Search

Your search keyword '"Villari, Donata"' showing total 11 results
Start Over Author "Villari, Donata" Database OpenAIRE
11 results on '"Villari, Donata"'

5. Gender-related health in tuscany

Author

Abbate, Rosanna, Bruni, Vincenzina, Buselli, Rodolfo, Tommaso, Mariarosa Di, Fisher, Alessandra Daphne, Gensini, Gianfranco, Maggi, Mario, Mazzei, Teresita, and Villari, Donata

Subjects
Gender
Published
2015

9. IMPACT OF GENDER IN NEPHRON-SPARING SURGERY: COMPARISON OF PERIOPERATIVE AND PATHOLOGICAL OUTCOMES FROM THE DEFINITIVE RESULTS OF RECORD1 PROJECT

Author

Mari, Andrea, Villari, Donata, Sessa, Francesco, Antonelli, Alessandro, Riccardo Bertolo, Bianchi, Giampaolo, Bigazzi, Barbara, Longo, Nicola, Martorana, Giuseppe, Mirone, Vincenzo, Morgia, Giuseppe, Porpiglia, Francesco, Rocco, Bernardo, Rovereto, Bruno, Schiavina, Riccardo, Simeone, Claudio, Sodano, Mario, Volpe, Alessandro, Novara, Giacomo, Serni, Sergio, Carini, Marco, Minervini, Andrea, Mari, Andrea, Villari, Donata, Sessa, Francesco, Antonelli, Alessandro, Bertolo, Riccardo, Bianchi, Giampaolo, Bigazzi, Barbara, Longo, Nicola, Martorana, Giuseppe, Mirone, Vincenzo, Morgia, Giuseppe, Porpiglia, Francesco, Rocco, Bernardo, Rovereto, Bruno, Schiavina, Riccardo, Simeone, Claudio, Sodano, Mario, Volpe, Alessandro, Novara, Giacomo, Serni, Sergio, Carini, Marco, and Minervini, Andrea

Subjects
RECORD1, fungi, NEPHRON-SPARING SURGERY, RECORD1 PROJECT, IMPACT OF GENDER IN NEPHRON-SPARING SURGERY: COMPARISON OF PERIOPERATIVE AND PATHOLOGICAL OUTCOMES FROM THE DEFINITIVE RESULTS OF RECORD1 PROJECT

10. Is partial nephrectomy safe and effective in the setting of frail comorbid patients affected by renal cell carcinoma? Insights from the RECORD 2 multicentre prospective study

Author

Alessandro Antonelli, Vincenzo Ficarra, Riccardo Tellini, Francesco Porpiglia, Andrea Mari, Marco Allasia, Umberto Capitanio, Fabrizio Di Maida, Claudio Simeone, Marco Carini, Eugenio Brunocilla, Sebastiano Nazzani, Nicola Longo, Giancarlo Marra, Donata Villari, Francesco Montorsi, Angelo Porreca, Carlo Terrone, Riccardo Schiavina, Bernardo Rocco, Paolo Gontero, M. Barale, Andrea Gallioli, Andrea Minervini, Gontero, Paolo, Mari, Andrea, Marra, Giancarlo, Nazzani, Sebastiano, Allasia, Marco, Antonelli, Alessandro, Barale, Maurizio, Brunocilla, Eugenio, Capitanio, Umberto, Di Maida, Fabrizio, Gallioli, Andrea, Longo, Nicola, Montorsi, Francesco, Porpiglia, Francesco, Porreca, Angelo, Rocco, Bernardo, Simeone, Claudio, Schiavina, Riccardo, Tellini, Riccardo, Terrone, Carlo, Villari, Donata, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, Gontero P., Mari A., Marra G., Nazzani S., Allasia M., Antonelli A., Barale M., Brunocilla E., Capitanio U., Di Maida F., Gallioli A., Longo N., Montorsi F., Porpiglia F., Porreca A., Rocco B., Simeone C., Schiavina R., Tellini R., Terrone C., Villari D., Ficarra V., Carini M., and Minervini A.

Subjects
Male, medicine.medical_specialty, Frailty, Life expectancy, Nephron-sparing surgery, Partial nephrectomy, Renal cell carcinoma, Robot-assisted partial nephrectomy, Urology, medicine.medical_treatment, Population, 030232 urology & nephrology, Renal function, Aged, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Nephrectomy, Postoperative Complications, Prospective Studies, Treatment Outcome, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Kidney surgery, Prospective cohort study, education, education.field_of_study, business.industry, Carcinoma, Postoperative complication, Renal Cell, Perioperative, renal carcinoma, medicine.disease, Oncology, 030220 oncology & carcinogenesis, business
Abstract

Background: To investigate the perioperative and morbidity outcomes after partial nephrectomy (PN) in patients with short life expectancy (SLE) (≥95% 10-year expected mortality (10y-EM)), to assess the main predictors of outcomes in this population and to compare these results with those of a group at the opposite upper range with long LE (LLE, ≤5% 10y-EM) relying on a multicenter Italian prospective registry of kidney surgery (the RECORD 2 project). Methods: Clinical data of 4,325 patients undergone kidney surgery were collected at 26 urological Italian Centers from 2013 to 2016. SLE was defined as a ≥95% 10y-EM (assessed using the age-adjusted Charlson comorbidity index [CCI]). A multivariable logistic regression for overall postoperative complications, acute kidney injury (AKI), positive surgical margins (SM) and ∆ estimated glomerular filtration rate (eGFR) ≥25% at 2 years from surgery was performed in patients with SLE including clinically relevant variables. Adjusted outcomes reported as mean (SD) of the 2 groups were generated using separate multivariable logistic regression models and compared. Results: Overall, 559 patients with SLE were selected. Patients had an ASA score ≥3 in 58.4% of cases. A clinical T1a, T1b, and T2 stage was found in 412 (74.5%), 124 (22.4%), and 17 (3.1%) patients. The median PADUA score was 7 (6–8). Surgical and medical postoperative complication rates were registered in 14.8% and 6% cases. Postoperative AKI was reported in 27.3% cases, positive surgical margins (PSM) in 9.3% cases. In this subgroup of patients, ASA score, cerebrovascular disease, surgery in low volume centers, and open surgery were independent predictors of overall complications. ASA and PADUA scores, renal clamping, resection technique and lower eGFR at baseline were independent predictors of AKI. PADUA score, open approach and resection technique were independent predictors of PSM. Cardiovascular disease, hilar clamping, and resection technique were independent predictors of eGFR decrease >25% at 2 years from surgery. Patients with SLE were compared with those with LLE (n = 302). All analyzed parameters at baseline were significantly different among the groups with the exception of cancer laterality. After adjusting for several clinical variables, the SLE group had a significantly higher risk rate of adjusted overall postoperative complication rate compared to the LLE group (20.6% ± 0.36 vs. 9.9% ± 0.65, P < 0.0001), while the overall intraoperative complications (4.1% ±0.13 vs. 2.3% ± 0.23), overall postoperative major complications (3.8% ± 0.09 vs. 1.9% ± 0.14) adjusted AKI (24.2% ± 0.37 vs. 22.6% ± 0.92), positive surgical margins (8% ± 0.22 vs. 6.4% ± 0.49), and 2-year RF loss (13.4% ± 0.17 vs. 12.4% ± 0.74). Conclusion: In selected patients with SLE, PN is feasible with an acceptable safety profile that is overall comparable to patients with no LE limitations. While a robotic approach and surgery performed in high volume centers could reduce the risk of complications, an off-clamp approach and a SE surgical technique may decrease the risk of postoperative AKI and of longer term eGFR decrease.

Published
2021

11. Predicting positive surgical margins in partial nephrectomy: A prospective multicentre observational study (the RECORd 2 project)

Author

Riccardo Schiavina, Andrea Mari, Lorenzo Bianchi, Daniele Amparore, Alessandro Antonelli, Walter Artibani, Eugenio Brunocilla, Umberto Capitanio, Cristian Fiori, Fabrizio Di Maida, Paolo Gontero, Alessandro Larcher, Vincenzo Li Marzi, Nicola Longo, Giancarlo Marra, Emanuele Montanari, Francesco Porpiglia, Marco Roscigno, Claudio Simeone, Salvatore Siracusano, Riccardo Tellini, Carlo Terrone, Donata Villari, Vincenzo Ficarra, Marco Carini, Andrea Minervini, Vincenzo Altieri, Francesco Berardinelli, Marco Borghesi, Carlo Andrea Bravi, Pierluigi Bove, Giovanni Enrico Cacciamani, Riccardo Campi, Antonio Celia, Elisabetta Costantini, Luigi Da Pozzo, Mario Falsaperla, Matteo Ferro, Maria Furlan, Simone Sforza, Francesco Marson, Francesco Montorsi, Sebastiano Nazzani, Angelo Porreca, Giorgio Ivan Russo, Luigi Schips, Cesare Selli, Alchiede Simonato, Carlo Trombetta, Schiavina R, Mari A, Bianchi L, Amparore D, Antonelli A, Artibani W, Brunocilla E, Capitanio U, Fiori C, Di Maida F, Gontero P, Larcher A, Li Marzi V, Longo N, Marra G, Montanari E, Porpiglia F, Roscigno M, Simeone C, Siracusano S, Tellini R, Terrone C, Villari D, Ficarra V, Carini M, Minervini A, Collaborators, Schiavina R., Mari A., Bianchi L., Amparore D., Antonelli A., Artibani W., Brunocilla E., Capitanio U., Fiori C., Di Maida F., Gontero P., Larcher A., Li Marzi V., Longo N., Marra G., Montanari E., Porpiglia F., Roscigno M., Simeone C., Siracusano S., Tellini R., Terrone C., Villari D., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Borghesi M., Bravi C.A., Bove P., Cacciamani G.E., Campi R., Celia A., Costantini E., Da Pozzo L., Falsaperla M., Ferro M., Furlan M., Marson F., Montorsi F., Nazzani S., Porreca A., Russo G.I., Schips L., Selli C., Simonato A., Trombetta C., Schiavina, R., Mari, A., Bianchi, L., Amparore, D., Antonelli, A., Artibani, W., Brunocilla, E., Capitanio, U., Fiori, C., Di Maida, F., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Marra, G., Montanari, E., Porpiglia, F., Roscigno, M., Simeone, C., Siracusano, S., Tellini, R., Terrone, C., Villari, D., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Borghesi, M., Bravi, C. A., Bove, P., Cacciamani, G. E., Campi, R., Celia, A., Costantini, E., Da Pozzo, L., Falsaperla, M., Ferro, M., Furlan, M., Sforza, S., Marson, F., Montorsi, F., Nazzani, S., Porreca, A., Russo, G. I., Schips, L., Selli, C., Simonato, A., Trombetta, C., Schiavina, Riccardo, Mari, Andrea, Bianchi, Lorenzo, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Brunocilla, Eugenio, Capitanio, Umberto, Fiori, Cristian, Di Maida, Fabrizio, Gontero, Paolo, Larcher, Alessandro, Li Marzi, Vincenzo, Longo, Nicola, Marra, Giancarlo, Montanari, Emanuele, Porpiglia, Francesco, Roscigno, Marco, Simeone, Claudio, Siracusano, Salvatore, Tellini, Riccardo, Terrone, Carlo, Villari, Donata, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, and Trombetta, Carlo

Subjects
Male, Neoplasm, Residual, Databases, Factual, multicenter prospective observational study, medicine.medical_treatment, 030232 urology & nephrology, Nephron-sparing surgery, Nephrectomy, Nomogram, 0302 clinical medicine, Renal cell carcinoma, Risk Factors, clinical predictor, Partial nephrectomy, Prospective Studies, Stage (cooking), Prospective cohort study, Surgical margins, Nephron-sparing surgery, Nomogram, Partial nephrectomy, Renal cell carcinoma, Robot-assisted partial nephrectomy, Surgical margins, Robot-assisted partial nephrectomy, Margins of Excision, General Medicine, Middle Aged, Kidney Neoplasms, Hospitals, Oncology, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Area Under Curve, Residual, Female, positive surgical margin, Positive Surgical Margin, Elective Surgical Procedure, medicine.medical_specialty, Hospitals, Low-Volume, High-Volume, 03 medical and health sciences, Databases, Internal medicine, Low-Volume, medicine, Humans, Neoplasm Invasiveness, Carcinoma, Renal Cell, Factual, Aged, Neoplasm Staging, business.industry, Carcinoma, Renal Cell, medicine.disease, Nomograms, Settore MED/24, Logistic Models, ROC Curve, Neoplasm, Surgery, Observational study, business, Hospitals, High-Volume
Abstract

PURPOSE: to evaluate clinical predictors of positive surgical margins (PSMs) in a large multicenter prospective observational study and to develop a clinic nomogram to predict the likelihood of PSMs after partial nephrectomy (PN). MATERIALS AND METHODS: We prospectively evaluated 4308 patients who had surgical treatment for renal tumors between January 2013 and December 2016 at 26 urological Italian Centers (RECORd 2 project). Two multivariable logistic models were evaluated to predict the likelihood of PSMs. Center caseload was dichotomized using a visual assessment adjusted for several predictors of PSMs. A nomogram predicting PSMs was developed. RESULTS: Overall, 2076 patients treated with PN were evaluated. pT1a, pT1b, pT2 and pT3a were recorded in 68.7%, 22.6%, 2.1% and 6.6% of the patients, respectively. PSMs were recorded in 342 (16.5%) patients. From a null multivariable model against number of PN/year, 60 PN/year were identified as the best cut-off to define a high-volume centre. At multivariable analysis, clinical stage (cT1a vs. cT2 [OR 1.94]; p = 0.03), volume centre (≤60 PN/year) (OR 2.22; p

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results