancing science education curricula, pedagogy and assessment practices and supporting science educators in embedding Inquiry-Based Education or Responsible Research and Innovation principles in science education is presented. Finally, an innovative Doctoral Degree in Sustainability Science, which seeks transformative education that challenges the attitudes of both professors and students is presented and some of its most relevant aspects are discussed.