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10 results on '"Villard C"'

1. Primary brain cells organisation on multi-rigidities substrates

Author

Tomba, C., Villard, C., Nicolas, A., Laboratoire des technologies de la microélectronique (LTM ), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Clot, Marielle

Subjects
[SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

2. Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications

Author

Correard F, Maximova K, Estève MA, Villard C, Roy M, Al-Kattan A, Sentis M, Gingras M, Kabashin AV, and Braguer D

Subjects
Medicine (General), R5-920
Abstract

Florian Correard,1,2 Ksenia Maximova,3 Marie-Anne Estève,1,2 Claude Villard,1 Myriam Roy,4 Ahmed Al-Kattan,3 Marc Sentis,3 Marc Gingras,4 Andrei V Kabashin,3 Diane Braguer1,2 1Aix Marseille Université, INSERM, CR02 UMR_S911, Marseille, France; 2APHM, Hôpital Timone, Marseille, France; 3Aix Marseille Université, CNRS, LP3 UMR 7341, Marseille, France; 4Aix Marseille Université, CNRS, CINAM, UMR 7325 Marseille, France Abstract: Due to excellent biocompatibility, chemical stability, and promising optical properties, gold nanoparticles (Au-NPs) are the focus of research and applications in nanomedicine. Au-NPs prepared by laser ablation in aqueous biocompatible solutions present an essentially novel object that is unique in avoiding any residual toxic contaminant. This paper is conceived as the next step in development of laser-ablated Au-NPs for future in vivo applications. The aim of the study was to assess the safety, uptake, and biological behavior of laser-synthesized Au-NPs prepared in water or polymer solutions in human cell lines. Our results showed that laser ablation allows the obtaining of stable and monodisperse Au-NPs in water, polyethylene glycol, and dextran solutions. The three types of Au-NPs were internalized in human cell lines, as shown by transmission electron microscopy. Biocompatibility and safety of Au-NPs were demonstrated by analyzing cell survival and cell morphology. Furthermore, incubation of the three Au-NPs in serum-containing culture medium modified their physicochemical characteristics, such as the size and the charge. The composition of the protein corona adsorbed on Au-NPs was investigated by mass spectrometry. Regarding composition of complement C3 proteins and apolipoproteins, Au-NPs prepared in dextran solution appeared as a promising drug carrier. Altogether, our results revealed the safety of laser-ablated Au-NPs in human cell lines and support their use for theranostic applications. Keywords: protein corona, nanocarrier, cytotoxicity, green chemistry, neuroblastoma, glioblastoma

Published
2014

5. Applications of Coated Conductors in FCL's

Author

Tixador, Pascal, Cointe, Yannick, Villard, C., Usoskin, A., Centre de Recherches sur les Très Basses Températures (CRTBT), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF), Laboratoire de Génie Electrique de Grenoble (G2ELab), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), and Garcia, Sylvie

Subjects
[SPI.NRJ]Engineering Sciences [physics]/Electric power, ComputingMilieux_MISCELLANEOUS, [SPI.NRJ] Engineering Sciences [physics]/Electric power
Abstract

International audience

Published
2006

6. DC superconducting fault current limiter

Author

Cointe, Yannick, Hadjsaid, Nouredine, Tixador, Pascal, Villard, C., Laboratoire de Génie Electrique de Grenoble (G2ELab), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Centre de Recherches sur les Très Basses Températures (CRTBT), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF), and Garcia, Sylvie

Subjects
[SPI.NRJ]Engineering Sciences [physics]/Electric power, ComputingMilieux_MISCELLANEOUS, [SPI.NRJ] Engineering Sciences [physics]/Electric power
Abstract

International audience

Published
2005

7. Limitation of dc currents by YBa2Cu3O7-Δ/Au superconducting films

Author

Villard, C., Peroz, C., Guinand, Benjamin, Tixador, Pascal, Centre de Recherches sur les Très Basses Températures (CRTBT), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF), Laboratoire de Génie Electrique de Grenoble (G2ELab), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Garcia, Sylvie, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )

Subjects
[SPI.NRJ]Engineering Sciences [physics]/Electric power, ComputingMilieux_MISCELLANEOUS, [SPI.NRJ] Engineering Sciences [physics]/Electric power
Abstract

International audience

Published
2005

8. On the origin of the irreversibility line in thin YBaCuO7 films with and without columnar defects

Author

Prozorov, R., Konczykowski, M., Schmidt, B., Yeshurun, Y., Shaulov, A., Villard, C., and Koren, G.

Subjects
Superconductivity (cond-mat.supr-con), Condensed Matter::Superconductivity, Condensed Matter - Superconductivity, FOS: Physical sciences
Abstract

We report on measurements of the angular dependence of the irreversibility temperature $T_{irr}(\theta) $ in $YBa_2Cu_3O_{7-\delta }$ thin films, defined by the onset of a third harmonic signal and measured by a miniature Hall probe. From the functional form of $T_{irr}(\theta)$ we conclude that the origin of the irreversibility line in unirradiated films is a dynamic crossover from an unpinned to a pinned vortex liquid. In irradiated films the irreversibility temperature is determined by the trapping angle., Comment: 19 pages, LaTex, 6 PostScript figures; Author's Homepage: http://www.biu.ac.il:80/~prozorr

Published
1996

10. Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Author

Philippe Chavrier, Mathieu Maurin, Mabel San Roman, Claudio Tripodo, Clotilde Cadart, Catherine Villard, Nicolas Manel, Giorgio Scita, Matteo Gentili, Jérôme Galon, Sonia Agüera-Gonzalez, Rodrigo Nalio Ramos, Catalina Lodillinsky, Ayako Yamada, Andrea Palamidessi, Fiona Routet, Alice Williart, Matthieu Gratia, Emilie Lagoutte, Valeria Cancila, Guilherme Pedreira de Freitas Nader, Jean-Louis Viovy, Matthieu Piel, Piel, Matthieu, Centre de recherche de l'Institut Curie [Paris], Institut Curie [Paris], Università degli studi di Palermo - University of Palermo, University of California (UC), IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Massachusetts Institute of Technology (MIT), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Nader G.P.D.F., Aguera-Gonzalez S., Routet F., Gratia M., Maurin M., Cancila V., Cadart C., Palamidessi A., Ramos R.N., San Roman M., Gentili M., Yamada A., Williart A., Lodillinsky C., Lagoutte E., Villard C., Viovy J.-L., Tripodo C., Galon J., Scita G., Manel N., Chavrier P., and Piel M.

Subjects
Senescence, Exonuclease, DNA damage, Nuclear Envelope, [SDV]Life Sciences [q-bio], Breast Neoplasms, Biology, Settore MED/08 - Anatomia Patologica, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, medicine, Settore MED/05 - Patologia Clinica, Animals, Humans, Neoplasm Invasiveness, Epithelial–mesenchymal transition, Cellular Senescence, Endoplasmic reticulum, Phosphoproteins, Xenograft Model Antitumor Assays, Cell biology, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Exodeoxyribonucleases, Cancer cell, Proteolysis, biology.protein, TREX1, nuclear envelope rupture, DNA damage, mammary duct carcinoma, tumor invasion, senescence, breast cancer, cGAS, confinement, epithelial to mesenchymal transition, Animals, Breast Neoplasms, Cell Line, Cellular Senescence, Collagen, Disease Progression, Exodeoxyribonucleases, Female, Humans, Mice, Neoplasm Invasiveness,Nuclear Envelope, Phosphoproteins,Proteolysis, Xenograft Model Antitumor Assays, DNA Damage, Disease Progression, Female, Collagen, Nucleus, Extracellular Matrix Degradation, DNA Damage
Abstract

Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we show that nuclear envelope ruptures induce DNA damage that promotes senescence in non-transformed cells and induces an invasive phenotype in human breast cancer cells. We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1-dependent DNA damage, thereby driving the progression of in situ carcinoma to the invasive stage. DNA damage and nuclear envelope rupture markers were also enriched at the invasive edge of human tumors. We propose that DNA damage in mechanically challenged nuclei could affect the pathophysiology of crowded tissues by modulating proliferation and extracellular matrix degradation of normal and transformed cells.

Published
2021

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