1. Histopathological analysis of chronic gastritis and correlation of pathological features with each other and with endoscopic findings
- Author
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Ajit Sood, Vineeta Malhotra, Bhavna Garg, Vineet Sandhu, and Neena Sood
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Chronic gastritis ,Endoscopy, Gastrointestinal ,Helicobacter Infections ,Pathology and Forensic Medicine ,Epithelial Damage ,Gastric glands ,medicine ,Humans ,Inflammation ,Helicobacter pylori ,biology ,business.industry ,Intestinal metaplasia ,Histology ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,Gastritis ,Chronic Disease ,Female ,medicine.symptom ,Chronic Inflammatory Infiltrate ,business - Abstract
Chronic gastritis is a very common disorder which is commonly caused by Helicobacter pylori. Histopathological examination is the mainstay of the diagnosis. We evaluated 300 gastric antral biopsies using revised Sydney system and concluded that it helps to analyse gastric biopsies in a very comprehensive manner. It was seen that H. pylori, chronic inflammatory infiltrate, neutrophilic infiltration, presence of lymphoid follicles and aggregates and surface epithelial damage are strongly associated with each other. The presence of one of these histological feature is a strong indicator for presence of other features. On the other hand intestinal metaplasia and atrophy of gastric glands was not associated with the above mentioned histological features. In the presence of dense chronic inflammation and infiltration by neutrophils one should carefully search for H. pylori organism. We also correlated histological features with endoscopy and found that cases of duodenal ulcer had more severe antral gastritis on histology as compared to those with hyperemia or antral erosions.
- Published
- 2012
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